Cefpodoxime

DB01416

small molecule approved vet_approved

Deskripsi

Cefpodoxime is an oral third generation cephalosporin antibiotic with effectiveness against most Gram positive and Gram negative bacteria. Commonly used to treat acute otitis media, pharyngitis, and sinusitis, cefpodoxime proxetil is a prodrug which is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime.

Struktur Molekul 2D

Berat 427.455
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 2.09 to 2.84 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Cefpodoxime proxetil is a prodrug that is absorbed from the gastrointestinal tract and de-esterified to its active metabolite, cefpodoxime. Following oral administration of 100 mg of cefpodoxime proxetil to fasting subjects, approximately 50% of the administered cefpodoxime dose was absorbed systemically.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Over the recommended dosing range (100 to 400 mg), approximately 29 to 33% of the administered cefpodoxime dose was excreted unchanged in the urine in 12 hours.

Interaksi Makanan

1 Data
  • 1. Take on an empty stomach. Take at least 1 hour before or 2 hours after meals.

Interaksi Obat

821 Data
Probenecid The serum concentration of Cefpodoxime can be increased when it is combined with Probenecid.
Foscarnet The risk or severity of nephrotoxicity can be increased when Cefpodoxime is combined with Foscarnet.
Mannitol The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Cefpodoxime.
Tenofovir disoproxil Cefpodoxime may increase the nephrotoxic activities of Tenofovir disoproxil.
Tenofovir alafenamide Cefpodoxime may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir Cefpodoxime may increase the nephrotoxic activities of Tenofovir.
Olanzapine Olanzapine can cause a decrease in the absorption of Cefpodoxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cimetidine Cimetidine can cause a decrease in the absorption of Cefpodoxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nizatidine Nizatidine can cause a decrease in the absorption of Cefpodoxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ranitidine Ranitidine can cause a decrease in the absorption of Cefpodoxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Famotidine Famotidine can cause a decrease in the absorption of Cefpodoxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Methantheline Methantheline can cause a decrease in the absorption of Cefpodoxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Promethazine Promethazine can cause a decrease in the absorption of Cefpodoxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Doxepin Doxepin can cause a decrease in the absorption of Cefpodoxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Asenapine Asenapine can cause a decrease in the absorption of Cefpodoxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Metiamide Metiamide can cause a decrease in the absorption of Cefpodoxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Roxatidine acetate Roxatidine acetate can cause a decrease in the absorption of Cefpodoxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lafutidine Lafutidine can cause a decrease in the absorption of Cefpodoxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lavoltidine Lavoltidine can cause a decrease in the absorption of Cefpodoxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Niperotidine Niperotidine can cause a decrease in the absorption of Cefpodoxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Epinastine Epinastine can cause a decrease in the absorption of Cefpodoxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium oxide The serum concentration of Cefpodoxime can be decreased when it is combined with Magnesium oxide.
Sodium bicarbonate The serum concentration of Cefpodoxime can be decreased when it is combined with Sodium bicarbonate.
Aluminum hydroxide The serum concentration of Cefpodoxime can be decreased when it is combined with Aluminum hydroxide.
Calcium carbonate The serum concentration of Cefpodoxime can be decreased when it is combined with Calcium carbonate.
Magaldrate The serum concentration of Cefpodoxime can be decreased when it is combined with Magaldrate.
Magnesium hydroxide The serum concentration of Cefpodoxime can be decreased when it is combined with Magnesium hydroxide.
Magnesium trisilicate The serum concentration of Cefpodoxime can be decreased when it is combined with Magnesium trisilicate.
Magnesium carbonate The serum concentration of Cefpodoxime can be decreased when it is combined with Magnesium carbonate.
Bismuth subnitrate The serum concentration of Cefpodoxime can be decreased when it is combined with Bismuth subnitrate.
Magnesium silicate The serum concentration of Cefpodoxime can be decreased when it is combined with Magnesium silicate.
Aluminium acetoacetate The serum concentration of Cefpodoxime can be decreased when it is combined with Aluminium acetoacetate.
Hydrotalcite The serum concentration of Cefpodoxime can be decreased when it is combined with Hydrotalcite.
Magnesium peroxide The serum concentration of Cefpodoxime can be decreased when it is combined with Magnesium peroxide.
Almasilate The serum concentration of Cefpodoxime can be decreased when it is combined with Almasilate.
Aluminium glycinate The serum concentration of Cefpodoxime can be decreased when it is combined with Aluminium glycinate.
Aloglutamol The serum concentration of Cefpodoxime can be decreased when it is combined with Aloglutamol.
Calcium silicate The serum concentration of Cefpodoxime can be decreased when it is combined with Calcium silicate.
Aluminium phosphate The serum concentration of Cefpodoxime can be decreased when it is combined with Aluminium phosphate.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefpodoxime.
Cyclosporine The risk or severity of nephrotoxicity can be increased when Cyclosporine is combined with Cefpodoxime.
Icosapent The risk or severity of nephrotoxicity can be increased when Icosapent is combined with Cefpodoxime.
Cefotiam The risk or severity of nephrotoxicity can be increased when Cefotiam is combined with Cefpodoxime.
Mesalazine The risk or severity of nephrotoxicity can be increased when Mesalazine is combined with Cefpodoxime.
