Midomafetamine

DB01454

small molecule experimental illicit investigational

Deskripsi

An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems.

Struktur Molekul 2D

Berat 193.2423
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 6–10 (though duration of effects is typically actually 3–5 hours)
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Midomafetamine, or MDMA, is reported to undergo extensive CYP-mediated hepatic metabolism, with CYP2D6 playing a major role in humans. Other CYP enzymes contributing to MDMA metabolism are CYP3A4 and COMT. MDMA is metabolized via two primary metabolic pathways. It may undergo O-demethylenation followed by catechol-O-methyltransferase (COMT)-catalyzed methylation and/or glucuronide/sulfate conjugation. In contrast, it may also undergo N-dealkylation, deamination, and oxidation to the corresponding benzoic acid derivatives conjugated with glycine. Due to autoinhibition of CYP2D6 and CYP2D8, MDMA displays a complex, nonlinear pharmacokinetics profile, with the zeroth order kinetics occurring at higher doses. It is thought that this can result in sustained and higher concentrations of MDMA if the user takes consecutive doses of the drug.

Rute Eliminasi

renal

Interaksi Obat

1461 Data
Valsartan Midomafetamine may decrease the antihypertensive activities of Valsartan.
Ramipril Midomafetamine may decrease the antihypertensive activities of Ramipril.
Remikiren Midomafetamine may decrease the antihypertensive activities of Remikiren.
Torasemide Midomafetamine may decrease the antihypertensive activities of Torasemide.
Isradipine Midomafetamine may decrease the antihypertensive activities of Isradipine.
Olmesartan Midomafetamine may decrease the antihypertensive activities of Olmesartan.
Chlorthalidone Midomafetamine may decrease the antihypertensive activities of Chlorthalidone.
Nitroprusside Midomafetamine may decrease the antihypertensive activities of Nitroprusside.
Minoxidil Midomafetamine may decrease the antihypertensive activities of Minoxidil.
Treprostinil Midomafetamine may decrease the antihypertensive activities of Treprostinil.
Amlodipine Midomafetamine may decrease the antihypertensive activities of Amlodipine.
Nimodipine Midomafetamine may decrease the antihypertensive activities of Nimodipine.
Nisoldipine Midomafetamine may decrease the antihypertensive activities of Nisoldipine.
Bendroflumethiazide Midomafetamine may decrease the antihypertensive activities of Bendroflumethiazide.
Fosinopril Midomafetamine may decrease the antihypertensive activities of Fosinopril.
Trandolapril Midomafetamine may decrease the antihypertensive activities of Trandolapril.
Metolazone Midomafetamine may decrease the antihypertensive activities of Metolazone.
Benazepril Midomafetamine may decrease the antihypertensive activities of Benazepril.
Bosentan Midomafetamine may decrease the antihypertensive activities of Bosentan.
Enalapril Midomafetamine may decrease the antihypertensive activities of Enalapril.
Cyclothiazide Midomafetamine may decrease the antihypertensive activities of Cyclothiazide.
Candoxatril Midomafetamine may decrease the antihypertensive activities of Candoxatril.
Mecamylamine Midomafetamine may decrease the antihypertensive activities of Mecamylamine.
Losartan Midomafetamine may decrease the antihypertensive activities of Losartan.
Moexipril Midomafetamine may decrease the antihypertensive activities of Moexipril.
Eplerenone Midomafetamine may decrease the antihypertensive activities of Eplerenone.
Lisinopril Midomafetamine may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Midomafetamine may decrease the antihypertensive activities of Nitroglycerin.
Hydroflumethiazide Midomafetamine may decrease the antihypertensive activities of Hydroflumethiazide.
Cryptenamine Midomafetamine may decrease the antihypertensive activities of Cryptenamine.
Perindopril Midomafetamine may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil Midomafetamine may decrease the antihypertensive activities of Candesartan cilexetil.
Fenoldopam Midomafetamine may decrease the antihypertensive activities of Fenoldopam.
Indapamide Midomafetamine may decrease the antihypertensive activities of Indapamide.
Tadalafil Midomafetamine may decrease the antihypertensive activities of Tadalafil.
Eprosartan Midomafetamine may decrease the antihypertensive activities of Eprosartan.
Chlorothiazide Midomafetamine may decrease the antihypertensive activities of Chlorothiazide.
Quinapril Midomafetamine may decrease the antihypertensive activities of Quinapril.
Telmisartan Midomafetamine may decrease the antihypertensive activities of Telmisartan.
Methyldopa Midomafetamine may decrease the antihypertensive activities of Methyldopa.
Hydrochlorothiazide Midomafetamine may decrease the antihypertensive activities of Hydrochlorothiazide.
Trichlormethiazide Midomafetamine may decrease the antihypertensive activities of Trichlormethiazide.
Irbesartan Midomafetamine may decrease the antihypertensive activities of Irbesartan.
Nitrendipine Midomafetamine may decrease the antihypertensive activities of Nitrendipine.
Deserpidine Midomafetamine may decrease the antihypertensive activities of Deserpidine.
Pentolinium Midomafetamine may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Midomafetamine may decrease the antihypertensive activities of Trimethaphan.
Diazoxide Midomafetamine may decrease the antihypertensive activities of Diazoxide.
