Meticillin

DB01603

small molecule approved investigational

Deskripsi

One of the penicillins which is resistant to penicillinase but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.

Struktur Molekul 2D

Berat 380.415
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 25-60 minutes
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Not absorbed following oral administration.

Metabolisme

Hepatic (20-40%).

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

192 Data
Methotrexate The excretion of Methotrexate can be decreased when combined with Meticillin.
Probenecid The excretion of Meticillin can be decreased when combined with Probenecid.
Doxycycline The therapeutic efficacy of Meticillin can be decreased when used in combination with Doxycycline.
Lymecycline The therapeutic efficacy of Meticillin can be decreased when used in combination with Lymecycline.
Clomocycline The therapeutic efficacy of Meticillin can be decreased when used in combination with Clomocycline.
Tigecycline The therapeutic efficacy of Meticillin can be decreased when used in combination with Tigecycline.
Oxytetracycline The therapeutic efficacy of Meticillin can be decreased when used in combination with Oxytetracycline.
Demeclocycline The therapeutic efficacy of Meticillin can be decreased when used in combination with Demeclocycline.
Tetracycline The therapeutic efficacy of Meticillin can be decreased when used in combination with Tetracycline.
Metacycline The therapeutic efficacy of Meticillin can be decreased when used in combination with Metacycline.
Minocycline The therapeutic efficacy of Meticillin can be decreased when used in combination with Minocycline.
Rolitetracycline The therapeutic efficacy of Meticillin can be decreased when used in combination with Rolitetracycline.
Sarecycline The therapeutic efficacy of Meticillin can be decreased when used in combination with Sarecycline.
Eravacycline The therapeutic efficacy of Meticillin can be decreased when used in combination with Eravacycline.
Omadacycline The therapeutic efficacy of Meticillin can be decreased when used in combination with Omadacycline.
Penimepicycline The therapeutic efficacy of Meticillin can be decreased when used in combination with Penimepicycline.
Mycophenolate mofetil The serum concentration of Mycophenolate mofetil can be decreased when it is combined with Meticillin.
Mycophenolic acid The serum concentration of Mycophenolic acid can be decreased when it is combined with Meticillin.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Meticillin.
Dicoumarol Meticillin may increase the anticoagulant activities of Dicoumarol.
Phenindione Meticillin may increase the anticoagulant activities of Phenindione.
Warfarin Meticillin may increase the anticoagulant activities of Warfarin.
Phenprocoumon Meticillin may increase the anticoagulant activities of Phenprocoumon.
Acenocoumarol Meticillin may increase the anticoagulant activities of Acenocoumarol.
4-hydroxycoumarin Meticillin may increase the anticoagulant activities of 4-hydroxycoumarin.
Coumarin Meticillin may increase the anticoagulant activities of Coumarin.
(R)-warfarin Meticillin may increase the anticoagulant activities of (R)-warfarin.
Ethyl biscoumacetate Meticillin may increase the anticoagulant activities of Ethyl biscoumacetate.
Fluindione Meticillin may increase the anticoagulant activities of Fluindione.
Clorindione Meticillin may increase the anticoagulant activities of Clorindione.
Diphenadione Meticillin may increase the anticoagulant activities of Diphenadione.
Tioclomarol Meticillin may increase the anticoagulant activities of Tioclomarol.
(S)-Warfarin Meticillin may increase the anticoagulant activities of (S)-Warfarin.
Diethylstilbestrol The therapeutic efficacy of Diethylstilbestrol can be decreased when used in combination with Meticillin.
Etonogestrel The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Meticillin.
Desogestrel The therapeutic efficacy of Desogestrel can be decreased when used in combination with Meticillin.
Megestrol acetate The therapeutic efficacy of Megestrol acetate can be decreased when used in combination with Meticillin.
Levonorgestrel The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with Meticillin.
Progesterone The therapeutic efficacy of Progesterone can be decreased when used in combination with Meticillin.
Medroxyprogesterone acetate The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with Meticillin.
Norethisterone The therapeutic efficacy of Norethisterone can be decreased when used in combination with Meticillin.
Estradiol The therapeutic efficacy of Estradiol can be decreased when used in combination with Meticillin.
Ethynodiol diacetate The therapeutic efficacy of Ethynodiol diacetate can be decreased when used in combination with Meticillin.
Mifepristone The therapeutic efficacy of Mifepristone can be decreased when used in combination with Meticillin.
Norgestimate The therapeutic efficacy of Norgestimate can be decreased when used in combination with Meticillin.
Ethinylestradiol The therapeutic efficacy of Ethinylestradiol can be decreased when used in combination with Meticillin.
Mestranol The therapeutic efficacy of Mestranol can be decreased when used in combination with Meticillin.
Drospirenone The therapeutic efficacy of Drospirenone can be decreased when used in combination with Meticillin.
Estrone sulfate The therapeutic efficacy of Estrone sulfate can be decreased when used in combination with Meticillin.
Octylphenoxy polyethoxyethanol The therapeutic efficacy of Octylphenoxy polyethoxyethanol can be decreased when used in combination with Meticillin.
Cyproterone acetate The therapeutic efficacy of Cyproterone acetate can be decreased when used in combination with Meticillin.
