Theobromine (3,7-dimethylxanthine) is the principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than theophylline and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Deferasirox | The serum concentration of Theobromine can be increased when it is combined with Deferasirox. |
| Peginterferon alfa-2b | The serum concentration of Theobromine can be increased when it is combined with Peginterferon alfa-2b. |
| Leflunomide | The serum concentration of Theobromine can be decreased when it is combined with Leflunomide. |
| Teriflunomide | The serum concentration of Theobromine can be decreased when it is combined with Teriflunomide. |
| Regadenoson | Theobromine may decrease effectiveness of Regadenoson as a diagnostic agent. |
| Adalimumab | The serum concentration of Theobromine can be decreased when it is combined with Adalimumab. |
| Adenosine | The therapeutic efficacy of Adenosine can be decreased when used in combination with Theobromine. |
| Allopurinol | The serum concentration of Theobromine can be increased when it is combined with Allopurinol. |
| Carbamazepine | The serum concentration of Theobromine can be decreased when it is combined with Carbamazepine. |
| Cimetidine | The metabolism of Theobromine can be decreased when combined with Cimetidine. |
| Disulfiram | The serum concentration of Theobromine can be increased when it is combined with Disulfiram. |
| Febuxostat | The serum concentration of the active metabolites of Theobromine can be increased when Theobromine is used in combination with Febuxostat. |
| Fluvoxamine | The metabolism of Theobromine can be decreased when combined with Fluvoxamine. |
| Formoterol | The risk or severity of hypokalemia can be increased when Theobromine is combined with Formoterol. |
| Indacaterol | The risk or severity of adverse effects can be increased when Theobromine is combined with Indacaterol. |
| Isoniazid | The serum concentration of Theobromine can be increased when it is combined with Isoniazid. |
| Lithium citrate | The serum concentration of Lithium citrate can be decreased when it is combined with Theobromine. |
| Lithium carbonate | The serum concentration of Lithium carbonate can be decreased when it is combined with Theobromine. |
| Lithium hydroxide | The serum concentration of Lithium hydroxide can be decreased when it is combined with Theobromine. |
| Mexiletine | The metabolism of Theobromine can be decreased when combined with Mexiletine. |
| Olodaterol | Theobromine may increase the hyperkalemic activities of Olodaterol. |
| Pancuronium | The therapeutic efficacy of Pancuronium can be decreased when used in combination with Theobromine. |
| Pentoxifylline | The serum concentration of Theobromine can be increased when it is combined with Pentoxifylline. |
| Phenytoin | The serum concentration of Theobromine can be decreased when it is combined with Phenytoin. |
| Fosphenytoin | The serum concentration of Theobromine can be decreased when it is combined with Fosphenytoin. |
| Propafenone | The serum concentration of Theobromine can be increased when it is combined with Propafenone. |
| Quinine | The serum concentration of Theobromine can be increased when it is combined with Quinine. |
| Quinidine | The serum concentration of Theobromine can be increased when it is combined with Quinidine. |
| Riociguat | Theobromine may increase the hypotensive activities of Riociguat. |
| Thiabendazole | The metabolism of Theobromine can be decreased when combined with Thiabendazole. |
| Ticlopidine | The metabolism of Theobromine can be decreased when combined with Ticlopidine. |
| Zafirlukast | The serum concentration of Zafirlukast can be decreased when it is combined with Theobromine. |
| Probenecid | The serum concentration of Theobromine can be increased when it is combined with Probenecid. |
| Abiraterone | The serum concentration of Theobromine can be increased when it is combined with Abiraterone. |
| Isoprenaline | The serum concentration of Theobromine can be decreased when it is combined with Isoprenaline. |
| Cyproterone acetate | The metabolism of Theobromine can be increased when combined with Cyproterone acetate. |
| Amphetamine | The risk or severity of adverse effects can be increased when Amphetamine is combined with Theobromine. |
| Phentermine | The risk or severity of adverse effects can be increased when Phentermine is combined with Theobromine. |
| Midodrine | The risk or severity of adverse effects can be increased when Midodrine is combined with Theobromine. |
| Norepinephrine | The risk or severity of adverse effects can be increased when Norepinephrine is combined with Theobromine. |
| Phenylephrine | The risk or severity of adverse effects can be increased when Phenylephrine is combined with Theobromine. |
| Phenylpropanolamine | The risk or severity of adverse effects can be increased when Phenylpropanolamine is combined with Theobromine. |
| Labetalol | The risk or severity of adverse effects can be increased when Labetalol is combined with Theobromine. |
| Metaraminol | The risk or severity of adverse effects can be increased when Metaraminol is combined with Theobromine. |
| Epinephrine | The risk or severity of adverse effects can be increased when Epinephrine is combined with Theobromine. |
| Methoxamine | The risk or severity of adverse effects can be increased when Methoxamine is combined with Theobromine. |
| Orciprenaline | The risk or severity of adverse effects can be increased when Orciprenaline is combined with Theobromine. |
| Phenmetrazine | The risk or severity of adverse effects can be increased when Phenmetrazine is combined with Theobromine. |
| Dobutamine | The risk or severity of adverse effects can be increased when Dobutamine is combined with Theobromine. |
| Pseudoephedrine | The risk or severity of adverse effects can be increased when Pseudoephedrine is combined with Theobromine. |
| Benzphetamine | The risk or severity of adverse effects can be increased when Benzphetamine is combined with Theobromine. |
