Peringatan Keamanan

Can produce hypotension and atropine-like toxic effects. Fatality has occurred following overdose with very high doses.

Alverine

DB01616

small molecule approved investigational

Deskripsi

Alverine is a smooth muscle relaxant used to relieve cramps or spasms of the stomach and intestines. It is therefore useful in treating irritable bowel syndrome (IBS) and similar conditions. It can also be used to help relieve period pain.

Struktur Molekul 2D

Berat 281.4351
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The plasma half-life averages 0.8 hours for alverine and 5.7 hours for the active primary metabolite.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Rapidly converted to its primary active metabolite, which is then further converted to two secondary metabolites.

Rute Eliminasi

High renal clearance of all metabolites indicating that they are eliminated by active renal secretion.

Interaksi Obat

677 Data
Buprenorphine Alverine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Alverine.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Alverine.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Alverine.
Hydrocodone Alverine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Alverine.
Magnesium sulfate The therapeutic efficacy of Alverine can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Alverine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Alverine may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Alverine.
Mirtazapine Alverine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Alverine.
Orphenadrine Alverine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Alverine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Alverine.
Pramipexole Alverine may increase the sedative activities of Pramipexole.
Ropinirole Alverine may increase the sedative activities of Ropinirole.
Rotigotine Alverine may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Alverine.
Sodium oxybate Alverine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Alverine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Alverine.
Thalidomide Alverine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Alverine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Alverine.
Dicoumarol The risk or severity of adverse effects can be increased when Alverine is combined with Dicoumarol.
Phenindione The risk or severity of adverse effects can be increased when Alverine is combined with Phenindione.
Warfarin The risk or severity of adverse effects can be increased when Alverine is combined with Warfarin.
Phenprocoumon The risk or severity of adverse effects can be increased when Alverine is combined with Phenprocoumon.
Acenocoumarol The risk or severity of adverse effects can be increased when Alverine is combined with Acenocoumarol.
4-hydroxycoumarin The risk or severity of adverse effects can be increased when Alverine is combined with 4-hydroxycoumarin.
Coumarin The risk or severity of adverse effects can be increased when Alverine is combined with Coumarin.
(R)-warfarin The risk or severity of adverse effects can be increased when Alverine is combined with (R)-warfarin.
Ethyl biscoumacetate The risk or severity of adverse effects can be increased when Alverine is combined with Ethyl biscoumacetate.
Fluindione The risk or severity of adverse effects can be increased when Alverine is combined with Fluindione.
Clorindione The risk or severity of adverse effects can be increased when Alverine is combined with Clorindione.
Diphenadione The risk or severity of adverse effects can be increased when Alverine is combined with Diphenadione.
Tioclomarol The risk or severity of adverse effects can be increased when Alverine is combined with Tioclomarol.
(S)-Warfarin The risk or severity of adverse effects can be increased when Alverine is combined with (S)-Warfarin.
Ethanol Alverine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Alverine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Alverine.
Fluvoxamine The risk or severity of adverse effects can be increased when Alverine is combined with Fluvoxamine.
Citalopram The risk or severity of adverse effects can be increased when Alverine is combined with Citalopram.
Duloxetine The risk or severity of adverse effects can be increased when Alverine is combined with Duloxetine.
Trazodone The risk or severity of adverse effects can be increased when Alverine is combined with Trazodone.
Paroxetine The risk or severity of adverse effects can be increased when Alverine is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when Alverine is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Alverine is combined with Sibutramine.
Nefazodone The risk or severity of adverse effects can be increased when Alverine is combined with Nefazodone.
Escitalopram The risk or severity of adverse effects can be increased when Alverine is combined with Escitalopram.
Zimelidine The risk or severity of adverse effects can be increased when Alverine is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Alverine is combined with Dapoxetine.
Milnacipran The risk or severity of adverse effects can be increased when Alverine is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Alverine is combined with Desvenlafaxine.
Seproxetine The risk or severity of adverse effects can be increased when Alverine is combined with Seproxetine.
Indalpine The risk or severity of adverse effects can be increased when Alverine is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Alverine is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Alverine is combined with Alaproclate.
Zopiclone The risk or severity of adverse effects can be increased when Alverine is combined with Zopiclone.
Botulinum toxin type B The risk or severity of CNS depression can be increased when Botulinum toxin type B is combined with Alverine.
Botulinum toxin type A The risk or severity of CNS depression can be increased when Botulinum toxin type A is combined with Alverine.
Tryptophan The risk or severity of CNS depression can be increased when Tryptophan is combined with Alverine.
Baclofen Baclofen may increase the central nervous system depressant (CNS depressant) activities of Alverine.
Lorazepam The risk or severity of CNS depression can be increased when Lorazepam is combined with Alverine.
Ethchlorvynol The risk or severity of CNS depression can be increased when Ethchlorvynol is combined with Alverine.
Succinylcholine The risk or severity of CNS depression can be increased when Succinylcholine is combined with Alverine.
Reserpine The risk or severity of CNS depression can be increased when Reserpine is combined with Alverine.
Eletriptan The risk or severity of CNS depression can be increased when Eletriptan is combined with Alverine.
Enflurane The risk or severity of CNS depression can be increased when Enflurane is combined with Alverine.
Temazepam The risk or severity of CNS depression can be increased when Temazepam is combined with Alverine.
Reboxetine The risk or severity of CNS depression can be increased when Reboxetine is combined with Alverine.
Butabarbital The risk or severity of CNS depression can be increased when Butabarbital is combined with Alverine.
Butalbital The risk or severity of CNS depression can be increased when Butalbital is combined with Alverine.
Methysergide The risk or severity of CNS depression can be increased when Methysergide is combined with Alverine.
Cabergoline The risk or severity of CNS depression can be increased when Cabergoline is combined with Alverine.
Phenytoin The risk or severity of CNS depression can be increased when Phenytoin is combined with Alverine.
Topiramate The risk or severity of CNS depression can be increased when Topiramate is combined with Alverine.
Clemastine The risk or severity of CNS depression can be increased when Clemastine is combined with Alverine.
Venlafaxine The risk or severity of CNS depression can be increased when Venlafaxine is combined with Alverine.
Etomidate The risk or severity of CNS depression can be increased when Etomidate is combined with Alverine.
Morphine The risk or severity of CNS depression can be increased when Morphine is combined with Alverine.
Talbutal The risk or severity of CNS depression can be increased when Talbutal is combined with Alverine.
Pentobarbital The risk or severity of CNS depression can be increased when Pentobarbital is combined with Alverine.
Valproic acid The risk or severity of CNS depression can be increased when Valproic acid is combined with Alverine.
Zolmitriptan The risk or severity of CNS depression can be increased when Zolmitriptan is combined with Alverine.
Codeine The risk or severity of CNS depression can be increased when Codeine is combined with Alverine.
Dihydroergotamine The risk or severity of CNS depression can be increased when Dihydroergotamine is combined with Alverine.
Amitriptyline The risk or severity of CNS depression can be increased when Amitriptyline is combined with Alverine.
Tolcapone The risk or severity of CNS depression can be increased when Tolcapone is combined with Alverine.
Hydromorphone The risk or severity of CNS depression can be increased when Hydromorphone is combined with Alverine.
Olanzapine The risk or severity of CNS depression can be increased when Olanzapine is combined with Alverine.
Cetirizine The risk or severity of CNS depression can be increased when Cetirizine is combined with Alverine.
Protriptyline The risk or severity of CNS depression can be increased when Protriptyline is combined with Alverine.
Trimethadione The risk or severity of CNS depression can be increased when Trimethadione is combined with Alverine.
Clobazam The risk or severity of sedation, somnolence, and CNS depression can be increased when Clobazam is combined with Alverine.
Chlorzoxazone The risk or severity of CNS depression can be increased when Chlorzoxazone is combined with Alverine.
Clozapine The risk or severity of CNS depression can be increased when Clozapine is combined with Alverine.
Meprobamate The risk or severity of CNS depression can be increased when Meprobamate is combined with Alverine.
Thiethylperazine The risk or severity of CNS depression can be increased when Thiethylperazine is combined with Alverine.

Target Protein

5-hydroxytryptamine receptor 1A HTR1A

Referensi & Sumber

Artikel (PubMed)
  • PMID: 17934514
    Hayase M, Hashitani H, Suzuki H, Kohri K, Brading AF: Evolving mechanisms of action of alverine citrate on phasic smooth muscles. Br J Pharmacol. 2007 Dec;152(8):1228-38. Epub 2007 Oct 15.
  • PMID: 20003095
    Wittmann T, Paradowski L, Ducrotte P, Bueno L, Andro Delestrain MC: Clinical trial: the efficacy of alverine citrate/simeticone combination on abdominal pain/discomfort in irritable bowel syndrome--a randomized, double-blind, placebo-controlled study. Aliment Pharmacol Ther. 2010 Mar;31(6):615-24. doi: 10.1111/j.1365-2036.2009.04216.x. Epub 2009 Dec 10.
  • PMID: 19148544
    Ju D, Wang X, Xie Y: Dyclonine and alverine citrate enhance the cytotoxic effects of proteasome inhibitor MG132 on breast cancer cells. Int J Mol Med. 2009 Feb;23(2):205-9.

Contoh Produk & Brand

Produk: 0 • International brands: 4
International Brands
  • Audmonal
  • Profenil
  • Spasmaverine
  • Spasmonal

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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