Peringatan Keamanan

Reports have showed a potential stimulation of cancerous tissue growth. The potential testosterone propionate accumulation in the body produces a high risk of edema secondaryh to water and sodium retention.L1162

Testosterone propionate

DB01420

small molecule approved investigational vet_approved withdrawn

Deskripsi

Testosterone propionate is a slower-releasing anabolic steroid with a short half-life. It is a synthetic androstane steroid derivative of testosterone in the form of 17? propionate ester of testosterone.T83 Testosterone propionate was developed initially by Watson labs, and FDA approved on February 5, 1974. Currently, this drug has been discontinued in humans, but the vet application is still available as an OTC.L1160

Struktur Molekul 2D

Berat 344.4877
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Testosterone propionate possesses a relatively short half-life compared with other testosterone esters at approximately 4.5 days.
Volume Distribusi The registered volume of distribution for testosterone propionate is in the range of 75-120 L/kg.[A31625]
Klirens (Clearance) Testosterone propionate has a reduced clearance rate compared to testosterone.[L1162] The reported clearance rate is of approximately 2000 ml/min.[A31625]

Absorpsi

Testosterone propionate presents a slow absorption from the intramuscular site of administration. This slow absorption is due to the presence of the less polar ester group.L1162 The absorption rate of testosterone propionate generates a frequent injection requirement when compared with testosterone enanthate or testosterone cypionate. It presents absorption parameters of AUC and residence time of 180-210 ng h/ml and 40-60 h, respectively.A31625

Metabolisme

As all testosterone esters, testosterone propionate is rapidly hydrolysed into free testosterone in plasma.A31625 Testosterone is metabolized to 17-keto steroids through two different pathways. The major active metabolites are estradiol and dihydrotestosterone (DHT).L1162

Rute Eliminasi

About 90% of a dose of testosterone given intramuscularly is excreted in the urine as glucuronic and sulfuric acid conjugates of testosterone and its metabolites. From the rest of the dose, approximately 6% of a dose is excreted in the feces, mostly in the unconjugated form.L1162

Interaksi Obat

1094 Data
Deferasirox The metabolism of Deferasirox can be increased when combined with Testosterone propionate.
Prasterone The serum concentration of Testosterone propionate can be increased when it is combined with Prasterone.
Tramadol The metabolism of Tramadol can be increased when combined with Testosterone propionate.
Troglitazone The metabolism of Troglitazone can be increased when combined with Testosterone propionate.
Morphine The metabolism of Morphine can be increased when combined with Testosterone propionate.
Acetaminophen The metabolism of Acetaminophen can be increased when combined with Testosterone propionate.
Indomethacin The metabolism of Indomethacin can be increased when combined with Testosterone propionate.
Minoxidil The metabolism of Minoxidil can be increased when combined with Testosterone propionate.
Cerivastatin The metabolism of Cerivastatin can be increased when combined with Testosterone propionate.
Raloxifene The metabolism of Raloxifene can be increased when combined with Testosterone propionate.
Zidovudine The metabolism of Zidovudine can be increased when combined with Testosterone propionate.
Lamotrigine The metabolism of Lamotrigine can be increased when combined with Testosterone propionate.
Diclofenac The metabolism of Diclofenac can be increased when combined with Testosterone propionate.
Mycophenolate mofetil The metabolism of Mycophenolate mofetil can be increased when combined with Testosterone propionate.
Naltrexone The metabolism of Naltrexone can be increased when combined with Testosterone propionate.
Flurbiprofen The metabolism of Flurbiprofen can be increased when combined with Testosterone propionate.
Estradiol The metabolism of Estradiol can be increased when combined with Testosterone propionate.
Naproxen The metabolism of Naproxen can be increased when combined with Testosterone propionate.
Propofol The metabolism of Propofol can be increased when combined with Testosterone propionate.
Tiagabine The metabolism of Tiagabine can be increased when combined with Testosterone propionate.
Zonisamide The metabolism of Zonisamide can be increased when combined with Testosterone propionate.
Metronidazole The metabolism of Metronidazole can be increased when combined with Testosterone propionate.
Buprenorphine The metabolism of Buprenorphine can be increased when combined with Testosterone propionate.
Fulvestrant The metabolism of Fulvestrant can be increased when combined with Testosterone propionate.
Ezetimibe The metabolism of Ezetimibe can be increased when combined with Testosterone propionate.
Ethinylestradiol The metabolism of Ethinylestradiol can be increased when combined with Testosterone propionate.
Ketoprofen The metabolism of Ketoprofen can be increased when combined with Testosterone propionate.
Abacavir The metabolism of Abacavir can be increased when combined with Testosterone propionate.
Ibuprofen The metabolism of Ibuprofen can be increased when combined with Testosterone propionate.
Glipizide The metabolism of Glipizide can be increased when combined with Testosterone propionate.
Fluvastatin The metabolism of Fluvastatin can be increased when combined with Testosterone propionate.
Carvedilol The metabolism of Carvedilol can be increased when combined with Testosterone propionate.
Gemfibrozil The metabolism of Gemfibrozil can be increased when combined with Testosterone propionate.
Fusidic acid The metabolism of Fusidic acid can be increased when combined with Testosterone propionate.
Alvocidib The metabolism of Alvocidib can be increased when combined with Testosterone propionate.
Ezogabine The metabolism of Ezogabine can be increased when combined with Testosterone propionate.
Migalastat Testosterone propionate may decrease the excretion rate of Migalastat which could result in a higher serum level.
Indacaterol The metabolism of Indacaterol can be increased when combined with Testosterone propionate.
Eltrombopag The metabolism of Eltrombopag can be increased when combined with Testosterone propionate.
Bazedoxifene The metabolism of Bazedoxifene can be increased when combined with Testosterone propionate.
Muraglitazar The metabolism of Muraglitazar can be increased when combined with Testosterone propionate.
Gavestinel The metabolism of Gavestinel can be increased when combined with Testosterone propionate.
Raltegravir The metabolism of Raltegravir can be increased when combined with Testosterone propionate.
Dolutegravir The metabolism of Dolutegravir can be increased when combined with Testosterone propionate.
Eslicarbazepine acetate The metabolism of Eslicarbazepine acetate can be increased when combined with Testosterone propionate.
Propacetamol The metabolism of Propacetamol can be increased when combined with Testosterone propionate.
Bictegravir The metabolism of Bictegravir can be increased when combined with Testosterone propionate.
Delafloxacin The metabolism of Delafloxacin can be increased when combined with Testosterone propionate.
Letermovir The metabolism of Letermovir can be increased when combined with Testosterone propionate.
Estradiol acetate The metabolism of Estradiol acetate can be increased when combined with Testosterone propionate.
Estradiol benzoate The metabolism of Estradiol benzoate can be increased when combined with Testosterone propionate.
Estradiol cypionate The metabolism of Estradiol cypionate can be increased when combined with Testosterone propionate.
Estradiol dienanthate The metabolism of Estradiol dienanthate can be increased when combined with Testosterone propionate.
