Chloral hydrate

DB01563

small molecule approved illicit investigational vet_approved

Deskripsi

A hypnotic and sedative used in the treatment of insomnia. The safety margin is too narrow for chloral hydrate to be used as a general anesthetic in humans, but it is commonly used for that purpose in animal experiments. It is no longer considered useful as an anti-anxiety medication.

Struktur Molekul 2D

Berat 165.403
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Rapidly absorbed in the GI tract following oral or rectal administration. Chloral hydrate and its active metabolite, trichloroethanol, have been detected in CSF, umbilical cord blood, fetal blood, and amniotic fluid.

Metabolisme

Metabolized by the liver and erythrocytes to form trichloroethanol, an active metabolite. This reaction is catalyzed by alcohol dehydrogenase and other enzymes. Oxidation of chloral hydrate and trichloroethanol to trichloroacetic acid in the liver and kidneys also occurs to a lesser extent. Trichloroethanol also undergoes glucuronidation to produce an inactive metabolism.

Rute Eliminasi

Trichloroethanol, trichloroethanol glucuronide, and trichloroacetic acid are excreted in the urine. Some trichloroethanol glucuronide may be secreted into bile and excreted in the feces.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol. Ingesting alcohol may cause a disulfiram-like-reaction (flushing, dizziness, tachycardia).
  • 2. Take after a meal. If chloral hydrate is being used for sedation, it should be taken after meals. Otherwise, it can be taken with or without food.

