Peringatan Keamanan

Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.

Ketazolam

DB01587

small molecule approved

Deskripsi

Ketazolam is a benzodiazepine derivative with anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant activity. Ketazolam is not approved in Canada or America.

Struktur Molekul 2D

Berat 368.814
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 26-200 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Ketazolam is metabolized to diazepam, followed by demoxepam, and finally desmethyldiazepam.

Rute Eliminasi

Diazepam and its metabolites are excreted mainly in the urine, predominantly as their glucuronide conjugates.

Interaksi Makanan

4 Data
  • 1. Avoid alcohol.
  • 2. Avoid grapefruit products.
  • 3. Limit caffeine intake.
  • 4. Take with food.

Interaksi Obat

1507 Data
Buprenorphine Ketazolam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Ketazolam.
Dronabinol The serum concentration of Dronabinol can be increased when it is combined with Ketazolam.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Ketazolam.
Hydrocodone Ketazolam may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ketazolam.
Magnesium sulfate The therapeutic efficacy of Ketazolam can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Ketazolam may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Ketazolam may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Ketazolam.
Mirtazapine Ketazolam may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Ketazolam.
Orphenadrine Ketazolam may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Ketazolam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Ketazolam.
Pramipexole Ketazolam may increase the sedative activities of Pramipexole.
Ropinirole Ketazolam may increase the sedative activities of Ropinirole.
Rotigotine Ketazolam may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Ketazolam.
Suvorexant Ketazolam may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Ketazolam.
Thalidomide Ketazolam may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Ketazolam may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Clozapine The risk or severity of adverse effects can be increased when Ketazolam is combined with Clozapine.
Methadone Ketazolam may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Sodium oxybate Ketazolam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Teduglutide The serum concentration of Ketazolam can be increased when it is combined with Teduglutide.
Yohimbine The therapeutic efficacy of Ketazolam can be increased when used in combination with Yohimbine.
Eliglustat The metabolism of Eliglustat can be decreased when combined with Ketazolam.
Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Ketazolam.
Cilostazol The metabolism of Cilostazol can be decreased when combined with Ketazolam.
Colchicine The metabolism of Colchicine can be decreased when combined with Ketazolam.
Fentanyl The risk or severity of adverse effects can be increased when Fentanyl is combined with Ketazolam.
Iloperidone The metabolism of Iloperidone can be decreased when combined with Ketazolam.
Retapamulin The metabolism of Retapamulin can be decreased when combined with Ketazolam.
Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Ketazolam.
Vardenafil The metabolism of Vardenafil can be decreased when combined with Ketazolam.
Zopiclone The metabolism of Zopiclone can be decreased when combined with Ketazolam.
Lovastatin The metabolism of Lovastatin can be decreased when combined with Ketazolam.
Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Ketazolam.
Alprazolam The metabolism of Alprazolam can be decreased when combined with Ketazolam.
Warfarin The serum concentration of Warfarin can be increased when it is combined with Ketazolam.
Acenocoumarol The serum concentration of Acenocoumarol can be increased when it is combined with Ketazolam.
(R)-warfarin The serum concentration of (R)-warfarin can be increased when it is combined with Ketazolam.
R,S-Warfarin alcohol The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Ketazolam.
S,R-Warfarin alcohol The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Ketazolam.
(S)-Warfarin The serum concentration of (S)-Warfarin can be increased when it is combined with Ketazolam.
Midazolam The serum concentration of Midazolam can be increased when it is combined with Ketazolam.
Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Ketazolam.
Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Ketazolam.
Ethanol Ketazolam may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Ketazolam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Ketazolam.
Zimelidine The risk or severity of adverse effects can be increased when Ketazolam is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Ketazolam is combined with Dapoxetine.
Seproxetine The risk or severity of adverse effects can be increased when Ketazolam is combined with Seproxetine.
Fluvoxamine The risk or severity of adverse effects can be increased when Ketazolam is combined with Fluvoxamine.
Citalopram The risk or severity of adverse effects can be increased when Ketazolam is combined with Citalopram.
Duloxetine The risk or severity of adverse effects can be increased when Ketazolam is combined with Duloxetine.
Trazodone The risk or severity of adverse effects can be increased when Ketazolam is combined with Trazodone.
Paroxetine The risk or severity of adverse effects can be increased when Ketazolam is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when Ketazolam is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Ketazolam is combined with Sibutramine.
Escitalopram The risk or severity of adverse effects can be increased when Ketazolam is combined with Escitalopram.
Milnacipran The risk or severity of adverse effects can be increased when Ketazolam is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Ketazolam is combined with Desvenlafaxine.
Levomilnacipran The risk or severity of adverse effects can be increased when Ketazolam is combined with Levomilnacipran.
Indalpine The risk or severity of adverse effects can be increased when Ketazolam is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Ketazolam is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Ketazolam is combined with Alaproclate.
Benzatropine Benzatropine may decrease the excretion rate of Ketazolam which could result in a higher serum level.
Cyproheptadine The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Ketazolam.
Propiomazine The risk or severity of CNS depression can be increased when Propiomazine is combined with Ketazolam.
Propantheline Propantheline may decrease the excretion rate of Ketazolam which could result in a higher serum level.
Dicyclomine Dicyclomine may decrease the excretion rate of Ketazolam which could result in a higher serum level.
Flavoxate Flavoxate may decrease the excretion rate of Ketazolam which could result in a higher serum level.
Aclidinium Ketazolam may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Disopyramide Disopyramide may decrease the excretion rate of Ketazolam which could result in a higher serum level.
Tolterodine Tolterodine may decrease the excretion rate of Ketazolam which could result in a higher serum level.
Tiotropium Tiotropium may decrease the excretion rate of Ketazolam which could result in a higher serum level.
Trimebutine Ketazolam may decrease the excretion rate of Trimebutine which could result in a higher serum level.
Imidafenacin Ketazolam may decrease the excretion rate of Imidafenacin which could result in a higher serum level.
Propiverine Ketazolam may decrease the excretion rate of Propiverine which could result in a higher serum level.
Amitriptyline The risk or severity of CNS depression can be increased when Amitriptyline is combined with Ketazolam.
Imipramine The risk or severity of CNS depression can be increased when Imipramine is combined with Ketazolam.
Nicardipine The metabolism of Ketazolam can be decreased when combined with Nicardipine.
Scopolamine The risk or severity of CNS depression can be increased when Scopolamine is combined with Ketazolam.
Promethazine The risk or severity of CNS depression can be increased when Promethazine is combined with Ketazolam.
Doxepin The risk or severity of CNS depression can be increased when Doxepin is combined with Ketazolam.
Fesoterodine Ketazolam may decrease the excretion rate of Fesoterodine which could result in a higher serum level.
Desipramine The risk or severity of CNS depression can be increased when Desipramine is combined with Ketazolam.
Caffeine The therapeutic efficacy of Ketazolam can be decreased when used in combination with Caffeine.
Dyphylline The therapeutic efficacy of Ketazolam can be decreased when used in combination with Dyphylline.
Pentoxifylline The therapeutic efficacy of Ketazolam can be decreased when used in combination with Pentoxifylline.
Mercaptopurine The therapeutic efficacy of Ketazolam can be decreased when used in combination with Mercaptopurine.
Oxtriphylline The therapeutic efficacy of Ketazolam can be decreased when used in combination with Oxtriphylline.
Theobromine The therapeutic efficacy of Ketazolam can be decreased when used in combination with Theobromine.
Fenethylline The therapeutic efficacy of Ketazolam can be decreased when used in combination with Fenethylline.
8-azaguanine The therapeutic efficacy of Ketazolam can be decreased when used in combination with 8-azaguanine.
7,9-Dimethylguanine The therapeutic efficacy of Ketazolam can be decreased when used in combination with 7,9-Dimethylguanine.

Target Protein

GABA(A) Receptor GABRA1
GABA(A) Receptor Benzodiazepine Binding Site GABRA1

Referensi & Sumber

Synthesis reference: U.S. Patent 3,575,965.

Contoh Produk & Brand

Produk: 1 • International brands: 11
Produk
  • Loftran Cap 30mg
    Capsule • 30 mg / cap • Oral • Canada • Approved
International Brands
  • Anseren — Novartis
  • Ansieten — Ivax
  • Ansietil — Medicamenta Ecuatoriana, Ecuador
  • Atenual — Tecnofarma
  • Loftran
  • Marcen — Vegal
  • Sedatival F.P. — Recalcine
  • Sedavital — Farmindustria
  • Sedotime — Faes
  • Solatran — GlaxoSmithKline

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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