Hypermetabolic state indistinguishable from thyrotoxicosis of endogenous origin. Symptoms of thyrotoxicosis include weight loss, increased appetite, palpitations, nervousness, diarrhea, abdominal cramps, sweating, tachycardia, increased pulse and blood pressure, cardiac arrhythmias, tremors, insomnia, heat intolerance, fever, and menstrual irregularities.
Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal secretion. It is now known that the thyroid gland secretes approximately ten times more T4 than T3 and that 80% of serum T3 is derived from deiodination of T4 in peripheral tissues. Administration of levothyroxine alone is sufficient for maintaining serum T4 and T3 levels in most patients and combination hormone replacement therapy generally offers no therapeutic advantage. In fact, administration of T3 may result in supratherapeutic levels of T3.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Succinic acid | The excretion of Succinic acid can be decreased when combined with Liotrix. |
| Citrulline | The excretion of Citrulline can be decreased when combined with Liotrix. |
| Pravastatin | The excretion of Pravastatin can be decreased when combined with Liotrix. |
| Oseltamivir | The excretion of Oseltamivir can be decreased when combined with Liotrix. |
| Cefotiam | The excretion of Cefotiam can be decreased when combined with Liotrix. |
| Tenofovir disoproxil | The excretion of Tenofovir disoproxil can be decreased when combined with Liotrix. |
| Piperacillin | The excretion of Piperacillin can be decreased when combined with Liotrix. |
| Indomethacin | The excretion of Indomethacin can be decreased when combined with Liotrix. |
| Aminohippuric acid | The excretion of Aminohippuric acid can be decreased when combined with Liotrix. |
| Trifluridine | The excretion of Trifluridine can be decreased when combined with Liotrix. |
| Allopurinol | The excretion of Allopurinol can be decreased when combined with Liotrix. |
| Zidovudine | The excretion of Zidovudine can be decreased when combined with Liotrix. |
| Cimetidine | The excretion of Cimetidine can be decreased when combined with Liotrix. |
| Cefdinir | The excretion of Cefdinir can be decreased when combined with Liotrix. |
| Methotrexate | The excretion of Methotrexate can be decreased when combined with Liotrix. |
| Cephalexin | The excretion of Cephalexin can be decreased when combined with Liotrix. |
| Valaciclovir | The excretion of Valaciclovir can be decreased when combined with Liotrix. |
| Levocarnitine | The excretion of Levocarnitine can be decreased when combined with Liotrix. |
| Leucovorin | The excretion of Leucovorin can be decreased when combined with Liotrix. |
| Fluorescein | The excretion of Fluorescein can be decreased when combined with Liotrix. |
| Acyclovir | The excretion of Acyclovir can be decreased when combined with Liotrix. |
| Cefaclor | The excretion of Cefaclor can be decreased when combined with Liotrix. |
| Ranitidine | The excretion of Ranitidine can be decreased when combined with Liotrix. |
| Quinapril | The excretion of Quinapril can be decreased when combined with Liotrix. |
| Bumetanide | The excretion of Bumetanide can be decreased when combined with Liotrix. |
| Dinoprostone | The excretion of Dinoprostone can be decreased when combined with Liotrix. |
| Famotidine | The excretion of Famotidine can be decreased when combined with Liotrix. |
| Fexofenadine | The excretion of Fexofenadine can be decreased when combined with Liotrix. |
| Benzylpenicillin | The excretion of Benzylpenicillin can be decreased when combined with Liotrix. |
| Rosuvastatin | The excretion of Rosuvastatin can be decreased when combined with Liotrix. |
| Captopril | The excretion of Captopril can be decreased when combined with Liotrix. |
| Cefazolin | The excretion of Cefazolin can be decreased when combined with Liotrix. |
| Ceftizoxime | The excretion of Ceftizoxime can be decreased when combined with Liotrix. |
| Cefacetrile | The excretion of Cefacetrile can be decreased when combined with Liotrix. |
| Ceftibuten | The excretion of Ceftibuten can be decreased when combined with Liotrix. |
| Tazobactam | The excretion of Tazobactam can be decreased when combined with Liotrix. |
| Cyclic adenosine monophosphate | The excretion of Cyclic adenosine monophosphate can be decreased when combined with Liotrix. |
| Cholic Acid | The excretion of Cholic Acid can be decreased when combined with Liotrix. |
| Glutaric Acid | The excretion of Glutaric Acid can be decreased when combined with Liotrix. |
| Oxalic Acid | The excretion of Oxalic Acid can be decreased when combined with Liotrix. |
| Taurocholic acid | The excretion of Taurocholic acid can be decreased when combined with Liotrix. |
| Doripenem | The excretion of Doripenem can be decreased when combined with Liotrix. |
| Ellagic acid | The excretion of Ellagic acid can be decreased when combined with Liotrix. |
| Cefaloridine | The excretion of Cefaloridine can be decreased when combined with Liotrix. |
| Avibactam | The excretion of Avibactam can be decreased when combined with Liotrix. |
| Eluxadoline | The excretion of Eluxadoline can be decreased when combined with Liotrix. |
| Silibinin | The excretion of Silibinin can be decreased when combined with Liotrix. |
| Tenofovir alafenamide | The excretion of Tenofovir alafenamide can be decreased when combined with Liotrix. |
| Baricitinib | The serum concentration of Baricitinib can be increased when it is combined with Liotrix. |
| Relebactam | The excretion of Relebactam can be decreased when combined with Liotrix. |
| Tenofovir | The excretion of Tenofovir can be decreased when combined with Liotrix. |
