Drowsiness and ataxia are dose related. Central nervous system toxicity may result in respiratory depression and loss of consciousness. As such, pre-existing central nervous system depression and severe hepatic impairment are two particular contraindications for use.
Cloxazolam is a benzodiazepine with anxiolytic, sedative/hypnotic, muscle relaxant, and antiepileptic effects. It is marketed in the Argentina, Australia, Portugal, Belgium, Switzerland, Luxembourg, Germany, Taiwan and Japan -- mainly for anti-anxiety. The usual dose of cloxazolam in adults is 3-12mg/day for anti-anxiety. Although less commonly noted, it has also been reported as clinically effective in the treatment of depression, schizophrenia, and neurosis. As well, it has also been studied in Japan in doses of 15-30mg/day as an adjunct in the treatment of intractable epilepsy, for which it has demonstrated effectiveness.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Buprenorphine | Cloxazolam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. |
| Doxylamine | Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Cloxazolam. |
| Dronabinol | Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Cloxazolam. |
| Droperidol | Droperidol may increase the central nervous system depressant (CNS depressant) activities of Cloxazolam. |
| Hydrocodone | Cloxazolam may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. |
| Hydroxyzine | Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Cloxazolam. |
| Magnesium sulfate | The therapeutic efficacy of Cloxazolam can be increased when used in combination with Magnesium sulfate. |
| Methotrimeprazine | Cloxazolam may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine. |
| Metyrosine | Cloxazolam may increase the sedative activities of Metyrosine. |
| Minocycline | Minocycline may increase the central nervous system depressant (CNS depressant) activities of Cloxazolam. |
| Mirtazapine | Cloxazolam may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine. |
| Nabilone | Nabilone may increase the central nervous system depressant (CNS depressant) activities of Cloxazolam. |
| Orphenadrine | Cloxazolam may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Paraldehyde | Cloxazolam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. |
| Perampanel | Perampanel may increase the central nervous system depressant (CNS depressant) activities of Cloxazolam. |
| Pramipexole | Cloxazolam may increase the sedative activities of Pramipexole. |
| Ropinirole | Cloxazolam may increase the sedative activities of Ropinirole. |
| Rotigotine | Cloxazolam may increase the sedative activities of Rotigotine. |
| Rufinamide | The risk or severity of adverse effects can be increased when Rufinamide is combined with Cloxazolam. |
| Suvorexant | Cloxazolam may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Tapentadol | Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Cloxazolam. |
| Thalidomide | Cloxazolam may increase the central nervous system depressant (CNS depressant) activities of Thalidomide. |
| Zolpidem | Cloxazolam may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. |
| Clozapine | The risk or severity of adverse effects can be increased when Cloxazolam is combined with Clozapine. |
| Methadone | Cloxazolam may increase the central nervous system depressant (CNS depressant) activities of Methadone. |
| Phenytoin | The serum concentration of Phenytoin can be increased when it is combined with Cloxazolam. |
| Fosphenytoin | The serum concentration of Fosphenytoin can be increased when it is combined with Cloxazolam. |
| Sodium oxybate | Cloxazolam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate. |
| Teduglutide | The serum concentration of Cloxazolam can be increased when it is combined with Teduglutide. |
| Yohimbine | The therapeutic efficacy of Cloxazolam can be increased when used in combination with Yohimbine. |
| Ethanol | Cloxazolam may increase the central nervous system depressant (CNS depressant) activities of Ethanol. |
| Azelastine | Cloxazolam may increase the central nervous system depressant (CNS depressant) activities of Azelastine. |
| Brimonidine | Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Cloxazolam. |
| Fluvoxamine | The risk or severity of adverse effects can be increased when Cloxazolam is combined with Fluvoxamine. |
| Citalopram | The risk or severity of adverse effects can be increased when Cloxazolam is combined with Citalopram. |
| Duloxetine | The risk or severity of adverse effects can be increased when Cloxazolam is combined with Duloxetine. |
| Trazodone | The risk or severity of adverse effects can be increased when Cloxazolam is combined with Trazodone. |
| Paroxetine | The risk or severity of adverse effects can be increased when Cloxazolam is combined with Paroxetine. |
| Sertraline | The risk or severity of adverse effects can be increased when Cloxazolam is combined with Sertraline. |
| Sibutramine | The risk or severity of adverse effects can be increased when Cloxazolam is combined with Sibutramine. |
| Nefazodone | The risk or severity of adverse effects can be increased when Cloxazolam is combined with Nefazodone. |
| Escitalopram | The risk or severity of adverse effects can be increased when Cloxazolam is combined with Escitalopram. |
| Zimelidine | The risk or severity of adverse effects can be increased when Cloxazolam is combined with Zimelidine. |
| Dapoxetine | The risk or severity of adverse effects can be increased when Cloxazolam is combined with Dapoxetine. |
