Camazepam

DB01489

small molecule experimental illicit

Deskripsi

Camazepam is a benzodiazepine which is a dimethyl carbamate ester of tamzepam, a metabolite of diazepam. Similarly to other drugs in its class, it has antxiolytic, anticonvulsant, hypnotic, and skeletal muscle relaxant properties. However, unlike other benzodiapeines camazepam is predominantly anxiolytic and is relatively weak as an anticonvulsant, hypnotic and skeletal muscle relaxant.

Camazepam also has less side effects, such as impaired cognition and reaction times, compared to other benzodiazepines. However, impairment of cognition and disrupted sleep patterns will occur at doses higher than 40mg of carazepam. Camazepam is also believed to increase attention, and is associated with skin disorders.

In the United States camazepam is regulated as a Schedule IV controlled substance.

Struktur Molekul 2D

Berat 371.818
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Almost completely absorbed into the bloodstream after oral administration. 90% bioavailability can be achieved in humans.

Metabolisme

Metabolized by the liver into more than 10 metabolites, some of which are also active and posses anticonvulsant properties. 3 One active metabolite of note is temazepam which has roughly equal in effectiveness as an anxiolytic, but is less anticonvulsant, sedating, and motor-impairing. Camazepam undergoes enantioselective metabolism by human liver microsomes. 1

Rute Eliminasi

Renally eliminated.