| Hydrochlorothiazide | The excretion of Hydrochlorothiazide can be decreased when combined with Liotrix. |
| Hydrocortisone | The excretion of Hydrocortisone can be decreased when combined with Liotrix. |
| Tetracycline | The excretion of Tetracycline can be decreased when combined with Liotrix. |
| Oxytetracycline | The excretion of Oxytetracycline can be decreased when combined with Liotrix. |
| Polythiazide | The excretion of Polythiazide can be decreased when combined with Liotrix. |
| Dexamethasone acetate | The excretion of Dexamethasone acetate can be decreased when combined with Liotrix. |
| Tolevamer | Tolevamer can cause a decrease in the absorption of Liotrix resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Chlorotrianisene | The therapeutic efficacy of Liotrix can be decreased when used in combination with Chlorotrianisene. |
| Tibolone | The therapeutic efficacy of Liotrix can be decreased when used in combination with Tibolone. |
| Polyestradiol phosphate | The therapeutic efficacy of Liotrix can be decreased when used in combination with Polyestradiol phosphate. |
| Zeranol | The therapeutic efficacy of Liotrix can be decreased when used in combination with Zeranol. |
| Equol | The therapeutic efficacy of Liotrix can be decreased when used in combination with Equol. |
| Methallenestril | The therapeutic efficacy of Liotrix can be decreased when used in combination with Methallenestril. |
| Epimestrol | The therapeutic efficacy of Liotrix can be decreased when used in combination with Epimestrol. |
| Moxestrol | The therapeutic efficacy of Liotrix can be decreased when used in combination with Moxestrol. |
| Biochanin A | The therapeutic efficacy of Liotrix can be decreased when used in combination with Biochanin A. |
| Formononetin | The therapeutic efficacy of Liotrix can be decreased when used in combination with Formononetin. |
| Ritanserin | The therapeutic efficacy of Liotrix can be decreased when used in combination with Ritanserin. |
| Alaproclate | The therapeutic efficacy of Liotrix can be decreased when used in combination with Alaproclate. |
| Citalopram | The therapeutic efficacy of Liotrix can be decreased when used in combination with Citalopram. |
| Fluoxetine | The therapeutic efficacy of Liotrix can be decreased when used in combination with Fluoxetine. |
| Duloxetine | The therapeutic efficacy of Liotrix can be decreased when used in combination with Duloxetine. |
| Trazodone | The therapeutic efficacy of Liotrix can be decreased when used in combination with Trazodone. |
| Paroxetine | The therapeutic efficacy of Liotrix can be decreased when used in combination with Paroxetine. |
| Sertraline | The therapeutic efficacy of Liotrix can be decreased when used in combination with Sertraline. |
| Sibutramine | The therapeutic efficacy of Liotrix can be decreased when used in combination with Sibutramine. |
| Escitalopram | The therapeutic efficacy of Liotrix can be decreased when used in combination with Escitalopram. |
| Dapoxetine | The therapeutic efficacy of Liotrix can be decreased when used in combination with Dapoxetine. |
| Colesevelam | The therapeutic efficacy of Liotrix can be decreased when used in combination with Colesevelam. |
| Calcium acetate | The therapeutic efficacy of Liotrix can be decreased when used in combination with Calcium acetate. |
| Calcium glucoheptonate | The therapeutic efficacy of Liotrix can be decreased when used in combination with Calcium glucoheptonate. |
| Calcium chloride | The therapeutic efficacy of Liotrix can be decreased when used in combination with Calcium chloride. |
| Calcium | The therapeutic efficacy of Liotrix can be decreased when used in combination with Calcium. |
| Calcium carbonate | The therapeutic efficacy of Liotrix can be decreased when used in combination with Calcium carbonate. |
| Calcium citrate | The therapeutic efficacy of Liotrix can be decreased when used in combination with Calcium citrate. |
| Calcium gluconate | The therapeutic efficacy of Liotrix can be decreased when used in combination with Calcium gluconate. |
| Calcium Phosphate | The therapeutic efficacy of Liotrix can be decreased when used in combination with Calcium Phosphate. |
| Calcium glubionate anhydrous | The therapeutic efficacy of Liotrix can be decreased when used in combination with Calcium glubionate anhydrous. |
| Calcium lactate | The therapeutic efficacy of Liotrix can be decreased when used in combination with Calcium lactate. |
| Calcium lactate gluconate | The therapeutic efficacy of Liotrix can be decreased when used in combination with Calcium lactate gluconate. |
| Calcium pangamate | The therapeutic efficacy of Liotrix can be decreased when used in combination with Calcium pangamate. |
| Calcium levulinate | The therapeutic efficacy of Liotrix can be decreased when used in combination with Calcium levulinate. |
| Calcium cation | The therapeutic efficacy of Liotrix can be decreased when used in combination with Calcium cation. |
| Calcium polycarbophil | The therapeutic efficacy of Liotrix can be decreased when used in combination with Calcium polycarbophil. |
| Lanthanum carbonate | Lanthanum carbonate can cause a decrease in the absorption of Liotrix resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Piracetam | The risk or severity of confusion, irritability, and sleep disorders can be increased when Liotrix is combined with Piracetam. |
| Pitolisant | The serum concentration of Liotrix can be decreased when it is combined with Pitolisant. |
| Valsartan | The excretion of Liotrix can be decreased when combined with Valsartan. |
| Reserpine | The excretion of Liotrix can be decreased when combined with Reserpine. |