Coenzyme A

DB01992

small molecule investigational nutraceutical

Deskripsi

Coenzyme A (CoA, CoASH, or HSCoA) is a coenzyme, well known for it's role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric acid cycle. All genomes sequenced to date encode enzymes that use coenzyme A as a substrate, and around 4% of cellular enzymes use it, or a thioester form of it, as a substrate. It is used as a supplement for the hypothetical treatment of acne.

Struktur Molekul 2D

Berat 767.534

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) -

Volume Distribusi -

Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

0 Data

Tidak ada data.

Target Protein

3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR

Carnitine O-acetyltransferase CRAT

Galactoside O-acetyltransferase lacA

Fatty acid metabolism regulator protein fadR

Histone acetyltransferase KAT5 KAT5

2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase dapD

Acetyl-CoA acetyltransferase, cytosolic ACAT2

Acetyl-CoA acetyltransferase phbA

Streptogramin A acetyltransferase vatD

Citrate synthase, mitochondrial CS

3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH

Formyl-CoA:oxalate CoA-transferase frc

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

Pantothenate kinase coaA

Acetyl-coenzyme A synthetase acs

Acyl-CoA-binding protein DBI

Formyl-CoA:oxalate CoA-transferase frc

L-carnitine CoA-transferase caiB

Formate acetyltransferase 1 pflB

Malate synthase G glcB

3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA

Phosphopantetheine adenylyltransferase coaD

Holo-[acyl-carrier-protein] synthase acpS

Spermidine/spermine N(1)-acetyltransferase paiA

Gentamicin 3-N-acetyltransferase aacC1

Bifunctional protein GlmU glmU

Acetyl transferase rimL

Uncharacterized N-acetyltransferase YvbK yvbK

Aminoglycoside N(6')-acetyltransferase type 1

Acyl-CoA hydrolase

Uncharacterized acyl-CoA thioester hydrolase HI_0827

3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH

Mycothiol acetyltransferase mshD

Histone acetyltransferase KAT2A KAT2A

Acyl-CoA hydrolase

Histone acetyltransferase KAT2B KAT2B

1,4-Dihydroxy-2-naphthoyl-CoA synthase menB

Citrate synthase cit

Aminoglycoside 2'-N-acetyltransferase aac

Aac(6')-Ii protein aac(6')-Ii

4'-phosphopantetheinyl transferase sfp sfp

Uncharacterized protein

Serine acetyltransferase cysE

2-methylcitrate synthase gltA

4-hydroxybenzoyl-CoA thioesterase fcbC

Referensi & Sumber

Synthesis reference: Shigeru Ikuta, Shigeyuki Imamura, Hidehiko Ishikawa, Kazuo Matsuura, Masaki Takada, Hideo Misaki, "Process for the production of acyl-Coenzyme A oxidase." U.S. Patent US4346173, issued September, 1980.

Contoh Produk & Brand

Produk: 0 • International brands: 0

Belum ada data produk/brand untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field produk/brand.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.