Bezitramide

DB01459

small molecule experimental illicit withdrawn

Deskripsi

Bezitramide is a narcotic analgesic which was discovered in 1961, clinically tested around the 1970's A14383, and marketed under the name Burgodin. After cases of fatal overdose in the Netherlands in 2004 the drug was withdrawn from the market.

Bezitramide has never been FDA approved and is currently a schedule II drug.

Struktur Molekul 2D

Berat 492.6114
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 11-24h. [A14383]
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Bezitramide has poor water solubility, thus administration is restricted to the oral route. A14383

Metabolisme

Bezitramide is a prodrug which undergoes rapid hydrolysis of a proprionyl-group to form the major metabolite, R-4618. R-4618 has analgesic properties similar to the parent compound.A14383 Metabolism occurs in the gastrointestinal tract under both acidic and alkaline conditions A14383.

Rute Eliminasi

Less than 0.3% of the dose was excreted unchanged in the urine. High concentrations in feces suggested incomplete absorption of biliary excretion. Experiments in rats demonstrated extensive (up to 70%) biliary excretion, and less than 3% urinary excretion. A14383

Interaksi Obat

621 Data
Alvimopan The risk or severity of adverse effects can be increased when Bezitramide is combined with Alvimopan.
Desmopressin The risk or severity of hyponatremia can be increased when Bezitramide is combined with Desmopressin.
Morphine The risk or severity of adverse effects can be increased when Morphine is combined with Bezitramide.
Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Bezitramide.
Hydromorphone The risk or severity of adverse effects can be increased when Hydromorphone is combined with Bezitramide.
Meperidine The risk or severity of adverse effects can be increased when Meperidine is combined with Bezitramide.
Oxycodone The risk or severity of adverse effects can be increased when Oxycodone is combined with Bezitramide.
Dextropropoxyphene The risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Bezitramide.
Naltrexone The therapeutic efficacy of Bezitramide can be decreased when used in combination with Naltrexone.
Sufentanil The risk or severity of adverse effects can be increased when Sufentanil is combined with Bezitramide.
Alfentanil The risk or severity of adverse effects can be increased when Alfentanil is combined with Bezitramide.
Fentanyl The risk or severity of adverse effects can be increased when Fentanyl is combined with Bezitramide.
Levorphanol The risk or severity of adverse effects can be increased when Levorphanol is combined with Bezitramide.
Remifentanil The risk or severity of adverse effects can be increased when Remifentanil is combined with Bezitramide.
Diphenoxylate The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Bezitramide.
Oxymorphone The risk or severity of adverse effects can be increased when Oxymorphone is combined with Bezitramide.
Dezocine The risk or severity of adverse effects can be increased when Dezocine is combined with Bezitramide.
Methadyl acetate The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Bezitramide.
Dihydroetorphine The risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Bezitramide.
Diamorphine The risk or severity of adverse effects can be increased when Diamorphine is combined with Bezitramide.
Ethylmorphine The risk or severity of adverse effects can be increased when Bezitramide is combined with Ethylmorphine.
Etorphine The risk or severity of adverse effects can be increased when Bezitramide is combined with Etorphine.
Dextromoramide The risk or severity of adverse effects can be increased when Bezitramide is combined with Dextromoramide.
Desomorphine The risk or severity of adverse effects can be increased when Bezitramide is combined with Desomorphine.
Carfentanil The risk or severity of adverse effects can be increased when Bezitramide is combined with Carfentanil.
Dihydrocodeine The risk or severity of adverse effects can be increased when Bezitramide is combined with Dihydrocodeine.
Alphacetylmethadol The risk or severity of adverse effects can be increased when Bezitramide is combined with Alphacetylmethadol.
Dihydromorphine The risk or severity of adverse effects can be increased when Bezitramide is combined with Dihydromorphine.
Tapentadol The risk or severity of serotonin syndrome can be increased when Bezitramide is combined with Tapentadol.
Ketobemidone The risk or severity of adverse effects can be increased when Bezitramide is combined with Ketobemidone.
DPDPE The risk or severity of adverse effects can be increased when Bezitramide is combined with DPDPE.
Lofentanil The risk or severity of adverse effects can be increased when Bezitramide is combined with Lofentanil.
Opium The risk or severity of adverse effects can be increased when Bezitramide is combined with Opium.
Normethadone The risk or severity of adverse effects can be increased when Bezitramide is combined with Normethadone.
Piritramide The risk or severity of adverse effects can be increased when Bezitramide is combined with Piritramide.
Alphaprodine The risk or severity of adverse effects can be increased when Bezitramide is combined with Alphaprodine.
Nicomorphine The risk or severity of adverse effects can be increased when Bezitramide is combined with Nicomorphine.
Meptazinol The therapeutic efficacy of Bezitramide can be decreased when used in combination with Meptazinol.
Phenoperidine The risk or severity of adverse effects can be increased when Bezitramide is combined with Phenoperidine.
Phenazocine The risk or severity of adverse effects can be increased when Bezitramide is combined with Phenazocine.
Tilidine The risk or severity of adverse effects can be increased when Bezitramide is combined with Tilidine.
Carfentanil, C-11 The risk or severity of adverse effects can be increased when Bezitramide is combined with Carfentanil, C-11.
Naloxegol The risk or severity of adverse effects can be increased when Bezitramide is combined with Naloxegol.
Benzhydrocodone The risk or severity of adverse effects can be increased when Bezitramide is combined with Benzhydrocodone.
