Pivmecillinam

DB01605

small molecule approved

Deskripsi

Pivmecillinam is a mecillinam prodrug, a pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. It is active against gram-negative organisms and used as for amdinocillin. PubChem

Struktur Molekul 2D

Berat 439.569
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Well absorbed following oral administration.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Take with or without food. The absorption is unaffected by food.

Interaksi Obat

192 Data
Methotrexate The excretion of Methotrexate can be decreased when combined with Pivmecillinam.
Probenecid The excretion of Pivmecillinam can be decreased when combined with Probenecid.
Doxycycline The therapeutic efficacy of Pivmecillinam can be decreased when used in combination with Doxycycline.
Lymecycline The therapeutic efficacy of Pivmecillinam can be decreased when used in combination with Lymecycline.
Clomocycline The therapeutic efficacy of Pivmecillinam can be decreased when used in combination with Clomocycline.
Tigecycline The therapeutic efficacy of Pivmecillinam can be decreased when used in combination with Tigecycline.
Oxytetracycline The therapeutic efficacy of Pivmecillinam can be decreased when used in combination with Oxytetracycline.
Demeclocycline The therapeutic efficacy of Pivmecillinam can be decreased when used in combination with Demeclocycline.
Tetracycline The therapeutic efficacy of Pivmecillinam can be decreased when used in combination with Tetracycline.
Metacycline The therapeutic efficacy of Pivmecillinam can be decreased when used in combination with Metacycline.
Minocycline The therapeutic efficacy of Pivmecillinam can be decreased when used in combination with Minocycline.
Rolitetracycline The therapeutic efficacy of Pivmecillinam can be decreased when used in combination with Rolitetracycline.
Sarecycline The therapeutic efficacy of Pivmecillinam can be decreased when used in combination with Sarecycline.
Eravacycline The therapeutic efficacy of Pivmecillinam can be decreased when used in combination with Eravacycline.
Omadacycline The therapeutic efficacy of Pivmecillinam can be decreased when used in combination with Omadacycline.
Penimepicycline The therapeutic efficacy of Pivmecillinam can be decreased when used in combination with Penimepicycline.
Mycophenolate mofetil The serum concentration of Mycophenolate mofetil can be decreased when it is combined with Pivmecillinam.
Mycophenolic acid The serum concentration of Mycophenolic acid can be decreased when it is combined with Pivmecillinam.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Pivmecillinam.
Dicoumarol Pivmecillinam may increase the anticoagulant activities of Dicoumarol.
Phenindione Pivmecillinam may increase the anticoagulant activities of Phenindione.
Warfarin Pivmecillinam may increase the anticoagulant activities of Warfarin.
Phenprocoumon Pivmecillinam may increase the anticoagulant activities of Phenprocoumon.
Acenocoumarol Pivmecillinam may increase the anticoagulant activities of Acenocoumarol.
4-hydroxycoumarin Pivmecillinam may increase the anticoagulant activities of 4-hydroxycoumarin.
Coumarin Pivmecillinam may increase the anticoagulant activities of Coumarin.
(R)-warfarin Pivmecillinam may increase the anticoagulant activities of (R)-warfarin.
Ethyl biscoumacetate Pivmecillinam may increase the anticoagulant activities of Ethyl biscoumacetate.
Fluindione Pivmecillinam may increase the anticoagulant activities of Fluindione.
Clorindione Pivmecillinam may increase the anticoagulant activities of Clorindione.
Diphenadione Pivmecillinam may increase the anticoagulant activities of Diphenadione.
Tioclomarol Pivmecillinam may increase the anticoagulant activities of Tioclomarol.
(S)-Warfarin Pivmecillinam may increase the anticoagulant activities of (S)-Warfarin.
Diethylstilbestrol The therapeutic efficacy of Diethylstilbestrol can be decreased when used in combination with Pivmecillinam.
Etonogestrel The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Pivmecillinam.
Desogestrel The therapeutic efficacy of Desogestrel can be decreased when used in combination with Pivmecillinam.
Megestrol acetate The therapeutic efficacy of Megestrol acetate can be decreased when used in combination with Pivmecillinam.
Levonorgestrel The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with Pivmecillinam.
Progesterone The therapeutic efficacy of Progesterone can be decreased when used in combination with Pivmecillinam.
Medroxyprogesterone acetate The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with Pivmecillinam.
Norethisterone The therapeutic efficacy of Norethisterone can be decreased when used in combination with Pivmecillinam.
Estradiol The therapeutic efficacy of Estradiol can be decreased when used in combination with Pivmecillinam.
Ethynodiol diacetate The therapeutic efficacy of Ethynodiol diacetate can be decreased when used in combination with Pivmecillinam.
Mifepristone The therapeutic efficacy of Mifepristone can be decreased when used in combination with Pivmecillinam.
Norgestimate The therapeutic efficacy of Norgestimate can be decreased when used in combination with Pivmecillinam.
Ethinylestradiol The therapeutic efficacy of Ethinylestradiol can be decreased when used in combination with Pivmecillinam.
Mestranol The therapeutic efficacy of Mestranol can be decreased when used in combination with Pivmecillinam.
Drospirenone The therapeutic efficacy of Drospirenone can be decreased when used in combination with Pivmecillinam.
Estrone sulfate The therapeutic efficacy of Estrone sulfate can be decreased when used in combination with Pivmecillinam.
Octylphenoxy polyethoxyethanol The therapeutic efficacy of Octylphenoxy polyethoxyethanol can be decreased when used in combination with Pivmecillinam.
Cyproterone acetate The therapeutic efficacy of Cyproterone acetate can be decreased when used in combination with Pivmecillinam.
Trestolone The therapeutic efficacy of Trestolone can be decreased when used in combination with Pivmecillinam.
Norelgestromin The therapeutic efficacy of Norelgestromin can be decreased when used in combination with Pivmecillinam.
Gestodene The therapeutic efficacy of Gestodene can be decreased when used in combination with Pivmecillinam.
Hydroxyprogesterone caproate The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Pivmecillinam.
Ulipristal The therapeutic efficacy of Ulipristal can be decreased when used in combination with Pivmecillinam.
Dienogest The therapeutic efficacy of Dienogest can be decreased when used in combination with Pivmecillinam.
Norethynodrel The therapeutic efficacy of Norethynodrel can be decreased when used in combination with Pivmecillinam.
Norgestrel The therapeutic efficacy of Norgestrel can be decreased when used in combination with Pivmecillinam.
Cloprostenol The therapeutic efficacy of Cloprostenol can be decreased when used in combination with Pivmecillinam.
Gestrinone The therapeutic efficacy of Gestrinone can be decreased when used in combination with Pivmecillinam.
Nomegestrol The therapeutic efficacy of Nomegestrol can be decreased when used in combination with Pivmecillinam.
Lynestrenol The therapeutic efficacy of Lynestrenol can be decreased when used in combination with Pivmecillinam.
Gossypol The therapeutic efficacy of Gossypol can be decreased when used in combination with Pivmecillinam.
Ormeloxifene The therapeutic efficacy of Ormeloxifene can be decreased when used in combination with Pivmecillinam.
Chlormadinone The therapeutic efficacy of Chlormadinone can be decreased when used in combination with Pivmecillinam.
Norgestrienone The therapeutic efficacy of Norgestrienone can be decreased when used in combination with Pivmecillinam.
Quingestanol The therapeutic efficacy of Quingestanol can be decreased when used in combination with Pivmecillinam.
Demegestone The therapeutic efficacy of Demegestone can be decreased when used in combination with Pivmecillinam.
Etynodiol The therapeutic efficacy of Etynodiol can be decreased when used in combination with Pivmecillinam.
Testosterone enanthate The therapeutic efficacy of Testosterone enanthate can be decreased when used in combination with Pivmecillinam.
