Death has followed ingestion of 10 to 30 g of salicylates in adults, but much larger amounts have been ingested without fatal outcome.
Salsalate is a nonsteroidal anti-inflammatory agent for oral administration. Salsalate's mode of action as an anti-inflammatory and antirheumatic agent may be due to inhibition of synthesis and release of prostaglandins. The usefulness of salicylic acid, the active in vivo product of salsalate, in the treatment of arthritic disorders has been established. In contrast to aspirin, salsalate causes no greater fecal gastrointestinal blood loss than placebo. Salsalate is readily soluble in the small intestine where it is partially hydrolyzed to two molecules of salicylic acid. A significant portion of the parent compound is absorbed unchanged and undergoes rapid esterase hydrolysis in the body. The parent compound has an elimination half-life of about 1 hour. Salicylic acid (the active metabolite) biotransformation is saturated at anti-inflammatory doses of salsalate. Such capacity limited biotransformation results in an increase in the half-life of salicylic acid from 3.5 to 16 or more hours.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Amlodipine | Salsalate may decrease the antihypertensive activities of Amlodipine. |
| Phentermine | The risk or severity of hypertension can be increased when Phentermine is combined with Salsalate. |
| Midodrine | The risk or severity of hypertension can be increased when Midodrine is combined with Salsalate. |
| Eletriptan | The risk or severity of hypertension can be increased when Eletriptan is combined with Salsalate. |
| Isoetharine | The risk or severity of hypertension can be increased when Isoetharine is combined with Salsalate. |
| Ziprasidone | The risk or severity of hypertension can be increased when Ziprasidone is combined with Salsalate. |
| Methysergide | The risk or severity of hypertension can be increased when Methysergide is combined with Salsalate. |
| Cabergoline | The risk or severity of hypertension can be increased when Cabergoline is combined with Salsalate. |
| Zolmitriptan | The risk or severity of hypertension can be increased when Zolmitriptan is combined with Salsalate. |
| Dihydroergotamine | The risk or severity of hypertension can be increased when Dihydroergotamine is combined with Salsalate. |
| Methylergometrine | The risk or severity of hypertension can be increased when Methylergometrine is combined with Salsalate. |
| Norepinephrine | The risk or severity of hypertension can be increased when Norepinephrine is combined with Salsalate. |
| Mirtazapine | The risk or severity of hypertension can be increased when Mirtazapine is combined with Salsalate. |
| Phenylephrine | The risk or severity of hypertension can be increased when Phenylephrine is combined with Salsalate. |
| Phenylpropanolamine | The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Salsalate. |
| Promazine | The risk or severity of hypertension can be increased when Promazine is combined with Salsalate. |
| Droperidol | The risk or severity of hypertension can be increased when Droperidol is combined with Salsalate. |
| Doxapram | The risk or severity of hypertension can be increased when Doxapram is combined with Salsalate. |
| Atropine | The risk or severity of hypertension can be increased when Atropine is combined with Salsalate. |
| Lisuride | The risk or severity of hypertension can be increased when Lisuride is combined with Salsalate. |
| Linezolid | The risk or severity of hypertension can be increased when Linezolid is combined with Salsalate. |
| Metaraminol | The risk or severity of hypertension can be increased when Metaraminol is combined with Salsalate. |
| Furazolidone | The risk or severity of hypertension can be increased when Furazolidone is combined with Salsalate. |
| Epinephrine | The risk or severity of hypertension can be increased when Epinephrine is combined with Salsalate. |
| Thioridazine | The risk or severity of hypertension can be increased when Thioridazine is combined with Salsalate. |
| Ergotamine | The risk or severity of hypertension can be increased when Ergotamine is combined with Salsalate. |
| Nicergoline | The risk or severity of hypertension can be increased when Nicergoline is combined with Salsalate. |
| Sufentanil | The risk or severity of hypertension can be increased when Sufentanil is combined with Salsalate. |
