Peringatan Keamanan

Acute overdosage of phendimetrazine may manifest itself by the following signs and symptoms: unusual restlessness, confusion, belligerance, hallucinations, and panic states. Fatigue and depression usually follow the central stimulation. Cardiovascular effects include arrhythmias, hypertension, or hypotension and circulatory collapse. Gastrointestinal symptoms include nausea, vomiting, diarrhea, and abdominal cramps. Poisoning may result in convulsions, coma and death.

Phendimetrazine

DB01579

small molecule approved illicit

Deskripsi

Phendimetrazine is a weight loss medication. Phendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention on Psychotropic Substances and in the US since 1970.

Struktur Molekul 2D

Berat 191.274
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 19-24 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Peak plasma levels occur within 1 to 3 hours. Absorption is usually complete by 4 to 6 hours.

Metabolisme

Approximately 30% of a given dose of phendimetrazine is metabolized into phenmetrazine, which may account for part of its anorectic effect, and probably also influences abuse potential; individuals who metabolise a greater proportion of phendimetrazine into phenmetrazine are more likely to develop problems with dependence and addiction

Rute Eliminasi

The major route of elimination is via the kidneys where most of the drug and metabolites are excreted.

Interaksi Makanan

1 Data
  • 1. Take separate from meals. Take phendimetrazine one hour before eating.

Interaksi Obat

899 Data
Valsartan Phendimetrazine may decrease the antihypertensive activities of Valsartan.
Ramipril Phendimetrazine may decrease the antihypertensive activities of Ramipril.
Remikiren Phendimetrazine may decrease the antihypertensive activities of Remikiren.
Torasemide Phendimetrazine may decrease the antihypertensive activities of Torasemide.
Isradipine Phendimetrazine may decrease the antihypertensive activities of Isradipine.
Olmesartan Phendimetrazine may decrease the antihypertensive activities of Olmesartan.
Chlorthalidone Phendimetrazine may decrease the antihypertensive activities of Chlorthalidone.
Nitroprusside Phendimetrazine may decrease the antihypertensive activities of Nitroprusside.
Diltiazem Phendimetrazine may decrease the antihypertensive activities of Diltiazem.
Minoxidil Phendimetrazine may decrease the antihypertensive activities of Minoxidil.
Treprostinil Phendimetrazine may decrease the antihypertensive activities of Treprostinil.
Amlodipine Phendimetrazine may decrease the antihypertensive activities of Amlodipine.
Nimodipine Phendimetrazine may decrease the antihypertensive activities of Nimodipine.
Nisoldipine Phendimetrazine may decrease the antihypertensive activities of Nisoldipine.
Bendroflumethiazide Phendimetrazine may decrease the antihypertensive activities of Bendroflumethiazide.
Fosinopril Phendimetrazine may decrease the antihypertensive activities of Fosinopril.
Trandolapril Phendimetrazine may decrease the antihypertensive activities of Trandolapril.
Metolazone Phendimetrazine may decrease the antihypertensive activities of Metolazone.
Lercanidipine Phendimetrazine may decrease the antihypertensive activities of Lercanidipine.
Benazepril Phendimetrazine may decrease the antihypertensive activities of Benazepril.
Bosentan Phendimetrazine may decrease the antihypertensive activities of Bosentan.
Enalapril Phendimetrazine may decrease the antihypertensive activities of Enalapril.
Cyclothiazide Phendimetrazine may decrease the antihypertensive activities of Cyclothiazide.
Candoxatril Phendimetrazine may decrease the antihypertensive activities of Candoxatril.
Mecamylamine Phendimetrazine may decrease the antihypertensive activities of Mecamylamine.
Losartan Phendimetrazine may decrease the antihypertensive activities of Losartan.
Moexipril Phendimetrazine may decrease the antihypertensive activities of Moexipril.
Eplerenone Phendimetrazine may decrease the antihypertensive activities of Eplerenone.
Lisinopril Phendimetrazine may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Phendimetrazine may decrease the antihypertensive activities of Nitroglycerin.
Metyrosine Phendimetrazine may decrease the antihypertensive activities of Metyrosine.
Hydroflumethiazide Phendimetrazine may decrease the antihypertensive activities of Hydroflumethiazide.
Cryptenamine Phendimetrazine may decrease the antihypertensive activities of Cryptenamine.
Perindopril Phendimetrazine may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil Phendimetrazine may decrease the antihypertensive activities of Candesartan cilexetil.
Fenoldopam Phendimetrazine may decrease the antihypertensive activities of Fenoldopam.
Indapamide Phendimetrazine may decrease the antihypertensive activities of Indapamide.
Tadalafil Phendimetrazine may decrease the antihypertensive activities of Tadalafil.
Eprosartan Phendimetrazine may decrease the antihypertensive activities of Eprosartan.
Chlorothiazide Phendimetrazine may decrease the antihypertensive activities of Chlorothiazide.
Quinapril Phendimetrazine may decrease the antihypertensive activities of Quinapril.
Telmisartan Phendimetrazine may decrease the antihypertensive activities of Telmisartan.
