Peringatan Keamanan

Overdosage of cephalosporins can cause cerebral irritation leading to convulsions.

Ceftibuten

DB01415

small molecule approved investigational

Deskripsi

Ceftibuten is a third-generation cephalosporin antibiotic that is orally-administered. It is typically used to treat acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsilitis.

Struktur Molekul 2D

Berat 410.425
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi * 0.21 L/kg [adult subjects] * 0.5 L/kg [fasting pediatric patients]
Klirens (Clearance) -

Absorpsi

Rapidly absorbed following oral administration.

Metabolisme

A study with radiolabeled ceftibuten administered to 6 healthy adult male volunteers demonstrated that cis-ceftibuten is the predominant component in both plasma and urine. About 10% of ceftibuten is converted to the trans-isomer is approximately 1/8 as antimicrobially potent as the cis-isomer.

Rute Eliminasi

Ceftibuten is excreted in the urine; 95% of the administered radioactivity was recovered either in urine or feces.

Interaksi Makanan

2 Data
  • 1. Take separate from meals. Take ceftibuten oral suspension at least one hour after eating, or two hours before eating.
  • 2. Take with or without food. Separating the administration of ceftibuten from food is not required for ceftibuten capsules because the impact of food on bioavailability is less significant.

Interaksi Obat

942 Data
Probenecid The serum concentration of Ceftibuten can be increased when it is combined with Probenecid.
Foscarnet The risk or severity of nephrotoxicity can be increased when Ceftibuten is combined with Foscarnet.
Mannitol The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Ceftibuten.
Tenofovir disoproxil Ceftibuten may increase the nephrotoxic activities of Tenofovir disoproxil.
Tenofovir alafenamide The serum concentration of Tenofovir alafenamide can be increased when it is combined with Ceftibuten.
Tenofovir Ceftibuten may increase the nephrotoxic activities of Tenofovir.
Aspartame The excretion of Ceftibuten can be decreased when combined with Aspartame.
Pravastatin The excretion of Ceftibuten can be decreased when combined with Pravastatin.
Aminohippuric acid The excretion of Ceftibuten can be decreased when combined with Aminohippuric acid.
Lansoprazole The excretion of Ceftibuten can be decreased when combined with Lansoprazole.
Zidovudine The excretion of Ceftibuten can be decreased when combined with Zidovudine.
Guanidine The excretion of Ceftibuten can be decreased when combined with Guanidine.
Enalapril The excretion of Ceftibuten can be decreased when combined with Enalapril.
Oxytetracycline The excretion of Ceftibuten can be decreased when combined with Oxytetracycline.
Leucovorin The excretion of Ceftibuten can be decreased when combined with Leucovorin.
Esomeprazole The excretion of Ceftibuten can be decreased when combined with Esomeprazole.
Dinoprostone The excretion of Ceftibuten can be decreased when combined with Dinoprostone.
Famotidine The excretion of Ceftibuten can be decreased when combined with Famotidine.
Minocycline The excretion of Ceftibuten can be decreased when combined with Minocycline.
Novobiocin The excretion of Ceftibuten can be decreased when combined with Novobiocin.
Benzylpenicillin The excretion of Ceftibuten can be decreased when combined with Benzylpenicillin.
Melatonin The excretion of Ceftibuten can be decreased when combined with Melatonin.
Ouabain The excretion of Ceftibuten can be decreased when combined with Ouabain.
Rosuvastatin The excretion of Ceftibuten can be decreased when combined with Rosuvastatin.
Succinic acid The excretion of Succinic acid can be decreased when combined with Ceftibuten.
Citrulline The excretion of Citrulline can be decreased when combined with Ceftibuten.
Cefdinir The excretion of Cefdinir can be decreased when combined with Ceftibuten.
Fluorescein The excretion of Fluorescein can be decreased when combined with Ceftibuten.
Hydrocortisone The excretion of Hydrocortisone can be decreased when combined with Ceftibuten.
Quinapril The excretion of Quinapril can be decreased when combined with Ceftibuten.
Fexofenadine The excretion of Fexofenadine can be decreased when combined with Ceftibuten.
Captopril The excretion of Captopril can be decreased when combined with Ceftibuten.
Tazobactam The excretion of Tazobactam can be decreased when combined with Ceftibuten.
Cyclic adenosine monophosphate The excretion of Cyclic adenosine monophosphate can be decreased when combined with Ceftibuten.
Cholic Acid The excretion of Cholic Acid can be decreased when combined with Ceftibuten.
Glutaric Acid The excretion of Glutaric Acid can be decreased when combined with Ceftibuten.
Oxalic Acid The excretion of Oxalic Acid can be decreased when combined with Ceftibuten.
Taurocholic acid The excretion of Taurocholic acid can be decreased when combined with Ceftibuten.
Ellagic acid The excretion of Ellagic acid can be decreased when combined with Ceftibuten.
Avibactam The excretion of Avibactam can be decreased when combined with Ceftibuten.
Eluxadoline The excretion of Eluxadoline can be decreased when combined with Ceftibuten.
Silibinin The excretion of Silibinin can be decreased when combined with Ceftibuten.
Relebactam The excretion of Relebactam can be decreased when combined with Ceftibuten.
