Bromazepam

DB01558

small molecule approved illicit investigational

Deskripsi

One of the benzodiazepines that is used in the treatment of anxiety disorders. It is a Schedule IV drug in the U.S. and Canada and under the Convention on Psychotropic Substances. It is a intermediate-acting benzodiazepine.

Struktur Molekul 2D

Berat 316.153
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 10-20 hours
Volume Distribusi 1.56 L/kg
Klirens (Clearance) 0.82 mL/min/kg.

Absorpsi

Bioavailability is 84% following oral administration. The time to peak plasma level is 1 - 4 hours. Bromazepam is generally well absorbed after oral administration.

Metabolisme

Hepatically, via oxidative pathways (via an enzyme belonging to the Cytochrome P450 family of enzymes). One of the main metabolites is 3-hydroxybromazepam. It is pharmacologically active and the half life is similar to that of the parent compound.

Rute Eliminasi

Urine (69%), as metabolites

Interaksi Makanan

2 Data
  • 1. Avoid alcohol. Ingesting alcohol may increase the sedative and CNS depressant effects of bromazepam.
  • 2. Take with or without food. Taking bromazepam with food may reduce its Cmax and AUC.

Interaksi Obat

1499 Data
Fluvoxamine The serum concentration of Bromazepam can be increased when it is combined with Fluvoxamine.
Deferasirox The serum concentration of Bromazepam can be increased when it is combined with Deferasirox.
Peginterferon alfa-2b The serum concentration of Bromazepam can be increased when it is combined with Peginterferon alfa-2b.
Leflunomide The serum concentration of Bromazepam can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of Bromazepam can be decreased when it is combined with Teriflunomide.
Buprenorphine Bromazepam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Bromazepam.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Bromazepam.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Bromazepam.
Hydrocodone Bromazepam may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Bromazepam.
Magnesium sulfate The therapeutic efficacy of Bromazepam can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Bromazepam may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Bromazepam may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Bromazepam.
Mirtazapine Bromazepam may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Bromazepam.
Orphenadrine Bromazepam may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Bromazepam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Bromazepam.
Pramipexole Bromazepam may increase the sedative activities of Pramipexole.
Ropinirole Bromazepam may increase the sedative activities of Ropinirole.
Rotigotine Bromazepam may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Bromazepam.
Suvorexant Bromazepam may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Bromazepam.
Thalidomide Bromazepam may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Bromazepam may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Clozapine The risk or severity of adverse effects can be increased when Bromazepam is combined with Clozapine.
Methadone Bromazepam may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Sodium oxybate Bromazepam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Teduglutide The serum concentration of Bromazepam can be increased when it is combined with Teduglutide.
Yohimbine The therapeutic efficacy of Bromazepam can be increased when used in combination with Yohimbine.
Flumazenil Flumazenil may decrease the sedative activities of Bromazepam.
Abiraterone The serum concentration of Bromazepam can be increased when it is combined with Abiraterone.
Cyproterone acetate The metabolism of Bromazepam can be increased when combined with Cyproterone acetate.
Ethanol Bromazepam may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Bromazepam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Bromazepam.
Zimelidine The risk or severity of adverse effects can be increased when Bromazepam is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Bromazepam is combined with Dapoxetine.
Seproxetine The risk or severity of adverse effects can be increased when Bromazepam is combined with Seproxetine.
Citalopram The risk or severity of adverse effects can be increased when Bromazepam is combined with Citalopram.
Duloxetine The risk or severity of adverse effects can be increased when Bromazepam is combined with Duloxetine.
Trazodone The risk or severity of adverse effects can be increased when Bromazepam is combined with Trazodone.
Paroxetine The risk or severity of adverse effects can be increased when Bromazepam is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when Bromazepam is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Bromazepam is combined with Sibutramine.
Nefazodone The risk or severity of adverse effects can be increased when Bromazepam is combined with Nefazodone.
Escitalopram The risk or severity of adverse effects can be increased when Bromazepam is combined with Escitalopram.
Milnacipran The risk or severity of adverse effects can be increased when Bromazepam is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Bromazepam is combined with Desvenlafaxine.