Cefmenoxime The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefpodoxime.
Cefmetazole The risk or severity of nephrotoxicity can be increased when Cefmetazole is combined with Cefpodoxime.
Indomethacin The risk or severity of nephrotoxicity can be increased when Indomethacin is combined with Cefpodoxime.
Triamterene The risk or severity of nephrotoxicity can be increased when Triamterene is combined with Cefpodoxime.
Cefpiramide The risk or severity of nephrotoxicity can be increased when Cefpiramide is combined with Cefpodoxime.
Loracarbef The risk or severity of nephrotoxicity can be increased when Loracarbef is combined with Cefpodoxime.
Cefalotin The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Cefpodoxime.
Nabumetone The risk or severity of nephrotoxicity can be increased when Nabumetone is combined with Cefpodoxime.
Ketorolac The risk or severity of nephrotoxicity can be increased when Ketorolac is combined with Cefpodoxime.
Tenoxicam The risk or severity of nephrotoxicity can be increased when Tenoxicam is combined with Cefpodoxime.
Celecoxib The risk or severity of nephrotoxicity can be increased when Celecoxib is combined with Cefpodoxime.
Cefotaxime The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Cefpodoxime.
Tolmetin The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Cefpodoxime.
Rofecoxib The risk or severity of nephrotoxicity can be increased when Rofecoxib is combined with Cefpodoxime.
Fenoprofen The risk or severity of nephrotoxicity can be increased when Fenoprofen is combined with Cefpodoxime.
Valdecoxib The risk or severity of nephrotoxicity can be increased when Valdecoxib is combined with Cefpodoxime.
Diclofenac The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Cefpodoxime.
Sulindac The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Cefpodoxime.
Bacitracin The risk or severity of nephrotoxicity can be increased when Bacitracin is combined with Cefpodoxime.
Amphotericin B The risk or severity of nephrotoxicity can be increased when Amphotericin B is combined with Cefpodoxime.
Cephaloglycin The risk or severity of nephrotoxicity can be increased when Cephaloglycin is combined with Cefpodoxime.
Adefovir dipivoxil The risk or severity of nephrotoxicity can be increased when Adefovir dipivoxil is combined with Cefpodoxime.
Pentamidine The risk or severity of nephrotoxicity can be increased when Pentamidine is combined with Cefpodoxime.
Mefenamic acid The risk or severity of nephrotoxicity can be increased when Mefenamic acid is combined with Cefpodoxime.
Naproxen The risk or severity of nephrotoxicity can be increased when Naproxen is combined with Cefpodoxime.
Sulfasalazine The risk or severity of nephrotoxicity can be increased when Sulfasalazine is combined with Cefpodoxime.
Phenylbutazone The risk or severity of nephrotoxicity can be increased when Phenylbutazone is combined with Cefpodoxime.
Meloxicam The risk or severity of methemoglobinemia can be increased when Cefpodoxime is combined with Meloxicam.
Carprofen The risk or severity of nephrotoxicity can be increased when Carprofen is combined with Cefpodoxime.
Tacrolimus The risk or severity of nephrotoxicity can be increased when Tacrolimus is combined with Cefpodoxime.
Etacrynic acid The risk or severity of nephrotoxicity can be increased when Etacrynic acid is combined with Cefpodoxime.
Ceforanide The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Cefpodoxime.
Salicylic acid The risk or severity of nephrotoxicity can be increased when Salicylic acid is combined with Cefpodoxime.
Acetylsalicylic acid The risk or severity of nephrotoxicity can be increased when Acetylsalicylic acid is combined with Cefpodoxime.
Hydrochlorothiazide The risk or severity of nephrotoxicity can be increased when Hydrochlorothiazide is combined with Cefpodoxime.
Balsalazide The risk or severity of nephrotoxicity can be increased when Balsalazide is combined with Cefpodoxime.
Cefditoren The risk or severity of nephrotoxicity can be increased when Cefditoren is combined with Cefpodoxime.
Atazanavir The risk or severity of nephrotoxicity can be increased when Atazanavir is combined with Cefpodoxime.
Colistimethate The risk or severity of nephrotoxicity can be increased when Colistimethate is combined with Cefpodoxime.
Cefuroxime The risk or severity of nephrotoxicity can be increased when Cefuroxime is combined with Cefpodoxime.
Cefapirin The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Cefpodoxime.
Cefprozil The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Cefpodoxime.
Olsalazine The risk or severity of nephrotoxicity can be increased when Cefpodoxime is combined with Olsalazine.
Lumiracoxib The risk or severity of nephrotoxicity can be increased when Lumiracoxib is combined with Cefpodoxime.
Cefamandole The risk or severity of nephrotoxicity can be increased when Cefamandole is combined with Cefpodoxime.
Cefazolin The risk or severity of nephrotoxicity can be increased when Cefazolin is combined with Cefpodoxime.
Cefonicid The risk or severity of nephrotoxicity can be increased when Cefonicid is combined with Cefpodoxime.
Cefoperazone The risk or severity of nephrotoxicity can be increased when Cefoperazone is combined with Cefpodoxime.
Cefoxitin The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Cefpodoxime.
Ceftizoxime The risk or severity of nephrotoxicity can be increased when Ceftizoxime is combined with Cefpodoxime.
Magnesium salicylate The risk or severity of nephrotoxicity can be increased when Magnesium salicylate is combined with Cefpodoxime.
Salsalate The risk or severity of nephrotoxicity can be increased when Salsalate is combined with Cefpodoxime.
Choline magnesium trisalicylate The risk or severity of nephrotoxicity can be increased when Choline magnesium trisalicylate is combined with Cefpodoxime.
Cefepime The risk or severity of nephrotoxicity can be increased when Cefepime is combined with Cefpodoxime.
Cefacetrile The risk or severity of nephrotoxicity can be increased when Cefacetrile is combined with Cefpodoxime.
Antrafenine The risk or severity of nephrotoxicity can be increased when Cefpodoxime is combined with Antrafenine.

Target Protein

Peptidoglycan synthase FtsI ftsI

Referensi & Sumber

Synthesis reference: Yatendra Kumar, Neera Tewari, Ram Aryan, Bishwa Rai, Hashim Nizar, "Process for the preparation of cefpodoxime acid." U.S. Patent US20050020561, issued January 27, 2005.

Contoh Produk & Brand

Produk: 45 • International brands: 2
Produk
  • Cefpodoxime Proxetil
    Tablet, film coated • 100 mg/1 • Oral • US • Generic • Approved
  • Cefpodoxime Proxetil
    Tablet, film coated • 200 mg/1 • Oral • US • Generic • Approved
  • Cefpodoxime Proxetil
    Granule, for suspension • 100 mg/5mL • Oral • US • Generic • Approved
  • Cefpodoxime Proxetil
    Tablet, film coated • 100 mg/1 • Oral • US • Generic • Approved
  • Cefpodoxime Proxetil
    Tablet, film coated • 200 mg/1 • Oral • US • Generic • Approved
  • Cefpodoxime Proxetil
    Granule, for suspension • 50 mg/5mL • Oral • US • Generic • Approved
  • Cefpodoxime Proxetil
    Granule, for suspension • 100 mg/5mL • Oral • US • Generic • Approved
  • Cefpodoxime Proxetil
    Tablet, film coated • 100 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 45 produk.
International Brands
  • Banan
  • Doxef

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul