Bacampicillin

DB01602

small molecule approved investigational

Deskripsi

Bacampicillin is a prodrug of ampicillin and is microbiologically inactive. It is absorbed following oral administration. During absorption from the gastrointestinal tract, bacampicillin is hydrolyzed by esterases present in the intestinal wall. It is microbiologically active as ampicillin, and exerts a bactericidal action through the inhibition of the biosynthesis of cell wall mucopeptides. It is used to cure infection of upper and lower respiratory tract; skin and soft tissue; urinary tract and acute uncomplicated gonococcal urethritis etc.

Struktur Molekul 2D

Berat 465.52
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Absorbed following oral administration.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

2 Data
  • 1. Take separate from antacids. Elevated gastric pH may reduce the bioavailability of bacampicillin.
  • 2. Take with or without food. Food may reduce the bioavailability of bacampicillin.

Interaksi Obat

192 Data
Methotrexate The excretion of Methotrexate can be decreased when combined with Bacampicillin.
Probenecid The excretion of Bacampicillin can be decreased when combined with Probenecid.
Doxycycline The therapeutic efficacy of Bacampicillin can be decreased when used in combination with Doxycycline.
Lymecycline The therapeutic efficacy of Bacampicillin can be decreased when used in combination with Lymecycline.
Clomocycline The therapeutic efficacy of Bacampicillin can be decreased when used in combination with Clomocycline.
Tigecycline The therapeutic efficacy of Bacampicillin can be decreased when used in combination with Tigecycline.
Oxytetracycline The therapeutic efficacy of Bacampicillin can be decreased when used in combination with Oxytetracycline.
Demeclocycline The therapeutic efficacy of Bacampicillin can be decreased when used in combination with Demeclocycline.
Tetracycline The therapeutic efficacy of Bacampicillin can be decreased when used in combination with Tetracycline.
Metacycline The therapeutic efficacy of Bacampicillin can be decreased when used in combination with Metacycline.
Minocycline The therapeutic efficacy of Bacampicillin can be decreased when used in combination with Minocycline.
Rolitetracycline The therapeutic efficacy of Bacampicillin can be decreased when used in combination with Rolitetracycline.
Sarecycline The therapeutic efficacy of Bacampicillin can be decreased when used in combination with Sarecycline.
Eravacycline The therapeutic efficacy of Bacampicillin can be decreased when used in combination with Eravacycline.
Omadacycline The therapeutic efficacy of Bacampicillin can be decreased when used in combination with Omadacycline.
Penimepicycline The therapeutic efficacy of Bacampicillin can be decreased when used in combination with Penimepicycline.
Mycophenolate mofetil The serum concentration of Mycophenolate mofetil can be decreased when it is combined with Bacampicillin.
Mycophenolic acid The serum concentration of Mycophenolic acid can be decreased when it is combined with Bacampicillin.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Bacampicillin.
Dicoumarol Bacampicillin may increase the anticoagulant activities of Dicoumarol.
Phenindione Bacampicillin may increase the anticoagulant activities of Phenindione.
Warfarin Bacampicillin may increase the anticoagulant activities of Warfarin.
Phenprocoumon Bacampicillin may increase the anticoagulant activities of Phenprocoumon.
Acenocoumarol Bacampicillin may increase the anticoagulant activities of Acenocoumarol.
4-hydroxycoumarin Bacampicillin may increase the anticoagulant activities of 4-hydroxycoumarin.
Coumarin Bacampicillin may increase the anticoagulant activities of Coumarin.
(R)-warfarin Bacampicillin may increase the anticoagulant activities of (R)-warfarin.
Ethyl biscoumacetate Bacampicillin may increase the anticoagulant activities of Ethyl biscoumacetate.
Fluindione Bacampicillin may increase the anticoagulant activities of Fluindione.
Clorindione Bacampicillin may increase the anticoagulant activities of Clorindione.
Diphenadione Bacampicillin may increase the anticoagulant activities of Diphenadione.
Tioclomarol Bacampicillin may increase the anticoagulant activities of Tioclomarol.
