Peringatan Keamanan

Symptoms of overdose include convulsions, spastic movements, and coma.

Methotrimeprazine

DB01403

small molecule approved investigational

Deskripsi

A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)

Struktur Molekul 2D

Berat 328.472
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Approximately 20 hours.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Methotrimeprazine has an incomplete oral bioavailability, because it undergoes considerable first-pass-metabolism in the liver. Oral bioavailability is approximately 50 to 60%.

Metabolisme

Hepatic. Methotrimeprazine is metabolized in the liver and degraded to a sulfoxid-, a glucuronid- and a demethyl-moiety.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Take with food. Food reduces irritation.

Interaksi Obat

1784 Data
Valsartan Methotrimeprazine may decrease the antihypertensive activities of Valsartan.
Remikiren Methotrimeprazine may decrease the antihypertensive activities of Remikiren.
Torasemide Methotrimeprazine may decrease the antihypertensive activities of Torasemide.
Guanadrel Methotrimeprazine may decrease the antihypertensive activities of Guanadrel.
Olmesartan Methotrimeprazine may decrease the antihypertensive activities of Olmesartan.
Nitroprusside Methotrimeprazine may decrease the antihypertensive activities of Nitroprusside.
Minoxidil Methotrimeprazine may decrease the antihypertensive activities of Minoxidil.
Fosinopril Methotrimeprazine may decrease the antihypertensive activities of Fosinopril.
Trandolapril Methotrimeprazine may decrease the antihypertensive activities of Trandolapril.
Benazepril Methotrimeprazine may decrease the antihypertensive activities of Benazepril.
Bosentan Methotrimeprazine may decrease the antihypertensive activities of Bosentan.
Enalapril Methotrimeprazine may decrease the antihypertensive activities of Enalapril.
Cyclothiazide Methotrimeprazine may decrease the antihypertensive activities of Cyclothiazide.
Candoxatril Methotrimeprazine may decrease the antihypertensive activities of Candoxatril.
Mecamylamine Methotrimeprazine may decrease the antihypertensive activities of Mecamylamine.
Eplerenone Methotrimeprazine may decrease the antihypertensive activities of Eplerenone.
Lisinopril Methotrimeprazine may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Methotrimeprazine may decrease the antihypertensive activities of Nitroglycerin.
Cryptenamine Methotrimeprazine may decrease the antihypertensive activities of Cryptenamine.
Candesartan cilexetil Methotrimeprazine may decrease the antihypertensive activities of Candesartan cilexetil.
Eprosartan Methotrimeprazine may decrease the antihypertensive activities of Eprosartan.
Quinapril Methotrimeprazine may decrease the antihypertensive activities of Quinapril.
Telmisartan Methotrimeprazine may decrease the antihypertensive activities of Telmisartan.
Irbesartan Methotrimeprazine may decrease the antihypertensive activities of Irbesartan.
Deserpidine Methotrimeprazine may decrease the antihypertensive activities of Deserpidine.
Pentolinium Methotrimeprazine may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Methotrimeprazine may decrease the antihypertensive activities of Trimethaphan.
Diazoxide Methotrimeprazine may decrease the antihypertensive activities of Diazoxide.
Guanethidine Methotrimeprazine may decrease the antihypertensive activities of Guanethidine.
Epoprostenol Methotrimeprazine may decrease the antihypertensive activities of Epoprostenol.
Hydralazine Methotrimeprazine may decrease the antihypertensive activities of Hydralazine.
Cilazapril Methotrimeprazine may decrease the antihypertensive activities of Cilazapril.
Saprisartan Methotrimeprazine may decrease the antihypertensive activities of Saprisartan.
Spirapril Methotrimeprazine may decrease the antihypertensive activities of Spirapril.
Tienilic acid Methotrimeprazine may decrease the antihypertensive activities of Tienilic acid.
Sitaxentan Methotrimeprazine may decrease the antihypertensive activities of Sitaxentan.
Ambrisentan Methotrimeprazine may decrease the antihypertensive activities of Ambrisentan.
Diethylnorspermine Methotrimeprazine may decrease the antihypertensive activities of Diethylnorspermine.
Pinacidil Methotrimeprazine may decrease the antihypertensive activities of Pinacidil.
Temocapril Methotrimeprazine may decrease the antihypertensive activities of Temocapril.
Riociguat Methotrimeprazine may decrease the antihypertensive activities of Riociguat.
Macitentan Methotrimeprazine may decrease the antihypertensive activities of Macitentan.
Aliskiren Methotrimeprazine may decrease the antihypertensive activities of Aliskiren.
Nicorandil Methotrimeprazine may decrease the antihypertensive activities of Nicorandil.
Rauwolfia serpentina root Methotrimeprazine may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Methotrimeprazine may decrease the antihypertensive activities of Enalaprilat.
Selexipag Methotrimeprazine may decrease the antihypertensive activities of Selexipag.
Angiotensin 1-7 Methotrimeprazine may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Methotrimeprazine may decrease the antihypertensive activities of Imidapril.
BQ-123 Methotrimeprazine may decrease the antihypertensive activities of BQ-123.
Dihydralazine Methotrimeprazine may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Methotrimeprazine may decrease the antihypertensive activities of Zofenopril.
Guanoxan Methotrimeprazine may decrease the antihypertensive activities of Guanoxan.
Delapril Methotrimeprazine may decrease the antihypertensive activities of Delapril.
Vincamine Methotrimeprazine may decrease the antihypertensive activities of Vincamine.
Linsidomine Methotrimeprazine may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Methotrimeprazine may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Methotrimeprazine may decrease the antihypertensive activities of Tolonidine.
Endralazine Methotrimeprazine may decrease the antihypertensive activities of Endralazine.
Cadralazine Methotrimeprazine may decrease the antihypertensive activities of Cadralazine.
Bietaserpine Methotrimeprazine may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Methotrimeprazine may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Methotrimeprazine may decrease the antihypertensive activities of Methoserpidine.
Guanoclor Methotrimeprazine may decrease the antihypertensive activities of Guanoclor.
Muzolimine Methotrimeprazine may decrease the antihypertensive activities of Muzolimine.
Xipamide Methotrimeprazine may decrease the antihypertensive activities of Xipamide.
Candesartan Methotrimeprazine may decrease the antihypertensive activities of Candesartan.
Tocopherylquinone Methotrimeprazine may decrease the antihypertensive activities of Tocopherylquinone.
Benazeprilat Methotrimeprazine may decrease the antihypertensive activities of Benazeprilat.
Fosinoprilat Methotrimeprazine may decrease the antihypertensive activities of Fosinoprilat.
Ramiprilat Methotrimeprazine may decrease the antihypertensive activities of Ramiprilat.
Perindoprilat Methotrimeprazine may decrease the antihypertensive activities of Perindoprilat.
Quinaprilat Methotrimeprazine may decrease the antihypertensive activities of Quinaprilat.
Furosemide Methotrimeprazine may decrease the antihypertensive activities of Furosemide.
Captopril Methotrimeprazine may decrease the antihypertensive activities of Captopril.
Ramipril Methotrimeprazine may decrease the antihypertensive activities of Ramipril.
Perindopril Methotrimeprazine may decrease the antihypertensive activities of Perindopril.
Levamlodipine Methotrimeprazine may decrease the antihypertensive activities of Levamlodipine.
Buthiazide Methotrimeprazine may decrease the antihypertensive activities of Buthiazide.
Azilsartan medoxomil Methotrimeprazine may decrease the antihypertensive activities of Azilsartan medoxomil.
Buprenorphine Methotrimeprazine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Hydrocodone Methotrimeprazine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Magnesium sulfate The therapeutic efficacy of Methotrimeprazine can be increased when used in combination with Magnesium sulfate.
Botulinum toxin type B Botulinum toxin type B may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Baclofen Baclofen may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Ethchlorvynol Ethchlorvynol may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Succinylcholine Succinylcholine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Eletriptan Eletriptan may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Enflurane Enflurane may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Butabarbital Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Butalbital Butalbital may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Methysergide Methysergide may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Cabergoline Cabergoline may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Phenytoin Phenytoin may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Clemastine Clemastine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Etomidate Etomidate may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Morphine Morphine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.

