Clotiazepam

DB01559

small molecule approved illicit

Deskripsi

Clotiazepam is a thienodiazepine, not approved for sale in the U.S. or Canada, but has been approved in the U.K. It is a schedule IV drug in Canada.

Struktur Molekul 2D

Berat 318.821
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 4 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Hepatic.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

872 Data
Buprenorphine Clotiazepam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Clotiazepam.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Clotiazepam.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Clotiazepam.
Hydrocodone Clotiazepam may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Clotiazepam.
Magnesium sulfate The therapeutic efficacy of Clotiazepam can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Clotiazepam may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Clotiazepam may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Clotiazepam.
Mirtazapine Clotiazepam may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Clotiazepam.
Orphenadrine Clotiazepam may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Clotiazepam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Clotiazepam.
Pramipexole Clotiazepam may increase the sedative activities of Pramipexole.
Ropinirole Clotiazepam may increase the sedative activities of Ropinirole.
Rotigotine Clotiazepam may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Clotiazepam.
Suvorexant Clotiazepam may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Clotiazepam.
Thalidomide Clotiazepam may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Clotiazepam may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Clozapine The risk or severity of adverse effects can be increased when Clotiazepam is combined with Clozapine.
Methadone Clotiazepam may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Sodium oxybate Clotiazepam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Teduglutide The serum concentration of Clotiazepam can be increased when it is combined with Teduglutide.
Yohimbine The therapeutic efficacy of Clotiazepam can be increased when used in combination with Yohimbine.
Ethanol Clotiazepam may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Clotiazepam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Clotiazepam.
Fluvoxamine The risk or severity of adverse effects can be increased when Clotiazepam is combined with Fluvoxamine.
Citalopram The risk or severity of adverse effects can be increased when Clotiazepam is combined with Citalopram.
Duloxetine The risk or severity of adverse effects can be increased when Clotiazepam is combined with Duloxetine.
Trazodone The risk or severity of adverse effects can be increased when Clotiazepam is combined with Trazodone.
Paroxetine The risk or severity of adverse effects can be increased when Clotiazepam is combined with Paroxetine.
Sibutramine The risk or severity of adverse effects can be increased when Clotiazepam is combined with Sibutramine.
Escitalopram The risk or severity of adverse effects can be increased when Clotiazepam is combined with Escitalopram.
Zimelidine The risk or severity of adverse effects can be increased when Clotiazepam is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Clotiazepam is combined with Dapoxetine.
Milnacipran The risk or severity of adverse effects can be increased when Clotiazepam is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Clotiazepam is combined with Desvenlafaxine.
Seproxetine The risk or severity of adverse effects can be increased when Clotiazepam is combined with Seproxetine.
Indalpine The risk or severity of adverse effects can be increased when Clotiazepam is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Clotiazepam is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Clotiazepam is combined with Alaproclate.
Cyproheptadine The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Clotiazepam.
Amoxapine The risk or severity of CNS depression can be increased when Amoxapine is combined with Clotiazepam.
Propiomazine The risk or severity of CNS depression can be increased when Propiomazine is combined with Clotiazepam.
Maprotiline The risk or severity of CNS depression can be increased when Maprotiline is combined with Clotiazepam.
Pizotifen The risk or severity of CNS depression can be increased when Clotiazepam is combined with Pizotifen.
Doxepin The risk or severity of CNS depression can be increased when Doxepin is combined with Clotiazepam.
Quetiapine The risk or severity of CNS depression can be increased when Quetiapine is combined with Clotiazepam.
Nortriptyline The risk or severity of CNS depression can be increased when Nortriptyline is combined with Clotiazepam.
Amitriptyline The risk or severity of CNS depression can be increased when Amitriptyline is combined with Clotiazepam.
Imipramine The risk or severity of CNS depression can be increased when Imipramine is combined with Clotiazepam.
