Peringatan Keamanan

Digitoxin exerts similar toxic effects to digoxin including anorexia, nausea, vomiting, diarrhoea, confusion, visual disturbances, and cardiac arrhythmias.

Digitoxin

DB01396

small molecule approved investigational

Deskripsi

A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)

Struktur Molekul 2D

Berat 764.9391
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Hepatic.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

2 Data
  • 1. Avoid avocado. Persea americana (avocado) is a plant that affects the heart by interfering with the Na+, K+, ATPase, which may cause an additive effect with digitoxin.
  • 2. Do not take with bran and high fiber foods. The absorption of digitoxin is more predictable than the absorption of digoxin in the presence of high-fiber food.

Interaksi Obat

1150 Data
Modafinil The metabolism of Digitoxin can be increased when combined with Modafinil.
Armodafinil The metabolism of Digitoxin can be increased when combined with Armodafinil.
Ranolazine The serum concentration of Digitoxin can be increased when it is combined with Ranolazine.
Metreleptin The metabolism of Digitoxin can be increased when combined with Metreleptin.
Amiodarone The serum concentration of Digitoxin can be increased when it is combined with Amiodarone.
Amphotericin B The risk or severity of adverse effects can be increased when Amphotericin B is combined with Digitoxin.
Edrophonium Edrophonium may increase the atrioventricular blocking (AV block) and arrhythmogenic activities of Digitoxin.
Itraconazole The serum concentration of Digitoxin can be increased when it is combined with Itraconazole.
Kaolin The serum concentration of Digitoxin can be decreased when it is combined with Kaolin.
Midodrine Digitoxin may increase the bradycardic, atrioventricular blocking (AV block), and arrhythmogenic activities of Midodrine.
Propafenone The serum concentration of Digitoxin can be increased when it is combined with Propafenone.
Quinine The serum concentration of Digitoxin can be increased when it is combined with Quinine.
Quinidine The serum concentration of Digitoxin can be increased when it is combined with Quinidine.
Reserpine The risk or severity of adverse effects can be increased when Reserpine is combined with Digitoxin.
Telmisartan The serum concentration of Digitoxin can be increased when it is combined with Telmisartan.
Crizotinib The metabolism of Digitoxin can be decreased when combined with Crizotinib.
Tolevamer The risk or severity of Cardiac Arrhythmia can be increased when Tolevamer is combined with Digitoxin.
Sulpiride The risk or severity of QTc prolongation can be increased when Sulpiride is combined with Digitoxin.
Parathyroid hormone The risk or severity of adverse effects can be increased when Parathyroid hormone is combined with Digitoxin.
Calcifediol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Calcifediol is combined with Digitoxin.
Ergocalciferol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Ergocalciferol is combined with Digitoxin.
Dihydrotachysterol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Dihydrotachysterol is combined with Digitoxin.
Alfacalcidol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Alfacalcidol is combined with Digitoxin.
Seocalcitol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Seocalcitol is combined with Digitoxin.
Inecalcitol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Inecalcitol is combined with Digitoxin.
Becocalcidiol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Becocalcidiol is combined with Digitoxin.
Eldecalcitol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Eldecalcitol is combined with Digitoxin.
1alpha,24S-Dihydroxyvitamin D2 The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when 1alpha,24S-Dihydroxyvitamin D2 is combined with Digitoxin.
Elocalcitol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Elocalcitol is combined with Digitoxin.
Maxacalcitol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Maxacalcitol is combined with Digitoxin.
Doxercalciferol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Doxercalciferol is combined with Digitoxin.
1alpha-Hydroxyvitamin D5 The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when 1alpha-Hydroxyvitamin D5 is combined with Digitoxin.