Estradiol valerate The metabolism of Estradiol valerate can be increased when combined with Testosterone propionate.
Eslicarbazepine The metabolism of Eslicarbazepine can be increased when combined with Testosterone propionate.
Dexibuprofen The metabolism of Dexibuprofen can be increased when combined with Testosterone propionate.
Labetalol The metabolism of Labetalol can be increased when combined with Testosterone propionate.
Lumateperone The metabolism of Lumateperone can be increased when combined with Testosterone propionate.
Simvastatin The metabolism of Simvastatin can be increased when combined with Testosterone propionate.
Atorvastatin The metabolism of Atorvastatin can be increased when combined with Testosterone propionate.
Nintedanib The metabolism of Nintedanib can be increased when combined with Testosterone propionate.
Darolutamide The metabolism of Darolutamide can be increased when combined with Testosterone propionate.
Selumetinib The metabolism of Selumetinib can be increased when combined with Testosterone propionate.
Norgestimate The metabolism of Norgestimate can be increased when combined with Testosterone propionate.
Cabotegravir The metabolism of Cabotegravir can be increased when combined with Testosterone propionate.
Febuxostat The metabolism of Febuxostat can be increased when combined with Testosterone propionate.
Ponesimod The metabolism of Ponesimod can be increased when combined with Testosterone propionate.
Pipamperone The therapeutic efficacy of Pipamperone can be decreased when used in combination with Testosterone propionate.
Cyclosporine The risk or severity of liver damage can be increased when Testosterone propionate is combined with Cyclosporine.
Insulin human Testosterone propionate may increase the hypoglycemic activities of Insulin human.
Insulin lispro Testosterone propionate may increase the hypoglycemic activities of Insulin lispro.
Insulin glargine Testosterone propionate may increase the hypoglycemic activities of Insulin glargine.
Insulin pork Testosterone propionate may increase the hypoglycemic activities of Insulin pork.
Glimepiride Testosterone propionate may increase the hypoglycemic activities of Glimepiride.
Sulfisoxazole Testosterone propionate may increase the hypoglycemic activities of Sulfisoxazole.
Acetohexamide Testosterone propionate may increase the hypoglycemic activities of Acetohexamide.
Miglitol Testosterone propionate may increase the hypoglycemic activities of Miglitol.
Phenformin Testosterone propionate may increase the hypoglycemic activities of Phenformin.
Gliclazide Testosterone propionate may increase the hypoglycemic activities of Gliclazide.
Gliquidone Testosterone propionate may increase the hypoglycemic activities of Gliquidone.
Mitiglinide Testosterone propionate may increase the hypoglycemic activities of Mitiglinide.
Exenatide Testosterone propionate may increase the hypoglycemic activities of Exenatide.
Mecasermin Testosterone propionate may increase the hypoglycemic activities of Mecasermin.
Pramlintide Testosterone propionate may increase the hypoglycemic activities of Pramlintide.
Glisoxepide Testosterone propionate may increase the hypoglycemic activities of Glisoxepide.
Insulin aspart Testosterone propionate may increase the hypoglycemic activities of Insulin aspart.
Insulin detemir Testosterone propionate may increase the hypoglycemic activities of Insulin detemir.
Insulin glulisine Testosterone propionate may increase the hypoglycemic activities of Insulin glulisine.
Glymidine Testosterone propionate may increase the hypoglycemic activities of Glymidine.
AICA ribonucleotide Testosterone propionate may increase the hypoglycemic activities of AICA ribonucleotide.
Buformin Testosterone propionate may increase the hypoglycemic activities of Buformin.
Vildagliptin Testosterone propionate may increase the hypoglycemic activities of Vildagliptin.
Voglibose Testosterone propionate may increase the hypoglycemic activities of Voglibose.
NN344 Testosterone propionate may increase the hypoglycemic activities of NN344.
AMG-222 Testosterone propionate may increase the hypoglycemic activities of AMG-222.
Bisegliptin Testosterone propionate may increase the hypoglycemic activities of Bisegliptin.
Liraglutide Testosterone propionate may increase the hypoglycemic activities of Liraglutide.
Gosogliptin Testosterone propionate may increase the hypoglycemic activities of Gosogliptin.
Glibornuride Testosterone propionate may increase the hypoglycemic activities of Glibornuride.
Benfluorex Testosterone propionate may increase the hypoglycemic activities of Benfluorex.

Target Protein

Androgen receptor AR

Referensi & Sumber

Artikel (PubMed)
  • PMID: 3782423
    Fujioka M, Shinohara Y, Baba S, Irie M, Inoue K: Pharmacokinetic properties of testosterone propionate in normal men. J Clin Endocrinol Metab. 1986 Dec;63(6):1361-4. doi: 10.1210/jcem-63-6-1361.
Textbook
  • Elks J. and Ganellin C.R. (1990). The dictionary of drugs. Springer Science.
  • Woo T.M. and Robinson M. (2016). Pharmacotherapeutics for advanced practice nurse prescribers (4th ed.). Davis Company.

Contoh Produk & Brand

Produk: 4 • International brands: 1
Produk
  • Malogen In Oil Liq 100mg/ml
    Liquid • 100 mg / mL • Intramuscular • Canada • Approved
  • Testosterone Propionate Inj 100mg/ml
    Liquid • 100 mg / mL • Intramuscular • Canada • Approved
  • Testosterone Propionate Injection, USP
    Liquid • 100 mg / mL • Intramuscular • Canada • Approved
  • Testosterone Propionate Micro
    Powder • 1 g/1g • Not applicable • US
International Brands
  • Testex

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