Desipramine The risk or severity of CNS depression can be increased when Desipramine is combined with Clotiazepam.
Olanzapine The risk or severity of CNS depression can be increased when Olanzapine is combined with Clotiazepam.
Nicardipine The metabolism of Clotiazepam can be decreased when combined with Nicardipine.
Zopiclone The risk or severity of adverse effects can be increased when Clotiazepam is combined with Zopiclone.
Caffeine The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Caffeine.
Dyphylline The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Dyphylline.
Pentoxifylline The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Pentoxifylline.
Mercaptopurine The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Mercaptopurine.
Oxtriphylline The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Oxtriphylline.
Theobromine The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Theobromine.
Fenethylline The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Fenethylline.
8-azaguanine The therapeutic efficacy of Clotiazepam can be decreased when used in combination with 8-azaguanine.
7,9-Dimethylguanine The therapeutic efficacy of Clotiazepam can be decreased when used in combination with 7,9-Dimethylguanine.
Xanthine The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Xanthine.
7-Deazaguanine The therapeutic efficacy of Clotiazepam can be decreased when used in combination with 7-Deazaguanine.
Guanine The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Guanine.
9-Methylguanine The therapeutic efficacy of Clotiazepam can be decreased when used in combination with 9-Methylguanine.
Peldesine The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Peldesine.
Hypoxanthine The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Hypoxanthine.
9-Deazaguanine The therapeutic efficacy of Clotiazepam can be decreased when used in combination with 9-Deazaguanine.
Propentofylline The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Propentofylline.
Valomaciclovir The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Valomaciclovir.
3-isobutyl-1-methyl-7H-xanthine The therapeutic efficacy of Clotiazepam can be decreased when used in combination with 3-isobutyl-1-methyl-7H-xanthine.
Uric acid The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Uric acid.
Doxofylline The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Doxofylline.
6-O-benzylguanine The therapeutic efficacy of Clotiazepam can be decreased when used in combination with 6-O-benzylguanine.
Lisofylline The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Lisofylline.
Lobucavir The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Lobucavir.
Cafedrine The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Cafedrine.
Theodrenaline The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Theodrenaline.
Bamifylline The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Bamifylline.
Proxyphylline The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Proxyphylline.
Acefylline The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Acefylline.
Etamiphylline The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Etamiphylline.
Pentifylline The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Pentifylline.
Bufylline The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Bufylline.
Bromotheophylline The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Bromotheophylline.
Furafylline The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Furafylline.
8-chlorotheophylline The therapeutic efficacy of Clotiazepam can be decreased when used in combination with 8-chlorotheophylline.
PCS-499 The therapeutic efficacy of Clotiazepam can be decreased when used in combination with PCS-499.
Theophylline The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Theophylline.
Aminophylline The therapeutic efficacy of Clotiazepam can be decreased when used in combination with Aminophylline.
Botulinum toxin type B The risk or severity of CNS depression can be increased when Botulinum toxin type B is combined with Clotiazepam.
Botulinum toxin type A The risk or severity of CNS depression can be increased when Botulinum toxin type A is combined with Clotiazepam.

Target Protein

GABA(A) Receptor GABRA1
Translocator protein TSPO
GABA(A) Receptor Benzodiazepine Binding Site GABRA1

Referensi & Sumber

Synthesis reference: Nakanishi, M., Araki, K.,Tahara, T. and Shiroki, M.; US. Patent 3,849,405; November 19, 1974; assigned to Yoshitomi Pharmaceutical Industries, Ltd.
Artikel (PubMed)
  • PMID: 709
    Nakazawa Y, Kotorii M, Oshima M, Horikawa S, Tachibana H: Effects of thienodiazepine derivatives on human sleep as compared to those of benzodiazepine derivatives. Psychopharmacologia. 1975 Oct 31;44(2):165-71.

Contoh Produk & Brand

Produk: 0 • International brands: 5
International Brands
  • Clozan — Pfizer
  • Distensan — Esteve
  • Rize — Dae Woong
  • Rizen — Formenti
  • Tienor — Farmaka

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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