Target Protein

D(2) dopamine receptor DRD2
D(1A) dopamine receptor DRD1
D(1B) dopamine receptor DRD5
D(3) dopamine receptor DRD3
D(4) dopamine receptor DRD4
5-hydroxytryptamine receptor 2A HTR2A
5-hydroxytryptamine receptor 2C HTR2C
Histamine H1 receptor HRH1
Muscarinic acetylcholine receptor M1 CHRM1
Muscarinic acetylcholine receptor M2 CHRM2
Muscarinic acetylcholine receptor M3 CHRM3
Muscarinic acetylcholine receptor M4 CHRM4
Muscarinic acetylcholine receptor M5 CHRM5
Alpha-1A adrenergic receptor ADRA1A
Alpha-1B adrenergic receptor ADRA1B
Alpha-1D adrenergic receptor ADRA1D
Alpha-2A adrenergic receptor ADRA2A
Alpha-2B adrenergic receptor ADRA2B
Alpha-2C adrenergic receptor ADRA2C

Referensi & Sumber

Synthesis reference: Christian Berger, "Process for preparing levomepromazine hydrogen maleate." U.S. Patent US4798895, issued January 17, 1989.
Link

Contoh Produk & Brand

Produk: 24 • International brands: 4
Produk
  • Methoprazine
    Tablet • 2 mg • Oral • Canada • Approved
  • Methoprazine
    Tablet • 5 mg • Oral • Canada • Approved
  • Methoprazine
    Tablet • 25 mg • Oral • Canada • Approved
  • Methoprazine
    Tablet • 50 mg • Oral • Canada • Approved
  • Methotrimeprazine-2
    Tablet • 2 mg • Oral • Canada • Approved
  • Methotrimeprazine-25
    Tablet • 25 mg • Oral • Canada • Approved
  • Methotrimeprazine-5
    Tablet • 5 mg • Oral • Canada • Approved
  • Methotrimeprazine-50
    Tablet • 50 mg • Oral • Canada • Approved
Menampilkan 8 dari 24 produk.
International Brands
  • Levoprome
  • Neurocil
  • Nosinan
  • Nozinan

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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