Alizapride

DB01425

small molecule investigational

Deskripsi

Alizapride is a dopamine antagonist that is capable of demonstrating both prokinetic and antiemetic effects. This kind of pharmacological activity makes it effective for use in the treatment of various kinds of nausea and vomiting, including that which may occur postoperatively.

Struktur Molekul 2D

Berat 315.3702
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 3 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

renal

Interaksi Obat

25 Data
Tetrabenazine The risk or severity of adverse effects can be increased when Alizapride is combined with Tetrabenazine.
Deutetrabenazine The risk or severity of adverse effects can be increased when Alizapride is combined with Deutetrabenazine.
Apomorphine The therapeutic efficacy of Apomorphine can be decreased when used in combination with Alizapride.
Bromocriptine The therapeutic efficacy of Bromocriptine can be decreased when used in combination with Alizapride.
Levodopa The therapeutic efficacy of Levodopa can be decreased when used in combination with Alizapride.
Rotigotine The therapeutic efficacy of Rotigotine can be decreased when used in combination with Alizapride.
Piribedil The therapeutic efficacy of Piribedil can be decreased when used in combination with Alizapride.
Cabergoline The therapeutic efficacy of Cabergoline can be decreased when used in combination with Alizapride.
Dihydroergotamine The therapeutic efficacy of Dihydroergotamine can be decreased when used in combination with Alizapride.
Lisuride The therapeutic efficacy of Lisuride can be decreased when used in combination with Alizapride.
Fenoldopam The therapeutic efficacy of Fenoldopam can be decreased when used in combination with Alizapride.
Ergoloid mesylate The therapeutic efficacy of Ergoloid mesylate can be decreased when used in combination with Alizapride.
Pergolide The therapeutic efficacy of Pergolide can be decreased when used in combination with Alizapride.
Aripiprazole The therapeutic efficacy of Aripiprazole can be decreased when used in combination with Alizapride.
Quinagolide The therapeutic efficacy of Quinagolide can be decreased when used in combination with Alizapride.
Brexpiprazole The therapeutic efficacy of Brexpiprazole can be decreased when used in combination with Alizapride.
Dihydroergocornine The therapeutic efficacy of Dihydroergocornine can be decreased when used in combination with Alizapride.
Dopexamine The therapeutic efficacy of Dopexamine can be decreased when used in combination with Alizapride.
Dihydrexidine The therapeutic efficacy of Dihydrexidine can be decreased when used in combination with Alizapride.
Dihydroergocryptine The therapeutic efficacy of Dihydroergocryptine can be decreased when used in combination with Alizapride.
Metergoline The therapeutic efficacy of Metergoline can be decreased when used in combination with Alizapride.
Ropinirole The therapeutic efficacy of Ropinirole can be decreased when used in combination with Alizapride.
Benzatropine The risk or severity of adverse effects can be increased when Alizapride is combined with Benzatropine.
Pramipexole The therapeutic efficacy of Pramipexole can be decreased when used in combination with Alizapride.
Epicriptine The therapeutic efficacy of Epicriptine can be decreased when used in combination with Alizapride.

Target Protein

D(2) dopamine receptor DRD2

Referensi & Sumber

Synthesis reference: Bulteau, G., Acher, J., Collignon, C. and Monier, J.C.; U S . Patent 4,039,672; August 2,1977; assigned to Societe D'Etudes Scientifiques et lndustrielles de I'lle-de-France.
Artikel (PubMed)
  • PMID: 3048762
    Bleiberg H, Gerard B, Dalesio O, Crespeigne N, Rozencweig M: Activity of a new antiemetic agent: alizapride. A randomized double-blind crossover controlled trial. Cancer Chemother Pharmacol. 1988;22(4):316-20.

Contoh Produk & Brand

Produk: 0 • International brands: 3
International Brands
  • Limican
  • Plitican — Delagrange
  • Vergentan — Delagrange

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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