Epothilone D

DB01873

small molecule investigational

Deskripsi

Struktur Molekul 2D

Berat 491.683
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

321 Data
Eliglustat The metabolism of Eliglustat can be decreased when combined with Epothilone D.
Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Epothilone D.
Alfentanil The serum concentration of Alfentanil can be increased when it is combined with Epothilone D.
Buspirone The metabolism of Buspirone can be decreased when combined with Epothilone D.
Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Epothilone D.
Cisapride The serum concentration of Cisapride can be increased when it is combined with Epothilone D.
Disopyramide Epothilone D may increase the QTc-prolonging activities of Disopyramide.
Estazolam The serum concentration of Estazolam can be increased when it is combined with Epothilone D.
Quinine The serum concentration of Quinine can be increased when it is combined with Epothilone D.
Quinidine The serum concentration of Quinidine can be increased when it is combined with Epothilone D.
Repaglinide The serum concentration of Repaglinide can be increased when it is combined with Epothilone D.
Sirolimus The metabolism of Sirolimus can be decreased when combined with Epothilone D.
Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Epothilone D.
Terfenadine The serum concentration of Terfenadine can be increased when it is combined with Epothilone D.
Triazolam The serum concentration of Triazolam can be increased when it is combined with Epothilone D.
Cilostazol The metabolism of Cilostazol can be decreased when combined with Epothilone D.
Colchicine The metabolism of Colchicine can be decreased when combined with Epothilone D.
Iloperidone The metabolism of Iloperidone can be decreased when combined with Epothilone D.
Retapamulin The metabolism of Retapamulin can be decreased when combined with Epothilone D.
Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Epothilone D.
Vardenafil The metabolism of Vardenafil can be decreased when combined with Epothilone D.
Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Epothilone D.
Zopiclone The metabolism of Zopiclone can be decreased when combined with Epothilone D.
Lovastatin The metabolism of Lovastatin can be decreased when combined with Epothilone D.
Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Epothilone D.
Alprazolam The serum concentration of Alprazolam can be increased when it is combined with Epothilone D.
Warfarin The serum concentration of Warfarin can be increased when it is combined with Epothilone D.
Acenocoumarol The serum concentration of Acenocoumarol can be increased when it is combined with Epothilone D.
(R)-warfarin The serum concentration of (R)-warfarin can be increased when it is combined with Epothilone D.
R,S-Warfarin alcohol The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Epothilone D.
S,R-Warfarin alcohol The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Epothilone D.
(S)-Warfarin The serum concentration of (S)-Warfarin can be increased when it is combined with Epothilone D.
Midazolam The serum concentration of Midazolam can be increased when it is combined with Epothilone D.
Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Epothilone D.
Telaprevir The serum concentration of Telaprevir can be increased when it is combined with Epothilone D.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Epothilone D.
Vintafolide The serum concentration of Vintafolide can be increased when it is combined with Epothilone D.
Vincamine The serum concentration of Vincamine can be increased when it is combined with Epothilone D.
Acetyldigitoxin The serum concentration of Acetyldigitoxin can be increased when it is combined with Epothilone D.
Deslanoside The serum concentration of Deslanoside can be increased when it is combined with Epothilone D.
Ouabain The serum concentration of Ouabain can be increased when it is combined with Epothilone D.
Oleandrin The serum concentration of Oleandrin can be increased when it is combined with Epothilone D.
Cymarin The serum concentration of Cymarin can be increased when it is combined with Epothilone D.
Proscillaridin The serum concentration of Proscillaridin can be increased when it is combined with Epothilone D.
Metildigoxin The serum concentration of Metildigoxin can be increased when it is combined with Epothilone D.
Lanatoside C The serum concentration of Lanatoside C can be increased when it is combined with Epothilone D.
Gitoformate The serum concentration of Gitoformate can be increased when it is combined with Epothilone D.
Acetyldigoxin The serum concentration of Acetyldigoxin can be increased when it is combined with Epothilone D.
Peruvoside The serum concentration of Peruvoside can be increased when it is combined with Epothilone D.
Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Epothilone D.
Dicoumarol The serum concentration of Dicoumarol can be increased when it is combined with Epothilone D.
Phenindione The serum concentration of Phenindione can be increased when it is combined with Epothilone D.
Coumarin The serum concentration of Coumarin can be increased when it is combined with Epothilone D.
Tioclomarol The serum concentration of Tioclomarol can be increased when it is combined with Epothilone D.
Ethyl biscoumacetate The serum concentration of Ethyl biscoumacetate can be increased when it is combined with Epothilone D.
