5-fluorouridine

DB01629

small molecule experimental

Deskripsi

5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid. This compound belongs to the pyrimidine nucleosides and analogues. These are compounds comprising a pyrimidine base attached to a sugar. 5-fluorouridine is known to target uridine phosphorylase. FUrd is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs.

Struktur Molekul 2D

Berat 262.1918
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

47 Data
Cimetidine The serum concentration of 5-fluorouridine can be increased when it is combined with Cimetidine.
Gemcitabine The serum concentration of 5-fluorouridine can be increased when it is combined with Gemcitabine.
Sorafenib The risk or severity of QTc prolongation can be increased when Sorafenib is combined with 5-fluorouridine.
Phenytoin The serum concentration of Phenytoin can be increased when it is combined with 5-fluorouridine.
Fosphenytoin The serum concentration of Fosphenytoin can be increased when it is combined with 5-fluorouridine.
Gimeracil The serum concentration of 5-fluorouridine can be increased when it is combined with Gimeracil.
Metronidazole The serum concentration of 5-fluorouridine can be increased when it is combined with Metronidazole.
Methotrexate The risk or severity of adverse effects can be increased when Methotrexate is combined with 5-fluorouridine.
Dicoumarol The risk or severity of bleeding can be increased when 5-fluorouridine is combined with Dicoumarol.
Phenindione The risk or severity of bleeding can be increased when 5-fluorouridine is combined with Phenindione.
Warfarin The risk or severity of bleeding can be increased when 5-fluorouridine is combined with Warfarin.
Phenprocoumon The risk or severity of bleeding can be increased when 5-fluorouridine is combined with Phenprocoumon.
Acenocoumarol The risk or severity of bleeding can be increased when 5-fluorouridine is combined with Acenocoumarol.
4-hydroxycoumarin The risk or severity of bleeding can be increased when 5-fluorouridine is combined with 4-hydroxycoumarin.
Coumarin The risk or severity of bleeding can be increased when 5-fluorouridine is combined with Coumarin.
(R)-warfarin The risk or severity of bleeding can be increased when 5-fluorouridine is combined with (R)-warfarin.
Ethyl biscoumacetate The risk or severity of bleeding can be increased when 5-fluorouridine is combined with Ethyl biscoumacetate.
Fluindione The risk or severity of bleeding can be increased when 5-fluorouridine is combined with Fluindione.
Clorindione The risk or severity of bleeding can be increased when 5-fluorouridine is combined with Clorindione.
Diphenadione The risk or severity of bleeding can be increased when 5-fluorouridine is combined with Diphenadione.
Tioclomarol The risk or severity of bleeding can be increased when 5-fluorouridine is combined with Tioclomarol.
(S)-Warfarin The risk or severity of bleeding can be increased when 5-fluorouridine is combined with (S)-Warfarin.
Sunitinib The risk or severity of QTc prolongation can be increased when 5-fluorouridine is combined with Sunitinib.
Tetrahydrofolic acid The risk or severity of adverse effects can be increased when Tetrahydrofolic acid is combined with 5-fluorouridine.
Folic acid The risk or severity of adverse effects can be increased when Folic acid is combined with 5-fluorouridine.
Leucovorin The risk or severity of adverse effects can be increased when Leucovorin is combined with 5-fluorouridine.
(6S)-5,6,7,8-tetrahydrofolic acid The risk or severity of adverse effects can be increased when (6S)-5,6,7,8-tetrahydrofolic acid is combined with 5-fluorouridine.
Triglu-5-formyl-tetrahydrofolate The risk or severity of adverse effects can be increased when Triglu-5-formyl-tetrahydrofolate is combined with 5-fluorouridine.
(6R)-Folinic acid The risk or severity of adverse effects can be increased when (6R)-Folinic acid is combined with 5-fluorouridine.
5-methyltetrahydrofolic acid The risk or severity of adverse effects can be increased when 5-methyltetrahydrofolic acid is combined with 5-fluorouridine.
Levomefolic acid The risk or severity of adverse effects can be increased when Levomefolic acid is combined with 5-fluorouridine.
Levoleucovorin The risk or severity of adverse effects can be increased when Levoleucovorin is combined with 5-fluorouridine.
Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with 5-fluorouridine.
Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with 5-fluorouridine.
Mephenytoin The therapeutic efficacy of Mephenytoin can be decreased when used in combination with 5-fluorouridine.
Carbamazepine The therapeutic efficacy of Carbamazepine can be decreased when used in combination with 5-fluorouridine.
Furosemide The therapeutic efficacy of Furosemide can be decreased when used in combination with 5-fluorouridine.
Nitrofurantoin The therapeutic efficacy of Nitrofurantoin can be decreased when used in combination with 5-fluorouridine.
Ethotoin The therapeutic efficacy of Ethotoin can be decreased when used in combination with 5-fluorouridine.
Meclofenamic acid The therapeutic efficacy of Meclofenamic acid can be decreased when used in combination with 5-fluorouridine.
Heparin The therapeutic efficacy of Heparin can be decreased when used in combination with 5-fluorouridine.
Dantrolene The therapeutic efficacy of Dantrolene can be decreased when used in combination with 5-fluorouridine.
Liotrix The therapeutic efficacy of Liotrix can be decreased when used in combination with 5-fluorouridine.
Etofenamate The therapeutic efficacy of Etofenamate can be decreased when used in combination with 5-fluorouridine.
Liothyronine I-131 The therapeutic efficacy of Liothyronine I-131 can be decreased when used in combination with 5-fluorouridine.
Neocitrullamon The therapeutic efficacy of Neocitrullamon can be decreased when used in combination with 5-fluorouridine.
Allantoin The therapeutic efficacy of Allantoin can be decreased when used in combination with 5-fluorouridine.

Target Protein

Superoxide dismutase [Cu-Zn] SOD1
Uridine phosphorylase udp

Referensi & Sumber

Synthesis reference: Setsuro Fujii, Eiichi Sakakibara, "2'-Deoxy-5-fluorouridine derivative and a process for producing the same and an antitumor agent comprising the same." U.S. Patent US4490366, issued October, 1977.
Artikel (PubMed)
  • PMID: 21744792
    Miracco EJ, Mueller EG: The products of 5-fluorouridine by the action of the pseudouridine synthase TruB disfavor one mechanism and suggest another. J Am Chem Soc. 2011 Aug 10;133(31):11826-9. doi: 10.1021/ja201179f. Epub 2011 Jul 15.
  • PMID: 12039627
    Arbos P, Campanero MA, Irache JM: RP-LC determination of 5-fluorouridine in nanoparticulate formulations. J Pharm Biomed Anal. 2002 Jun 1;28(5):857-66.

Contoh Produk & Brand

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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