An alkaloid found in the root of Rauwolfia serpentina, among other plant sources. It is a class Ia antiarrhythmic agent that apparently acts by changing the shape and threshold of cardiac action potentials. Ajmaline produces potent sodium channel blocking effects and a very short half-life which makes it a very useful drug for acute intravenous treatments. The drug has been very popular in some countries for the treatment of atrial fibrillation in patients with the Wolff–Parkinson–White syndrome and in well tolerated monomorphic ventricular tachycardias. It has also been used for many years as a drug to challenge the conduction system of the heart in cases of bundle branch block and syncope. In these cases, abnormal prolongation of the HV interval has been taken as a proof for infrahisian conduction defects tributary for permanent pacemaker implantation.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Amiodarone | Amiodarone may increase the QTc-prolonging activities of Ajmaline. |
| Fingolimod | Fingolimod may increase the arrhythmogenic activities of Ajmaline. |
| Propafenone | Propafenone may increase the arrhythmogenic activities of Ajmaline. |
| Metoprolol | Metoprolol may increase the arrhythmogenic activities of Ajmaline. |
| Lidocaine | Lidocaine may increase the arrhythmogenic activities of Ajmaline. |
| Atenolol | Atenolol may increase the arrhythmogenic activities of Ajmaline. |
| Mexiletine | Mexiletine may increase the arrhythmogenic activities of Ajmaline. |
| Nisoldipine | Nisoldipine may increase the arrhythmogenic activities of Ajmaline. |
| Acetyldigitoxin | Acetyldigitoxin may increase the arrhythmogenic activities of Ajmaline. |
| Lercanidipine | Lercanidipine may increase the arrhythmogenic activities of Ajmaline. |
| Magnesium sulfate | Magnesium sulfate may increase the arrhythmogenic activities of Ajmaline. |
| Alprenolol | Alprenolol may increase the arrhythmogenic activities of Ajmaline. |
| Tocainide | Tocainide may increase the arrhythmogenic activities of Ajmaline. |
| Deslanoside | Deslanoside may increase the arrhythmogenic activities of Ajmaline. |
| Carvedilol | Carvedilol may increase the arrhythmogenic activities of Ajmaline. |
| Nadolol | Nadolol may increase the arrhythmogenic activities of Ajmaline. |
| Practolol | Practolol may increase the arrhythmogenic activities of Ajmaline. |
| Carteolol | Ajmaline may increase the arrhythmogenic activities of Carteolol. |
| Metipranolol | Ajmaline may increase the arrhythmogenic activities of Metipranolol. |
| Aprindine | Ajmaline may increase the arrhythmogenic activities of Aprindine. |
| Dexpropranolol | Ajmaline may increase the arrhythmogenic activities of Dexpropranolol. |
| Nimesulide | Ajmaline may increase the arrhythmogenic activities of Nimesulide. |
| Cyclandelate | Ajmaline may increase the arrhythmogenic activities of Cyclandelate. |
| Flunarizine | Ajmaline may increase the arrhythmogenic activities of Flunarizine. |
| Nebivolol | Ajmaline may increase the arrhythmogenic activities of Nebivolol. |
| Clevidipine | Ajmaline may increase the arrhythmogenic activities of Clevidipine. |
| Seletracetam | Ajmaline may increase the arrhythmogenic activities of Seletracetam. |
| Nylidrin | Ajmaline may increase the arrhythmogenic activities of Nylidrin. |
| Dotarizine | Ajmaline may increase the arrhythmogenic activities of Dotarizine. |
| Xylometazoline | Ajmaline may increase the arrhythmogenic activities of Xylometazoline. |
| Sparteine | Ajmaline may increase the arrhythmogenic activities of Sparteine. |
| Tranilast | Ajmaline may increase the arrhythmogenic activities of Tranilast. |
| Fasudil | Ajmaline may increase the arrhythmogenic activities of Fasudil. |
| Agmatine | Ajmaline may increase the arrhythmogenic activities of Agmatine. |
| Nicorandil | Ajmaline may increase the arrhythmogenic activities of Nicorandil. |
| Barnidipine | Ajmaline may increase the arrhythmogenic activities of Barnidipine. |
| Azelnidipine | Ajmaline may increase the arrhythmogenic activities of Azelnidipine. |
| Cilnidipine | Ajmaline may increase the arrhythmogenic activities of Cilnidipine. |
| Darodipine | Ajmaline may increase the arrhythmogenic activities of Darodipine. |
| Manidipine | Ajmaline may increase the arrhythmogenic activities of Manidipine. |
| Niludipine | Ajmaline may increase the arrhythmogenic activities of Niludipine. |
| Tropisetron | Ajmaline may increase the arrhythmogenic activities of Tropisetron. |
| Carboxyamidotriazole | Ajmaline may increase the arrhythmogenic activities of Carboxyamidotriazole. |
| Naftopidil | Ajmaline may increase the arrhythmogenic activities of Naftopidil. |
