Peringatan Keamanan

In adults, death has been reported after 5 g. The usual lethal dose is 10 to 20g, although survival after a dose of 28 g has been reported.

Glutethimide

DB01437

small molecule approved illicit

Deskripsi

Glutethimide is a hypnotic and sedative. Its use has been largely superseded by other drugs.

Struktur Molekul 2D

Berat 217.2637
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 10-12 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Variable

Metabolisme

Hepatic. Glutethimide is almost completely metabolized.

Rute Eliminasi

glutethimide is inactivated by conjugation and the metabolites are excreted in urine, only 2% of the parent substance is excreted in urine, up to 2% of the dose has been reported to be found in the faeces.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol.
  • 2. Take with or without food. The absorption is unaffected by food.

Interaksi Obat

679 Data
Buprenorphine Glutethimide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.
Hydrocodone Glutethimide may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.
Magnesium sulfate The therapeutic efficacy of Glutethimide can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Glutethimide may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Glutethimide may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.
Mirtazapine Glutethimide may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.
Orphenadrine Glutethimide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Glutethimide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.
Pramipexole Glutethimide may increase the sedative activities of Pramipexole.
Ropinirole Glutethimide may increase the sedative activities of Ropinirole.
Rotigotine Glutethimide may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Glutethimide.
Suvorexant Glutethimide may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.
Thalidomide Glutethimide may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Glutethimide may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Glutethimide.
Sodium oxybate Glutethimide may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Dicoumarol The therapeutic efficacy of Dicoumarol can be decreased when used in combination with Glutethimide.
Phenindione The therapeutic efficacy of Phenindione can be decreased when used in combination with Glutethimide.
Warfarin The therapeutic efficacy of Warfarin can be decreased when used in combination with Glutethimide.
Phenprocoumon The therapeutic efficacy of Phenprocoumon can be decreased when used in combination with Glutethimide.
Acenocoumarol The therapeutic efficacy of Acenocoumarol can be decreased when used in combination with Glutethimide.
4-hydroxycoumarin The therapeutic efficacy of 4-hydroxycoumarin can be decreased when used in combination with Glutethimide.
Coumarin The therapeutic efficacy of Coumarin can be decreased when used in combination with Glutethimide.
(R)-warfarin The therapeutic efficacy of (R)-warfarin can be decreased when used in combination with Glutethimide.
Ethyl biscoumacetate The therapeutic efficacy of Ethyl biscoumacetate can be decreased when used in combination with Glutethimide.
Fluindione The therapeutic efficacy of Fluindione can be decreased when used in combination with Glutethimide.
Clorindione The therapeutic efficacy of Clorindione can be decreased when used in combination with Glutethimide.
Diphenadione The therapeutic efficacy of Diphenadione can be decreased when used in combination with Glutethimide.
Tioclomarol The therapeutic efficacy of Tioclomarol can be decreased when used in combination with Glutethimide.
(S)-Warfarin The therapeutic efficacy of (S)-Warfarin can be decreased when used in combination with Glutethimide.
Ethanol Glutethimide may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Glutethimide may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.
Fluvoxamine The risk or severity of adverse effects can be increased when Glutethimide is combined with Fluvoxamine.
Citalopram The risk or severity of adverse effects can be increased when Glutethimide is combined with Citalopram.
Duloxetine The risk or severity of adverse effects can be increased when Glutethimide is combined with Duloxetine.
Trazodone The risk or severity of adverse effects can be increased when Glutethimide is combined with Trazodone.
Paroxetine The risk or severity of adverse effects can be increased when Glutethimide is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when Glutethimide is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Glutethimide is combined with Sibutramine.
Nefazodone The risk or severity of adverse effects can be increased when Glutethimide is combined with Nefazodone.
Escitalopram The risk or severity of adverse effects can be increased when Glutethimide is combined with Escitalopram.
Zimelidine The risk or severity of adverse effects can be increased when Glutethimide is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Glutethimide is combined with Dapoxetine.
Milnacipran The risk or severity of adverse effects can be increased when Glutethimide is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Glutethimide is combined with Desvenlafaxine.
Seproxetine The risk or severity of adverse effects can be increased when Glutethimide is combined with Seproxetine.
Indalpine The risk or severity of adverse effects can be increased when Glutethimide is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Glutethimide is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Glutethimide is combined with Alaproclate.
Cyproheptadine The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Glutethimide.
Propiomazine The risk or severity of CNS depression can be increased when Propiomazine is combined with Glutethimide.
Maprotiline The risk or severity of CNS depression can be increased when Maprotiline is combined with Glutethimide.
Pizotifen The risk or severity of CNS depression can be increased when Glutethimide is combined with Pizotifen.
Amitriptyline The risk or severity of CNS depression can be increased when Amitriptyline is combined with Glutethimide.
Imipramine The risk or severity of CNS depression can be increased when Imipramine is combined with Glutethimide.
Nortriptyline The risk or severity of CNS depression can be increased when Nortriptyline is combined with Glutethimide.
Amoxapine The risk or severity of CNS depression can be increased when Amoxapine is combined with Glutethimide.
Doxepin The risk or severity of CNS depression can be increased when Doxepin is combined with Glutethimide.
Desipramine The risk or severity of CNS depression can be increased when Desipramine is combined with Glutethimide.
Dosulepin The risk or severity of CNS depression can be increased when Glutethimide is combined with Dosulepin.
Zopiclone The risk or severity of adverse effects can be increased when Glutethimide is combined with Zopiclone.
Botulinum toxin type B The risk or severity of CNS depression can be increased when Botulinum toxin type B is combined with Glutethimide.
Botulinum toxin type A The risk or severity of CNS depression can be increased when Botulinum toxin type A is combined with Glutethimide.
Tryptophan The risk or severity of CNS depression can be increased when Tryptophan is combined with Glutethimide.
Baclofen Baclofen may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.
Lorazepam The risk or severity of CNS depression can be increased when Lorazepam is combined with Glutethimide.
Ethchlorvynol The risk or severity of CNS depression can be increased when Ethchlorvynol is combined with Glutethimide.
Succinylcholine The risk or severity of CNS depression can be increased when Succinylcholine is combined with Glutethimide.
Reserpine The risk or severity of CNS depression can be increased when Reserpine is combined with Glutethimide.
Enflurane The risk or severity of CNS depression can be increased when Enflurane is combined with Glutethimide.
Temazepam The risk or severity of CNS depression can be increased when Temazepam is combined with Glutethimide.
Reboxetine The risk or severity of CNS depression can be increased when Reboxetine is combined with Glutethimide.
Butabarbital The risk or severity of CNS depression can be increased when Butabarbital is combined with Glutethimide.
Butalbital The risk or severity of CNS depression can be increased when Butalbital is combined with Glutethimide.
Methysergide The risk or severity of CNS depression can be increased when Methysergide is combined with Glutethimide.
Cabergoline The risk or severity of CNS depression can be increased when Cabergoline is combined with Glutethimide.
Phenytoin The risk or severity of CNS depression can be increased when Phenytoin is combined with Glutethimide.
Topiramate The risk or severity of CNS depression can be increased when Topiramate is combined with Glutethimide.
Clemastine The risk or severity of CNS depression can be increased when Clemastine is combined with Glutethimide.
Venlafaxine The risk or severity of CNS depression can be increased when Venlafaxine is combined with Glutethimide.
Etomidate The risk or severity of CNS depression can be increased when Etomidate is combined with Glutethimide.
Morphine The risk or severity of CNS depression can be increased when Morphine is combined with Glutethimide.
Talbutal The risk or severity of CNS depression can be increased when Talbutal is combined with Glutethimide.
Pentobarbital The risk or severity of CNS depression can be increased when Pentobarbital is combined with Glutethimide.
Valproic acid The risk or severity of CNS depression can be increased when Valproic acid is combined with Glutethimide.
Zolmitriptan The risk or severity of CNS depression can be increased when Zolmitriptan is combined with Glutethimide.
Codeine The risk or severity of CNS depression can be increased when Codeine is combined with Glutethimide.
Dihydroergotamine The risk or severity of CNS depression can be increased when Dihydroergotamine is combined with Glutethimide.
Tolcapone The risk or severity of CNS depression can be increased when Tolcapone is combined with Glutethimide.
Hydromorphone The risk or severity of CNS depression can be increased when Hydromorphone is combined with Glutethimide.

Target Protein

Gamma-aminobutyric acid receptor subunit alpha-1 GABRA1
Cytochrome P450 2D6 CYP2D6
GABA(A) Receptor GABRA1

Referensi & Sumber

Synthesis reference: Hoffmann, K. and Tagmann, E.; U.S. Patent 2,673,205; March 23, 1954; assigned to Ciba Pharmaceutical Products, Inc.

Contoh Produk & Brand

Produk: 0 • International brands: 5
International Brands
  • Doriden — U.S.V .
  • Elrodorm
  • Glimid — Polfa Pabianice
  • Glutethimid — Balkanpharma
  • Noxyron

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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