Peringatan Keamanan

Topically applied calcipotriene can be absorbed in sufficient amounts to produce systemic effects. Elevated serum calcium has been observed with excessive use of calcipotriene.

Calcipotriol

DB02300

small molecule approved

Deskripsi

Calcipotriol (INN) or calcipotriene (USAN) is a sythetic derivative of calcitriol or Vitamin D.

Struktur Molekul 2D

Berat 412.6047
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Clinical studies with radiolabeled ointment indicate that approximately 6% (+3%, SD) of the applied dose of calcipotriene is absorbed systemically when the ointment is applied topically to psoriasis plaques or 5% (+2.6%, SO) when applied to normal skin.

Metabolisme

Hepatic. Calcipotriene metabolism following systemic uptake is rapid, and occurs via a similar pathway to the natural hormone. The primary metabolites are much less potent than the parent compound.

Rute Eliminasi

The active form of the vitamin, 1,25-dihydroxy vitamin D3 (calcitriol), is known to be recycled via the liver and excreted in the bile. There is evidence that maternal 1,25-dihydroxy vitamin D3 (calcitriol) may enter the fetal circulation, but it is not known whether it is excreted in human milk.

Interaksi Obat

17 Data
Calcium acetate The risk or severity of adverse effects can be increased when Calcipotriol is combined with Calcium acetate.
Calcium glucoheptonate The risk or severity of adverse effects can be increased when Calcipotriol is combined with Calcium glucoheptonate.
Calcium chloride The risk or severity of adverse effects can be increased when Calcipotriol is combined with Calcium chloride.
Calcium The risk or severity of adverse effects can be increased when Calcipotriol is combined with Calcium.
Calcium carbonate The risk or severity of adverse effects can be increased when Calcipotriol is combined with Calcium carbonate.
Calcium citrate The risk or severity of adverse effects can be increased when Calcipotriol is combined with Calcium citrate.
Calcium gluconate The risk or severity of adverse effects can be increased when Calcipotriol is combined with Calcium gluconate.
Calcium Phosphate The risk or severity of adverse effects can be increased when Calcipotriol is combined with Calcium Phosphate.
Calcium glubionate anhydrous The risk or severity of adverse effects can be increased when Calcipotriol is combined with Calcium glubionate anhydrous.
Calcium lactate The risk or severity of adverse effects can be increased when Calcipotriol is combined with Calcium lactate.
Calcium lactate gluconate The risk or severity of adverse effects can be increased when Calcipotriol is combined with Calcium lactate gluconate.
Calcium pangamate The risk or severity of adverse effects can be increased when Calcipotriol is combined with Calcium pangamate.
Calcium levulinate The risk or severity of adverse effects can be increased when Calcipotriol is combined with Calcium levulinate.
Calcium cation The risk or severity of adverse effects can be increased when Calcipotriol is combined with Calcium cation.
Calcium polycarbophil The risk or severity of adverse effects can be increased when Calcipotriol is combined with Calcium polycarbophil.
Phenytoin The serum concentration of Calcipotriol can be decreased when it is combined with Phenytoin.
Fosphenytoin The serum concentration of Calcipotriol can be decreased when it is combined with Fosphenytoin.

Target Protein

Vitamin D3 receptor VDR

Referensi & Sumber

Synthesis reference: Andrzej Kutner, Michal Chodynski, Teresa Ryznar, Hanna Fitak, Jerzy Winiarski, Bartlomiej Gorecki, Agnieszka Burzynska, Wieslaw Szelejewski, "Process for Preparation of Pharmaceutically Pure Anhydrous Calcipotriol." U.S. Patent US20080214876, issued September 04, 2008.

Contoh Produk & Brand

Produk: 74 • International brands: 1
Produk
  • Calcipotriene
    Cream • 50 ug/1g • Topical • US • Generic • Approved
  • Calcipotriene
    Solution • 0.05 mg/1mL • Topical • US • Generic • Approved
  • Calcipotriene
    Ointment • 0.05 mg/1g • Topical • US • Generic • Approved
  • Calcipotriene
    Solution • 0.05 mg/1mL • Topical • US • Generic • Approved
  • Calcipotriene
    Solution • 0.05 mg/1mL • Topical • US • Generic • Approved
  • Calcipotriene
    Solution • 0.05 mg/1mL • Topical • US • Generic • Approved
  • Calcipotriene
    Cream • 0.05 mg/1g • Topical • US • Generic • Approved
  • Calcipotriene
    Cream • 50 ug/1g • Topical • US • Generic • Approved
Menampilkan 8 dari 74 produk.
International Brands
  • Daivonex

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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