Oral LD50 (rat):5628 mg/kg; Skin LD50 (rabbit): 15800 mg/kg; Subcutaneous LD50 (mouse):9800 mg/kg; Intraperitoneal LD50 (rabbit):1826 mg/kg
Hyperforin is a phytochemical generated by the plants of the Hypericum family. One of the most important members of this family, due to its medical properties, is Hypericum perforatum, also known as St John's wort.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Eluxadoline | The serum concentration of Eluxadoline can be increased when it is combined with Hyperforin. |
| Pravastatin | The excretion of Pravastatin can be decreased when combined with Hyperforin. |
| Valsartan | The excretion of Valsartan can be decreased when combined with Hyperforin. |
| Erythromycin | The excretion of Erythromycin can be decreased when combined with Hyperforin. |
| Torasemide | The excretion of Torasemide can be decreased when combined with Hyperforin. |
| Liothyronine | The excretion of Liothyronine can be decreased when combined with Hyperforin. |
| Conjugated estrogens | The excretion of Conjugated estrogens can be decreased when combined with Hyperforin. |
| Digoxin | The excretion of Digoxin can be decreased when combined with Hyperforin. |
| Cerivastatin | The excretion of Cerivastatin can be decreased when combined with Hyperforin. |
| Raloxifene | The excretion of Raloxifene can be decreased when combined with Hyperforin. |
| Caspofungin | The excretion of Caspofungin can be decreased when combined with Hyperforin. |
| Bosentan | The excretion of Bosentan can be decreased when combined with Hyperforin. |
| Methotrexate | The excretion of Methotrexate can be decreased when combined with Hyperforin. |
| Enalapril | The excretion of Enalapril can be decreased when combined with Hyperforin. |
| Simvastatin | The excretion of Simvastatin can be decreased when combined with Hyperforin. |
| Sumatriptan | The excretion of Sumatriptan can be decreased when combined with Hyperforin. |
| Mycophenolate mofetil | The excretion of Mycophenolate mofetil can be decreased when combined with Hyperforin. |
| Penicillamine | The excretion of Penicillamine can be decreased when combined with Hyperforin. |
| Repaglinide | The excretion of Repaglinide can be decreased when combined with Hyperforin. |
| Dinoprostone | The excretion of Dinoprostone can be decreased when combined with Hyperforin. |
| Fexofenadine | The excretion of Fexofenadine can be decreased when combined with Hyperforin. |
| Ezetimibe | The excretion of Ezetimibe can be decreased when combined with Hyperforin. |
| Benzylpenicillin | The excretion of Benzylpenicillin can be decreased when combined with Hyperforin. |
| Atorvastatin | The excretion of Atorvastatin can be decreased when combined with Hyperforin. |
| Ouabain | The excretion of Ouabain can be decreased when combined with Hyperforin. |
| Fluvastatin | The excretion of Fluvastatin can be decreased when combined with Hyperforin. |
| Rosuvastatin | The excretion of Rosuvastatin can be decreased when combined with Hyperforin. |
| Liotrix | The excretion of Liotrix can be decreased when combined with Hyperforin. |
| Cholic Acid | The excretion of Cholic Acid can be decreased when combined with Hyperforin. |
| Taurocholic acid | The excretion of Taurocholic acid can be decreased when combined with Hyperforin. |
| Atrasentan | The excretion of Atrasentan can be decreased when combined with Hyperforin. |
| Simeprevir | The excretion of Simeprevir can be decreased when combined with Hyperforin. |
| Ambrisentan | The excretion of Ambrisentan can be decreased when combined with Hyperforin. |
| Axitinib | The excretion of Axitinib can be decreased when combined with Hyperforin. |
| Gimatecan | The excretion of Gimatecan can be decreased when combined with Hyperforin. |
| Temocapril | The excretion of Temocapril can be decreased when combined with Hyperforin. |
| Cholecystokinin | The excretion of Cholecystokinin can be decreased when combined with Hyperforin. |
| Gadoxetic acid | The excretion of Gadoxetic acid can be decreased when combined with Hyperforin. |
| Technetium Tc-99m mebrofenin | The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Hyperforin. |
| Fimasartan | The excretion of Fimasartan can be decreased when combined with Hyperforin. |
| Paritaprevir | The excretion of Paritaprevir can be decreased when combined with Hyperforin. |
| Tenofovir alafenamide | The excretion of Tenofovir alafenamide can be decreased when combined with Hyperforin. |
| Selexipag | The excretion of Selexipag can be decreased when combined with Hyperforin. |
| Grazoprevir | The excretion of Grazoprevir can be decreased when combined with Hyperforin. |
| Asunaprevir | The excretion of Asunaprevir can be decreased when combined with Hyperforin. |
| Elagolix | The excretion of Elagolix can be decreased when combined with Hyperforin. |
| Voxilaprevir | The excretion of Voxilaprevir can be decreased when combined with Hyperforin. |
| Letermovir | The excretion of Letermovir can be decreased when combined with Hyperforin. |
| Levosalbutamol | The excretion of Levosalbutamol can be decreased when combined with Hyperforin. |
| Glecaprevir | The excretion of Glecaprevir can be decreased when combined with Hyperforin. |
| Belantamab mafodotin | The excretion of Belantamab mafodotin can be decreased when combined with Hyperforin. |
| Revefenacin | Hyperforin may decrease the excretion rate of Revefenacin which could result in a higher serum level. |
| Brincidofovir | The serum concentration of Brincidofovir can be increased when it is combined with Hyperforin. |
| Atogepant | The serum concentration of Atogepant can be increased when it is combined with Hyperforin. |
| Mesalazine | The excretion of Mesalazine can be decreased when combined with Hyperforin. |
| Tezacaftor | The excretion of Tezacaftor can be decreased when combined with Hyperforin. |
| Momelotinib | The serum concentration of Momelotinib can be increased when it is combined with Hyperforin. |
| Resmetirom | The serum concentration of Resmetirom can be increased when it is combined with Hyperforin. |