Interaksi Obat

714 Data
Buprenorphine Camazepam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Camazepam.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Camazepam.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Camazepam.
Hydrocodone Camazepam may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Camazepam.
Magnesium sulfate The therapeutic efficacy of Camazepam can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Camazepam may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Camazepam may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Camazepam.
Mirtazapine Camazepam may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Camazepam.
Orphenadrine Camazepam may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Camazepam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Camazepam.
Pramipexole Camazepam may increase the sedative activities of Pramipexole.
Ropinirole Camazepam may increase the sedative activities of Ropinirole.
Rotigotine Camazepam may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Camazepam.
Suvorexant Camazepam may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Camazepam.
Thalidomide Camazepam may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Camazepam may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Clozapine The risk or severity of adverse effects can be increased when Camazepam is combined with Clozapine.
Methadone Camazepam may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Olanzapine The risk or severity of adverse effects can be increased when Camazepam is combined with Olanzapine.
Phenytoin The serum concentration of Phenytoin can be increased when it is combined with Camazepam.
Fosphenytoin The serum concentration of Fosphenytoin can be increased when it is combined with Camazepam.
Sodium oxybate Camazepam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Teduglutide The serum concentration of Camazepam can be increased when it is combined with Teduglutide.
Yohimbine The therapeutic efficacy of Camazepam can be increased when used in combination with Yohimbine.
Ethanol Camazepam may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Camazepam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Camazepam.
Fluvoxamine The risk or severity of adverse effects can be increased when Camazepam is combined with Fluvoxamine.
Citalopram The risk or severity of adverse effects can be increased when Camazepam is combined with Citalopram.
Duloxetine The risk or severity of adverse effects can be increased when Camazepam is combined with Duloxetine.
Trazodone The risk or severity of adverse effects can be increased when Camazepam is combined with Trazodone.
Paroxetine The risk or severity of adverse effects can be increased when Camazepam is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when Camazepam is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Camazepam is combined with Sibutramine.
Nefazodone The risk or severity of adverse effects can be increased when Camazepam is combined with Nefazodone.
Escitalopram The risk or severity of adverse effects can be increased when Camazepam is combined with Escitalopram.
Zimelidine The risk or severity of adverse effects can be increased when Camazepam is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Camazepam is combined with Dapoxetine.
Milnacipran The risk or severity of adverse effects can be increased when Camazepam is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Camazepam is combined with Desvenlafaxine.
Seproxetine The risk or severity of adverse effects can be increased when Camazepam is combined with Seproxetine.
Indalpine The risk or severity of adverse effects can be increased when Camazepam is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Camazepam is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Camazepam is combined with Alaproclate.
Amitriptyline The risk or severity of CNS depression can be increased when Amitriptyline is combined with Camazepam.
Cyproheptadine The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Camazepam.
Imipramine The risk or severity of CNS depression can be increased when Imipramine is combined with Camazepam.
Nortriptyline The risk or severity of CNS depression can be increased when Nortriptyline is combined with Camazepam.
Amoxapine The risk or severity of CNS depression can be increased when Amoxapine is combined with Camazepam.
Propiomazine The risk or severity of CNS depression can be increased when Propiomazine is combined with Camazepam.
Maprotiline The risk or severity of CNS depression can be increased when Maprotiline is combined with Camazepam.
Doxepin The risk or severity of CNS depression can be increased when Doxepin is combined with Camazepam.
Desipramine The risk or severity of CNS depression can be increased when Desipramine is combined with Camazepam.
Pizotifen The risk or severity of CNS depression can be increased when Camazepam is combined with Pizotifen.
Dosulepin The risk or severity of CNS depression can be increased when Camazepam is combined with Dosulepin.
Zopiclone The risk or severity of adverse effects can be increased when Camazepam is combined with Zopiclone.
Caffeine The therapeutic efficacy of Camazepam can be decreased when used in combination with Caffeine.
Theophylline The therapeutic efficacy of Camazepam can be decreased when used in combination with Theophylline.
Dyphylline The therapeutic efficacy of Camazepam can be decreased when used in combination with Dyphylline.
Pentoxifylline The therapeutic efficacy of Camazepam can be decreased when used in combination with Pentoxifylline.
Mercaptopurine The therapeutic efficacy of Camazepam can be decreased when used in combination with Mercaptopurine.
Aminophylline The therapeutic efficacy of Camazepam can be decreased when used in combination with Aminophylline.
Oxtriphylline The therapeutic efficacy of Camazepam can be decreased when used in combination with Oxtriphylline.
Theobromine The therapeutic efficacy of Camazepam can be decreased when used in combination with Theobromine.
Fenethylline The therapeutic efficacy of Camazepam can be decreased when used in combination with Fenethylline.
8-azaguanine The therapeutic efficacy of Camazepam can be decreased when used in combination with 8-azaguanine.
7,9-Dimethylguanine The therapeutic efficacy of Camazepam can be decreased when used in combination with 7,9-Dimethylguanine.
Xanthine The therapeutic efficacy of Camazepam can be decreased when used in combination with Xanthine.
7-Deazaguanine The therapeutic efficacy of Camazepam can be decreased when used in combination with 7-Deazaguanine.
Guanine The therapeutic efficacy of Camazepam can be decreased when used in combination with Guanine.
9-Methylguanine The therapeutic efficacy of Camazepam can be decreased when used in combination with 9-Methylguanine.
Peldesine The therapeutic efficacy of Camazepam can be decreased when used in combination with Peldesine.
Hypoxanthine The therapeutic efficacy of Camazepam can be decreased when used in combination with Hypoxanthine.
9-Deazaguanine The therapeutic efficacy of Camazepam can be decreased when used in combination with 9-Deazaguanine.
Propentofylline The therapeutic efficacy of Camazepam can be decreased when used in combination with Propentofylline.
Valomaciclovir The therapeutic efficacy of Camazepam can be decreased when used in combination with Valomaciclovir.
3-isobutyl-1-methyl-7H-xanthine The therapeutic efficacy of Camazepam can be decreased when used in combination with 3-isobutyl-1-methyl-7H-xanthine.
Uric acid The therapeutic efficacy of Camazepam can be decreased when used in combination with Uric acid.
Doxofylline The therapeutic efficacy of Camazepam can be decreased when used in combination with Doxofylline.
6-O-benzylguanine The therapeutic efficacy of Camazepam can be decreased when used in combination with 6-O-benzylguanine.
Lisofylline The therapeutic efficacy of Camazepam can be decreased when used in combination with Lisofylline.
Lobucavir The therapeutic efficacy of Camazepam can be decreased when used in combination with Lobucavir.
Cafedrine The therapeutic efficacy of Camazepam can be decreased when used in combination with Cafedrine.
Theodrenaline The therapeutic efficacy of Camazepam can be decreased when used in combination with Theodrenaline.
Bamifylline The therapeutic efficacy of Camazepam can be decreased when used in combination with Bamifylline.
Proxyphylline The therapeutic efficacy of Camazepam can be decreased when used in combination with Proxyphylline.
Acefylline The therapeutic efficacy of Camazepam can be decreased when used in combination with Acefylline.
Etamiphylline The therapeutic efficacy of Camazepam can be decreased when used in combination with Etamiphylline.
Pentifylline The therapeutic efficacy of Camazepam can be decreased when used in combination with Pentifylline.
Bufylline The therapeutic efficacy of Camazepam can be decreased when used in combination with Bufylline.
Bromotheophylline The therapeutic efficacy of Camazepam can be decreased when used in combination with Bromotheophylline.
Furafylline The therapeutic efficacy of Camazepam can be decreased when used in combination with Furafylline.
8-chlorotheophylline The therapeutic efficacy of Camazepam can be decreased when used in combination with 8-chlorotheophylline.

Target Protein

GABA(A) Receptor GABRA1
GABA(A) Receptor Benzodiazepine Binding Site GABRA1

Referensi & Sumber

Synthesis reference: Ferrari, G. and Casagrande, C.; U.S. Patent 3,799,920; March 26,1974; assigned to Siphar SA.
Artikel (PubMed)
  • PMID: 7911374
    Lu XL, Yang SK: Enantiomer resolution of camazepam and its derivatives and enantioselective metabolism of camazepam by human liver microsomes. J Chromatogr A. 1994 Apr 22;666(1-2):249-57.
  • PMID: 2878071
    Morino A, Sasaki H, Mukai H, Sugiyama M: Receptor-mediated model relating anticonvulsant effect to brain levels of camazepam in the presence of its active metabolites. J Pharmacokinet Biopharm. 1986 Jun;14(3):309-21.
  • PMID: 2868088
    Morino A, Sugiyama M: Relation between time courses of pharmacological effects and of plasma levels of camazepam and its active metabolites in rats. J Pharmacobiodyn. 1985 Aug;8(8):597-606.

Contoh Produk & Brand

Produk: 0 • International brands: 3
International Brands
  • Albego — Boehringer Ingelheim
  • Limpidon — Crinos
  • Paxor

Sekuens Gen/Protein (FASTA)

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