Diphenadione The serum concentration of Diphenadione can be increased when it is combined with Epothilone D.
4-hydroxycoumarin The serum concentration of 4-hydroxycoumarin can be increased when it is combined with Epothilone D.
Fluindione The serum concentration of Fluindione can be increased when it is combined with Epothilone D.
Clorindione The serum concentration of Clorindione can be increased when it is combined with Epothilone D.
Oxtriphylline The metabolism of Oxtriphylline can be decreased when combined with Epothilone D.
Doxofylline The metabolism of Doxofylline can be decreased when combined with Epothilone D.
Bamifylline The metabolism of Bamifylline can be decreased when combined with Epothilone D.
Acefylline The metabolism of Acefylline can be decreased when combined with Epothilone D.
Bufylline The metabolism of Bufylline can be decreased when combined with Epothilone D.
Fenethylline The metabolism of Fenethylline can be decreased when combined with Epothilone D.
Proxyphylline The metabolism of Proxyphylline can be decreased when combined with Epothilone D.
Bromotheophylline The metabolism of Bromotheophylline can be decreased when combined with Epothilone D.
Pentoxifylline The metabolism of Pentoxifylline can be decreased when combined with Epothilone D.
8-azaguanine The metabolism of 8-azaguanine can be decreased when combined with Epothilone D.
7,9-Dimethylguanine The metabolism of 7,9-Dimethylguanine can be decreased when combined with Epothilone D.
Xanthine The metabolism of Xanthine can be decreased when combined with Epothilone D.
7-Deazaguanine The metabolism of 7-Deazaguanine can be decreased when combined with Epothilone D.
Guanine The metabolism of Guanine can be decreased when combined with Epothilone D.
9-Methylguanine The metabolism of 9-Methylguanine can be decreased when combined with Epothilone D.
Peldesine The metabolism of Peldesine can be decreased when combined with Epothilone D.
Hypoxanthine The metabolism of Hypoxanthine can be decreased when combined with Epothilone D.
9-Deazaguanine The metabolism of 9-Deazaguanine can be decreased when combined with Epothilone D.
Valomaciclovir The metabolism of Valomaciclovir can be decreased when combined with Epothilone D.
3-isobutyl-1-methyl-7H-xanthine The metabolism of 3-isobutyl-1-methyl-7H-xanthine can be decreased when combined with Epothilone D.
Uric acid The metabolism of Uric acid can be decreased when combined with Epothilone D.
6-O-benzylguanine The metabolism of 6-O-benzylguanine can be decreased when combined with Epothilone D.
Lisofylline The metabolism of Lisofylline can be decreased when combined with Epothilone D.
Lobucavir The metabolism of Lobucavir can be decreased when combined with Epothilone D.
Cafedrine The metabolism of Cafedrine can be decreased when combined with Epothilone D.
Theodrenaline The metabolism of Theodrenaline can be decreased when combined with Epothilone D.
Etamiphylline The metabolism of Etamiphylline can be decreased when combined with Epothilone D.
Pentifylline The metabolism of Pentifylline can be decreased when combined with Epothilone D.
Furafylline The metabolism of Furafylline can be decreased when combined with Epothilone D.
Theobromine The metabolism of Theobromine can be decreased when combined with Epothilone D.
Propentofylline The metabolism of Propentofylline can be decreased when combined with Epothilone D.
Caffeine The metabolism of Caffeine can be decreased when combined with Epothilone D.
8-chlorotheophylline The metabolism of 8-chlorotheophylline can be decreased when combined with Epothilone D.
Mercaptopurine The metabolism of Mercaptopurine can be decreased when combined with Epothilone D.
PCS-499 The metabolism of PCS-499 can be decreased when combined with Epothilone D.
Methylergometrine The serum concentration of Methylergometrine can be increased when it is combined with Epothilone D.
Lisuride The serum concentration of Lisuride can be increased when it is combined with Epothilone D.
Nicergoline The serum concentration of Nicergoline can be increased when it is combined with Epothilone D.
Ergoloid mesylate The serum concentration of Ergoloid mesylate can be increased when it is combined with Epothilone D.
Pergolide The serum concentration of Pergolide can be increased when it is combined with Epothilone D.
Ergometrine The serum concentration of Ergometrine can be increased when it is combined with Epothilone D.

Target Protein

Tubulin beta chain TUBB
Tubulin beta-1 chain TUBB1
Tubulin beta-4B chain TUBB4B
Tubulin beta-4A chain TUBB4A
Tubulin alpha-4A chain TUBA4A
Tubulin beta-3 chain TUBB3
Tubulin alpha-1C chain TUBA1C
Tubulin alpha-8 chain TUBA8
Tubulin alpha-1B chain TUBA1B
Tubulin alpha-1A chain TUBA1A
Tubulin alpha 3C/D chain TUBA3C

Referensi & Sumber

Synthesis reference: Ludger Wessjohann, "Epothilone synthesis building blocks III and IV: asymmetrically substituted acyloins and acyloin derivatives, methods for their production and methods for the production of epothilones B, D and epothilone derivatives." U.S. Patent US20040082651, issued April 29, 2004.

Contoh Produk & Brand

Produk: 0 • International brands: 0
Belum ada data produk/brand untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field produk/brand.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul