This reduced activity is the cause of reduced gastrointestinal toxicity, as demonstrated in several large clinical trials performed with different COXIB (see below links on NEJM and The Lancet). Some clinical trials and meta-analysis showed that treatment with COXIB lead to increased incidence of cardiovascular adverse events compared to placebo
Etoricoxib is a new COX-2 selective inhibitor. Current therapeutic indications are: treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain and gout. Like any other COX-2 selective inhibitor, Etoricoxib selectively inhibits isoform 2 of cyclo-oxigenase enzyme (COX-2) to reduce the generation of prostaglandins (PGs) from arachidonic acid. It is approved in more than 60 countries worldwide but not in the US.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Cilostazol | The serum concentration of Cilostazol can be increased when it is combined with Etoricoxib. |
| Peginterferon alfa-2b | The serum concentration of Etoricoxib can be increased when it is combined with Peginterferon alfa-2b. |
| Leflunomide | The serum concentration of Etoricoxib can be decreased when it is combined with Leflunomide. |
| Teriflunomide | The serum concentration of Etoricoxib can be decreased when it is combined with Teriflunomide. |
| Amlodipine | The metabolism of Etoricoxib can be decreased when combined with Amlodipine. |
| Eliglustat | The metabolism of Eliglustat can be decreased when combined with Etoricoxib. |
| Ibrutinib | The metabolism of Ibrutinib can be decreased when combined with Etoricoxib. |
| Midodrine | The risk or severity of hypertension can be increased when Midodrine is combined with Etoricoxib. |
| Isoetharine | The risk or severity of hypertension can be increased when Isoetharine is combined with Etoricoxib. |
| Norepinephrine | The risk or severity of hypertension can be increased when Norepinephrine is combined with Etoricoxib. |
| Phenylpropanolamine | The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Etoricoxib. |
| Droperidol | The risk or severity of hypertension can be increased when Droperidol is combined with Etoricoxib. |
| Doxapram | The risk or severity of hypertension can be increased when Doxapram is combined with Etoricoxib. |
| Atropine | The risk or severity of hypertension can be increased when Atropine is combined with Etoricoxib. |
| Linezolid | The risk or severity of hypertension can be increased when Linezolid is combined with Etoricoxib. |
| Metaraminol | The risk or severity of hypertension can be increased when Metaraminol is combined with Etoricoxib. |
| Furazolidone | The risk or severity of hypertension can be increased when Furazolidone is combined with Etoricoxib. |
| Methoxamine | The risk or severity of hypertension can be increased when Methoxamine is combined with Etoricoxib. |
| Propiomazine | The risk or severity of hypertension can be increased when Propiomazine is combined with Etoricoxib. |
| Orciprenaline | The risk or severity of hypertension can be increased when Orciprenaline is combined with Etoricoxib. |
| Phenmetrazine | The risk or severity of hypertension can be increased when Phenmetrazine is combined with Etoricoxib. |
| Pseudoephedrine | The risk or severity of hypertension can be increased when Pseudoephedrine is combined with Etoricoxib. |
| Ritodrine | The risk or severity of hypertension can be increased when Ritodrine is combined with Etoricoxib. |
| Flupentixol | The risk or severity of hypertension can be increased when Flupentixol is combined with Etoricoxib. |
| Remifentanil | The risk or severity of hypertension can be increased when Remifentanil is combined with Etoricoxib. |
| Bitolterol | The risk or severity of hypertension can be increased when Bitolterol is combined with Etoricoxib. |
| Oxymetazoline | The risk or severity of hypertension can be increased when Oxymetazoline is combined with Etoricoxib. |
| Diethylpropion | The risk or severity of hypertension can be increased when Diethylpropion is combined with Etoricoxib. |
| Naratriptan | The risk or severity of hypertension can be increased when Naratriptan is combined with Etoricoxib. |
| Isoprenaline | The risk or severity of hypertension can be increased when Isoprenaline is combined with Etoricoxib. |
| Arbutamine | The risk or severity of hypertension can be increased when Arbutamine is combined with Etoricoxib. |
| Desflurane | The risk or severity of hypertension can be increased when Desflurane is combined with Etoricoxib. |
| Isocarboxazid | The risk or severity of hypertension can be increased when Isocarboxazid is combined with Etoricoxib. |
| Lisdexamfetamine | The serum concentration of dextroamphetamine, an active metabolite of Lisdexamfetamine, can be increased when used in combination with Etoricoxib. |
| Fenoterol | The risk or severity of hypertension can be increased when Fenoterol is combined with Etoricoxib. |
| Pirbuterol | The risk or severity of hypertension can be increased when Pirbuterol is combined with Etoricoxib. |
| Ephedra sinica root | The risk or severity of hypertension can be increased when Ephedra sinica root is combined with Etoricoxib. |
| Ephedrine | The risk or severity of hypertension can be increased when Ephedrine is combined with Etoricoxib. |
| Mephentermine | The risk or severity of hypertension can be increased when Mephentermine is combined with Etoricoxib. |
| Procaterol | The risk or severity of hypertension can be increased when Procaterol is combined with Etoricoxib. |
| Clenbuterol | The risk or severity of hypertension can be increased when Clenbuterol is combined with Etoricoxib. |
| Bambuterol | The risk or severity of hypertension can be increased when Bambuterol is combined with Etoricoxib. |
| MMDA | The risk or severity of hypertension can be increased when MMDA is combined with Etoricoxib. |
| 2,5-Dimethoxy-4-ethylamphetamine | The risk or severity of hypertension can be increased when 2,5-Dimethoxy-4-ethylamphetamine is combined with Etoricoxib. |
| 4-Bromo-2,5-dimethoxyamphetamine | The risk or severity of hypertension can be increased when 4-Bromo-2,5-dimethoxyamphetamine is combined with Etoricoxib. |
| Tenamfetamine | The risk or severity of hypertension can be increased when Tenamfetamine is combined with Etoricoxib. |
| Chlorphentermine | The risk or severity of hypertension can be increased when Chlorphentermine is combined with Etoricoxib. |
| Dextroamphetamine | The risk or severity of hypertension can be increased when Dextroamphetamine is combined with Etoricoxib. |
| Phendimetrazine | The risk or severity of hypertension can be increased when Phendimetrazine is combined with Etoricoxib. |
| Periciazine | The risk or severity of hypertension can be increased when Periciazine is combined with Etoricoxib. |
| Acepromazine | The risk or severity of hypertension can be increased when Acepromazine is combined with Etoricoxib. |
| Thioproperazine | The risk or severity of hypertension can be increased when Thioproperazine is combined with Etoricoxib. |
| Epicaptopril | The risk or severity of hypertension can be increased when Etoricoxib is combined with Epicaptopril. |
| Clorgiline | The risk or severity of hypertension can be increased when Etoricoxib is combined with Clorgiline. |
| 1-benzylimidazole | The risk or severity of hypertension can be increased when Etoricoxib is combined with 1-benzylimidazole. |
| Nialamide | The risk or severity of hypertension can be increased when Etoricoxib is combined with Nialamide. |
| Amibegron | The risk or severity of hypertension can be increased when Etoricoxib is combined with Amibegron. |
| Naluzotan | The risk or severity of hypertension can be increased when Etoricoxib is combined with Naluzotan. |
| Pizotifen | The risk or severity of hypertension can be increased when Etoricoxib is combined with Pizotifen. |
| Solabegron | The risk or severity of hypertension can be increased when Etoricoxib is combined with Solabegron. |
| Nitrous oxide | The risk or severity of hypertension can be increased when Etoricoxib is combined with Nitrous oxide. |
| Xylometazoline | The risk or severity of hypertension can be increased when Etoricoxib is combined with Xylometazoline. |
| Dexmethylphenidate | The risk or severity of hypertension can be increased when Etoricoxib is combined with Dexmethylphenidate. |
| Isometheptene | The risk or severity of hypertension can be increased when Etoricoxib is combined with Isometheptene. |
| Levonordefrin | The risk or severity of hypertension can be increased when Etoricoxib is combined with Levonordefrin. |
| Naphazoline | The risk or severity of hypertension can be increased when Etoricoxib is combined with Naphazoline. |
| Tetryzoline | The risk or severity of hypertension can be increased when Etoricoxib is combined with Tetryzoline. |
| Cinitapride | The risk or severity of hypertension can be increased when Etoricoxib is combined with Cinitapride. |
| Tyramine | The risk or severity of hypertension can be increased when Etoricoxib is combined with Tyramine. |
| Adrafinil | The risk or severity of hypertension can be increased when Etoricoxib is combined with Adrafinil. |
| Isoxsuprine | The risk or severity of hypertension can be increased when Etoricoxib is combined with Isoxsuprine. |
| Ifenprodil | The risk or severity of hypertension can be increased when Etoricoxib is combined with Ifenprodil. |
| Hexoprenaline | The risk or severity of hypertension can be increased when Etoricoxib is combined with Hexoprenaline. |
| Etilefrine | The risk or severity of hypertension can be increased when Etoricoxib is combined with Etilefrine. |
| Cirazoline | The risk or severity of hypertension can be increased when Etoricoxib is combined with Cirazoline. |
| Synephrine | The risk or severity of hypertension can be increased when Etoricoxib is combined with Synephrine. |
| Hydracarbazine | The risk or severity of hypertension can be increased when Etoricoxib is combined with Hydracarbazine. |
| Benmoxin | The risk or severity of hypertension can be increased when Etoricoxib is combined with Benmoxin. |
| Mebanazine | The risk or severity of hypertension can be increased when Etoricoxib is combined with Mebanazine. |
| Octamoxin | The risk or severity of hypertension can be increased when Etoricoxib is combined with Octamoxin. |
| Pheniprazine | The risk or severity of hypertension can be increased when Etoricoxib is combined with Pheniprazine. |
| Phenoxypropazine | The risk or severity of hypertension can be increased when Etoricoxib is combined with Phenoxypropazine. |
| Pivhydrazine | The risk or severity of hypertension can be increased when Etoricoxib is combined with Pivhydrazine. |
| Safrazine | The risk or severity of hypertension can be increased when Etoricoxib is combined with Safrazine. |
| Caroxazone | The risk or severity of hypertension can be increased when Etoricoxib is combined with Caroxazone. |
| Iofetamine I-123 | The risk or severity of hypertension can be increased when Etoricoxib is combined with Iofetamine I-123. |
| Racepinephrine | The risk or severity of hypertension can be increased when Etoricoxib is combined with Racepinephrine. |
| Amitraz | The risk or severity of hypertension can be increased when Etoricoxib is combined with Amitraz. |
| Medetomidine | The risk or severity of hypertension can be increased when Etoricoxib is combined with Medetomidine. |
| Xylazine | The risk or severity of hypertension can be increased when Etoricoxib is combined with Xylazine. |
| Atipamezole | The risk or severity of hypertension can be increased when Etoricoxib is combined with Atipamezole. |
| Ractopamine | The risk or severity of hypertension can be increased when Etoricoxib is combined with Ractopamine. |
| Romifidine | The risk or severity of hypertension can be increased when Etoricoxib is combined with Romifidine. |
| Detomidine | The risk or severity of hypertension can be increased when Etoricoxib is combined with Detomidine. |
| Tetrahydrocannabivarin | The risk or severity of hypertension can be increased when Etoricoxib is combined with Tetrahydrocannabivarin. |
| PF-00610355 | The risk or severity of hypertension can be increased when Etoricoxib is combined with PF-00610355. |
| Ritobegron | The risk or severity of hypertension can be increased when Etoricoxib is combined with Ritobegron. |
| Abediterol | The risk or severity of hypertension can be increased when Etoricoxib is combined with Abediterol. |
| Tulobuterol | The risk or severity of hypertension can be increased when Etoricoxib is combined with Tulobuterol. |
| Dopexamine | The risk or severity of hypertension can be increased when Etoricoxib is combined with Dopexamine. |