Interaksi Obat

1303 Data
Buprenorphine Chloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.
Hydrocodone Chloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.
Magnesium sulfate The therapeutic efficacy of Chloral hydrate can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Chloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Chloral hydrate may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.
Mirtazapine Chloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.
Orphenadrine Chloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Chloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.
Pramipexole Chloral hydrate may increase the sedative activities of Pramipexole.
Ropinirole Chloral hydrate may increase the sedative activities of Ropinirole.
Rotigotine Chloral hydrate may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Chloral hydrate.
Suvorexant Chloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.
Thalidomide Chloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Chloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Chloral hydrate.
Sodium oxybate Chloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Dicoumarol The protein binding of Dicoumarol can be decreased when combined with Chloral hydrate.
Phenindione The protein binding of Phenindione can be decreased when combined with Chloral hydrate.
Warfarin The protein binding of Warfarin can be decreased when combined with Chloral hydrate.
Phenprocoumon The protein binding of Phenprocoumon can be decreased when combined with Chloral hydrate.
Acenocoumarol The protein binding of Acenocoumarol can be decreased when combined with Chloral hydrate.
4-hydroxycoumarin The protein binding of 4-hydroxycoumarin can be decreased when combined with Chloral hydrate.
Coumarin The protein binding of Coumarin can be decreased when combined with Chloral hydrate.
(R)-warfarin The protein binding of (R)-warfarin can be decreased when combined with Chloral hydrate.
Ethyl biscoumacetate The protein binding of Ethyl biscoumacetate can be decreased when combined with Chloral hydrate.
Fluindione The protein binding of Fluindione can be decreased when combined with Chloral hydrate.
Clorindione The protein binding of Clorindione can be decreased when combined with Chloral hydrate.
Diphenadione The protein binding of Diphenadione can be decreased when combined with Chloral hydrate.
Tioclomarol The protein binding of Tioclomarol can be decreased when combined with Chloral hydrate.
(S)-Warfarin The protein binding of (S)-Warfarin can be decreased when combined with Chloral hydrate.
Furosemide The risk or severity of adverse effects can be increased when Furosemide is combined with Chloral hydrate.
Ethanol Chloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Chloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.
Fluvoxamine The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Fluvoxamine.
Citalopram The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Citalopram.
Duloxetine The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Duloxetine.
Trazodone The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Trazodone.
Paroxetine The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Sibutramine.
Nefazodone The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Nefazodone.
Escitalopram The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Escitalopram.
Zimelidine The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Dapoxetine.
Milnacipran The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Desvenlafaxine.
Seproxetine The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Seproxetine.
Levomilnacipran Chloral hydrate may decrease the excretion rate of Levomilnacipran which could result in a higher serum level.
Indalpine The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Alaproclate.
Benzatropine Benzatropine may decrease the excretion rate of Chloral hydrate which could result in a higher serum level.
Disopyramide Disopyramide may decrease the excretion rate of Chloral hydrate which could result in a higher serum level.
Cyproheptadine The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Chloral hydrate.
Nortriptyline The risk or severity of CNS depression can be increased when Nortriptyline is combined with Chloral hydrate.
Amoxapine The risk or severity of CNS depression can be increased when Amoxapine is combined with Chloral hydrate.
Propiomazine The risk or severity of CNS depression can be increased when Propiomazine is combined with Chloral hydrate.
Propantheline Propantheline may decrease the excretion rate of Chloral hydrate which could result in a higher serum level.
Dicyclomine Dicyclomine may decrease the excretion rate of Chloral hydrate which could result in a higher serum level.
Maprotiline The risk or severity of CNS depression can be increased when Maprotiline is combined with Chloral hydrate.
Tolterodine Tolterodine may decrease the excretion rate of Chloral hydrate which could result in a higher serum level.
Flavoxate Flavoxate may decrease the excretion rate of Chloral hydrate which could result in a higher serum level.
Tiotropium Tiotropium may decrease the excretion rate of Chloral hydrate which could result in a higher serum level.
Pizotifen The risk or severity of CNS depression can be increased when Chloral hydrate is combined with Pizotifen.
Fesoterodine Chloral hydrate may decrease the excretion rate of Fesoterodine which could result in a higher serum level.
Aclidinium Chloral hydrate may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Trimebutine Chloral hydrate may decrease the excretion rate of Trimebutine which could result in a higher serum level.
Dosulepin The risk or severity of CNS depression can be increased when Chloral hydrate is combined with Dosulepin.
Imidafenacin Chloral hydrate may decrease the excretion rate of Imidafenacin which could result in a higher serum level.
Propiverine Chloral hydrate may decrease the excretion rate of Propiverine which could result in a higher serum level.
Amitriptyline The risk or severity of CNS depression can be increased when Amitriptyline is combined with Chloral hydrate.
Imipramine The risk or severity of CNS depression can be increased when Imipramine is combined with Chloral hydrate.
Doxepin The risk or severity of CNS depression can be increased when Doxepin is combined with Chloral hydrate.
Desipramine The risk or severity of CNS depression can be increased when Desipramine is combined with Chloral hydrate.
Zopiclone The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Zopiclone.
Botulinum toxin type B The risk or severity of CNS depression can be increased when Botulinum toxin type B is combined with Chloral hydrate.
Botulinum toxin type A The risk or severity of CNS depression can be increased when Botulinum toxin type A is combined with Chloral hydrate.
Tryptophan The risk or severity of CNS depression can be increased when Tryptophan is combined with Chloral hydrate.
Baclofen Baclofen may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.
Lorazepam The risk or severity of CNS depression can be increased when Lorazepam is combined with Chloral hydrate.
Ethchlorvynol The risk or severity of CNS depression can be increased when Ethchlorvynol is combined with Chloral hydrate.
Succinylcholine The risk or severity of CNS depression can be increased when Succinylcholine is combined with Chloral hydrate.
Eletriptan The risk or severity of CNS depression can be increased when Eletriptan is combined with Chloral hydrate.
Enflurane The risk or severity of CNS depression can be increased when Enflurane is combined with Chloral hydrate.
Temazepam The risk or severity of CNS depression can be increased when Temazepam is combined with Chloral hydrate.
Reboxetine The risk or severity of CNS depression can be increased when Reboxetine is combined with Chloral hydrate.
Butabarbital The risk or severity of CNS depression can be increased when Butabarbital is combined with Chloral hydrate.
Butalbital The risk or severity of CNS depression can be increased when Butalbital is combined with Chloral hydrate.
Methysergide The risk or severity of CNS depression can be increased when Methysergide is combined with Chloral hydrate.
Cabergoline The risk or severity of CNS depression can be increased when Cabergoline is combined with Chloral hydrate.

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 9 • International brands: 1
Produk
  • Analgesic Balm
    Ointment • - • Topical • Canada • OTC • Approved
  • Apo-chloral Hydrate Syrup
    Syrup • 100 mg / mL • Oral • Canada • Generic • Approved
  • Calmitol Itching Relief Ont
    Ointment • - • Topical • Canada • OTC • Approved
  • Chloral Hydrate Capsules 500mg
    Capsule • 500 mg / cap • Oral • Canada • Approved
  • Chloral Hydrate Syrup Odan
    Syrup • 500 mg / 5 mL • Oral • Canada • Approved
  • Novo-chlorhydrate Cap 500mg
    Capsule • 500 mg / cap • Oral • Canada • Generic • Approved
  • PMS-chloral Hydrate Capsules 500mg
    Capsule • 500 mg • Oral • Canada • Generic • Approved
  • PMS-chloral Hydrate Syrup 100mg/ml
    Syrup • 500 mg / 5 mL • Oral • Canada • Generic • Approved
Menampilkan 8 dari 9 produk.
International Brands
  • Aquachloral Supprettes — Amerifit Pharma

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