| Methoxamine | The risk or severity of hypertension can be increased when Methoxamine is combined with Salsalate. |
| Risperidone | The risk or severity of hypertension can be increased when Risperidone is combined with Salsalate. |
| Tranylcypromine | The risk or severity of hypertension can be increased when Tranylcypromine is combined with Salsalate. |
| Isoflurane | The risk or severity of hypertension can be increased when Isoflurane is combined with Salsalate. |
| Propiomazine | The risk or severity of hypertension can be increased when Propiomazine is combined with Salsalate. |
| Alfentanil | The risk or severity of hypertension can be increased when Alfentanil is combined with Salsalate. |
| Minaprine | The risk or severity of hypertension can be increased when Minaprine is combined with Salsalate. |
| Orciprenaline | The risk or severity of hypertension can be increased when Orciprenaline is combined with Salsalate. |
| Propofol | The risk or severity of hypertension can be increased when Propofol is combined with Salsalate. |
| Phenmetrazine | The risk or severity of hypertension can be increased when Phenmetrazine is combined with Salsalate. |
| Trifluoperazine | The risk or severity of hypertension can be increased when Trifluoperazine is combined with Salsalate. |
| Pseudoephedrine | The risk or severity of hypertension can be increased when Pseudoephedrine is combined with Salsalate. |
| Benzphetamine | The risk or severity of hypertension can be increased when Benzphetamine is combined with Salsalate. |
| Ritodrine | The risk or severity of hypertension can be increased when Ritodrine is combined with Salsalate. |
| Flupentixol | The risk or severity of hypertension can be increased when Flupentixol is combined with Salsalate. |
| Remifentanil | The risk or severity of hypertension can be increased when Remifentanil is combined with Salsalate. |
| Bitolterol | The risk or severity of hypertension can be increased when Bitolterol is combined with Salsalate. |
| Oxymetazoline | The risk or severity of hypertension can be increased when Oxymetazoline is combined with Salsalate. |
| Diethylpropion | The risk or severity of hypertension can be increased when Diethylpropion is combined with Salsalate. |
| Salmeterol | The risk or severity of hypertension can be increased when Salmeterol is combined with Salsalate. |
| Naratriptan | The risk or severity of hypertension can be increased when Naratriptan is combined with Salsalate. |
| Formoterol | The risk or severity of hypertension can be increased when Formoterol is combined with Salsalate. |
| Frovatriptan | The risk or severity of hypertension can be increased when Frovatriptan is combined with Salsalate. |
| Methoxyflurane | The risk or severity of hypertension can be increased when Methoxyflurane is combined with Salsalate. |
| Selegiline | The risk or severity of hypertension can be increased when Selegiline is combined with Salsalate. |
| Ergoloid mesylate | The risk or severity of hypertension can be increased when Ergoloid mesylate is combined with Salsalate. |
| Isoprenaline | The risk or severity of hypertension can be increased when Isoprenaline is combined with Salsalate. |
| Arbutamine | The risk or severity of hypertension can be increased when Arbutamine is combined with Salsalate. |
| Dutasteride | The risk or severity of hypertension can be increased when Dutasteride is combined with Salsalate. |
| Halothane | The risk or severity of hypertension can be increased when Halothane is combined with Salsalate. |
| Moclobemide | The risk or severity of hypertension can be increased when Moclobemide is combined with Salsalate. |
| Pergolide | The risk or severity of hypertension can be increased when Pergolide is combined with Salsalate. |
| Desflurane | The risk or severity of hypertension can be increased when Desflurane is combined with Salsalate. |
| Bromocriptine | The risk or severity of hypertension can be increased when Bromocriptine is combined with Salsalate. |
| Finasteride | The risk or severity of hypertension can be increased when Finasteride is combined with Salsalate. |
| Aripiprazole | The risk or severity of hypertension can be increased when Aripiprazole is combined with Salsalate. |
