Overdosage of Neostigmine can cause cholinergic crisis, which is characterized by increasing muscle weakness, and through involvement of the muscles of respiration, may result in death. The LD 50 of neostigmine methylsulfate in mice is 0.3 ± 0.02 mg/kg intravenously, 0.54 ± 0.03 mg/kg subcutaneously, and 0.395 ± 0.025 mg/kg intramuscularly; in rats the LD 50 is 0.315 ± 0.019 mg/kg intravenously, 0.445 ± 0.032 mg/kg subcutaneously, and 0.423 ± 0.032 mg/kg intramuscularly.
A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Dipyridamole | The therapeutic efficacy of Neostigmine can be decreased when used in combination with Dipyridamole. |
| Ephedrine | Neostigmine may increase the neuromuscular blocking activities of Ephedrine. |
| Bambuterol | Neostigmine may increase the neuromuscular blocking activities of Bambuterol. |
| Clevidipine | Neostigmine may increase the neuromuscular blocking activities of Clevidipine. |
| Sar9, Met (O2)11-Substance P | Neostigmine may increase the neuromuscular blocking activities of Sar9, Met (O2)11-Substance P. |
| Moxisylyte | Neostigmine may increase the neuromuscular blocking activities of Moxisylyte. |
| Propacetamol | Neostigmine may increase the neuromuscular blocking activities of Propacetamol. |
| Procaine | Neostigmine may increase the neuromuscular blocking activities of Procaine. |
| Cocaine | Neostigmine may increase the neuromuscular blocking activities of Cocaine. |
| Trimethaphan | Neostigmine may increase the neuromuscular blocking activities of Trimethaphan. |
| Doxacurium | Neostigmine may increase the neuromuscular blocking activities of Doxacurium. |
| Chloroprocaine | Neostigmine may increase the neuromuscular blocking activities of Chloroprocaine. |
| Tubocurarine | Neostigmine may increase the neuromuscular blocking activities of Tubocurarine. |
| Aclidinium | Neostigmine may increase the neuromuscular blocking activities of Aclidinium. |
| Butyrylthiocholine | Neostigmine may increase the neuromuscular blocking activities of Butyrylthiocholine. |
| Mirabegron | Neostigmine may increase the neuromuscular blocking activities of Mirabegron. |
| Oxybuprocaine | Neostigmine may increase the neuromuscular blocking activities of Oxybuprocaine. |
| Benzonatate | Neostigmine may increase the neuromuscular blocking activities of Benzonatate. |
| Succinylcholine | The metabolism of Succinylcholine can be decreased when combined with Neostigmine. |
| Tramadol | The therapeutic efficacy of Tramadol can be decreased when used in combination with Neostigmine. |
| Trospium | The therapeutic efficacy of Trospium can be decreased when used in combination with Neostigmine. |
| Oxyphenonium | The therapeutic efficacy of Oxyphenonium can be decreased when used in combination with Neostigmine. |
| Butabarbital | The therapeutic efficacy of Butabarbital can be decreased when used in combination with Neostigmine. |
| Butalbital | The therapeutic efficacy of Butalbital can be decreased when used in combination with Neostigmine. |
| Benzatropine | The therapeutic efficacy of Benzatropine can be decreased when used in combination with Neostigmine. |
| Ziprasidone | The therapeutic efficacy of Ziprasidone can be decreased when used in combination with Neostigmine. |
| Disopyramide | The therapeutic efficacy of Disopyramide can be decreased when used in combination with Neostigmine. |
| Talbutal | The therapeutic efficacy of Talbutal can be decreased when used in combination with Neostigmine. |
| Pentobarbital | The therapeutic efficacy of Pentobarbital can be decreased when used in combination with Neostigmine. |
| Amitriptyline | The therapeutic efficacy of Amitriptyline can be decreased when used in combination with Neostigmine. |
| Ipratropium | The therapeutic efficacy of Ipratropium can be decreased when used in combination with Neostigmine. |
| Methadone | The therapeutic efficacy of Methadone can be decreased when used in combination with Neostigmine. |
| Olanzapine | The therapeutic efficacy of Olanzapine can be decreased when used in combination with Neostigmine. |