Liotrix The excretion of Ceftibuten can be decreased when combined with Liotrix.
Cilastatin The excretion of Ceftibuten can be decreased when combined with Cilastatin.
trans-2-hydroxycinnamic acid The excretion of Ceftibuten can be decreased when combined with trans-2-hydroxycinnamic acid.
Benzoic acid The excretion of Ceftibuten can be decreased when combined with Benzoic acid.
Caprylic acid The excretion of Ceftibuten can be decreased when combined with Caprylic acid.
Ataluren The excretion of Ceftibuten can be decreased when combined with Ataluren.
Teriflunomide The excretion of Ceftibuten can be decreased when combined with Teriflunomide.
Dabrafenib The excretion of Ceftibuten can be decreased when combined with Dabrafenib.
Dolutegravir The excretion of Ceftibuten can be decreased when combined with Dolutegravir.
Lenvatinib The excretion of Ceftibuten can be decreased when combined with Lenvatinib.
Cabotegravir The excretion of Ceftibuten can be decreased when combined with Cabotegravir.
Pradigastat The excretion of Ceftibuten can be decreased when combined with Pradigastat.
Enasidenib The excretion of Ceftibuten can be decreased when combined with Enasidenib.
Cefotiam The excretion of Ceftibuten can be decreased when combined with Cefotiam.
Indomethacin The excretion of Ceftibuten can be decreased when combined with Indomethacin.
Cefalotin The excretion of Ceftibuten can be decreased when combined with Cefalotin.
Tenoxicam The excretion of Ceftibuten can be decreased when combined with Tenoxicam.
Cefotaxime The excretion of Ceftibuten can be decreased when combined with Cefotaxime.
Piroxicam The excretion of Ceftibuten can be decreased when combined with Piroxicam.
Methotrexate The excretion of Ceftibuten can be decreased when combined with Methotrexate.
Cephalexin The excretion of Ceftibuten can be decreased when combined with Cephalexin.
Valaciclovir The excretion of Valaciclovir can be decreased when combined with Ceftibuten.
Diclofenac The excretion of Ceftibuten can be decreased when combined with Diclofenac.
Acyclovir The excretion of Ceftibuten can be decreased when combined with Acyclovir.
Phenylbutazone The excretion of Ceftibuten can be decreased when combined with Phenylbutazone.
Cefaclor The excretion of Ceftibuten can be decreased when combined with Cefaclor.
Bumetanide The excretion of Ceftibuten can be decreased when combined with Bumetanide.
Salicylic acid The excretion of Ceftibuten can be decreased when combined with Salicylic acid.
Acetylsalicylic acid The excretion of Ceftibuten can be decreased when combined with Acetylsalicylic acid.
Ketoprofen The excretion of Ceftibuten can be decreased when combined with Ketoprofen.
Ibuprofen The excretion of Ceftibuten can be decreased when combined with Ibuprofen.
Cefadroxil The excretion of Ceftibuten can be decreased when combined with Cefadroxil.
Ceftriaxone The excretion of Ceftibuten can be decreased when combined with Ceftriaxone.
Cefamandole The excretion of Ceftibuten can be decreased when combined with Cefamandole.
Cefazolin The excretion of Ceftibuten can be decreased when combined with Cefazolin.
Cefoperazone The excretion of Ceftibuten can be decreased when combined with Cefoperazone.
Ceftizoxime The excretion of Ceftibuten can be decreased when combined with Ceftizoxime.
Cefacetrile The excretion of Ceftibuten can be decreased when combined with Cefacetrile.
Oseltamivir The excretion of Oseltamivir can be decreased when combined with Ceftibuten.
Pantoprazole The excretion of Ceftibuten can be decreased when combined with Pantoprazole.
Liothyronine The excretion of Ceftibuten can be decreased when combined with Liothyronine.
Conjugated estrogens The excretion of Ceftibuten can be decreased when combined with Conjugated estrogens.
Piperacillin The excretion of Piperacillin can be decreased when combined with Ceftibuten.
Trifluridine The excretion of Trifluridine can be decreased when combined with Ceftibuten.
Allopurinol The excretion of Allopurinol can be decreased when combined with Ceftibuten.
Cimetidine The excretion of Ceftibuten can be decreased when combined with Cimetidine.
Levocarnitine The excretion of Levocarnitine can be decreased when combined with Ceftibuten.
Tetracycline The excretion of Ceftibuten can be decreased when combined with Tetracycline.
Estradiol The excretion of Estradiol can be decreased when combined with Ceftibuten.
Ranitidine The excretion of Ranitidine can be decreased when combined with Ceftibuten.
Ganciclovir The excretion of Ceftibuten can be decreased when combined with Ganciclovir.
Gemfibrozil The excretion of Ceftibuten can be decreased when combined with Gemfibrozil.
Sitagliptin The excretion of Sitagliptin can be decreased when combined with Ceftibuten.
Topiroxostat The excretion of Ceftibuten can be decreased when combined with Topiroxostat.
Doripenem The excretion of Doripenem can be decreased when combined with Ceftibuten.
Saxagliptin The excretion of Saxagliptin can be decreased when combined with Ceftibuten.
Baricitinib The serum concentration of Baricitinib can be increased when it is combined with Ceftibuten.

Target Protein

Peptidoglycan synthase FtsI ftsI
Penicillin-binding protein 1A mrcA
Penicillin-binding protein 1B mrcB
Penicillin-binding protein 2 mrdA

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

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