Dihydromorphine

DB01565

small molecule experimental illicit

Deskripsi

A semisynthetic analgesic used in the study of narcotic receptors. It has abuse potential. PubChem

Struktur Molekul 2D

Berat 287.3535
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

915 Data
Buprenorphine Dihydromorphine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Dihydromorphine.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Dihydromorphine.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Dihydromorphine.
Hydrocodone Dihydromorphine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Dihydromorphine.
Magnesium sulfate The therapeutic efficacy of Dihydromorphine can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Dihydromorphine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Dihydromorphine may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Dihydromorphine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Dihydromorphine.
Orphenadrine Dihydromorphine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Dihydromorphine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Dihydromorphine.
Pramipexole Dihydromorphine may increase the sedative activities of Pramipexole.
Ropinirole Dihydromorphine may increase the sedative activities of Ropinirole.
Rotigotine Dihydromorphine may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Dihydromorphine.
Sodium oxybate Dihydromorphine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Dihydromorphine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Dihydromorphine.
Thalidomide Dihydromorphine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Dihydromorphine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Alvimopan The risk or severity of adverse effects can be increased when Dihydromorphine is combined with Alvimopan.
Desmopressin The risk or severity of hyponatremia can be increased when Dihydromorphine is combined with Desmopressin.
Morphine The risk or severity of adverse effects can be increased when Morphine is combined with Dihydromorphine.
Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Dihydromorphine.
Hydromorphone The risk or severity of adverse effects can be increased when Hydromorphone is combined with Dihydromorphine.
Meperidine The risk or severity of adverse effects can be increased when Meperidine is combined with Dihydromorphine.
Oxycodone The risk or severity of adverse effects can be increased when Oxycodone is combined with Dihydromorphine.
Dextropropoxyphene The risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Dihydromorphine.
Naltrexone The therapeutic efficacy of Dihydromorphine can be decreased when used in combination with Naltrexone.
Sufentanil The risk or severity of adverse effects can be increased when Sufentanil is combined with Dihydromorphine.
Alfentanil The risk or severity of adverse effects can be increased when Alfentanil is combined with Dihydromorphine.
Fentanyl The risk or severity of adverse effects can be increased when Fentanyl is combined with Dihydromorphine.
Levorphanol The risk or severity of adverse effects can be increased when Levorphanol is combined with Dihydromorphine.
Remifentanil The risk or severity of adverse effects can be increased when Remifentanil is combined with Dihydromorphine.
Diphenoxylate The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Dihydromorphine.
Oxymorphone The risk or severity of adverse effects can be increased when Oxymorphone is combined with Dihydromorphine.
Dezocine The risk or severity of adverse effects can be increased when Dezocine is combined with Dihydromorphine.
Methadyl acetate The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Dihydromorphine.
Dihydroetorphine The risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Dihydromorphine.
Diamorphine The risk or severity of adverse effects can be increased when Diamorphine is combined with Dihydromorphine.
Bezitramide The risk or severity of adverse effects can be increased when Bezitramide is combined with Dihydromorphine.
Ethylmorphine The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Dihydromorphine.
Etorphine The risk or severity of adverse effects can be increased when Etorphine is combined with Dihydromorphine.
Dextromoramide The risk or severity of adverse effects can be increased when Dextromoramide is combined with Dihydromorphine.
Desomorphine The risk or severity of adverse effects can be increased when Desomorphine is combined with Dihydromorphine.
Carfentanil The risk or severity of adverse effects can be increased when Carfentanil is combined with Dihydromorphine.
Dihydrocodeine The risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Dihydromorphine.
Alphacetylmethadol The risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Dihydromorphine.
Ketobemidone The risk or severity of adverse effects can be increased when Dihydromorphine is combined with Ketobemidone.
DPDPE The risk or severity of adverse effects can be increased when Dihydromorphine is combined with DPDPE.
Lofentanil The risk or severity of adverse effects can be increased when Dihydromorphine is combined with Lofentanil.
Opium The risk or severity of adverse effects can be increased when Dihydromorphine is combined with Opium.
Normethadone The risk or severity of adverse effects can be increased when Dihydromorphine is combined with Normethadone.