| Metixene | The therapeutic efficacy of Metixene can be decreased when used in combination with Neostigmine. |
| Terfenadine | The therapeutic efficacy of Terfenadine can be decreased when used in combination with Neostigmine. |
| Buclizine | The therapeutic efficacy of Buclizine can be decreased when used in combination with Neostigmine. |
| Clozapine | The therapeutic efficacy of Clozapine can be decreased when used in combination with Neostigmine. |
| Doxylamine | The therapeutic efficacy of Doxylamine can be decreased when used in combination with Neostigmine. |
| Trihexyphenidyl | The therapeutic efficacy of Trihexyphenidyl can be decreased when used in combination with Neostigmine. |
| Oxyphencyclimine | The therapeutic efficacy of Oxyphencyclimine can be decreased when used in combination with Neostigmine. |
| Procyclidine | The therapeutic efficacy of Procyclidine can be decreased when used in combination with Neostigmine. |
| Profenamine | The therapeutic efficacy of Profenamine can be decreased when used in combination with Neostigmine. |
| Secobarbital | The therapeutic efficacy of Secobarbital can be decreased when used in combination with Neostigmine. |
| Promazine | The therapeutic efficacy of Promazine can be decreased when used in combination with Neostigmine. |
| Hyoscyamine | The therapeutic efficacy of Hyoscyamine can be decreased when used in combination with Neostigmine. |
| Cyproheptadine | The therapeutic efficacy of Cyproheptadine can be decreased when used in combination with Neostigmine. |
| Imipramine | The therapeutic efficacy of Imipramine can be decreased when used in combination with Neostigmine. |
| Methscopolamine bromide | The therapeutic efficacy of Methscopolamine bromide can be decreased when used in combination with Neostigmine. |
| Metharbital | The therapeutic efficacy of Metharbital can be decreased when used in combination with Neostigmine. |
| Fluoxetine | The therapeutic efficacy of Fluoxetine can be decreased when used in combination with Neostigmine. |
| Chlorpromazine | The therapeutic efficacy of Chlorpromazine can be decreased when used in combination with Neostigmine. |
| Darifenacin | The therapeutic efficacy of Darifenacin can be decreased when used in combination with Neostigmine. |
| Tridihexethyl | The therapeutic efficacy of Tridihexethyl can be decreased when used in combination with Neostigmine. |
| Triflupromazine | The therapeutic efficacy of Triflupromazine can be decreased when used in combination with Neostigmine. |
| Dextromethorphan | The therapeutic efficacy of Dextromethorphan can be decreased when used in combination with Neostigmine. |
| Anisotropine methylbromide | The therapeutic efficacy of Anisotropine methylbromide can be decreased when used in combination with Neostigmine. |
| Nortriptyline | The therapeutic efficacy of Nortriptyline can be decreased when used in combination with Neostigmine. |
| Amoxapine | The therapeutic efficacy of Amoxapine can be decreased when used in combination with Neostigmine. |
| Atropine | The therapeutic efficacy of Atropine can be decreased when used in combination with Neostigmine. |
| Thiopental | The therapeutic efficacy of Thiopental can be decreased when used in combination with Neostigmine. |
| Nicardipine | The therapeutic efficacy of Nicardipine can be decreased when used in combination with Neostigmine. |
| Mecamylamine | The therapeutic efficacy of Mecamylamine can be decreased when used in combination with Neostigmine. |
| Pirenzepine | The therapeutic efficacy of Pirenzepine can be decreased when used in combination with Neostigmine. |
| Paroxetine | The therapeutic efficacy of Paroxetine can be decreased when used in combination with Neostigmine. |
| Homatropine methylbromide | The therapeutic efficacy of Homatropine methylbromide can be decreased when used in combination with Neostigmine. |
| Scopolamine | The therapeutic efficacy of Scopolamine can be decreased when used in combination with Neostigmine. |
| Isoflurane | The therapeutic efficacy of Isoflurane can be decreased when used in combination with Neostigmine. |
| Benzquinamide | The therapeutic efficacy of Benzquinamide can be decreased when used in combination with Neostigmine. |
| Clidinium | The therapeutic efficacy of Clidinium can be decreased when used in combination with Neostigmine. |
| Propiomazine | The therapeutic efficacy of Propiomazine can be decreased when used in combination with Neostigmine. |
| Propantheline | The therapeutic efficacy of Propantheline can be decreased when used in combination with Neostigmine. |
| Primidone | The therapeutic efficacy of Primidone can be decreased when used in combination with Neostigmine. |
| Dicyclomine | The therapeutic efficacy of Dicyclomine can be decreased when used in combination with Neostigmine. |
| Biperiden | The therapeutic efficacy of Biperiden can be decreased when used in combination with Neostigmine. |
| Brompheniramine | The therapeutic efficacy of Brompheniramine can be decreased when used in combination with Neostigmine. |
| Methylphenobarbital | The therapeutic efficacy of Methylphenobarbital can be decreased when used in combination with Neostigmine. |
| Quinidine | The therapeutic efficacy of Quinidine can be decreased when used in combination with Neostigmine. |
| Amantadine | The therapeutic efficacy of Amantadine can be decreased when used in combination with Neostigmine. |
| Maprotiline | The therapeutic efficacy of Maprotiline can be decreased when used in combination with Neostigmine. |
| Methantheline | The therapeutic efficacy of Methantheline can be decreased when used in combination with Neostigmine. |
| Hexafluronium | The therapeutic efficacy of Hexafluronium can be decreased when used in combination with Neostigmine. |
| Cycrimine | The therapeutic efficacy of Cycrimine can be decreased when used in combination with Neostigmine. |
| Desloratadine | The therapeutic efficacy of Desloratadine can be decreased when used in combination with Neostigmine. |
| Tolterodine | The therapeutic efficacy of Tolterodine can be decreased when used in combination with Neostigmine. |
| Oxybutynin | The therapeutic efficacy of Oxybutynin can be decreased when used in combination with Neostigmine. |
| Promethazine | The therapeutic efficacy of Promethazine can be decreased when used in combination with Neostigmine. |
| Diphenhydramine | The therapeutic efficacy of Diphenhydramine can be decreased when used in combination with Neostigmine. |
| Pentolinium | The therapeutic efficacy of Pentolinium can be decreased when used in combination with Neostigmine. |
| Doxepin | The therapeutic efficacy of Doxepin can be decreased when used in combination with Neostigmine. |
| Flavoxate | The therapeutic efficacy of Flavoxate can be decreased when used in combination with Neostigmine. |
| Desipramine | The therapeutic efficacy of Desipramine can be decreased when used in combination with Neostigmine. |
| Orphenadrine | The therapeutic efficacy of Orphenadrine can be decreased when used in combination with Neostigmine. |
| Phenobarbital | The therapeutic efficacy of Phenobarbital can be decreased when used in combination with Neostigmine. |
| Escitalopram | The therapeutic efficacy of Escitalopram can be decreased when used in combination with Neostigmine. |
| Quetiapine | The therapeutic efficacy of Quetiapine can be decreased when used in combination with Neostigmine. |
| Levacetylmethadol | The therapeutic efficacy of Levacetylmethadol can be decreased when used in combination with Neostigmine. |
| Diphenidol | The therapeutic efficacy of Diphenidol can be decreased when used in combination with Neostigmine. |
| Aripiprazole | The therapeutic efficacy of Aripiprazole can be decreased when used in combination with Neostigmine. |
| Chlorprothixene | The therapeutic efficacy of Chlorprothixene can be decreased when used in combination with Neostigmine. |
| Fenoterol | The therapeutic efficacy of Fenoterol can be decreased when used in combination with Neostigmine. |