Levomilnacipran The risk or severity of adverse effects can be increased when Bromazepam is combined with Levomilnacipran.
Indalpine The risk or severity of adverse effects can be increased when Bromazepam is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Bromazepam is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Bromazepam is combined with Alaproclate.
Benzatropine Benzatropine may decrease the excretion rate of Bromazepam which could result in a higher serum level.
Cyproheptadine The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Bromazepam.
Propiomazine The risk or severity of CNS depression can be increased when Propiomazine is combined with Bromazepam.
Dicyclomine Dicyclomine may decrease the excretion rate of Bromazepam which could result in a higher serum level.
Tolterodine Tolterodine may decrease the excretion rate of Bromazepam which could result in a higher serum level.
Flavoxate Flavoxate may decrease the excretion rate of Bromazepam which could result in a higher serum level.
Tiotropium Tiotropium may decrease the excretion rate of Bromazepam which could result in a higher serum level.
Fesoterodine Bromazepam may decrease the excretion rate of Fesoterodine which could result in a higher serum level.
Aclidinium Bromazepam may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Trimebutine Bromazepam may decrease the excretion rate of Trimebutine which could result in a higher serum level.
Imidafenacin Bromazepam may decrease the excretion rate of Imidafenacin which could result in a higher serum level.
Propiverine Bromazepam may decrease the excretion rate of Propiverine which could result in a higher serum level.
Amitriptyline The risk or severity of CNS depression can be increased when Amitriptyline is combined with Bromazepam.
Imipramine The metabolism of Bromazepam can be decreased when combined with Imipramine.
Doxepin The risk or severity of CNS depression can be increased when Doxepin is combined with Bromazepam.
Desipramine The risk or severity of CNS depression can be increased when Desipramine is combined with Bromazepam.
Zopiclone The risk or severity of adverse effects can be increased when Bromazepam is combined with Zopiclone.
Caffeine The therapeutic efficacy of Bromazepam can be decreased when used in combination with Caffeine.
Dyphylline The therapeutic efficacy of Bromazepam can be decreased when used in combination with Dyphylline.
Pentoxifylline The therapeutic efficacy of Bromazepam can be decreased when used in combination with Pentoxifylline.
Mercaptopurine The therapeutic efficacy of Bromazepam can be decreased when used in combination with Mercaptopurine.
Oxtriphylline The therapeutic efficacy of Bromazepam can be decreased when used in combination with Oxtriphylline.
Theobromine The therapeutic efficacy of Bromazepam can be decreased when used in combination with Theobromine.
Fenethylline The therapeutic efficacy of Bromazepam can be decreased when used in combination with Fenethylline.
8-azaguanine The therapeutic efficacy of Bromazepam can be decreased when used in combination with 8-azaguanine.
7,9-Dimethylguanine The therapeutic efficacy of Bromazepam can be decreased when used in combination with 7,9-Dimethylguanine.
Xanthine The therapeutic efficacy of Bromazepam can be decreased when used in combination with Xanthine.
7-Deazaguanine The therapeutic efficacy of Bromazepam can be decreased when used in combination with 7-Deazaguanine.
Guanine The therapeutic efficacy of Bromazepam can be decreased when used in combination with Guanine.
9-Methylguanine The therapeutic efficacy of Bromazepam can be decreased when used in combination with 9-Methylguanine.
Peldesine The therapeutic efficacy of Bromazepam can be decreased when used in combination with Peldesine.
Hypoxanthine The therapeutic efficacy of Bromazepam can be decreased when used in combination with Hypoxanthine.
9-Deazaguanine The therapeutic efficacy of Bromazepam can be decreased when used in combination with 9-Deazaguanine.
Propentofylline The therapeutic efficacy of Bromazepam can be decreased when used in combination with Propentofylline.
Valomaciclovir The therapeutic efficacy of Bromazepam can be decreased when used in combination with Valomaciclovir.
3-isobutyl-1-methyl-7H-xanthine The therapeutic efficacy of Bromazepam can be decreased when used in combination with 3-isobutyl-1-methyl-7H-xanthine.
Uric acid The therapeutic efficacy of Bromazepam can be decreased when used in combination with Uric acid.
Doxofylline The therapeutic efficacy of Bromazepam can be decreased when used in combination with Doxofylline.
6-O-benzylguanine The therapeutic efficacy of Bromazepam can be decreased when used in combination with 6-O-benzylguanine.
Lisofylline The therapeutic efficacy of Bromazepam can be decreased when used in combination with Lisofylline.
Lobucavir The therapeutic efficacy of Bromazepam can be decreased when used in combination with Lobucavir.
Cafedrine The therapeutic efficacy of Bromazepam can be decreased when used in combination with Cafedrine.
Theodrenaline The therapeutic efficacy of Bromazepam can be decreased when used in combination with Theodrenaline.
Bamifylline The therapeutic efficacy of Bromazepam can be decreased when used in combination with Bamifylline.