| Milnacipran | The risk or severity of adverse effects can be increased when Cloxazolam is combined with Milnacipran. |
| Desvenlafaxine | The risk or severity of adverse effects can be increased when Cloxazolam is combined with Desvenlafaxine. |
| Seproxetine | The risk or severity of adverse effects can be increased when Cloxazolam is combined with Seproxetine. |
| Indalpine | The risk or severity of adverse effects can be increased when Cloxazolam is combined with Indalpine. |
| Ritanserin | The risk or severity of adverse effects can be increased when Cloxazolam is combined with Ritanserin. |
| Alaproclate | The risk or severity of adverse effects can be increased when Cloxazolam is combined with Alaproclate. |
| Amitriptyline | The risk or severity of CNS depression can be increased when Amitriptyline is combined with Cloxazolam. |
| Cyproheptadine | The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Cloxazolam. |
| Imipramine | The risk or severity of CNS depression can be increased when Imipramine is combined with Cloxazolam. |
| Nortriptyline | The risk or severity of CNS depression can be increased when Nortriptyline is combined with Cloxazolam. |
| Amoxapine | The risk or severity of CNS depression can be increased when Amoxapine is combined with Cloxazolam. |
| Propiomazine | The risk or severity of CNS depression can be increased when Propiomazine is combined with Cloxazolam. |
| Maprotiline | The risk or severity of CNS depression can be increased when Maprotiline is combined with Cloxazolam. |
| Doxepin | The risk or severity of CNS depression can be increased when Doxepin is combined with Cloxazolam. |
| Desipramine | The risk or severity of CNS depression can be increased when Desipramine is combined with Cloxazolam. |
| Pizotifen | The risk or severity of CNS depression can be increased when Cloxazolam is combined with Pizotifen. |
| Dosulepin | The risk or severity of CNS depression can be increased when Cloxazolam is combined with Dosulepin. |
| Olanzapine | The risk or severity of CNS depression can be increased when Olanzapine is combined with Cloxazolam. |
| Zopiclone | The risk or severity of adverse effects can be increased when Cloxazolam is combined with Zopiclone. |
| Caffeine | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Caffeine. |
| Theophylline | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Theophylline. |
| Dyphylline | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Dyphylline. |
| Pentoxifylline | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Pentoxifylline. |
| Mercaptopurine | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Mercaptopurine. |
| Aminophylline | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Aminophylline. |
| Oxtriphylline | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Oxtriphylline. |
| Theobromine | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Theobromine. |
| Fenethylline | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Fenethylline. |
| 8-azaguanine | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with 8-azaguanine. |
| 7,9-Dimethylguanine | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with 7,9-Dimethylguanine. |
| Xanthine | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Xanthine. |
| 7-Deazaguanine | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with 7-Deazaguanine. |
| Guanine | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Guanine. |
| 9-Methylguanine | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with 9-Methylguanine. |
| Peldesine | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Peldesine. |
| Hypoxanthine | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Hypoxanthine. |
| 9-Deazaguanine | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with 9-Deazaguanine. |
| Propentofylline | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Propentofylline. |
| Valomaciclovir | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Valomaciclovir. |
| 3-isobutyl-1-methyl-7H-xanthine | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with 3-isobutyl-1-methyl-7H-xanthine. |
| Uric acid | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Uric acid. |
| Doxofylline | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Doxofylline. |
| 6-O-benzylguanine | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with 6-O-benzylguanine. |
| Lisofylline | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Lisofylline. |
| Lobucavir | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Lobucavir. |
| Cafedrine | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Cafedrine. |
| Theodrenaline | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Theodrenaline. |
| Bamifylline | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Bamifylline. |
| Proxyphylline | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Proxyphylline. |
| Acefylline | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Acefylline. |
| Etamiphylline | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Etamiphylline. |
| Pentifylline | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Pentifylline. |
| Bufylline | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Bufylline. |
| Bromotheophylline | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Bromotheophylline. |
| Furafylline | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with Furafylline. |
| 8-chlorotheophylline | The therapeutic efficacy of Cloxazolam can be decreased when used in combination with 8-chlorotheophylline. |