Trestolone The therapeutic efficacy of Trestolone can be decreased when used in combination with Meticillin.
Norelgestromin The therapeutic efficacy of Norelgestromin can be decreased when used in combination with Meticillin.
Gestodene The therapeutic efficacy of Gestodene can be decreased when used in combination with Meticillin.
Hydroxyprogesterone caproate The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Meticillin.
Ulipristal The therapeutic efficacy of Ulipristal can be decreased when used in combination with Meticillin.
Dienogest The therapeutic efficacy of Dienogest can be decreased when used in combination with Meticillin.
Norethynodrel The therapeutic efficacy of Norethynodrel can be decreased when used in combination with Meticillin.
Norgestrel The therapeutic efficacy of Norgestrel can be decreased when used in combination with Meticillin.
Cloprostenol The therapeutic efficacy of Cloprostenol can be decreased when used in combination with Meticillin.
Gestrinone The therapeutic efficacy of Gestrinone can be decreased when used in combination with Meticillin.
Nomegestrol The therapeutic efficacy of Nomegestrol can be decreased when used in combination with Meticillin.
Lynestrenol The therapeutic efficacy of Lynestrenol can be decreased when used in combination with Meticillin.
Gossypol The therapeutic efficacy of Gossypol can be decreased when used in combination with Meticillin.
Ormeloxifene The therapeutic efficacy of Ormeloxifene can be decreased when used in combination with Meticillin.
Chlormadinone The therapeutic efficacy of Chlormadinone can be decreased when used in combination with Meticillin.
Norgestrienone The therapeutic efficacy of Norgestrienone can be decreased when used in combination with Meticillin.
Quingestanol The therapeutic efficacy of Quingestanol can be decreased when used in combination with Meticillin.
Demegestone The therapeutic efficacy of Demegestone can be decreased when used in combination with Meticillin.
Etynodiol The therapeutic efficacy of Etynodiol can be decreased when used in combination with Meticillin.
Testosterone enanthate The therapeutic efficacy of Testosterone enanthate can be decreased when used in combination with Meticillin.
Estradiol benzoate The therapeutic efficacy of Estradiol benzoate can be decreased when used in combination with Meticillin.
Estradiol cypionate The therapeutic efficacy of Estradiol cypionate can be decreased when used in combination with Meticillin.
Estradiol valerate The therapeutic efficacy of Estradiol valerate can be decreased when used in combination with Meticillin.
Nomegestrol acetate The therapeutic efficacy of Nomegestrol acetate can be decreased when used in combination with Meticillin.
Norethindrone enanthate The therapeutic efficacy of Norethindrone enanthate can be decreased when used in combination with Meticillin.
Capreomycin The serum concentration of Capreomycin can be decreased when it is combined with Meticillin.
Framycetin The serum concentration of Framycetin can be decreased when it is combined with Meticillin.
Amikacin The serum concentration of Amikacin can be decreased when it is combined with Meticillin.
Tobramycin The serum concentration of Tobramycin can be decreased when it is combined with Meticillin.
Gentamicin The serum concentration of Gentamicin can be decreased when it is combined with Meticillin.
Netilmicin The serum concentration of Netilmicin can be decreased when it is combined with Meticillin.
Neomycin The serum concentration of Neomycin can be decreased when it is combined with Meticillin.
Streptomycin The serum concentration of Streptomycin can be decreased when it is combined with Meticillin.
Kanamycin The serum concentration of Kanamycin can be decreased when it is combined with Meticillin.
Paromomycin The serum concentration of Paromomycin can be decreased when it is combined with Meticillin.
Ribostamycin The serum concentration of Ribostamycin can be decreased when it is combined with Meticillin.
Geneticin The serum concentration of Geneticin can be decreased when it is combined with Meticillin.
Apramycin The serum concentration of Apramycin can be decreased when it is combined with Meticillin.
Gentamicin C1a The serum concentration of Gentamicin C1a can be decreased when it is combined with Meticillin.
Neamine The serum concentration of Neamine can be decreased when it is combined with Meticillin.
Arbekacin The serum concentration of Arbekacin can be decreased when it is combined with Meticillin.
Puromycin The serum concentration of Puromycin can be decreased when it is combined with Meticillin.
Dihydrostreptomycin The serum concentration of Dihydrostreptomycin can be decreased when it is combined with Meticillin.
Hygromycin B The serum concentration of Hygromycin B can be decreased when it is combined with Meticillin.
Sisomicin The serum concentration of Sisomicin can be decreased when it is combined with Meticillin.
Plazomicin The serum concentration of Plazomicin can be decreased when it is combined with Meticillin.
Isepamicin The serum concentration of Isepamicin can be decreased when it is combined with Meticillin.
Colistin The serum concentration of Colistin can be decreased when it is combined with Meticillin.
BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Meticillin.

Target Protein

MecA PBP2' (penicillin binding protein 2') mecA
Penicillin-binding protein 2a pbp2a
Penicillin-binding protein 1b pbp1b
Penicillin-binding protein 2B penA
Penicillin-binding protein 3 pbp3
Penicillin-binding protein 1A pbpA

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 0 • International brands: 2
International Brands
  • Dimocillin
  • Metacillin

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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