Epoprostenol Midomafetamine may decrease the antihypertensive activities of Epoprostenol.
Hydralazine Midomafetamine may decrease the antihypertensive activities of Hydralazine.
Polythiazide Midomafetamine may decrease the antihypertensive activities of Polythiazide.
Cilazapril Midomafetamine may decrease the antihypertensive activities of Cilazapril.
Saprisartan Midomafetamine may decrease the antihypertensive activities of Saprisartan.
Spirapril Midomafetamine may decrease the antihypertensive activities of Spirapril.
Tienilic acid Midomafetamine may decrease the antihypertensive activities of Tienilic acid.
Sitaxentan Midomafetamine may decrease the antihypertensive activities of Sitaxentan.
Ambrisentan Midomafetamine may decrease the antihypertensive activities of Ambrisentan.
Diethylnorspermine Midomafetamine may decrease the antihypertensive activities of Diethylnorspermine.
Nilvadipine Midomafetamine may decrease the antihypertensive activities of Nilvadipine.
Pinacidil Midomafetamine may decrease the antihypertensive activities of Pinacidil.
Temocapril Midomafetamine may decrease the antihypertensive activities of Temocapril.
Riociguat Midomafetamine may decrease the antihypertensive activities of Riociguat.
Macitentan Midomafetamine may decrease the antihypertensive activities of Macitentan.
Aliskiren Midomafetamine may decrease the antihypertensive activities of Aliskiren.
Nicorandil Midomafetamine may decrease the antihypertensive activities of Nicorandil.
Efonidipine Midomafetamine may decrease the antihypertensive activities of Efonidipine.
Lacidipine Midomafetamine may decrease the antihypertensive activities of Lacidipine.
Rauwolfia serpentina root Midomafetamine may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Midomafetamine may decrease the antihypertensive activities of Enalaprilat.
Selexipag Midomafetamine may decrease the antihypertensive activities of Selexipag.
Angiotensin 1-7 Midomafetamine may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Midomafetamine may decrease the antihypertensive activities of Imidapril.
BQ-123 Midomafetamine may decrease the antihypertensive activities of BQ-123.
Cicletanine Midomafetamine may decrease the antihypertensive activities of Cicletanine.
Dihydralazine Midomafetamine may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Midomafetamine may decrease the antihypertensive activities of Zofenopril.
Guanoxan Midomafetamine may decrease the antihypertensive activities of Guanoxan.
Delapril Midomafetamine may decrease the antihypertensive activities of Delapril.
Vincamine Midomafetamine may decrease the antihypertensive activities of Vincamine.
Linsidomine Midomafetamine may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Midomafetamine may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Midomafetamine may decrease the antihypertensive activities of Tolonidine.
Endralazine Midomafetamine may decrease the antihypertensive activities of Endralazine.
Cadralazine Midomafetamine may decrease the antihypertensive activities of Cadralazine.
Cyclopenthiazide Midomafetamine may decrease the antihypertensive activities of Cyclopenthiazide.
Bietaserpine Midomafetamine may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Midomafetamine may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Midomafetamine may decrease the antihypertensive activities of Methoserpidine.
Guanoclor Midomafetamine may decrease the antihypertensive activities of Guanoclor.
Muzolimine Midomafetamine may decrease the antihypertensive activities of Muzolimine.
Xipamide Midomafetamine may decrease the antihypertensive activities of Xipamide.
Candesartan Midomafetamine may decrease the antihypertensive activities of Candesartan.
Dexniguldipine Midomafetamine may decrease the antihypertensive activities of Dexniguldipine.
Tocopherylquinone Midomafetamine may decrease the antihypertensive activities of Tocopherylquinone.
Benazeprilat Midomafetamine may decrease the antihypertensive activities of Benazeprilat.
Fosinoprilat Midomafetamine may decrease the antihypertensive activities of Fosinoprilat.
Ramiprilat Midomafetamine may decrease the antihypertensive activities of Ramiprilat.
Perindoprilat Midomafetamine may decrease the antihypertensive activities of Perindoprilat.
Quinaprilat Midomafetamine may decrease the antihypertensive activities of Quinaprilat.
Furosemide Midomafetamine may decrease the antihypertensive activities of Furosemide.

Target Protein

Synaptic vesicular amine transporter SLC18A2
Sodium-dependent noradrenaline transporter SLC6A2
Sodium-dependent serotonin transporter SLC6A4
5-hydroxytryptamine receptor 2C HTR2C
5-hydroxytryptamine receptor 2A HTR2A
5-hydroxytryptamine receptor 2B HTR2B
Sodium-dependent dopamine transporter SLC6A3

Referensi & Sumber

Artikel (PubMed)
  • PMID: 16911722
    Freudenmann RW, Oxler F, Bernschneider-Reif S: The origin of MDMA (ecstasy) revisited: the true story reconstructed from the original documents. Addiction. 2006 Sep;101(9):1241-5.
  • PMID: 16353949
    Jayanthi LD, Ramamoorthy S: Regulation of monoamine transporters: influence of psychostimulants and therapeutic antidepressants. AAPS J. 2005 Oct 27;7(3):E728-38.
  • PMID: 16220332
    Verrico CD, Miller GM, Madras BK: MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment. Psychopharmacology (Berl). 2007 Jan;189(4):489-503. Epub 2005 Oct 12.

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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