Overdosage may result in severe extrapyramidal symptoms with dysphagia, marked sialorrhea, persistent and rapidly increasing hyperthermia, pulmonary syndrome, state of shock with pallor and profuse sweating, which may be followed by collapse and coma. LD50 in mice is 70 mg/kg I.V., 120 mg/kg I.P., 500 mg/kg S.C. and 830 mg/kg P.O.
Thioproperazine is a potent neuroleptic with antipsychotic properties. Thioproperazine has a marked cataleptic and antiapomorphine activity associated with relatively slight sedative, hypothermic and spasmolytic effects. It is virtually without antiserotonin and hypotensive action and has no antihistaminic property. It is used for the treatment of all types of acute and chronic schizophrenia, including those which did not respond to the usual neuroleptics; manic syndromes.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Valsartan | Thioproperazine may decrease the antihypertensive activities of Valsartan. |
| Ramipril | Thioproperazine may decrease the antihypertensive activities of Ramipril. |
| Remikiren | Thioproperazine may decrease the antihypertensive activities of Remikiren. |
| Torasemide | Thioproperazine may decrease the antihypertensive activities of Torasemide. |
| Guanadrel | Thioproperazine may decrease the antihypertensive activities of Guanadrel. |
| Olmesartan | Thioproperazine may decrease the antihypertensive activities of Olmesartan. |
| Chlorthalidone | Thioproperazine may decrease the antihypertensive activities of Chlorthalidone. |
| Nitroprusside | Thioproperazine may decrease the antihypertensive activities of Nitroprusside. |
| Minoxidil | Thioproperazine may decrease the antihypertensive activities of Minoxidil. |
| Treprostinil | Thioproperazine may decrease the antihypertensive activities of Treprostinil. |
| Bendroflumethiazide | Thioproperazine may decrease the antihypertensive activities of Bendroflumethiazide. |
| Fosinopril | Thioproperazine may decrease the antihypertensive activities of Fosinopril. |
| Trandolapril | Thioproperazine may decrease the antihypertensive activities of Trandolapril. |
| Metolazone | Thioproperazine may decrease the antihypertensive activities of Metolazone. |
| Benazepril | Thioproperazine may decrease the antihypertensive activities of Benazepril. |
| Bosentan | Thioproperazine may decrease the antihypertensive activities of Bosentan. |
| Enalapril | Thioproperazine may decrease the antihypertensive activities of Enalapril. |
| Cyclothiazide | Thioproperazine may decrease the antihypertensive activities of Cyclothiazide. |
| Candoxatril | Thioproperazine may decrease the antihypertensive activities of Candoxatril. |
| Mecamylamine | Thioproperazine may decrease the antihypertensive activities of Mecamylamine. |
| Losartan | Thioproperazine may decrease the antihypertensive activities of Losartan. |
| Moexipril | Thioproperazine may decrease the antihypertensive activities of Moexipril. |
| Eplerenone | Thioproperazine may decrease the antihypertensive activities of Eplerenone. |
| Lisinopril | Thioproperazine may decrease the antihypertensive activities of Lisinopril. |
| Nitroglycerin | Thioproperazine may decrease the antihypertensive activities of Nitroglycerin. |
| Hydroflumethiazide | Thioproperazine may decrease the antihypertensive activities of Hydroflumethiazide. |
| Cryptenamine | Thioproperazine may decrease the antihypertensive activities of Cryptenamine. |
| Perindopril | Thioproperazine may decrease the antihypertensive activities of Perindopril. |
| Candesartan cilexetil | Thioproperazine may decrease the antihypertensive activities of Candesartan cilexetil. |
| Indapamide | Thioproperazine may decrease the antihypertensive activities of Indapamide. |
| Eprosartan | Thioproperazine may decrease the antihypertensive activities of Eprosartan. |
| Chlorothiazide | Thioproperazine may decrease the antihypertensive activities of Chlorothiazide. |
| Quinapril | Thioproperazine may decrease the antihypertensive activities of Quinapril. |
| Telmisartan | Thioproperazine may decrease the antihypertensive activities of Telmisartan. |
| Hydrochlorothiazide | Thioproperazine may decrease the antihypertensive activities of Hydrochlorothiazide. |
| Trichlormethiazide | Thioproperazine may decrease the antihypertensive activities of Trichlormethiazide. |
| Irbesartan | Thioproperazine may decrease the antihypertensive activities of Irbesartan. |
| Deserpidine | Thioproperazine may decrease the antihypertensive activities of Deserpidine. |
| Pentolinium | Thioproperazine may decrease the antihypertensive activities of Pentolinium. |
| Trimethaphan | Thioproperazine may decrease the antihypertensive activities of Trimethaphan. |
| Diazoxide | Thioproperazine may decrease the antihypertensive activities of Diazoxide. |
| Bretylium | Thioproperazine may decrease the antihypertensive activities of Bretylium. |
| Guanethidine | Thioproperazine may decrease the antihypertensive activities of Guanethidine. |
| Captopril | Thioproperazine may decrease the antihypertensive activities of Captopril. |
| Epoprostenol | Thioproperazine may decrease the antihypertensive activities of Epoprostenol. |
| Hydralazine | Thioproperazine may decrease the antihypertensive activities of Hydralazine. |