| Vinpocetine | Ajmaline may increase the arrhythmogenic activities of Vinpocetine. |
| Landiolol | Ajmaline may increase the arrhythmogenic activities of Landiolol. |
| Spiradoline | Ajmaline may increase the arrhythmogenic activities of Spiradoline. |
| Cymarin | Ajmaline may increase the arrhythmogenic activities of Cymarin. |
| Metildigoxin | Ajmaline may increase the arrhythmogenic activities of Metildigoxin. |
| Tiracizine | Ajmaline may increase the arrhythmogenic activities of Tiracizine. |
| Ethacizine | Ajmaline may increase the arrhythmogenic activities of Ethacizine. |
| Hydroquinine | Ajmaline may increase the arrhythmogenic activities of Hydroquinine. |
| Bioallethrin | Ajmaline may increase the arrhythmogenic activities of Bioallethrin. |
| Tertatolol | Ajmaline may increase the arrhythmogenic activities of Tertatolol. |
| Caroverine | Ajmaline may increase the arrhythmogenic activities of Caroverine. |
| Fosfructose | Ajmaline may increase the arrhythmogenic activities of Fosfructose. |
| WIN 55212-2 | Ajmaline may increase the arrhythmogenic activities of WIN 55212-2. |
| Fish oil | Ajmaline may increase the arrhythmogenic activities of Fish oil. |
| Emopamil | Ajmaline may increase the arrhythmogenic activities of Emopamil. |
| Lomerizine | Ajmaline may increase the arrhythmogenic activities of Lomerizine. |
| Tetrandrine | Ajmaline may increase the arrhythmogenic activities of Tetrandrine. |
| Dexniguldipine | Ajmaline may increase the arrhythmogenic activities of Dexniguldipine. |
| Fosinoprilat | Ajmaline may increase the arrhythmogenic activities of Fosinoprilat. |
| Hydroquinidine | Ajmaline may increase the arrhythmogenic activities of Hydroquinidine. |
| SOR-C13 | Ajmaline may increase the arrhythmogenic activities of SOR-C13. |
| Betaxolol | Betaxolol may increase the arrhythmogenic activities of Ajmaline. |
| Diltiazem | Diltiazem may increase the arrhythmogenic activities of Ajmaline. |
| Nimodipine | Nimodipine may increase the arrhythmogenic activities of Ajmaline. |
| Cinnarizine | Cinnarizine may increase the arrhythmogenic activities of Ajmaline. |
| Propranolol | Propranolol may increase the arrhythmogenic activities of Ajmaline. |
| Atropine | Atropine may increase the arrhythmogenic activities of Ajmaline. |
| Adenosine | Adenosine may increase the arrhythmogenic activities of Ajmaline. |
| Loperamide | Loperamide may increase the arrhythmogenic activities of Ajmaline. |
| Levosimendan | Levosimendan may increase the arrhythmogenic activities of Ajmaline. |
| Nifedipine | Nifedipine may increase the arrhythmogenic activities of Ajmaline. |
| Acebutolol | Acebutolol may increase the arrhythmogenic activities of Ajmaline. |
| Flecainide | Flecainide may increase the arrhythmogenic activities of Ajmaline. |
| Mibefradil | Mibefradil may increase the arrhythmogenic activities of Ajmaline. |
| Oxprenolol | Ajmaline may increase the arrhythmogenic activities of Oxprenolol. |
| Prenylamine | Ajmaline may increase the arrhythmogenic activities of Prenylamine. |
| Fluspirilene | Ajmaline may increase the arrhythmogenic activities of Fluspirilene. |
| Azimilide | Ajmaline may increase the arrhythmogenic activities of Azimilide. |
| Tedisamil | Ajmaline may increase the arrhythmogenic activities of Tedisamil. |
| Nilvadipine | Ajmaline may increase the arrhythmogenic activities of Nilvadipine. |
| Indenolol | Ajmaline may increase the arrhythmogenic activities of Indenolol. |
| Fendiline | Ajmaline may increase the arrhythmogenic activities of Fendiline. |
| Eperisone | Ajmaline may increase the arrhythmogenic activities of Eperisone. |
| Melperone | Ajmaline may increase the arrhythmogenic activities of Melperone. |
| Benidipine | Ajmaline may increase the arrhythmogenic activities of Benidipine. |
| Simendan | Ajmaline may increase the arrhythmogenic activities of Simendan. |
| Otilonium | Ajmaline may increase the arrhythmogenic activities of Otilonium. |
| Nizofenone | Ajmaline may increase the arrhythmogenic activities of Nizofenone. |
| Bunaftine | Ajmaline may increase the arrhythmogenic activities of Bunaftine. |
| Lorcainide | Ajmaline may increase the arrhythmogenic activities of Lorcainide. |
| Penfluridol | Ajmaline may increase the arrhythmogenic activities of Penfluridol. |
| Dexverapamil | Ajmaline may increase the arrhythmogenic activities of Dexverapamil. |
| Dofetilide | Dofetilide may increase the arrhythmogenic activities of Ajmaline. |
| Disopyramide | Disopyramide may increase the arrhythmogenic activities of Ajmaline. |
| Ibutilide | Ibutilide may increase the arrhythmogenic activities of Ajmaline. |
| Sotalol | Sotalol may increase the arrhythmogenic activities of Ajmaline. |