Genistein

DB01645

small molecule investigational

Deskripsi

An isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA topoisomerases, type II) activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 phase arrest in human and murine cell lines.

Additionally, genistein has antihelmintic activity. It has been determined to be the active ingredient in Felmingia vestita, which is a plant traditionally used against worms. It has shown to be effective in the treatment of common liver fluke, pork trematode and poultry cestode.

Further, genistein is a phytoestrogen which has selective estrogen receptor modulator properties. It has been investigated in clinical trials as an alternative to classical hormone therapy to help prevent cardiovascular disease in postmenopausal women A14417.

Natural sources of genistein include tofu, fava beans, soybeans, kudzu, and lupin.

Struktur Molekul 2D

Berat 270.2369
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

781 Data
Tizanidine The serum concentration of Tizanidine can be increased when it is combined with Genistein.
Aripiprazole The metabolism of Aripiprazole can be increased when combined with Genistein.
Aripiprazole lauroxil The metabolism of Aripiprazole lauroxil can be increased when combined with Genistein.
Deferasirox The serum concentration of Genistein can be increased when it is combined with Deferasirox.
Peginterferon alfa-2b The serum concentration of Genistein can be increased when it is combined with Peginterferon alfa-2b.
Leflunomide The serum concentration of Genistein can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of Genistein can be decreased when it is combined with Teriflunomide.
Zolmitriptan The metabolism of Zolmitriptan can be decreased when combined with Genistein.
Acetaminophen The serum concentration of Acetaminophen can be increased when it is combined with Genistein.
Propacetamol The serum concentration of Propacetamol can be increased when it is combined with Genistein.
Ifosfamide The metabolism of Ifosfamide can be increased when combined with Genistein.
Perampanel The metabolism of Perampanel can be increased when combined with Genistein.
Warfarin The metabolism of Warfarin can be increased when combined with Genistein.
Acenocoumarol The metabolism of Acenocoumarol can be increased when combined with Genistein.
(R)-warfarin The metabolism of (R)-warfarin can be increased when combined with Genistein.
R,S-Warfarin alcohol The metabolism of R,S-Warfarin alcohol can be increased when combined with Genistein.
S,R-Warfarin alcohol The metabolism of S,R-Warfarin alcohol can be increased when combined with Genistein.
(S)-Warfarin The metabolism of (S)-Warfarin can be increased when combined with Genistein.
Abiraterone The serum concentration of Genistein can be increased when it is combined with Abiraterone.
Eluxadoline The serum concentration of Eluxadoline can be increased when it is combined with Genistein.
Cyproterone acetate The metabolism of Genistein can be increased when combined with Cyproterone acetate.
Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Genistein.
Primidone The metabolism of Genistein can be increased when combined with Primidone.
Albendazole The metabolism of Genistein can be increased when combined with Albendazole.
Rifampin The metabolism of Genistein can be increased when combined with Rifampicin.
Caffeine The metabolism of Genistein can be decreased when combined with Caffeine.
Moxifloxacin The metabolism of Genistein can be decreased when combined with Moxifloxacin.
Mexiletine The metabolism of Genistein can be decreased when combined with Mexiletine.
Alosetron The metabolism of Genistein can be decreased when combined with Alosetron.
Gatifloxacin The metabolism of Genistein can be decreased when combined with Gatifloxacin.
Pazufloxacin The metabolism of Genistein can be decreased when combined with Pazufloxacin.
Lidocaine The risk or severity of methemoglobinemia can be increased when Genistein is combined with Lidocaine.
Ketoconazole The metabolism of Genistein can be decreased when combined with Ketoconazole.
Osilodrostat The metabolism of Genistein can be decreased when combined with Osilodrostat.
Troglitazone The metabolism of Troglitazone can be decreased when combined with Genistein.
Torasemide The metabolism of Torasemide can be decreased when combined with Genistein.
Dapsone The metabolism of Dapsone can be decreased when combined with Genistein.
Trimethadione The metabolism of Trimethadione can be decreased when combined with Genistein.
Sulfadiazine The metabolism of Sulfadiazine can be decreased when combined with Genistein.
Rosiglitazone The metabolism of Rosiglitazone can be decreased when combined with Genistein.
Piroxicam The metabolism of Piroxicam can be decreased when combined with Genistein.
Diclofenac The metabolism of Diclofenac can be decreased when combined with Genistein.
Amodiaquine The metabolism of Amodiaquine can be decreased when combined with Genistein.
Paramethadione The metabolism of Paramethadione can be decreased when combined with Genistein.
Naproxen The metabolism of Naproxen can be decreased when combined with Genistein.
Tazarotene The metabolism of Tazarotene can be decreased when combined with Genistein.
Propofol The metabolism of Propofol can be decreased when combined with Genistein.
Terbinafine The metabolism of Terbinafine can be decreased when combined with Genistein.
Repaglinide The metabolism of Repaglinide can be decreased when combined with Genistein.
Almotriptan The metabolism of Almotriptan can be decreased when combined with Genistein.
Buprenorphine The metabolism of Buprenorphine can be decreased when combined with Genistein.
Azelastine The metabolism of Azelastine can be decreased when combined with Genistein.
Irbesartan The metabolism of Irbesartan can be decreased when combined with Genistein.
Selegiline The metabolism of Selegiline can be decreased when combined with Genistein.
Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Genistein.
Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Genistein.
Pioglitazone The metabolism of Pioglitazone can be decreased when combined with Genistein.
Zopiclone The metabolism of Zopiclone can be decreased when combined with Genistein.
Halofantrine The metabolism of Halofantrine can be decreased when combined with Genistein.
Ketamine The metabolism of Ketamine can be decreased when combined with Genistein.
Lapatinib The metabolism of Lapatinib can be decreased when combined with Genistein.
Mestranol The metabolism of Mestranol can be decreased when combined with Genistein.
Aminophenazone The metabolism of Aminophenazone can be decreased when combined with Genistein.
Antipyrine The metabolism of Antipyrine can be decreased when combined with Genistein.
Licofelone The metabolism of Licofelone can be decreased when combined with Genistein.
Beraprost The metabolism of Beraprost can be decreased when combined with Genistein.
Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Genistein.
Muraglitazar The metabolism of Muraglitazar can be decreased when combined with Genistein.
Ketobemidone The metabolism of Ketobemidone can be decreased when combined with Genistein.
Seratrodast The metabolism of Seratrodast can be decreased when combined with Genistein.
Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Genistein is combined with Benzyl alcohol.
Enzalutamide The metabolism of Enzalutamide can be decreased when combined with Genistein.
Perospirone The metabolism of Perospirone can be decreased when combined with Genistein.
Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Genistein.
Olodaterol The metabolism of Olodaterol can be decreased when combined with Genistein.
Lobeglitazone The metabolism of Genistein can be decreased when combined with Lobeglitazone.
Netoglitazone The metabolism of Netoglitazone can be decreased when combined with Genistein.
Rivoglitazone The metabolism of Rivoglitazone can be decreased when combined with Genistein.
Ciglitazone The metabolism of Ciglitazone can be decreased when combined with Genistein.
Apalutamide The metabolism of Apalutamide can be decreased when combined with Genistein.
Glasdegib The metabolism of Glasdegib can be decreased when combined with Genistein.
Balaglitazone The metabolism of Balaglitazone can be decreased when combined with Genistein.
Istradefylline The metabolism of Istradefylline can be decreased when combined with Genistein.
Dexibuprofen The metabolism of Dexibuprofen can be decreased when combined with Genistein.
Ketorolac The metabolism of Ketorolac can be decreased when combined with Genistein.
Capravirine The metabolism of Capravirine can be decreased when combined with Genistein.
Simvastatin The metabolism of Simvastatin can be decreased when combined with Genistein.
Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Genistein.
Selexipag The metabolism of Selexipag can be decreased when combined with Genistein.
Elagolix The metabolism of Elagolix can be decreased when combined with Genistein.
Diethylstilbestrol The metabolism of Diethylstilbestrol can be decreased when combined with Genistein.
Morphine The metabolism of Morphine can be decreased when combined with Genistein.
Chloroquine The metabolism of Chloroquine can be decreased when combined with Genistein.
Nicardipine The metabolism of Nicardipine can be decreased when combined with Genistein.
Loperamide The metabolism of Loperamide can be decreased when combined with Genistein.
Domperidone The metabolism of Domperidone can be decreased when combined with Genistein.
Anastrozole The metabolism of Anastrozole can be decreased when combined with Genistein.
Sitagliptin The metabolism of Sitagliptin can be decreased when combined with Genistein.
Odanacatib The metabolism of Odanacatib can be decreased when combined with Genistein.
Dasabuvir The metabolism of Dasabuvir can be decreased when combined with Genistein.