(S)-Warfarin Bacampicillin may increase the anticoagulant activities of (S)-Warfarin.
Diethylstilbestrol The therapeutic efficacy of Diethylstilbestrol can be decreased when used in combination with Bacampicillin.
Etonogestrel The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Bacampicillin.
Desogestrel The therapeutic efficacy of Desogestrel can be decreased when used in combination with Bacampicillin.
Megestrol acetate The therapeutic efficacy of Megestrol acetate can be decreased when used in combination with Bacampicillin.
Levonorgestrel The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with Bacampicillin.
Progesterone The therapeutic efficacy of Progesterone can be decreased when used in combination with Bacampicillin.
Medroxyprogesterone acetate The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with Bacampicillin.
Norethisterone The therapeutic efficacy of Norethisterone can be decreased when used in combination with Bacampicillin.
Estradiol The therapeutic efficacy of Estradiol can be decreased when used in combination with Bacampicillin.
Ethynodiol diacetate The therapeutic efficacy of Ethynodiol diacetate can be decreased when used in combination with Bacampicillin.
Mifepristone The therapeutic efficacy of Mifepristone can be decreased when used in combination with Bacampicillin.
Norgestimate The therapeutic efficacy of Norgestimate can be decreased when used in combination with Bacampicillin.
Ethinylestradiol The therapeutic efficacy of Ethinylestradiol can be decreased when used in combination with Bacampicillin.
Mestranol The therapeutic efficacy of Mestranol can be decreased when used in combination with Bacampicillin.
Drospirenone The therapeutic efficacy of Drospirenone can be decreased when used in combination with Bacampicillin.
Estrone sulfate The therapeutic efficacy of Estrone sulfate can be decreased when used in combination with Bacampicillin.
Octylphenoxy polyethoxyethanol The therapeutic efficacy of Octylphenoxy polyethoxyethanol can be decreased when used in combination with Bacampicillin.
Cyproterone acetate The therapeutic efficacy of Cyproterone acetate can be decreased when used in combination with Bacampicillin.
Trestolone The therapeutic efficacy of Trestolone can be decreased when used in combination with Bacampicillin.
Norelgestromin The therapeutic efficacy of Norelgestromin can be decreased when used in combination with Bacampicillin.
Gestodene The therapeutic efficacy of Gestodene can be decreased when used in combination with Bacampicillin.
Hydroxyprogesterone caproate The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Bacampicillin.
Ulipristal The therapeutic efficacy of Ulipristal can be decreased when used in combination with Bacampicillin.
Dienogest The therapeutic efficacy of Dienogest can be decreased when used in combination with Bacampicillin.
Norethynodrel The therapeutic efficacy of Norethynodrel can be decreased when used in combination with Bacampicillin.
Norgestrel The therapeutic efficacy of Norgestrel can be decreased when used in combination with Bacampicillin.
Cloprostenol The therapeutic efficacy of Cloprostenol can be decreased when used in combination with Bacampicillin.
Gestrinone The therapeutic efficacy of Gestrinone can be decreased when used in combination with Bacampicillin.
Nomegestrol The therapeutic efficacy of Nomegestrol can be decreased when used in combination with Bacampicillin.
Lynestrenol The therapeutic efficacy of Lynestrenol can be decreased when used in combination with Bacampicillin.
Gossypol The therapeutic efficacy of Gossypol can be decreased when used in combination with Bacampicillin.
Ormeloxifene The therapeutic efficacy of Ormeloxifene can be decreased when used in combination with Bacampicillin.
Chlormadinone The therapeutic efficacy of Chlormadinone can be decreased when used in combination with Bacampicillin.
Norgestrienone The therapeutic efficacy of Norgestrienone can be decreased when used in combination with Bacampicillin.
Quingestanol The therapeutic efficacy of Quingestanol can be decreased when used in combination with Bacampicillin.
Demegestone The therapeutic efficacy of Demegestone can be decreased when used in combination with Bacampicillin.
