Peringatan Keamanan

It is expected that an overdose of valganciclovir could also possibly result in increased renal toxicity.

Valganciclovir

DB01610

small molecule approved investigational

Deskripsi

Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases.

Struktur Molekul 2D

Berat 354.3617
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Approximately 4.08 hours. Increased in patients with renal function impairment.
Volume Distribusi * 0.703 ± 0.134 L/kg
Klirens (Clearance) * 3.07+/- 0.64 mL/min/kg [IV administration] * 5.3 L/hr [Patient with creatinine clearance of 70.4 mL/min]

Absorpsi

Valganciclovir is well absorbed from the gastrointestinal tract and the absolute bioavailability from valganciclovir tablets (following administration with food) is approximately 60%.

Metabolisme

Rapidly hydrolyzed in the intestinal wall and liver to ganciclovir. No other metabolites have been detected.

Rute Eliminasi

The major route of elimination of valganciclovir is by renal excretion as ganciclovir through glomerular filtration and active tubular secretion.

Interaksi Makanan

1 Data
  • 1. Take with food.

Interaksi Obat

820 Data
Imipenem The risk or severity of generalized seizure can be increased when Valganciclovir is combined with Imipenem.
Probenecid Probenecid may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Entecavir The risk or severity of cytopenia can be increased when Valganciclovir is combined with Entecavir.
Zidovudine The risk or severity of cytopenia can be increased when Valganciclovir is combined with Zidovudine.
Stavudine The risk or severity of cytopenia can be increased when Valganciclovir is combined with Stavudine.
Lamivudine The risk or severity of cytopenia can be increased when Valganciclovir is combined with Lamivudine.
Didanosine The risk or severity of cytopenia can be increased when Valganciclovir is combined with Didanosine.
Zalcitabine The risk or severity of cytopenia can be increased when Valganciclovir is combined with Zalcitabine.
Abacavir The risk or severity of cytopenia can be increased when Valganciclovir is combined with Abacavir.
Telbivudine The risk or severity of cytopenia can be increased when Valganciclovir is combined with Telbivudine.
Adefovir The risk or severity of cytopenia can be increased when Valganciclovir is combined with Adefovir.
Tenofovir The risk or severity of cytopenia can be increased when Valganciclovir is combined with Tenofovir.
Emtricitabine The risk or severity of cytopenia can be increased when Valganciclovir is combined with Emtricitabine.
Cyclosporine Cyclosporine may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Icosapent Icosapent may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Cefotiam Cefotiam may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Mesalazine Mesalazine may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Cefmenoxime Cefmenoxime may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Cefmetazole Cefmetazole may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Pamidronic acid Pamidronic acid may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Tenofovir disoproxil Tenofovir disoproxil may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Indomethacin Indomethacin may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Cidofovir Cidofovir may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Cefpiramide Cefpiramide may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Ceftazidime Ceftazidime may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Loracarbef Loracarbef may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Cefalotin Cefalotin may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Nabumetone Nabumetone may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Ketorolac Ketorolac may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Tenoxicam Tenoxicam may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Celecoxib Celecoxib may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Cefotaxime Cefotaxime may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Tolmetin Tolmetin may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Foscarnet Foscarnet may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Rofecoxib Rofecoxib may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Piroxicam Piroxicam may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Methotrexate Methotrexate may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Cephalexin Cephalexin may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Fenoprofen Fenoprofen may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Valaciclovir Valaciclovir may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Valdecoxib Valdecoxib may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Diclofenac Diclofenac may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Sulindac Sulindac may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Bacitracin Bacitracin may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Amphotericin B Amphotericin B may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Cephaloglycin Cephaloglycin may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Flurbiprofen Flurbiprofen may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Pentamidine Pentamidine may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Etodolac Etodolac may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Mefenamic acid Mefenamic acid may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Acyclovir Acyclovir may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Naproxen Naproxen may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Sulfasalazine Sulfasalazine may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Phenylbutazone Phenylbutazone may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Meloxicam Meloxicam may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Carprofen Carprofen may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Cefaclor Cefaclor may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Diflunisal Diflunisal may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Tacrolimus Tacrolimus may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Ceforanide Ceforanide may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Salicylic acid Salicylic acid may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Meclofenamic acid Meclofenamic acid may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Acetylsalicylic acid Acetylsalicylic acid may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Carboplatin Carboplatin may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Oxaprozin Oxaprozin may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Ketoprofen Ketoprofen may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Balsalazide Balsalazide may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Ibuprofen Ibuprofen may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Cefditoren Cefditoren may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Atazanavir Atazanavir may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Colistimethate Colistimethate may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Cefuroxime Cefuroxime may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Cefapirin Cefapirin may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Cefadroxil Cefadroxil may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Cefprozil Cefprozil may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Ceftriaxone Ceftriaxone may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Olsalazine Olsalazine may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Lumiracoxib Lumiracoxib may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Cefamandole Cefamandole may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Cefazolin Cefazolin may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Cefonicid Cefonicid may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Cefoperazone Cefoperazone may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Cefotetan Cefotetan may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Cefoxitin Cefoxitin may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Ceftizoxime Ceftizoxime may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Cefradine Cefradine may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Magnesium salicylate Magnesium salicylate may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Salsalate Salsalate may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Choline magnesium trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Cefepime Cefepime may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Cefacetrile Cefacetrile may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Ceftibuten Ceftibuten may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Cefpodoxime Cefpodoxime may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Antrafenine Antrafenine may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Aminophenazone Aminophenazone may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Antipyrine Antipyrine may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Tiaprofenic acid Tiaprofenic acid may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Lopinavir Lopinavir may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Etoricoxib Etoricoxib may decrease the excretion rate of Valganciclovir which could result in a higher serum level.

Target Protein

DNA polymerase catalytic subunit
DNA

Referensi & Sumber

Synthesis reference: Romi Singh, Vishnubhotla Nagaprasad, Nidhi Singh, "Processes for the Preparation of Solid Dosage Forms of Amorphous Valganciclovir Hydrochloride." U.S. Patent US20070292499, issued December 20, 2007.
Artikel (PubMed)
  • PMID: 15290873
    Umapathy NS, Ganapathy V, Ganapathy ME: Transport of amino acid esters and the amino-acid-based prodrug valganciclovir by the amino acid transporter ATB(0,+). Pharm Res. 2004 Jul;21(7):1303-10.

Contoh Produk & Brand

Produk: 46 • International brands: 2
Produk
  • Apo-valganciclovir
    Tablet • 450 mg • Oral • Canada • Generic • Approved
  • Auro-valganciclovir
    Tablet • 450 mg • Oral • Canada • Generic • Approved
  • Auro-valganciclovir
    Powder, for solution • 50 mg / mL • Oral • Canada • Generic • Approved
  • Mint-valganciclovir
    Tablet • 450 mg • Oral • Canada • Generic • Approved
  • Mylan-valganciclovir
    Tablet • 450 mg • Oral • Canada • Generic • Approved
  • Nat-valganciclovir
    Tablet • 450 mg • Oral • Canada • Generic • Approved
  • Teva-valganciclovir
    Tablet • 450 mg • Oral • Canada • Generic • Approved
  • Valcyte
    Tablet, film coated • 450 mg/1 • Oral • US • Approved
Menampilkan 8 dari 46 produk.
International Brands
  • Cymeval
  • Valcyt

Sekuens Gen/Protein (FASTA)

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