Danazol

DB01406

small molecule approved

Deskripsi

A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.

Struktur Molekul 2D

Berat 337.4553
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Approximately 24 hours.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Hepatic, to principal metabolites, ethisterone and 17-hydroxymethylethisterone.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Take with or without food. The absorption is unaffected by food.

Interaksi Obat

905 Data
Calcitriol Danazol may increase the hypercalcemic activities of Calcitriol.
Calcifediol Danazol may increase the hypercalcemic activities of Calcifediol.
Ergocalciferol Danazol may increase the hypercalcemic activities of Ergocalciferol.
Cholecalciferol Danazol may increase the hypercalcemic activities of Cholecalciferol.
Paricalcitol Danazol may increase the hypercalcemic activities of Paricalcitol.
Dihydrotachysterol Danazol may increase the hypercalcemic activities of Dihydrotachysterol.
Alfacalcidol Danazol may increase the hypercalcemic activities of Alfacalcidol.
Seocalcitol Danazol may increase the hypercalcemic activities of Seocalcitol.
Inecalcitol Danazol may increase the hypercalcemic activities of Inecalcitol.
Becocalcidiol Danazol may increase the hypercalcemic activities of Becocalcidiol.
Eldecalcitol Danazol may increase the hypercalcemic activities of Eldecalcitol.
1alpha,24S-Dihydroxyvitamin D2 Danazol may increase the hypercalcemic activities of 1alpha,24S-Dihydroxyvitamin D2.
Elocalcitol Danazol may increase the hypercalcemic activities of Elocalcitol.
Maxacalcitol Danazol may increase the hypercalcemic activities of Maxacalcitol.
Doxercalciferol Danazol may increase the hypercalcemic activities of Doxercalciferol.
Vitamin D Danazol may increase the hypercalcemic activities of Vitamin D.
1alpha-Hydroxyvitamin D5 Danazol may increase the hypercalcemic activities of 1alpha-Hydroxyvitamin D5.
Previtamin D(3) Danazol may increase the hypercalcemic activities of Previtamin D(3).
Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Danazol.
Eliglustat The metabolism of Eliglustat can be decreased when combined with Danazol.
Everolimus The metabolism of Everolimus can be decreased when combined with Danazol.
Flibanserin The metabolism of Flibanserin can be decreased when combined with Danazol.
Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Danazol.
Ivabradine The metabolism of Ivabradine can be decreased when combined with Danazol.
Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Danazol.
Lurasidone The metabolism of Lurasidone can be decreased when combined with Danazol.
Naloxegol The metabolism of Naloxegol can be decreased when combined with Danazol.
Olaparib The metabolism of Olaparib can be decreased when combined with Danazol.
Sonidegib The metabolism of Sonidegib can be decreased when combined with Danazol.
Cilostazol The metabolism of Cilostazol can be decreased when combined with Danazol.
Colchicine The metabolism of Colchicine can be decreased when combined with Danazol.
Fentanyl The metabolism of Fentanyl can be decreased when combined with Danazol.
Iloperidone The metabolism of Iloperidone can be decreased when combined with Danazol.
Retapamulin The metabolism of Retapamulin can be decreased when combined with Danazol.
Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Danazol.
Vardenafil The metabolism of Vardenafil can be decreased when combined with Danazol.
Pravastatin The serum concentration of Pravastatin can be increased when it is combined with Danazol.
Cerivastatin The serum concentration of Cerivastatin can be increased when it is combined with Danazol.
Atorvastatin The serum concentration of Atorvastatin can be increased when it is combined with Danazol.
Fluvastatin The serum concentration of Fluvastatin can be increased when it is combined with Danazol.
Rosuvastatin The serum concentration of Rosuvastatin can be increased when it is combined with Danazol.
Mevastatin The serum concentration of Mevastatin can be increased when it is combined with Danazol.
Pitavastatin The serum concentration of Pitavastatin can be increased when it is combined with Danazol.
Alprazolam The metabolism of Alprazolam can be decreased when combined with Danazol.
R,S-Warfarin alcohol The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Danazol.
S,R-Warfarin alcohol The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Danazol.
Midazolam The serum concentration of Midazolam can be increased when it is combined with Danazol.
Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Danazol.
Capromab pendetide Danazol may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Cyclosporine The risk or severity of liver damage can be increased when Danazol is combined with Cyclosporine.
Dicoumarol Danazol may increase the anticoagulant activities of Dicoumarol.
Phenindione Danazol may increase the anticoagulant activities of Phenindione.
Coumarin Danazol may increase the anticoagulant activities of Coumarin.
Tioclomarol Danazol may increase the anticoagulant activities of Tioclomarol.
4-hydroxycoumarin Danazol may increase the anticoagulant activities of 4-hydroxycoumarin.
Fluindione Danazol may increase the anticoagulant activities of Fluindione.
Clorindione Danazol may increase the anticoagulant activities of Clorindione.
Insulin human The therapeutic efficacy of Insulin human can be decreased when used in combination with Danazol.
Insulin lispro The therapeutic efficacy of Insulin lispro can be decreased when used in combination with Danazol.
Insulin glargine The therapeutic efficacy of Insulin glargine can be decreased when used in combination with Danazol.
Insulin pork The therapeutic efficacy of Insulin pork can be decreased when used in combination with Danazol.
Troglitazone The therapeutic efficacy of Troglitazone can be decreased when used in combination with Danazol.
Glimepiride The therapeutic efficacy of Glimepiride can be decreased when used in combination with Danazol.
Sulfisoxazole The therapeutic efficacy of Sulfisoxazole can be decreased when used in combination with Danazol.
Acarbose The therapeutic efficacy of Acarbose can be decreased when used in combination with Danazol.
Acetohexamide The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Danazol.
Miglitol The therapeutic efficacy of Miglitol can be decreased when used in combination with Danazol.
Chlorpropamide The therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Danazol.
Pentamidine The therapeutic efficacy of Pentamidine can be decreased when used in combination with Danazol.
Tolazamide The therapeutic efficacy of Tolazamide can be decreased when used in combination with Danazol.
Phenformin The therapeutic efficacy of Phenformin can be decreased when used in combination with Danazol.
Sulfamethoxazole The therapeutic efficacy of Sulfamethoxazole can be decreased when used in combination with Danazol.
Glipizide The therapeutic efficacy of Glipizide can be decreased when used in combination with Danazol.
Gliclazide The therapeutic efficacy of Gliclazide can be decreased when used in combination with Danazol.
Tolbutamide The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Danazol.
Gliquidone The therapeutic efficacy of Gliquidone can be decreased when used in combination with Danazol.
Mitiglinide The therapeutic efficacy of Mitiglinide can be decreased when used in combination with Danazol.
Exenatide The therapeutic efficacy of Exenatide can be decreased when used in combination with Danazol.
Mecasermin The therapeutic efficacy of Mecasermin can be decreased when used in combination with Danazol.
Pramlintide The therapeutic efficacy of Pramlintide can be decreased when used in combination with Danazol.
Glisoxepide The therapeutic efficacy of Glisoxepide can be decreased when used in combination with Danazol.
Insulin aspart The therapeutic efficacy of Insulin aspart can be decreased when used in combination with Danazol.
Insulin detemir The therapeutic efficacy of Insulin detemir can be decreased when used in combination with Danazol.
Insulin glulisine The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Danazol.
Glymidine The therapeutic efficacy of Glymidine can be decreased when used in combination with Danazol.
AICA ribonucleotide The therapeutic efficacy of AICA ribonucleotide can be decreased when used in combination with Danazol.
Buformin The therapeutic efficacy of Buformin can be decreased when used in combination with Danazol.
Vildagliptin The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Danazol.
Voglibose The therapeutic efficacy of Voglibose can be decreased when used in combination with Danazol.
NN344 The therapeutic efficacy of NN344 can be decreased when used in combination with Danazol.
AMG-222 The therapeutic efficacy of AMG-222 can be decreased when used in combination with Danazol.
Bisegliptin The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Danazol.
Liraglutide The therapeutic efficacy of Liraglutide can be decreased when used in combination with Danazol.
Gosogliptin The therapeutic efficacy of Gosogliptin can be decreased when used in combination with Danazol.
Glibornuride The therapeutic efficacy of Glibornuride can be decreased when used in combination with Danazol.
Benfluorex The therapeutic efficacy of Benfluorex can be decreased when used in combination with Danazol.
Empagliflozin The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Danazol.
Albiglutide The therapeutic efficacy of Albiglutide can be decreased when used in combination with Danazol.
Dulaglutide The therapeutic efficacy of Dulaglutide can be decreased when used in combination with Danazol.
Lixisenatide The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Danazol.