Estradiol benzoate The therapeutic efficacy of Estradiol benzoate can be decreased when used in combination with Pivmecillinam.
Estradiol cypionate The therapeutic efficacy of Estradiol cypionate can be decreased when used in combination with Pivmecillinam.
Estradiol valerate The therapeutic efficacy of Estradiol valerate can be decreased when used in combination with Pivmecillinam.
Nomegestrol acetate The therapeutic efficacy of Nomegestrol acetate can be decreased when used in combination with Pivmecillinam.
Norethindrone enanthate The therapeutic efficacy of Norethindrone enanthate can be decreased when used in combination with Pivmecillinam.
Capreomycin The serum concentration of Capreomycin can be decreased when it is combined with Pivmecillinam.
Framycetin The serum concentration of Framycetin can be decreased when it is combined with Pivmecillinam.
Amikacin The serum concentration of Amikacin can be decreased when it is combined with Pivmecillinam.
Tobramycin The serum concentration of Tobramycin can be decreased when it is combined with Pivmecillinam.
Gentamicin The serum concentration of Gentamicin can be decreased when it is combined with Pivmecillinam.
Netilmicin The serum concentration of Netilmicin can be decreased when it is combined with Pivmecillinam.
Neomycin The serum concentration of Neomycin can be decreased when it is combined with Pivmecillinam.
Streptomycin The serum concentration of Streptomycin can be decreased when it is combined with Pivmecillinam.
Kanamycin The serum concentration of Kanamycin can be decreased when it is combined with Pivmecillinam.
Paromomycin The serum concentration of Paromomycin can be decreased when it is combined with Pivmecillinam.
Ribostamycin The serum concentration of Ribostamycin can be decreased when it is combined with Pivmecillinam.
Geneticin The serum concentration of Geneticin can be decreased when it is combined with Pivmecillinam.
Apramycin The serum concentration of Apramycin can be decreased when it is combined with Pivmecillinam.
Gentamicin C1a The serum concentration of Gentamicin C1a can be decreased when it is combined with Pivmecillinam.
Neamine The serum concentration of Neamine can be decreased when it is combined with Pivmecillinam.
Arbekacin The serum concentration of Arbekacin can be decreased when it is combined with Pivmecillinam.
Puromycin The serum concentration of Puromycin can be decreased when it is combined with Pivmecillinam.
Dihydrostreptomycin The serum concentration of Dihydrostreptomycin can be decreased when it is combined with Pivmecillinam.
Hygromycin B The serum concentration of Hygromycin B can be decreased when it is combined with Pivmecillinam.
Sisomicin The serum concentration of Sisomicin can be decreased when it is combined with Pivmecillinam.
Plazomicin The serum concentration of Plazomicin can be decreased when it is combined with Pivmecillinam.
Isepamicin The serum concentration of Isepamicin can be decreased when it is combined with Pivmecillinam.
Colistin The serum concentration of Colistin can be decreased when it is combined with Pivmecillinam.
BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Pivmecillinam.

Target Protein

Penicillin-binding protein 1A pbpA

Referensi & Sumber

Artikel (PubMed)
  • PMID: 3547627
    Sjovall J, Huitfeldt B, Magni L, Nord CE: Effect of beta-lactam prodrugs on human intestinal microflora. Scand J Infect Dis Suppl. 1986;49:73-84.
  • PMID: 14527775
    Graninger W: Pivmecillinam--therapy of choice for lower urinary tract infection. Int J Antimicrob Agents. 2003 Oct;22 Suppl 2:73-8.
  • PMID: 214285
    Authors unspecified: Pivmecillinam (selexid). Drug Ther Bull. 1978 Dec 22;16(26):103-4.

Contoh Produk & Brand

Produk: 3 • International brands: 1
Produk
  • Selexid
    Tablet • 200 mg • Oral • Canada • Approved
  • Selexid
    Tablet • 400 mg • Oral • Canada • Approved
  • Selexid Tab 185mg
    Tablet • 185 mg • Oral • Canada • Approved
International Brands
  • Coactabs

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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