Methyldopa Phendimetrazine may decrease the antihypertensive activities of Methyldopa.
Hydrochlorothiazide Phendimetrazine may decrease the antihypertensive activities of Hydrochlorothiazide.
Trichlormethiazide Phendimetrazine may decrease the antihypertensive activities of Trichlormethiazide.
Irbesartan Phendimetrazine may decrease the antihypertensive activities of Irbesartan.
Nitrendipine Phendimetrazine may decrease the antihypertensive activities of Nitrendipine.
Deserpidine Phendimetrazine may decrease the antihypertensive activities of Deserpidine.
Pentolinium Phendimetrazine may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Phendimetrazine may decrease the antihypertensive activities of Trimethaphan.
Diazoxide Phendimetrazine may decrease the antihypertensive activities of Diazoxide.
Captopril Phendimetrazine may decrease the antihypertensive activities of Captopril.
Epoprostenol Phendimetrazine may decrease the antihypertensive activities of Epoprostenol.
Bepridil Phendimetrazine may decrease the antihypertensive activities of Bepridil.
Hydralazine Phendimetrazine may decrease the antihypertensive activities of Hydralazine.
Polythiazide Phendimetrazine may decrease the antihypertensive activities of Polythiazide.
Cilazapril Phendimetrazine may decrease the antihypertensive activities of Cilazapril.
Saprisartan Phendimetrazine may decrease the antihypertensive activities of Saprisartan.
Spirapril Phendimetrazine may decrease the antihypertensive activities of Spirapril.
Mibefradil Phendimetrazine may decrease the antihypertensive activities of Mibefradil.
Tienilic acid Phendimetrazine may decrease the antihypertensive activities of Tienilic acid.
Debrisoquine Phendimetrazine may decrease the antihypertensive activities of Debrisoquine.
Sitaxentan Phendimetrazine may decrease the antihypertensive activities of Sitaxentan.
Ambrisentan Phendimetrazine may decrease the antihypertensive activities of Ambrisentan.
Diethylnorspermine Phendimetrazine may decrease the antihypertensive activities of Diethylnorspermine.
Nilvadipine Phendimetrazine may decrease the antihypertensive activities of Nilvadipine.
Pinacidil Phendimetrazine may decrease the antihypertensive activities of Pinacidil.
Temocapril Phendimetrazine may decrease the antihypertensive activities of Temocapril.
Riociguat Phendimetrazine may decrease the antihypertensive activities of Riociguat.
Macitentan Phendimetrazine may decrease the antihypertensive activities of Macitentan.
Hexamethonium Phendimetrazine may decrease the antihypertensive activities of Hexamethonium.
Aliskiren Phendimetrazine may decrease the antihypertensive activities of Aliskiren.
Nicorandil Phendimetrazine may decrease the antihypertensive activities of Nicorandil.
Efonidipine Phendimetrazine may decrease the antihypertensive activities of Efonidipine.
Lacidipine Phendimetrazine may decrease the antihypertensive activities of Lacidipine.
Manidipine Phendimetrazine may decrease the antihypertensive activities of Manidipine.
Rauwolfia serpentina root Phendimetrazine may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Phendimetrazine may decrease the antihypertensive activities of Enalaprilat.
Selexipag Phendimetrazine may decrease the antihypertensive activities of Selexipag.
Angiotensin 1-7 Phendimetrazine may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Phendimetrazine may decrease the antihypertensive activities of Imidapril.
BQ-123 Phendimetrazine may decrease the antihypertensive activities of BQ-123.
Cicletanine Phendimetrazine may decrease the antihypertensive activities of Cicletanine.
Dihydralazine Phendimetrazine may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Phendimetrazine may decrease the antihypertensive activities of Zofenopril.
Guanoxan Phendimetrazine may decrease the antihypertensive activities of Guanoxan.
Delapril Phendimetrazine may decrease the antihypertensive activities of Delapril.
Vincamine Phendimetrazine may decrease the antihypertensive activities of Vincamine.
Linsidomine Phendimetrazine may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Phendimetrazine may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Phendimetrazine may decrease the antihypertensive activities of Tolonidine.
Endralazine Phendimetrazine may decrease the antihypertensive activities of Endralazine.
Cadralazine Phendimetrazine may decrease the antihypertensive activities of Cadralazine.
Cyclopenthiazide Phendimetrazine may decrease the antihypertensive activities of Cyclopenthiazide.
Bietaserpine Phendimetrazine may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Phendimetrazine may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Phendimetrazine may decrease the antihypertensive activities of Methoserpidine.
Guanoclor Phendimetrazine may decrease the antihypertensive activities of Guanoclor.
Muzolimine Phendimetrazine may decrease the antihypertensive activities of Muzolimine.
Xipamide Phendimetrazine may decrease the antihypertensive activities of Xipamide.

Target Protein

Alpha-1A adrenergic receptor ADRA1A
Sodium-dependent noradrenaline transporter SLC6A2
Alpha-1B adrenergic receptor ADRA1B

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

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