Peringatan Keamanan

Side effects include headache, abdominal or stomach pain, cough, dental pain, dizziness, fever, heartburn, skin rash, stuffy nose, weakness or unusual tiredness.

Pranlukast

DB01411

small molecule investigational

Deskripsi

Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens.

Struktur Molekul 2D

Berat 481.512
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Hepatic

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

302 Data
Loxapine The therapeutic efficacy of Pranlukast can be decreased when used in combination with Loxapine.
Pitolisant The serum concentration of Pranlukast can be decreased when it is combined with Pitolisant.
Metreleptin The metabolism of Pranlukast can be increased when combined with Metreleptin.
Valsartan The metabolism of Valsartan can be decreased when combined with Pranlukast.
Troglitazone The metabolism of Troglitazone can be decreased when combined with Pranlukast.
Torasemide The metabolism of Torasemide can be decreased when combined with Pranlukast.
Glimepiride The metabolism of Glimepiride can be decreased when combined with Pranlukast.
Dapsone The metabolism of Dapsone can be decreased when combined with Pranlukast.
Desogestrel The metabolism of Desogestrel can be decreased when combined with Pranlukast.
Bexarotene The metabolism of Bexarotene can be decreased when combined with Pranlukast.
Hydromorphone The metabolism of Hydromorphone can be decreased when combined with Pranlukast.
Indomethacin The metabolism of Indomethacin can be decreased when combined with Pranlukast.
Methadone The metabolism of Methadone can be decreased when combined with Pranlukast.
Diltiazem The metabolism of Pranlukast can be decreased when combined with Diltiazem.
Trimethadione The metabolism of Trimethadione can be decreased when combined with Pranlukast.
Treprostinil The metabolism of Treprostinil can be decreased when combined with Pranlukast.
Progesterone The metabolism of Progesterone can be decreased when combined with Pranlukast.
Rosiglitazone The metabolism of Rosiglitazone can be decreased when combined with Pranlukast.
Acetohexamide The metabolism of Acetohexamide can be decreased when combined with Pranlukast.
Promazine The metabolism of Promazine can be decreased when combined with Pranlukast.
Trimethoprim The metabolism of Trimethoprim can be decreased when combined with Pranlukast.
Lansoprazole The metabolism of Lansoprazole can be decreased when combined with Pranlukast.
Nabumetone The metabolism of Nabumetone can be decreased when combined with Pranlukast.
Quinine The metabolism of Quinine can be decreased when combined with Pranlukast.
Tenoxicam The metabolism of Tenoxicam can be decreased when combined with Pranlukast.
Dronabinol The serum concentration of Dronabinol can be increased when it is combined with Pranlukast.
Montelukast The metabolism of Montelukast can be decreased when combined with Pranlukast.
Fluoxetine The metabolism of Fluoxetine can be decreased when combined with Pranlukast.
Duloxetine The metabolism of Duloxetine can be decreased when combined with Pranlukast.
Celecoxib The metabolism of Celecoxib can be decreased when combined with Pranlukast.
Zidovudine The metabolism of Zidovudine can be decreased when combined with Pranlukast.
Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Pranlukast.
Mephenytoin The metabolism of Mephenytoin can be decreased when combined with Pranlukast.
Rofecoxib The metabolism of Rofecoxib can be decreased when combined with Pranlukast.
Zafirlukast The metabolism of Zafirlukast can be decreased when combined with Pranlukast.
Piroxicam The metabolism of Piroxicam can be decreased when combined with Pranlukast.
Bosentan The metabolism of Bosentan can be decreased when combined with Pranlukast.
Cinnarizine The metabolism of Cinnarizine can be decreased when combined with Pranlukast.
Valdecoxib The metabolism of Valdecoxib can be decreased when combined with Pranlukast.
Diclofenac The metabolism of Diclofenac can be decreased when combined with Pranlukast.
Doxazosin The metabolism of Doxazosin can be decreased when combined with Pranlukast.
Paramethadione The metabolism of Paramethadione can be decreased when combined with Pranlukast.
Testosterone The metabolism of Testosterone can be decreased when combined with Pranlukast.
Verapamil The metabolism of Pranlukast can be decreased when combined with Verapamil.
Chlorpropamide The metabolism of Chlorpropamide can be decreased when combined with Pranlukast.
Losartan The metabolism of Losartan can be decreased when combined with Pranlukast.
Flurbiprofen The metabolism of Flurbiprofen can be decreased when combined with Pranlukast.
Nateglinide The metabolism of Nateglinide can be decreased when combined with Pranlukast.
Zileuton The metabolism of Zileuton can be decreased when combined with Pranlukast.
Etodolac The metabolism of Etodolac can be decreased when combined with Pranlukast.
Clopidogrel The metabolism of Clopidogrel can be decreased when combined with Pranlukast.
Estradiol The metabolism of Estradiol can be decreased when combined with Pranlukast.