Target Protein

GABA(A) Receptor GABRA1
GABA(A) Receptor Benzodiazepine Binding Site GABRA1

Referensi & Sumber

Artikel (PubMed)
  • PMID: 2570451
    Oelschlager H: Chemical and pharmacologic aspects of benzodiazepines. Schweiz Rundsch Med Prax. 1989 Jul 4;78(27-28):766-72.
  • PMID: 14517708
    Oda M, Kotegawa T, Tsutsumi K, Ohtani Y, Kuwatani K, Nakano S: The effect of itraconazole on the pharmacokinetics and pharmacodynamics of bromazepam in healthy volunteers. Eur J Clin Pharmacol. 2003 Nov;59(8-9):615-9. Epub 2003 Sep 27.
  • PMID: 8846617
    van Harten J: Overview of the pharmacokinetics of fluvoxamine. Clin Pharmacokinet. 1995;29 Suppl 1:1-9. doi: 10.2165/00003088-199500291-00003.
  • PMID: 2882883
    Ochs HR, Greenblatt DJ, Friedman H, Burstein ES, Locniskar A, Harmatz JS, Shader RI: Bromazepam pharmacokinetics: influence of age, gender, oral contraceptives, cimetidine, and propranolol. Clin Pharmacol Ther. 1987 May;41(5):562-70.
Textbook
  • Lacy CF, Armstrong LL, Goldman MP, Lance LL eds (2007). Lexicomp drug information handbook (15th ed.). Lexicomp.

Contoh Produk & Brand

Produk: 24 • International brands: 11
Produk
  • Alti-bromazepam 1.5mg Tablets
    Tablet • 1.5 mg • Oral • Canada • Generic • Approved
  • Alti-bromazepam 3mg Tablets
    Tablet • 3 mg • Oral • Canada • Generic • Approved
  • Alti-bromazepam 6mg Tablets
    Tablet • 6 mg • Oral • Canada • Generic • Approved
  • Apo-bromazepam
    Tablet • 6 mg • Oral • Canada • Generic • Approved
  • Apo-bromazepam
    Tablet • 3 mg • Oral • Canada • Generic • Approved
  • Apo-bromazepam
    Tablet • 1.5 mg • Oral • Canada • Generic • Approved
  • Bromazepam
    Tablet • 1.5 mg • Oral • Canada • Approved
  • Bromazepam
    Tablet • 3 mg • Oral • Canada • Approved
Menampilkan 8 dari 24 produk.
International Brands
  • Calmepam
  • Creosedin
  • Durazanil
  • Lectopam
  • Lekotam
  • Lexaurin
  • Lexilium
  • Lexomil
  • Lexotan
  • Normoc

Sekuens Gen/Protein (FASTA)

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