Etynodiol The therapeutic efficacy of Etynodiol can be decreased when used in combination with Bacampicillin.
Testosterone enanthate The therapeutic efficacy of Testosterone enanthate can be decreased when used in combination with Bacampicillin.
Estradiol benzoate The therapeutic efficacy of Estradiol benzoate can be decreased when used in combination with Bacampicillin.
Estradiol cypionate The therapeutic efficacy of Estradiol cypionate can be decreased when used in combination with Bacampicillin.
Estradiol valerate The therapeutic efficacy of Estradiol valerate can be decreased when used in combination with Bacampicillin.
Nomegestrol acetate The therapeutic efficacy of Nomegestrol acetate can be decreased when used in combination with Bacampicillin.
Norethindrone enanthate The therapeutic efficacy of Norethindrone enanthate can be decreased when used in combination with Bacampicillin.
Capreomycin The serum concentration of Capreomycin can be decreased when it is combined with Bacampicillin.
Framycetin The serum concentration of Framycetin can be decreased when it is combined with Bacampicillin.
Amikacin The serum concentration of Amikacin can be decreased when it is combined with Bacampicillin.
Tobramycin The serum concentration of Tobramycin can be decreased when it is combined with Bacampicillin.
Gentamicin The serum concentration of Gentamicin can be decreased when it is combined with Bacampicillin.
Netilmicin The serum concentration of Netilmicin can be decreased when it is combined with Bacampicillin.
Neomycin The serum concentration of Neomycin can be decreased when it is combined with Bacampicillin.
Streptomycin The serum concentration of Streptomycin can be decreased when it is combined with Bacampicillin.
Kanamycin The serum concentration of Kanamycin can be decreased when it is combined with Bacampicillin.
Paromomycin The serum concentration of Paromomycin can be decreased when it is combined with Bacampicillin.
Ribostamycin The serum concentration of Ribostamycin can be decreased when it is combined with Bacampicillin.
Geneticin The serum concentration of Geneticin can be decreased when it is combined with Bacampicillin.
Apramycin The serum concentration of Apramycin can be decreased when it is combined with Bacampicillin.
Gentamicin C1a The serum concentration of Gentamicin C1a can be decreased when it is combined with Bacampicillin.
Neamine The serum concentration of Neamine can be decreased when it is combined with Bacampicillin.
Arbekacin The serum concentration of Arbekacin can be decreased when it is combined with Bacampicillin.
Puromycin The serum concentration of Puromycin can be decreased when it is combined with Bacampicillin.
Dihydrostreptomycin The serum concentration of Dihydrostreptomycin can be decreased when it is combined with Bacampicillin.
Hygromycin B The serum concentration of Hygromycin B can be decreased when it is combined with Bacampicillin.
Sisomicin The serum concentration of Sisomicin can be decreased when it is combined with Bacampicillin.
Plazomicin The serum concentration of Plazomicin can be decreased when it is combined with Bacampicillin.
Isepamicin The serum concentration of Isepamicin can be decreased when it is combined with Bacampicillin.
Colistin The serum concentration of Colistin can be decreased when it is combined with Bacampicillin.
BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Bacampicillin.

Target Protein

Penicillin-binding protein dacA

Referensi & Sumber

Synthesis reference: Luigi Ratti, "Novel synthesis route for bacampicillin." U.S. Patent US4619785, issued July, 1976.
Artikel (PubMed)
  • PMID: 25480295
    Cho H, Uehara T, Bernhardt TG: Beta-lactam antibiotics induce a lethal malfunctioning of the bacterial cell wall synthesis machinery. Cell. 2014 Dec 4;159(6):1300-11. doi: 10.1016/j.cell.2014.11.017.

Contoh Produk & Brand

Produk: 2 • International brands: 5
Produk
  • Penglobe Tab 400 mg
    Tablet • 400 mg • Oral • Canada • Approved
  • Penglobe Tab 800 mg
    Tablet • 800 mg / tab • Oral • Canada • Approved
International Brands
  • Ambaxin — Upjohn
  • BacaciI — Pfizer
  • Bamaxin — Upjohn
  • Penglobe — AstraZeneca
  • Spectrobid — Pfizer

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul