Antrafenine

DB01419

small molecule approved

Deskripsi

Antrafenine is a piperazine derivative drug that acts as an analgesic and anti-inflammatory drug with similar efficacy to naproxen. It is not widely used as it has largely been replaced by newer drugs.

Struktur Molekul 2D

Berat 588.5435
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1393 Data
Amlodipine Antrafenine may decrease the antihypertensive activities of Amlodipine.
Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Antrafenine.
Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Antrafenine.
Eletriptan The risk or severity of hypertension can be increased when Eletriptan is combined with Antrafenine.
Isoetharine The risk or severity of hypertension can be increased when Isoetharine is combined with Antrafenine.
Ziprasidone The risk or severity of hypertension can be increased when Ziprasidone is combined with Antrafenine.
Methysergide The risk or severity of hypertension can be increased when Methysergide is combined with Antrafenine.
Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Antrafenine.
Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Antrafenine.
Dihydroergotamine The risk or severity of hypertension can be increased when Dihydroergotamine is combined with Antrafenine.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Antrafenine.
Norepinephrine The risk or severity of hypertension can be increased when Norepinephrine is combined with Antrafenine.
Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Antrafenine.
Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Antrafenine.
Phenylpropanolamine The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Antrafenine.
Promazine The risk or severity of hypertension can be increased when Promazine is combined with Antrafenine.
Droperidol The risk or severity of hypertension can be increased when Droperidol is combined with Antrafenine.
Doxapram The risk or severity of hypertension can be increased when Doxapram is combined with Antrafenine.
Atropine The risk or severity of hypertension can be increased when Atropine is combined with Antrafenine.
Lisuride The risk or severity of hypertension can be increased when Lisuride is combined with Antrafenine.
Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Antrafenine.
Metaraminol The risk or severity of hypertension can be increased when Metaraminol is combined with Antrafenine.
Furazolidone The risk or severity of hypertension can be increased when Furazolidone is combined with Antrafenine.
Epinephrine The risk or severity of hypertension can be increased when Epinephrine is combined with Antrafenine.
Thioridazine The risk or severity of hypertension can be increased when Thioridazine is combined with Antrafenine.
Ergotamine The risk or severity of hypertension can be increased when Ergotamine is combined with Antrafenine.
Nicergoline The risk or severity of hypertension can be increased when Nicergoline is combined with Antrafenine.
Sufentanil The risk or severity of hypertension can be increased when Sufentanil is combined with Antrafenine.
Methoxamine The risk or severity of hypertension can be increased when Methoxamine is combined with Antrafenine.
Risperidone The risk or severity of hypertension can be increased when Risperidone is combined with Antrafenine.
Tranylcypromine The risk or severity of hypertension can be increased when Tranylcypromine is combined with Antrafenine.
Isoflurane The risk or severity of hypertension can be increased when Isoflurane is combined with Antrafenine.
Propiomazine The risk or severity of hypertension can be increased when Propiomazine is combined with Antrafenine.
Alfentanil The risk or severity of hypertension can be increased when Alfentanil is combined with Antrafenine.
Minaprine The risk or severity of hypertension can be increased when Minaprine is combined with Antrafenine.
Orciprenaline The risk or severity of hypertension can be increased when Orciprenaline is combined with Antrafenine.
Propofol The risk or severity of hypertension can be increased when Propofol is combined with Antrafenine.
Phenmetrazine The risk or severity of hypertension can be increased when Phenmetrazine is combined with Antrafenine.
Trifluoperazine The risk or severity of hypertension can be increased when Trifluoperazine is combined with Antrafenine.
Pseudoephedrine The risk or severity of hypertension can be increased when Pseudoephedrine is combined with Antrafenine.
Benzphetamine The risk or severity of hypertension can be increased when Benzphetamine is combined with Antrafenine.
Ritodrine The risk or severity of hypertension can be increased when Ritodrine is combined with Antrafenine.
Flupentixol The risk or severity of hypertension can be increased when Flupentixol is combined with Antrafenine.
Remifentanil The risk or severity of hypertension can be increased when Remifentanil is combined with Antrafenine.
Bitolterol The risk or severity of hypertension can be increased when Bitolterol is combined with Antrafenine.
Oxymetazoline The risk or severity of hypertension can be increased when Oxymetazoline is combined with Antrafenine.
Diethylpropion The risk or severity of hypertension can be increased when Diethylpropion is combined with Antrafenine.
Salmeterol The risk or severity of hypertension can be increased when Salmeterol is combined with Antrafenine.
Naratriptan The risk or severity of hypertension can be increased when Naratriptan is combined with Antrafenine.
Formoterol The risk or severity of hypertension can be increased when Formoterol is combined with Antrafenine.
Frovatriptan The risk or severity of hypertension can be increased when Frovatriptan is combined with Antrafenine.
Methoxyflurane The risk or severity of hypertension can be increased when Methoxyflurane is combined with Antrafenine.
Selegiline The risk or severity of hypertension can be increased when Selegiline is combined with Antrafenine.
Ergoloid mesylate The risk or severity of hypertension can be increased when Ergoloid mesylate is combined with Antrafenine.
Isoprenaline The risk or severity of hypertension can be increased when Isoprenaline is combined with Antrafenine.
Arbutamine The risk or severity of hypertension can be increased when Arbutamine is combined with Antrafenine.
Dutasteride The risk or severity of hypertension can be increased when Dutasteride is combined with Antrafenine.
Halothane The risk or severity of hypertension can be increased when Halothane is combined with Antrafenine.
Moclobemide The risk or severity of hypertension can be increased when Moclobemide is combined with Antrafenine.
Pergolide The risk or severity of hypertension can be increased when Pergolide is combined with Antrafenine.
Desflurane The risk or severity of hypertension can be increased when Desflurane is combined with Antrafenine.
Bromocriptine The risk or severity of hypertension can be increased when Bromocriptine is combined with Antrafenine.
Finasteride The risk or severity of hypertension can be increased when Finasteride is combined with Antrafenine.
Aripiprazole The risk or severity of hypertension can be increased when Aripiprazole is combined with Antrafenine.
Isocarboxazid The risk or severity of hypertension can be increased when Isocarboxazid is combined with Antrafenine.
Ergometrine The risk or severity of hypertension can be increased when Ergometrine is combined with Antrafenine.
Lisdexamfetamine The risk or severity of hypertension can be increased when Lisdexamfetamine is combined with Antrafenine.
Fenoterol The risk or severity of hypertension can be increased when Fenoterol is combined with Antrafenine.
Pirbuterol The risk or severity of hypertension can be increased when Pirbuterol is combined with Antrafenine.
Ephedra sinica root The risk or severity of hypertension can be increased when Ephedra sinica root is combined with Antrafenine.
Ephedrine The risk or severity of hypertension can be increased when Ephedrine is combined with Antrafenine.
Mephentermine The risk or severity of hypertension can be increased when Mephentermine is combined with Antrafenine.
Procaterol The risk or severity of hypertension can be increased when Procaterol is combined with Antrafenine.
Yohimbine The risk or severity of hypertension can be increased when Yohimbine is combined with Antrafenine.
Methotrimeprazine The risk or severity of hypertension can be increased when Methotrimeprazine is combined with Antrafenine.
Clenbuterol The risk or severity of hypertension can be increased when Clenbuterol is combined with Antrafenine.
Bambuterol The risk or severity of hypertension can be increased when Bambuterol is combined with Antrafenine.
MMDA The risk or severity of hypertension can be increased when Antrafenine is combined with MMDA.
Midomafetamine The risk or severity of hypertension can be increased when Antrafenine is combined with Midomafetamine.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of hypertension can be increased when Antrafenine is combined with 2,5-Dimethoxy-4-ethylamphetamine.
4-Methoxyamphetamine The risk or severity of hypertension can be increased when Antrafenine is combined with 4-Methoxyamphetamine.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of hypertension can be increased when Antrafenine is combined with 4-Bromo-2,5-dimethoxyamphetamine.
Tenamfetamine The risk or severity of hypertension can be increased when Antrafenine is combined with Tenamfetamine.
Chlorphentermine The risk or severity of hypertension can be increased when Antrafenine is combined with Chlorphentermine.
Dextroamphetamine The risk or severity of hypertension can be increased when Antrafenine is combined with Dextroamphetamine.
Phendimetrazine The risk or severity of hypertension can be increased when Antrafenine is combined with Phendimetrazine.
Solifenacin The risk or severity of hypertension can be increased when Antrafenine is combined with Solifenacin.
Periciazine The risk or severity of hypertension can be increased when Antrafenine is combined with Periciazine.
Acepromazine The risk or severity of hypertension can be increased when Antrafenine is combined with Acepromazine.
Thioproperazine The risk or severity of hypertension can be increased when Antrafenine is combined with Thioproperazine.
Zuclopenthixol The risk or severity of hypertension can be increased when Antrafenine is combined with Zuclopenthixol.
Epicaptopril The risk or severity of hypertension can be increased when Antrafenine is combined with Epicaptopril.
Clorgiline The risk or severity of hypertension can be increased when Antrafenine is combined with Clorgiline.
1-benzylimidazole The risk or severity of hypertension can be increased when Antrafenine is combined with 1-benzylimidazole.
Iproniazid The risk or severity of hypertension can be increased when Antrafenine is combined with Iproniazid.
Nialamide The risk or severity of hypertension can be increased when Antrafenine is combined with Nialamide.
Lysergic acid diethylamide The risk or severity of hypertension can be increased when Antrafenine is combined with Lysergic acid diethylamide.
Dronedarone The risk or severity of hypertension can be increased when Antrafenine is combined with Dronedarone.
Flibanserin The risk or severity of hypertension can be increased when Antrafenine is combined with Flibanserin.
Iloperidone The risk or severity of hypertension can be increased when Antrafenine is combined with Iloperidone.

Target Protein

Prostaglandin G/H synthase 1 PTGS1
Prostaglandin G/H synthase 2 PTGS2

Referensi & Sumber

Synthesis reference: Giudicelli, D.P.R.L., Najer, H., Manory, P.M.J. and Dumas, A.P.F.; January 27,1976; assigned to Synthelabo US. Patent 3,935,229.

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