| Polythiazide | Thioproperazine may decrease the antihypertensive activities of Polythiazide. |
| Cilazapril | Thioproperazine may decrease the antihypertensive activities of Cilazapril. |
| Saprisartan | Thioproperazine may decrease the antihypertensive activities of Saprisartan. |
| Spirapril | Thioproperazine may decrease the antihypertensive activities of Spirapril. |
| Tienilic acid | Thioproperazine may decrease the antihypertensive activities of Tienilic acid. |
| Debrisoquine | Thioproperazine may decrease the antihypertensive activities of Debrisoquine. |
| Sitaxentan | Thioproperazine may decrease the antihypertensive activities of Sitaxentan. |
| Ambrisentan | Thioproperazine may decrease the antihypertensive activities of Ambrisentan. |
| Diethylnorspermine | Thioproperazine may decrease the antihypertensive activities of Diethylnorspermine. |
| Pinacidil | Thioproperazine may decrease the antihypertensive activities of Pinacidil. |
| Temocapril | Thioproperazine may decrease the antihypertensive activities of Temocapril. |
| Riociguat | Thioproperazine may decrease the antihypertensive activities of Riociguat. |
| Macitentan | Thioproperazine may decrease the antihypertensive activities of Macitentan. |
| Aliskiren | Thioproperazine may decrease the antihypertensive activities of Aliskiren. |
| Nicorandil | Thioproperazine may decrease the antihypertensive activities of Nicorandil. |
| Rauwolfia serpentina root | Thioproperazine may decrease the antihypertensive activities of Rauwolfia serpentina root. |
| Enalaprilat | Thioproperazine may decrease the antihypertensive activities of Enalaprilat. |
| Selexipag | Thioproperazine may decrease the antihypertensive activities of Selexipag. |
| Angiotensin 1-7 | Thioproperazine may decrease the antihypertensive activities of Angiotensin 1-7. |
| Imidapril | Thioproperazine may decrease the antihypertensive activities of Imidapril. |
| BQ-123 | Thioproperazine may decrease the antihypertensive activities of BQ-123. |
| Cicletanine | Thioproperazine may decrease the antihypertensive activities of Cicletanine. |
| Dihydralazine | Thioproperazine may decrease the antihypertensive activities of Dihydralazine. |
| Zofenopril | Thioproperazine may decrease the antihypertensive activities of Zofenopril. |
| Guanoxan | Thioproperazine may decrease the antihypertensive activities of Guanoxan. |
| Delapril | Thioproperazine may decrease the antihypertensive activities of Delapril. |
| Vincamine | Thioproperazine may decrease the antihypertensive activities of Vincamine. |
| Linsidomine | Thioproperazine may decrease the antihypertensive activities of Linsidomine. |
| Guanoxabenz | Thioproperazine may decrease the antihypertensive activities of Guanoxabenz. |
| Tolonidine | Thioproperazine may decrease the antihypertensive activities of Tolonidine. |
| Endralazine | Thioproperazine may decrease the antihypertensive activities of Endralazine. |
| Cadralazine | Thioproperazine may decrease the antihypertensive activities of Cadralazine. |
| Cyclopenthiazide | Thioproperazine may decrease the antihypertensive activities of Cyclopenthiazide. |
| Bietaserpine | Thioproperazine may decrease the antihypertensive activities of Bietaserpine. |
| Guanazodine | Thioproperazine may decrease the antihypertensive activities of Guanazodine. |
| Methoserpidine | Thioproperazine may decrease the antihypertensive activities of Methoserpidine. |
| Guanoclor | Thioproperazine may decrease the antihypertensive activities of Guanoclor. |
| Muzolimine | Thioproperazine may decrease the antihypertensive activities of Muzolimine. |
| Xipamide | Thioproperazine may decrease the antihypertensive activities of Xipamide. |
| Candesartan | Thioproperazine may decrease the antihypertensive activities of Candesartan. |
| Tocopherylquinone | Thioproperazine may decrease the antihypertensive activities of Tocopherylquinone. |
| Benazeprilat | Thioproperazine may decrease the antihypertensive activities of Benazeprilat. |
| Fosinoprilat | Thioproperazine may decrease the antihypertensive activities of Fosinoprilat. |
| Ramiprilat | Thioproperazine may decrease the antihypertensive activities of Ramiprilat. |
| Perindoprilat | Thioproperazine may decrease the antihypertensive activities of Perindoprilat. |
| Quinaprilat | Thioproperazine may decrease the antihypertensive activities of Quinaprilat. |
| Furosemide | Thioproperazine may decrease the antihypertensive activities of Furosemide. |
| Levamlodipine | Thioproperazine may decrease the antihypertensive activities of Levamlodipine. |
| Buthiazide | Thioproperazine may decrease the antihypertensive activities of Buthiazide. |
| Azilsartan medoxomil | Thioproperazine may decrease the antihypertensive activities of Azilsartan medoxomil. |
| Buprenorphine | Thioproperazine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. |
| Doxylamine | Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Thioproperazine. |
| Dronabinol | Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Thioproperazine. |
| Droperidol | Droperidol may increase the central nervous system depressant (CNS depressant) activities of Thioproperazine. |