Mefenamic acid The metabolism of Mefenamic acid can be decreased when combined with Pranlukast.
Naproxen The metabolism of Naproxen can be decreased when combined with Pranlukast.
Candesartan cilexetil The metabolism of Candesartan cilexetil can be decreased when combined with Pranlukast.
Phenylbutazone The metabolism of Phenylbutazone can be decreased when combined with Pranlukast.
Meloxicam The metabolism of Meloxicam can be decreased when combined with Pranlukast.
Propofol The metabolism of Propofol can be decreased when combined with Pranlukast.
Diazepam The metabolism of Diazepam can be decreased when combined with Pranlukast.
Tolazamide The metabolism of Tolazamide can be decreased when combined with Pranlukast.
Donepezil The metabolism of Donepezil can be decreased when combined with Pranlukast.
Terbinafine The metabolism of Terbinafine can be decreased when combined with Pranlukast.
Ondansetron The metabolism of Ondansetron can be decreased when combined with Pranlukast.
Buprenorphine The metabolism of Buprenorphine can be decreased when combined with Pranlukast.
Salicylic acid The metabolism of Salicylic acid can be decreased when combined with Pranlukast.
Acetylsalicylic acid The metabolism of Acetylsalicylic acid can be decreased when combined with Pranlukast.
Alosetron The metabolism of Alosetron can be decreased when combined with Pranlukast.
Azelastine The metabolism of Azelastine can be decreased when combined with Pranlukast.
Ramelteon The metabolism of Ramelteon can be decreased when combined with Pranlukast.
Formoterol The metabolism of Formoterol can be decreased when combined with Pranlukast.
Sulfamethoxazole The metabolism of Sulfamethoxazole can be decreased when combined with Pranlukast.
Glyburide The metabolism of Glyburide can be decreased when combined with Pranlukast.
Methoxyflurane The metabolism of Methoxyflurane can be decreased when combined with Pranlukast.
Irbesartan The metabolism of Irbesartan can be decreased when combined with Pranlukast.
Tolterodine The metabolism of Tolterodine can be decreased when combined with Pranlukast.
Selegiline The metabolism of Selegiline can be decreased when combined with Pranlukast.
Thalidomide The metabolism of Thalidomide can be decreased when combined with Pranlukast.
Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Pranlukast.
Glipizide The metabolism of Glipizide can be decreased when combined with Pranlukast.
Diphenhydramine The metabolism of Diphenhydramine can be decreased when combined with Pranlukast.
Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Pranlukast.
Leflunomide The metabolism of Leflunomide can be decreased when combined with Pranlukast.
Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Pranlukast.
Sertraline The metabolism of Sertraline can be decreased when combined with Pranlukast.
Gliclazide The metabolism of Gliclazide can be decreased when combined with Pranlukast.
Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Pranlukast.
Proguanil The metabolism of Proguanil can be decreased when combined with Pranlukast.
Carvedilol The metabolism of Carvedilol can be decreased when combined with Pranlukast.
Thiamylal The metabolism of Thiamylal can be decreased when combined with Pranlukast.
Bupropion The metabolism of Bupropion can be decreased when combined with Pranlukast.
Halothane The metabolism of Halothane can be decreased when combined with Pranlukast.
Idarubicin The metabolism of Idarubicin can be decreased when combined with Pranlukast.
Zopiclone The metabolism of Zopiclone can be decreased when combined with Pranlukast.
Ketamine The metabolism of Ketamine can be decreased when combined with Pranlukast.
Gliquidone The metabolism of Gliquidone can be decreased when combined with Pranlukast.
Arformoterol The metabolism of Arformoterol can be decreased when combined with Pranlukast.
Lumiracoxib The metabolism of Lumiracoxib can be decreased when combined with Pranlukast.
Glisoxepide The metabolism of Glisoxepide can be decreased when combined with Pranlukast.
Hexobarbital The metabolism of Hexobarbital can be decreased when combined with Pranlukast.
Mestranol The metabolism of Mestranol can be decreased when combined with Pranlukast.

Target Protein

Cysteinyl leukotriene receptor 1 CYSLTR1
Tumor necrosis factor TNF
Interleukin-5 IL5
Eosinophil cationic protein RNASE3
Nuclear factor NF-kappa-B p105 subunit NFKB1
Mucin-2 MUC2
Nuclear factor NF-kappa-B NFKB2

Referensi & Sumber

Synthesis reference: Seiei Sasatani, Masashi Shiota, Yoshinori Ii, "Granules containing pranlukast, process for producing the granules, and method of improving adhesiveness of pranlukast." U.S. Patent US5876760, issued March, 1995.
Artikel (PubMed)
  • PMID: 16702733
    Nakade S, Ueda S, Ohno T, Nakayama K, Miyata Y, Yukawa E, Higuchi S: Population pharmacokinetics of pranlukast hydrate dry syrup in children with allergic rhinitis and bronchial asthma. Drug Metab Pharmacokinet. 2006 Apr;21(2):133-9.

Contoh Produk & Brand

Produk: 0 • International brands: 0
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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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