Pegvisomant The therapeutic efficacy of Pegvisomant can be decreased when used in combination with Bezitramide.
Succinylcholine The risk or severity of bradycardia can be increased when Succinylcholine is combined with Bezitramide.
Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Bezitramide.
Mirtazapine Bezitramide may increase the serotonergic activities of Mirtazapine.
Seproxetine The risk or severity of serotonin syndrome can be increased when Bezitramide is combined with Seproxetine.
Fluvoxamine The risk or severity of serotonin syndrome can be increased when Bezitramide is combined with Fluvoxamine.
Citalopram The risk or severity of serotonin syndrome can be increased when Bezitramide is combined with Citalopram.
Duloxetine The risk or severity of serotonin syndrome can be increased when Bezitramide is combined with Duloxetine.
Sertraline The risk or severity of serotonin syndrome can be increased when Bezitramide is combined with Sertraline.
Sibutramine The risk or severity of serotonin syndrome can be increased when Bezitramide is combined with Sibutramine.
Nefazodone The risk or severity of serotonin syndrome can be increased when Bezitramide is combined with Nefazodone.
Zimelidine The risk or severity of serotonin syndrome can be increased when Bezitramide is combined with Zimelidine.
Dapoxetine The risk or severity of serotonin syndrome can be increased when Bezitramide is combined with Dapoxetine.
Milnacipran The risk or severity of serotonin syndrome can be increased when Bezitramide is combined with Milnacipran.
Desvenlafaxine The risk or severity of serotonin syndrome can be increased when Desvenlafaxine is combined with Bezitramide.
Levomilnacipran The risk or severity of serotonin syndrome can be increased when Bezitramide is combined with Levomilnacipran.
Indalpine The risk or severity of serotonin syndrome can be increased when Bezitramide is combined with Indalpine.
Ritanserin The risk or severity of serotonin syndrome can be increased when Bezitramide is combined with Ritanserin.
Alaproclate The risk or severity of serotonin syndrome can be increased when Bezitramide is combined with Alaproclate.
Amphetamine Amphetamine may increase the analgesic activities of Bezitramide.
Phentermine Phentermine may increase the analgesic activities of Bezitramide.
Pseudoephedrine Pseudoephedrine may increase the analgesic activities of Bezitramide.
Benzphetamine Benzphetamine may increase the analgesic activities of Bezitramide.
Diethylpropion Diethylpropion may increase the analgesic activities of Bezitramide.
Lisdexamfetamine The risk or severity of serotonin syndrome can be increased when Bezitramide is combined with Lisdexamfetamine.
Mephentermine Mephentermine may increase the analgesic activities of Bezitramide.
MMDA MMDA may increase the analgesic activities of Bezitramide.
Midomafetamine Midomafetamine may increase the analgesic activities of Bezitramide.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may increase the analgesic activities of Bezitramide.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may increase the analgesic activities of Bezitramide.
Tenamfetamine Tenamfetamine may increase the analgesic activities of Bezitramide.
Chlorphentermine Chlorphentermine may increase the analgesic activities of Bezitramide.
Methylenedioxyethamphetamine Methylenedioxyethamphetamine may increase the analgesic activities of Bezitramide.
Dextroamphetamine Dextroamphetamine may increase the analgesic activities of Bezitramide.
Metamfetamine Metamfetamine may increase the analgesic activities of Bezitramide.
Iofetamine I-123 Iofetamine I-123 may increase the analgesic activities of Bezitramide.
Ritobegron Ritobegron may increase the analgesic activities of Bezitramide.
Mephedrone Mephedrone may increase the analgesic activities of Bezitramide.
Methoxyphenamine Methoxyphenamine may increase the analgesic activities of Bezitramide.
Gepefrine Gepefrine may increase the analgesic activities of Bezitramide.
2,5-Dimethoxy-4-ethylthioamphetamine 2,5-Dimethoxy-4-ethylthioamphetamine may increase the analgesic activities of Bezitramide.
Phendimetrazine Phendimetrazine may increase the analgesic activities of Bezitramide.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Bezitramide.
Levacetylmethadol The risk or severity of adverse effects can be increased when Levacetylmethadol is combined with Bezitramide.
Trospium The risk or severity of adverse effects can be increased when Trospium is combined with Bezitramide.
Oxyphenonium The risk or severity of adverse effects can be increased when Oxyphenonium is combined with Bezitramide.
Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Bezitramide.
Butalbital The risk or severity of adverse effects can be increased when Butalbital is combined with Bezitramide.
Benzatropine The risk or severity of adverse effects can be increased when Benzatropine is combined with Bezitramide.
Disopyramide The risk or severity of adverse effects can be increased when Disopyramide is combined with Bezitramide.
Talbutal The risk or severity of adverse effects can be increased when Talbutal is combined with Bezitramide.
Pentobarbital The risk or severity of adverse effects can be increased when Pentobarbital is combined with Bezitramide.
Ipratropium The risk or severity of adverse effects can be increased when Ipratropium is combined with Bezitramide.
Metixene The risk or severity of adverse effects can be increased when Metixene is combined with Bezitramide.
Terfenadine The risk or severity of adverse effects can be increased when Terfenadine is combined with Bezitramide.
Buclizine The risk or severity of adverse effects can be increased when Buclizine is combined with Bezitramide.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 6519169
    Meijer DK, Hovinga G, Versluis A, Broring J, van Aken K, Moolenaar F, Wesseling H: Pharmacokinetics of the oral narcotic analgesic bezitramide and preliminary observations on its effect on experimentally induced pain. Eur J Clin Pharmacol. 1984;27(5):615-8.

Contoh Produk & Brand

Produk: 0 • International brands: 1
International Brands
  • Burgodin — Janssen Pharmceutica

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