Ginseng

DB01404

biotech investigational nutraceutical

Deskripsi

Ginseng is promoted as an adaptogen (a product that increases the body's resistance to stress), one which can to a certain extent be supported with reference to its anticarcinogenic and antioxidant properties. Ginseng is also known to contain phytoestrogens.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

7 Data
Warfarin The metabolism of Warfarin can be decreased when combined with Ginseng.
Acenocoumarol The metabolism of Acenocoumarol can be decreased when combined with Ginseng.
(R)-warfarin The metabolism of (R)-warfarin can be decreased when combined with Ginseng.
R,S-Warfarin alcohol The metabolism of R,S-Warfarin alcohol can be decreased when combined with Ginseng.
S,R-Warfarin alcohol The metabolism of S,R-Warfarin alcohol can be decreased when combined with Ginseng.
(S)-Warfarin The metabolism of (S)-Warfarin can be decreased when combined with Ginseng.
Morphine The therapeutic efficacy of Morphine can be decreased when used in combination with Ginseng.

Target Protein

Aryl hydrocarbon receptor AHR
Interleukin-6 IL6
Prostaglandin G/H synthase 2 PTGS2

Referensi & Sumber

Synthesis reference: Iwao Hachiya, Keizo Mochizuki, Yukio Kuwada, "Method of preparing dried ginseng for drug." U.S. Patent US4446130, issued January, 1970.
Artikel (PubMed)
  • PMID: 12568360
    Lee YJ, Jin YR, Lim WC, Park WK, Cho JY, Jang S, Lee SK: Ginsenoside-Rb1 acts as a weak phytoestrogen in MCF-7 human breast cancer cells. Arch Pharm Res. 2003 Jan;26(1):58-63.
  • PMID: 12161497
    Chan RY, Chen WF, Dong A, Guo D, Wong MS: Estrogen-like activity of ginsenoside Rg1 derived from Panax notoginseng. J Clin Endocrinol Metab. 2002 Aug;87(8):3691-5.
  • PMID: 12732291
    Lee Y, Jin Y, Lim W, Ji S, Choi S, Jang S, Lee S: A ginsenoside-Rh1, a component of ginseng saponin, activates estrogen receptor in human breast carcinoma MCF-7 cells. J Steroid Biochem Mol Biol. 2003 Mar;84(4):463-8.
  • PMID: 14687309
    McElhaney JE, Gravenstein S, Cole SK, Davidson E, O'neill D, Petitjean S, Rumble B, Shan JJ: A placebo-controlled trial of a proprietary extract of North American ginseng (CVT-E002) to prevent acute respiratory illness in institutionalized older adults. J Am Geriatr Soc. 2004 Jan;52(1):13-9.
  • PMID: 6685799
    Lewis WH, Zenger VE, Lynch RG: No adaptogen response of mice to ginseng and Eleutherococcus infusions. J Ethnopharmacol. 1983 Aug;8(2):209-14.

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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