Piritramide The risk or severity of adverse effects can be increased when Dihydromorphine is combined with Piritramide.
Alphaprodine The risk or severity of adverse effects can be increased when Dihydromorphine is combined with Alphaprodine.
Nicomorphine The risk or severity of adverse effects can be increased when Dihydromorphine is combined with Nicomorphine.
Meptazinol The therapeutic efficacy of Dihydromorphine can be decreased when used in combination with Meptazinol.
Phenoperidine The risk or severity of adverse effects can be increased when Dihydromorphine is combined with Phenoperidine.
Phenazocine The risk or severity of adverse effects can be increased when Dihydromorphine is combined with Phenazocine.
Tilidine The risk or severity of adverse effects can be increased when Dihydromorphine is combined with Tilidine.
Carfentanil, C-11 The risk or severity of adverse effects can be increased when Dihydromorphine is combined with Carfentanil, C-11.
Naloxegol The risk or severity of adverse effects can be increased when Dihydromorphine is combined with Naloxegol.
Benzhydrocodone The risk or severity of adverse effects can be increased when Dihydromorphine is combined with Benzhydrocodone.
Pegvisomant The therapeutic efficacy of Pegvisomant can be decreased when used in combination with Dihydromorphine.
Succinylcholine The risk or severity of bradycardia can be increased when Succinylcholine is combined with Dihydromorphine.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Dihydromorphine.
Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Dihydromorphine.
Mirtazapine Dihydromorphine may increase the serotonergic activities of Mirtazapine.
Fluvoxamine The risk or severity of serotonin syndrome can be increased when Dihydromorphine is combined with Fluvoxamine.
Citalopram The risk or severity of serotonin syndrome can be increased when Dihydromorphine is combined with Citalopram.
Duloxetine The risk or severity of serotonin syndrome can be increased when Dihydromorphine is combined with Duloxetine.
Paroxetine The risk or severity of serotonin syndrome can be increased when Dihydromorphine is combined with Paroxetine.
Sertraline The risk or severity of serotonin syndrome can be increased when Dihydromorphine is combined with Sertraline.
Sibutramine The risk or severity of serotonin syndrome can be increased when Dihydromorphine is combined with Sibutramine.
Nefazodone The risk or severity of serotonin syndrome can be increased when Dihydromorphine is combined with Nefazodone.
Zimelidine The risk or severity of serotonin syndrome can be increased when Dihydromorphine is combined with Zimelidine.
Dapoxetine The risk or severity of serotonin syndrome can be increased when Dihydromorphine is combined with Dapoxetine.
Milnacipran The risk or severity of serotonin syndrome can be increased when Dihydromorphine is combined with Milnacipran.
Desvenlafaxine The risk or severity of serotonin syndrome can be increased when Desvenlafaxine is combined with Dihydromorphine.
Seproxetine The risk or severity of serotonin syndrome can be increased when Dihydromorphine is combined with Seproxetine.
Levomilnacipran The risk or severity of serotonin syndrome can be increased when Dihydromorphine is combined with Levomilnacipran.
Indalpine The risk or severity of serotonin syndrome can be increased when Dihydromorphine is combined with Indalpine.
Ritanserin The risk or severity of serotonin syndrome can be increased when Dihydromorphine is combined with Ritanserin.
Alaproclate The risk or severity of serotonin syndrome can be increased when Dihydromorphine is combined with Alaproclate.
Ethanol Dihydromorphine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Dihydromorphine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Dihydromorphine.
Phentermine Phentermine may increase the analgesic activities of Dihydromorphine.
Pseudoephedrine Pseudoephedrine may increase the analgesic activities of Dihydromorphine.
Benzphetamine Benzphetamine may increase the analgesic activities of Dihydromorphine.
Diethylpropion Diethylpropion may increase the analgesic activities of Dihydromorphine.
Lisdexamfetamine The risk or severity of serotonin syndrome can be increased when Dihydromorphine is combined with Lisdexamfetamine.
Mephentermine Mephentermine may increase the analgesic activities of Dihydromorphine.
MMDA MMDA may increase the analgesic activities of Dihydromorphine.
Midomafetamine Midomafetamine may increase the analgesic activities of Dihydromorphine.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may increase the analgesic activities of Dihydromorphine.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may increase the analgesic activities of Dihydromorphine.

Target Protein

Mu-type opioid receptor OPRM1
Kappa-type opioid receptor OPRK1
Delta-type opioid receptor OPRD1
E3 ubiquitin-protein ligase TRIM13 TRIM13
Pro-opiomelanocortin POMC

Referensi & Sumber

Synthesis reference: Herbert Merz, Ingrid Wiedemann, Helmut Ensinger, Klaus Stockhaus, Matthias Grauert, "14-hydroxy-N-(2-methoxyethyl)-7,8-dihydromorphine and -norisomorphine, processes for the preparation thereof and the use thereof as pharmaceutical compositions." U.S. Patent US5240933, issued August 31, 1993.

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Sekuens Gen/Protein (FASTA)

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