Target Protein

Estrogen receptor ESR1
Androgen receptor AR
Progesterone receptor PGR
Gonadotropin-releasing hormone receptor GNRHR
Putative gonadotropin-releasing hormone II receptor GNRHR2
C-C motif chemokine 2 CCL2

Referensi & Sumber

Synthesis reference: Clinton, R. and Hanson, A.; US. Patent 3,135,743; June 2, 1964; assigned to Sterling Drug.
Artikel (PubMed)
  • PMID: 2404115
    Dmowski WP: Danazol. A synthetic steroid with diverse biologic effects. J Reprod Med. 1990 Jan;35(1 Suppl):69-74; discussion 74-5.
  • PMID: 2486535
    Donaldson VH: Danazol. Am J Med. 1989 Sep;87(3N):49N-55N.
  • PMID: 6998453
    Jenkin G: Review: The mechanism of action of danazol, a novel steroid derivative. Aust N Z J Obstet Gynaecol. 1980 May;20(2):113-8.

Contoh Produk & Brand

Produk: 26 • International brands: 1
Produk
  • Cyclomen
    Capsule • 200 mg • Oral • Canada • Approved
  • Cyclomen
    Capsule • 100 mg • Oral • Canada • Approved
  • Cyclomen
    Capsule • 50 mg • Oral • Canada • Approved
  • Danazol
    Capsule • 200 mg/1 • Oral • US • Generic • Approved
  • Danazol
    Capsule • 200 mg/1 • Oral • US • Generic • Approved
  • Danazol
    Capsule • 200 mg/1 • Oral • US • Generic • Approved
  • Danazol
    Capsule • 50 mg/1 • Oral • US • Generic • Approved
  • Danazol
    Capsule • 100 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 26 produk.
International Brands
  • Danol — Sanofi

Sekuens Gen/Protein (FASTA)

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