Nitroxoline

DB01422

small molecule experimental

Deskripsi

Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. It is a hydroxyquinoline derivative unrelated to other classes of drugs.^A179251 Nitroxoline is active against bacterial gyrases.

Struktur Molekul 2D

Berat 190.1555

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) -

Volume Distribusi -

Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

14 Data

Dicoumarol	The therapeutic efficacy of Dicoumarol can be increased when used in combination with Nitroxoline.
Phenindione	The therapeutic efficacy of Phenindione can be increased when used in combination with Nitroxoline.
Warfarin	The therapeutic efficacy of Warfarin can be increased when used in combination with Nitroxoline.
Phenprocoumon	The therapeutic efficacy of Phenprocoumon can be increased when used in combination with Nitroxoline.
Acenocoumarol	The therapeutic efficacy of Acenocoumarol can be increased when used in combination with Nitroxoline.
4-hydroxycoumarin	The therapeutic efficacy of 4-hydroxycoumarin can be increased when used in combination with Nitroxoline.
Coumarin	The therapeutic efficacy of Coumarin can be increased when used in combination with Nitroxoline.
(R)-warfarin	The therapeutic efficacy of (R)-warfarin can be increased when used in combination with Nitroxoline.
Ethyl biscoumacetate	The therapeutic efficacy of Ethyl biscoumacetate can be increased when used in combination with Nitroxoline.
Fluindione	The therapeutic efficacy of Fluindione can be increased when used in combination with Nitroxoline.
Clorindione	The therapeutic efficacy of Clorindione can be increased when used in combination with Nitroxoline.
Diphenadione	The therapeutic efficacy of Diphenadione can be increased when used in combination with Nitroxoline.
Tioclomarol	The therapeutic efficacy of Tioclomarol can be increased when used in combination with Nitroxoline.
(S)-Warfarin	The therapeutic efficacy of (S)-Warfarin can be increased when used in combination with Nitroxoline.

Target Protein

Methionine aminopeptidase 2 METAP2

Magnesium cation

Manganese cation

Referensi & Sumber

Artikel (PubMed)

PMID: 30184207
Wijma RA, Huttner A, Koch BCP, Mouton JW, Muller AE: Review of the pharmacokinetic properties of nitrofurantoin and nitroxoline. J Antimicrob Chemother. 2018 Nov 1;73(11):2916-2926. doi: 10.1093/jac/dky255.

Contoh Produk & Brand

Produk: 0 • International brands: 1

International Brands

Nitroxoline

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.