Target Protein

Estrogen receptor beta ESR2
Nuclear receptor coactivator 1 NCOA1
Estrogen receptor ESR1
Nuclear receptor coactivator 2 NCOA2
Steroid hormone receptor ERR2 ESRRB
Steroid hormone receptor ERR1 ESRRA
Nuclear receptor subfamily 1 group I member 2 NR1I2
RAC-alpha serine/threonine-protein kinase AKT1
G-protein coupled estrogen receptor 1 GPER1
Cytochrome P450 1B1 CYP1B1
Sex hormone-binding globulin SHBG
DNA topoisomerase 2-alpha TOP2A
Protein-tyrosine kinase 2-beta PTK2B
Cystic fibrosis transmembrane conductance regulator CFTR

Referensi & Sumber

Synthesis reference: J. Mark Weber, Andreas Constantinou, Paul E. Hessler, "Process of preparing genistein." U.S. Patent US5554519, issued June, 1994.
Artikel (PubMed)
  • PMID: 15772566
    Crisafulli A, Altavilla D, Marini H, Bitto A, Cucinotta D, Frisina N, Corrado F, D'Anna R, Squadrito G, Adamo EB, Marini R, Romeo A, Cancellieri F, Buemi M, Squadrito F: Effects of the phytoestrogen genistein on cardiovascular risk factors in postmenopausal women. Menopause. 2005 Mar;12(2):186-92.
  • PMID: 18771609
    Toner E, Brennan GP, Wells K, McGeown JG, Fairweather I: Physiological and morphological effects of genistein against the liver fluke, Fasciola hepatica. Parasitology. 2008 Sep;135(10):1189-203. doi: 10.1017/S0031182008004630.

Contoh Produk & Brand

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International Brands
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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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