| Isocarboxazid | The risk or severity of hypertension can be increased when Isocarboxazid is combined with Salsalate. |
| Ergometrine | The risk or severity of hypertension can be increased when Ergometrine is combined with Salsalate. |
| Lisdexamfetamine | The risk or severity of hypertension can be increased when Lisdexamfetamine is combined with Salsalate. |
| Fenoterol | The risk or severity of hypertension can be increased when Fenoterol is combined with Salsalate. |
| Pirbuterol | The risk or severity of hypertension can be increased when Pirbuterol is combined with Salsalate. |
| Ephedra sinica root | The risk or severity of hypertension can be increased when Ephedra sinica root is combined with Salsalate. |
| Ephedrine | The risk or severity of hypertension can be increased when Ephedrine is combined with Salsalate. |
| Mephentermine | The risk or severity of hypertension can be increased when Mephentermine is combined with Salsalate. |
| Procaterol | The risk or severity of hypertension can be increased when Procaterol is combined with Salsalate. |
| Yohimbine | The risk or severity of hypertension can be increased when Yohimbine is combined with Salsalate. |
| Methotrimeprazine | The risk or severity of hypertension can be increased when Salsalate is combined with Methotrimeprazine. |
| Clenbuterol | The risk or severity of hypertension can be increased when Salsalate is combined with Clenbuterol. |
| Bambuterol | The risk or severity of hypertension can be increased when Salsalate is combined with Bambuterol. |
| MMDA | The risk or severity of hypertension can be increased when Salsalate is combined with MMDA. |
| Midomafetamine | The risk or severity of hypertension can be increased when Salsalate is combined with Midomafetamine. |
| 2,5-Dimethoxy-4-ethylamphetamine | The risk or severity of hypertension can be increased when Salsalate is combined with 2,5-Dimethoxy-4-ethylamphetamine. |
| 4-Methoxyamphetamine | The risk or severity of hypertension can be increased when Salsalate is combined with 4-Methoxyamphetamine. |
| 4-Bromo-2,5-dimethoxyamphetamine | The risk or severity of hypertension can be increased when Salsalate is combined with 4-Bromo-2,5-dimethoxyamphetamine. |
| Tenamfetamine | The risk or severity of hypertension can be increased when Salsalate is combined with Tenamfetamine. |
| Chlorphentermine | The risk or severity of hypertension can be increased when Salsalate is combined with Chlorphentermine. |
| Dextroamphetamine | The risk or severity of hypertension can be increased when Salsalate is combined with Dextroamphetamine. |
| Phendimetrazine | The risk or severity of hypertension can be increased when Salsalate is combined with Phendimetrazine. |
| Solifenacin | The risk or severity of hypertension can be increased when Salsalate is combined with Solifenacin. |
| Periciazine | The risk or severity of hypertension can be increased when Salsalate is combined with Periciazine. |
| Acepromazine | The risk or severity of hypertension can be increased when Salsalate is combined with Acepromazine. |
| Thioproperazine | The risk or severity of hypertension can be increased when Salsalate is combined with Thioproperazine. |
| Zuclopenthixol | The risk or severity of hypertension can be increased when Salsalate is combined with Zuclopenthixol. |
| Epicaptopril | The risk or severity of hypertension can be increased when Salsalate is combined with Epicaptopril. |
| Clorgiline | The risk or severity of hypertension can be increased when Salsalate is combined with Clorgiline. |
| 1-benzylimidazole | The risk or severity of hypertension can be increased when Salsalate is combined with 1-benzylimidazole. |
| Iproniazid | The risk or severity of hypertension can be increased when Salsalate is combined with Iproniazid. |
| Nialamide | The risk or severity of hypertension can be increased when Salsalate is combined with Nialamide. |
| Lysergic acid diethylamide | The risk or severity of hypertension can be increased when Salsalate is combined with Lysergic acid diethylamide. |
| Dronedarone | The risk or severity of hypertension can be increased when Salsalate is combined with Dronedarone. |
| Flibanserin | The risk or severity of hypertension can be increased when Salsalate is combined with Flibanserin. |
| Iloperidone | The risk or severity of hypertension can be increased when Salsalate is combined with Iloperidone. |