Dalfopristin

DB01764

small molecule approved

Deskripsi

Dalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome and quinupristin inhibits the late phase of protein synthesis.

Struktur Molekul 2D

Berat 690.85
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The elimination half-life is approximately 0.70 hours.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Converted to an active non-conjugated metabolite by hydrolysis.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

222 Data
Lomitapide The metabolism of Lomitapide can be decreased when combined with Dalfopristin.
Eliglustat The metabolism of Eliglustat can be decreased when combined with Dalfopristin.
Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Dalfopristin.
Cilostazol The metabolism of Cilostazol can be decreased when combined with Dalfopristin.
Colchicine The metabolism of Colchicine can be decreased when combined with Dalfopristin.
Iloperidone The metabolism of Iloperidone can be decreased when combined with Dalfopristin.
Retapamulin The metabolism of Retapamulin can be decreased when combined with Dalfopristin.
Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Dalfopristin.
Vardenafil The metabolism of Vardenafil can be decreased when combined with Dalfopristin.
Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Dalfopristin.
Zopiclone The metabolism of Zopiclone can be decreased when combined with Dalfopristin.
Lovastatin The metabolism of Lovastatin can be decreased when combined with Dalfopristin.
Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Dalfopristin.
Alprazolam The metabolism of Alprazolam can be decreased when combined with Dalfopristin.
Warfarin The serum concentration of Warfarin can be increased when it is combined with Dalfopristin.
Acenocoumarol The serum concentration of Acenocoumarol can be increased when it is combined with Dalfopristin.
(R)-warfarin The serum concentration of (R)-warfarin can be increased when it is combined with Dalfopristin.
R,S-Warfarin alcohol The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Dalfopristin.
S,R-Warfarin alcohol The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Dalfopristin.
(S)-Warfarin The serum concentration of (S)-Warfarin can be increased when it is combined with Dalfopristin.
Midazolam The serum concentration of Midazolam can be increased when it is combined with Dalfopristin.
Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Dalfopristin.
Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Dalfopristin.
BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Dalfopristin.
Typhoid vaccine The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Dalfopristin.
Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Dalfopristin.
Aripiprazole lauroxil The metabolism of Aripiprazole lauroxil can be decreased when combined with Dalfopristin.
Dicoumarol The risk or severity of bleeding can be increased when Dalfopristin is combined with Dicoumarol.
Phenindione The risk or severity of bleeding can be increased when Dalfopristin is combined with Phenindione.
Coumarin The risk or severity of bleeding can be increased when Dalfopristin is combined with Coumarin.
Tioclomarol The risk or severity of bleeding can be increased when Dalfopristin is combined with Tioclomarol.
Ethyl biscoumacetate The risk or severity of bleeding can be increased when Dalfopristin is combined with Ethyl biscoumacetate.
Diphenadione The risk or severity of bleeding can be increased when Dalfopristin is combined with Diphenadione.
4-hydroxycoumarin The risk or severity of bleeding can be increased when Dalfopristin is combined with 4-hydroxycoumarin.
Fluindione The risk or severity of bleeding can be increased when Dalfopristin is combined with Fluindione.
Clorindione The risk or severity of bleeding can be increased when Dalfopristin is combined with Clorindione.
Azithromycin The metabolism of Azithromycin can be decreased when combined with Dalfopristin.
Ziprasidone The metabolism of Ziprasidone can be decreased when combined with Dalfopristin.
Chlorpromazine The metabolism of Chlorpromazine can be decreased when combined with Dalfopristin.
Albendazole The metabolism of Albendazole can be decreased when combined with Dalfopristin.
Cephalexin The metabolism of Cephalexin can be decreased when combined with Dalfopristin.
Doxazosin The metabolism of Doxazosin can be decreased when combined with Dalfopristin.
Norethisterone The metabolism of Norethisterone can be decreased when combined with Dalfopristin.
Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Dalfopristin.
Atazanavir The metabolism of Atazanavir can be decreased when combined with Dalfopristin.
Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Dalfopristin.
Drospirenone The metabolism of Drospirenone can be decreased when combined with Dalfopristin.
Allylestrenol The metabolism of Allylestrenol can be decreased when combined with Dalfopristin.
Zuclopenthixol The metabolism of Zuclopenthixol can be decreased when combined with Dalfopristin.
Roflumilast The serum concentration of Roflumilast can be increased when it is combined with Dalfopristin.
Lacosamide The metabolism of Lacosamide can be decreased when combined with Dalfopristin.
Linagliptin The metabolism of Linagliptin can be decreased when combined with Dalfopristin.
Vorapaxar The metabolism of Vorapaxar can be decreased when combined with Dalfopristin.