| Ritodrine | The risk or severity of adverse effects can be increased when Ritodrine is combined with Theobromine. |
| Terbutaline | The risk or severity of adverse effects can be increased when Terbutaline is combined with Theobromine. |
| Oxymetazoline | The risk or severity of adverse effects can be increased when Oxymetazoline is combined with Theobromine. |
| Diethylpropion | The risk or severity of adverse effects can be increased when Diethylpropion is combined with Theobromine. |
| Dopamine | The risk or severity of adverse effects can be increased when Dopamine is combined with Theobromine. |
| Acebutolol | The risk or severity of adverse effects can be increased when Acebutolol is combined with Theobromine. |
| Lisdexamfetamine | The risk or severity of adverse effects can be increased when Lisdexamfetamine is combined with Theobromine. |
| Fenoterol | The risk or severity of adverse effects can be increased when Fenoterol is combined with Theobromine. |
| Ephedrine | The risk or severity of adverse effects can be increased when Ephedrine is combined with Theobromine. |
| Mephentermine | The risk or severity of adverse effects can be increased when Mephentermine is combined with Theobromine. |
| Procaterol | The risk or severity of adverse effects can be increased when Procaterol is combined with Theobromine. |
| Clenbuterol | The risk or severity of adverse effects can be increased when Clenbuterol is combined with Theobromine. |
| MMDA | The risk or severity of adverse effects can be increased when MMDA is combined with Theobromine. |
| Midomafetamine | The risk or severity of adverse effects can be increased when Midomafetamine is combined with Theobromine. |
| 2,5-Dimethoxy-4-ethylamphetamine | The risk or severity of adverse effects can be increased when 2,5-Dimethoxy-4-ethylamphetamine is combined with Theobromine. |
| 4-Bromo-2,5-dimethoxyamphetamine | The risk or severity of adverse effects can be increased when 4-Bromo-2,5-dimethoxyamphetamine is combined with Theobromine. |
| Tenamfetamine | The risk or severity of adverse effects can be increased when Tenamfetamine is combined with Theobromine. |
| Chlorphentermine | The risk or severity of adverse effects can be increased when Chlorphentermine is combined with Theobromine. |
| Methylenedioxyethamphetamine | The risk or severity of adverse effects can be increased when Methylenedioxyethamphetamine is combined with Theobromine. |
| Dextroamphetamine | The risk or severity of adverse effects can be increased when Dextroamphetamine is combined with Theobromine. |
| Metamfetamine | The risk or severity of adverse effects can be increased when Metamfetamine is combined with Theobromine. |
| Celiprolol | The risk or severity of adverse effects can be increased when Celiprolol is combined with Theobromine. |
| Nylidrin | The risk or severity of adverse effects can be increased when Nylidrin is combined with Theobromine. |
| Tetryzoline | The risk or severity of adverse effects can be increased when Tetryzoline is combined with Theobromine. |
| Tyramine | The risk or severity of adverse effects can be increased when Tyramine is combined with Theobromine. |
| Isoxsuprine | The risk or severity of adverse effects can be increased when Isoxsuprine is combined with Theobromine. |
| Etilefrine | The risk or severity of adverse effects can be increased when Etilefrine is combined with Theobromine. |
| Synephrine | The risk or severity of adverse effects can be increased when Synephrine is combined with Theobromine. |
| Hydroxyamphetamine | The risk or severity of adverse effects can be increased when Hydroxyamphetamine is combined with Theobromine. |
| Iofetamine I-123 | The risk or severity of adverse effects can be increased when Iofetamine I-123 is combined with Theobromine. |
| Racepinephrine | The risk or severity of adverse effects can be increased when Racepinephrine is combined with Theobromine. |
| Ritobegron | The risk or severity of adverse effects can be increased when Ritobegron is combined with Theobromine. |
| Bucindolol | The risk or severity of adverse effects can be increased when Bucindolol is combined with Theobromine. |
| Tramazoline | The risk or severity of adverse effects can be increased when Tramazoline is combined with Theobromine. |
| Mephedrone | The risk or severity of adverse effects can be increased when Mephedrone is combined with Theobromine. |
| Fenozolone | The risk or severity of adverse effects can be increased when Fenozolone is combined with Theobromine. |
| Methoxyphenamine | The risk or severity of adverse effects can be increased when Methoxyphenamine is combined with Theobromine. |
| Tretoquinol | The risk or severity of adverse effects can be increased when Tretoquinol is combined with Theobromine. |
| Gepefrine | The risk or severity of adverse effects can be increased when Gepefrine is combined with Theobromine. |
| Epanolol | The risk or severity of adverse effects can be increased when Epanolol is combined with Theobromine. |
| Prenalterol | The risk or severity of adverse effects can be increased when Prenalterol is combined with Theobromine. |
| Mefenorex | The risk or severity of adverse effects can be increased when Mefenorex is combined with Theobromine. |
| 2,5-Dimethoxy-4-ethylthioamphetamine | The risk or severity of adverse effects can be increased when 2,5-Dimethoxy-4-ethylthioamphetamine is combined with Theobromine. |
| Esmolol | The risk or severity of adverse effects can be increased when Esmolol is combined with Theobromine. |
| Betaxolol | The risk or severity of adverse effects can be increased when Betaxolol is combined with Theobromine. |
| Metoprolol | The risk or severity of adverse effects can be increased when Metoprolol is combined with Theobromine. |
| Atenolol | The risk or severity of adverse effects can be increased when Atenolol is combined with Theobromine. |
| Timolol | The risk or severity of adverse effects can be increased when Timolol is combined with Theobromine. |
| Sotalol | The risk or severity of adverse effects can be increased when Sotalol is combined with Theobromine. |