Although there have not been any cases of overdosage reported, the symptoms are likely to be somnolence, coma, extrapyramidal symptoms, convulsions, hypotension, shock, or hyper- or hypothermia.
Neuroleptic malignant syndrome may occur. Zuclopenthixol may potentiate anticholinergic effects of concurrent medications. Zuclopenthixol has a demonstrated antiemetic effect in animals, and may mask signs of toxicity due to other drug overdoses, or may mask symptoms of disease.
Zuclopenthixol, also known as Zuclopentixol or Zuclopenthixolum, is an antipsychotic agent. Zuclopenthixol is a thioxanthene-based neuroleptic with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors. Major brands of zuclopenthixol are Cisordinol, Acuphase, and Clopixol. This drug is a liquid. This compound belongs to the thioxanthenes. These are organic polycyclic compounds containing a thioxanthene moiety, which is an aromatic tricycle derived from xanthene by replacing the oxygen atom with a sulfur atom. Known drug targets of zuclopenthixol include 5-hydroxytryptamine receptor 2A, D(1B) dopamine receptor, D(2) dopamine receptor, D(1A) dopamine receptor, and alpha-1A adrenergic receptor. It is known that zuclopenthixol is metabolized by Cytochrome P450 2D6. Zuclopenthixol was approved for use in Canada in 2011, but is not approved for use in the United States.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Phenytoin | The metabolism of Zuclopenthixol can be increased when combined with Phenytoin. |
| Fosphenytoin | The metabolism of Zuclopenthixol can be increased when combined with Fosphenytoin. |
| Valsartan | Zuclopenthixol may decrease the antihypertensive activities of Valsartan. |
| Ramipril | Zuclopenthixol may decrease the antihypertensive activities of Ramipril. |
| Remikiren | Zuclopenthixol may decrease the antihypertensive activities of Remikiren. |
| Torasemide | Zuclopenthixol may decrease the antihypertensive activities of Torasemide. |
| Guanadrel | Zuclopenthixol may decrease the antihypertensive activities of Guanadrel. |
| Olmesartan | Zuclopenthixol may decrease the antihypertensive activities of Olmesartan. |
| Chlorthalidone | Zuclopenthixol may decrease the antihypertensive activities of Chlorthalidone. |
| Nitroprusside | Zuclopenthixol may decrease the antihypertensive activities of Nitroprusside. |
| Minoxidil | Zuclopenthixol may decrease the antihypertensive activities of Minoxidil. |
| Bendroflumethiazide | Zuclopenthixol may decrease the antihypertensive activities of Bendroflumethiazide. |
| Fosinopril | Zuclopenthixol may decrease the antihypertensive activities of Fosinopril. |
| Trandolapril | Zuclopenthixol may decrease the antihypertensive activities of Trandolapril. |
| Metolazone | Zuclopenthixol may decrease the antihypertensive activities of Metolazone. |
| Benazepril | Zuclopenthixol may decrease the antihypertensive activities of Benazepril. |
| Cyclothiazide | Zuclopenthixol may decrease the antihypertensive activities of Cyclothiazide. |
| Candoxatril | Zuclopenthixol may decrease the antihypertensive activities of Candoxatril. |
| Mecamylamine | Zuclopenthixol may decrease the antihypertensive activities of Mecamylamine. |
| Lisinopril | Zuclopenthixol may decrease the antihypertensive activities of Lisinopril. |
| Nitroglycerin | Zuclopenthixol may decrease the antihypertensive activities of Nitroglycerin. |
| Hydroflumethiazide | Zuclopenthixol may decrease the antihypertensive activities of Hydroflumethiazide. |
| Cryptenamine | Zuclopenthixol may decrease the antihypertensive activities of Cryptenamine. |
| Perindopril | Zuclopenthixol may decrease the antihypertensive activities of Perindopril. |
| Candesartan cilexetil | Zuclopenthixol may decrease the antihypertensive activities of Candesartan cilexetil. |
| Eprosartan | Zuclopenthixol may decrease the antihypertensive activities of Eprosartan. |
| Chlorothiazide | Zuclopenthixol may decrease the antihypertensive activities of Chlorothiazide. |
| Quinapril | Zuclopenthixol may decrease the antihypertensive activities of Quinapril. |
| Telmisartan | Zuclopenthixol may decrease the antihypertensive activities of Telmisartan. |
| Trichlormethiazide | Zuclopenthixol may decrease the antihypertensive activities of Trichlormethiazide. |
| Deserpidine | Zuclopenthixol may decrease the antihypertensive activities of Deserpidine. |
| Pentolinium | Zuclopenthixol may decrease the antihypertensive activities of Pentolinium. |
| Trimethaphan | Zuclopenthixol may decrease the antihypertensive activities of Trimethaphan. |
| Diazoxide | Zuclopenthixol may decrease the antihypertensive activities of Diazoxide. |
| Epoprostenol | Zuclopenthixol may decrease the antihypertensive activities of Epoprostenol. |
| Polythiazide | Zuclopenthixol may decrease the antihypertensive activities of Polythiazide. |
| Cilazapril | Zuclopenthixol may decrease the antihypertensive activities of Cilazapril. |
| Saprisartan | Zuclopenthixol may decrease the antihypertensive activities of Saprisartan. |
| Spirapril | Zuclopenthixol may decrease the antihypertensive activities of Spirapril. |
| Tienilic acid | Zuclopenthixol may decrease the antihypertensive activities of Tienilic acid. |
| Diethylnorspermine | Zuclopenthixol may decrease the antihypertensive activities of Diethylnorspermine. |
| Temocapril | Zuclopenthixol may decrease the antihypertensive activities of Temocapril. |
| Nicorandil | Zuclopenthixol may decrease the antihypertensive activities of Nicorandil. |
| Rauwolfia serpentina root | Zuclopenthixol may decrease the antihypertensive activities of Rauwolfia serpentina root. |
| Enalaprilat | Zuclopenthixol may decrease the antihypertensive activities of Enalaprilat. |
| Angiotensin 1-7 | Zuclopenthixol may decrease the antihypertensive activities of Angiotensin 1-7. |
| Imidapril | Zuclopenthixol may decrease the antihypertensive activities of Imidapril. |
| BQ-123 | Zuclopenthixol may decrease the antihypertensive activities of BQ-123. |
| Dihydralazine | Zuclopenthixol may decrease the antihypertensive activities of Dihydralazine. |
| Zofenopril | Zuclopenthixol may decrease the antihypertensive activities of Zofenopril. |
| Guanoxan | Zuclopenthixol may decrease the antihypertensive activities of Guanoxan. |
| Delapril | Zuclopenthixol may decrease the antihypertensive activities of Delapril. |
| Vincamine | Zuclopenthixol may decrease the antihypertensive activities of Vincamine. |
| Linsidomine | Zuclopenthixol may decrease the antihypertensive activities of Linsidomine. |
| Guanoxabenz | Zuclopenthixol may decrease the antihypertensive activities of Guanoxabenz. |
| Tolonidine | Zuclopenthixol may decrease the antihypertensive activities of Tolonidine. |
| Endralazine | Zuclopenthixol may decrease the antihypertensive activities of Endralazine. |
| Cadralazine | Zuclopenthixol may decrease the antihypertensive activities of Cadralazine. |
| Cyclopenthiazide | Zuclopenthixol may decrease the antihypertensive activities of Cyclopenthiazide. |
| Bietaserpine | Zuclopenthixol may decrease the antihypertensive activities of Bietaserpine. |
| Guanazodine | Zuclopenthixol may decrease the antihypertensive activities of Guanazodine. |
| Methoserpidine | Zuclopenthixol may decrease the antihypertensive activities of Methoserpidine. |
| Guanoclor | Zuclopenthixol may decrease the antihypertensive activities of Guanoclor. |
| Muzolimine | Zuclopenthixol may decrease the antihypertensive activities of Muzolimine. |
| Xipamide | Zuclopenthixol may decrease the antihypertensive activities of Xipamide. |
| Candesartan | Zuclopenthixol may decrease the antihypertensive activities of Candesartan. |
| Tocopherylquinone | Zuclopenthixol may decrease the antihypertensive activities of Tocopherylquinone. |
| Benazeprilat | Zuclopenthixol may decrease the antihypertensive activities of Benazeprilat. |
| Fosinoprilat | Zuclopenthixol may decrease the antihypertensive activities of Fosinoprilat. |
| Ramiprilat | Zuclopenthixol may decrease the antihypertensive activities of Ramiprilat. |
| Perindoprilat | Zuclopenthixol may decrease the antihypertensive activities of Perindoprilat. |
| Quinaprilat | Zuclopenthixol may decrease the antihypertensive activities of Quinaprilat. |
| Furosemide | Zuclopenthixol may decrease the antihypertensive activities of Furosemide. |
| Enalapril | Zuclopenthixol may decrease the antihypertensive activities of Enalapril. |
| Captopril | Zuclopenthixol may decrease the antihypertensive activities of Captopril. |
| Guanethidine | Zuclopenthixol may decrease the antihypertensive activities of Guanethidine. |
| Ambrisentan | Zuclopenthixol may decrease the antihypertensive activities of Ambrisentan. |
| Pinacidil | Zuclopenthixol may decrease the antihypertensive activities of Pinacidil. |
| Riociguat | Zuclopenthixol may decrease the antihypertensive activities of Riociguat. |
| Macitentan | Zuclopenthixol may decrease the antihypertensive activities of Macitentan. |
| Aliskiren | Zuclopenthixol may decrease the antihypertensive activities of Aliskiren. |
| Selexipag | Zuclopenthixol may decrease the antihypertensive activities of Selexipag. |
| Eplerenone | Zuclopenthixol may decrease the antihypertensive activities of Eplerenone. |
| Levamlodipine | Zuclopenthixol may decrease the antihypertensive activities of Levamlodipine. |
| Buthiazide | Zuclopenthixol may decrease the antihypertensive activities of Buthiazide. |
| Azilsartan medoxomil | Zuclopenthixol may decrease the antihypertensive activities of Azilsartan medoxomil. |
| Buprenorphine | Zuclopenthixol may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. |
| Doxylamine | Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Zuclopenthixol. |
| Dronabinol | Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Zuclopenthixol. |
| Droperidol | Droperidol may increase the central nervous system depressant (CNS depressant) activities of Zuclopenthixol. |
| Hydrocodone | Zuclopenthixol may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. |
| Magnesium sulfate | The therapeutic efficacy of Zuclopenthixol can be increased when used in combination with Magnesium sulfate. |
| Methotrimeprazine | Zuclopenthixol may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine. |
| Metyrosine | Zuclopenthixol may increase the sedative activities of Metyrosine. |
| Minocycline | Minocycline may increase the central nervous system depressant (CNS depressant) activities of Zuclopenthixol. |
| Nabilone | Nabilone may increase the central nervous system depressant (CNS depressant) activities of Zuclopenthixol. |
| Orphenadrine | Zuclopenthixol may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Paraldehyde | Zuclopenthixol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. |
| Perampanel | Perampanel may increase the central nervous system depressant (CNS depressant) activities of Zuclopenthixol. |
| Rotigotine | Zuclopenthixol may increase the sedative activities of Rotigotine. |