Suvorexant The metabolism of Suvorexant can be decreased when combined with Dalfopristin.
Netupitant The metabolism of Netupitant can be decreased when combined with Dalfopristin.
Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Dalfopristin.
Nintedanib The metabolism of Nintedanib can be decreased when combined with Dalfopristin.
Tenofovir alafenamide The metabolism of Tenofovir alafenamide can be decreased when combined with Dalfopristin.
Dihydroergocornine The metabolism of Dihydroergocornine can be decreased when combined with Dalfopristin.
Duvelisib The metabolism of Duvelisib can be decreased when combined with Dalfopristin.
Gilteritinib The metabolism of Gilteritinib can be decreased when combined with Dalfopristin.
9-aminocamptothecin The metabolism of 9-aminocamptothecin can be decreased when combined with Dalfopristin.
Methylprednisone The metabolism of Methylprednisone can be decreased when combined with Dalfopristin.
Dihydroergocristine The metabolism of Dihydroergocristine can be decreased when combined with Dalfopristin.
Dihydroergocryptine The metabolism of Dihydroergocryptine can be decreased when combined with Dalfopristin.
Medical Cannabis The metabolism of Medical Cannabis can be decreased when combined with Dalfopristin.
Elexacaftor The metabolism of Elexacaftor can be decreased when combined with Dalfopristin.
Fosaprepitant The metabolism of Fosaprepitant can be decreased when combined with Dalfopristin.
Lefamulin The metabolism of Lefamulin can be decreased when combined with Dalfopristin.
Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Dalfopristin.
Methysergide The metabolism of Methysergide can be decreased when combined with Dalfopristin.
Meperidine The metabolism of Meperidine can be decreased when combined with Dalfopristin.
Ebastine The metabolism of Ebastine can be decreased when combined with Dalfopristin.
Terfenadine The metabolism of Terfenadine can be decreased when combined with Dalfopristin.
Cisapride The metabolism of Cisapride can be decreased when combined with Dalfopristin.
Isavuconazole The metabolism of Isavuconazole can be decreased when combined with Dalfopristin.
Pretomanid The metabolism of Pretomanid can be decreased when combined with Dalfopristin.
Pimavanserin The metabolism of Pimavanserin can be decreased when combined with Dalfopristin.
Infigratinib The metabolism of Infigratinib can be decreased when combined with Dalfopristin.
Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Dalfopristin.
Dofetilide The metabolism of Dofetilide can be decreased when combined with Dalfopristin.
Theophylline The metabolism of Theophylline can be decreased when combined with Dalfopristin.
Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Dalfopristin.
Sirolimus The metabolism of Sirolimus can be decreased when combined with Dalfopristin.
Quinidine The metabolism of Quinidine can be decreased when combined with Dalfopristin.
Phenprocoumon The metabolism of Phenprocoumon can be decreased when combined with Dalfopristin.
Busulfan The metabolism of Busulfan can be decreased when combined with Dalfopristin.
Pimozide The metabolism of Pimozide can be decreased when combined with Dalfopristin.
Amiodarone The metabolism of Amiodarone can be decreased when combined with Dalfopristin.
Aminophylline The metabolism of Aminophylline can be decreased when combined with Dalfopristin.
Paclitaxel The metabolism of Paclitaxel can be decreased when combined with Dalfopristin.
Dasatinib The metabolism of Dasatinib can be decreased when combined with Dalfopristin.
Fosphenytoin The metabolism of Fosphenytoin can be decreased when combined with Dalfopristin.
Digitoxin The metabolism of Digitoxin can be decreased when combined with Dalfopristin.
Everolimus The metabolism of Everolimus can be decreased when combined with Dalfopristin.
Dronedarone The metabolism of Dronedarone can be decreased when combined with Dalfopristin.
Cobimetinib The metabolism of Cobimetinib can be decreased when combined with Dalfopristin.
Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Dalfopristin.
Idelalisib The metabolism of Idelalisib can be decreased when combined with Dalfopristin.
Ceritinib The metabolism of Ceritinib can be decreased when combined with Dalfopristin.

Target Protein

Streptogramin A acetyltransferase vatD

Referensi & Sumber

Artikel (PubMed)
  • PMID: 11219478
    Allington DR, Rivey MP: Quinupristin/dalfopristin: a therapeutic review. Clin Ther. 2001 Jan;23(1):24-44.
  • PMID: 10651391
    Lamb HM, Figgitt DP, Faulds D: Quinupristin/dalfopristin: a review of its use in the management of serious gram-positive infections. Drugs. 1999 Dec;58(6):1061-97.
  • PMID: 11764864
    Manzella JP: Quinupristin-dalfopristin: a new antibiotic for severe gram-positive infections. Am Fam Physician. 2001 Dec 1;64(11):1863-6.
  • PMID: 11190346
    Paradisi F, Corti G, Messeri D: Antistaphylococcal (MSSA, MRSA, MSSE, MRSE) antibiotics. Med Clin North Am. 2001 Jan;85(1):1-17.

Contoh Produk & Brand

Produk: 3 • International brands: 0
Produk
  • Synercid
    Powder, for solution • - • Intravenous • Canada • Approved
  • Synercid
    Injection, powder, lyophilized, for solution • - • Intravenous • US • Approved
  • Synercid
    Injection • - • Intravenous • US • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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