Cholecalciferol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Cholecalciferol is combined with Digitoxin.
Paricalcitol The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Paricalcitol is combined with Digitoxin.
Vitamin D The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Vitamin D is combined with Digitoxin.
Previtamin D(3) The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Previtamin D(3) is combined with Digitoxin.
Labetalol Labetalol may increase the bradycardic activities of Digitoxin.
Pindolol Pindolol may increase the bradycardic activities of Digitoxin.
Bevantolol Bevantolol may increase the bradycardic activities of Digitoxin.
Penbutolol Penbutolol may increase the bradycardic activities of Digitoxin.
Bufuralol Bufuralol may increase the bradycardic activities of Digitoxin.
Bopindolol Bopindolol may increase the bradycardic activities of Digitoxin.
Arotinolol Arotinolol may increase the bradycardic activities of Digitoxin.
Levobetaxolol Levobetaxolol may increase the bradycardic activities of Digitoxin.
Bucindolol Bucindolol may increase the bradycardic activities of Digitoxin.
Esatenolol Esatenolol may increase the bradycardic activities of Digitoxin.
Cloranolol Cloranolol may increase the bradycardic activities of Digitoxin.
Mepindolol Mepindolol may increase the bradycardic activities of Digitoxin.
Epanolol Epanolol may increase the bradycardic activities of Digitoxin.
Tylvalosin The serum concentration of Digitoxin can be increased when it is combined with Tylvalosin.
Josamycin The serum concentration of Digitoxin can be increased when it is combined with Josamycin.
Clindamycin The serum concentration of Digitoxin can be increased when it is combined with Clindamycin.
Mepartricin The serum concentration of Digitoxin can be increased when it is combined with Mepartricin.
Tilmicosin The serum concentration of Digitoxin can be increased when it is combined with Tilmicosin.
Tylosin The serum concentration of Digitoxin can be increased when it is combined with Tylosin.
Succinylcholine The risk or severity of Cardiac Arrhythmia can be increased when Succinylcholine is combined with Digitoxin.
Metocurine iodide The risk or severity of Cardiac Arrhythmia can be increased when Metocurine iodide is combined with Digitoxin.
Gallamine triethiodide The risk or severity of Cardiac Arrhythmia can be increased when Gallamine triethiodide is combined with Digitoxin.
Cisatracurium The risk or severity of Cardiac Arrhythmia can be increased when Cisatracurium is combined with Digitoxin.
Rocuronium The risk or severity of Cardiac Arrhythmia can be increased when Rocuronium is combined with Digitoxin.
Atracurium besylate The risk or severity of Cardiac Arrhythmia can be increased when Atracurium besylate is combined with Digitoxin.
Doxacurium The risk or severity of Cardiac Arrhythmia can be increased when Doxacurium is combined with Digitoxin.
Tubocurarine The risk or severity of Cardiac Arrhythmia can be increased when Tubocurarine is combined with Digitoxin.
Mivacurium The risk or severity of Cardiac Arrhythmia can be increased when Mivacurium is combined with Digitoxin.
Decamethonium The risk or severity of Cardiac Arrhythmia can be increased when Decamethonium is combined with Digitoxin.
Metocurine The risk or severity of Cardiac Arrhythmia can be increased when Metocurine is combined with Digitoxin.
Pancuronium The risk or severity of Cardiac Arrhythmia can be increased when Pancuronium is combined with Digitoxin.
Pipecuronium The risk or severity of Cardiac Arrhythmia can be increased when Pipecuronium is combined with Digitoxin.
Vecuronium The risk or severity of Cardiac Arrhythmia can be increased when Vecuronium is combined with Digitoxin.
Rapacuronium The risk or severity of Cardiac Arrhythmia can be increased when Rapacuronium is combined with Digitoxin.
Pyrantel The risk or severity of Cardiac Arrhythmia can be increased when Pyrantel is combined with Digitoxin.
Neosaxitoxin The risk or severity of Cardiac Arrhythmia can be increased when Neosaxitoxin is combined with Digitoxin.
Atracurium The risk or severity of Cardiac Arrhythmia can be increased when Atracurium is combined with Digitoxin.
Gallamine The risk or severity of Cardiac Arrhythmia can be increased when Gallamine is combined with Digitoxin.
Alcuronium The risk or severity of Cardiac Arrhythmia can be increased when Alcuronium is combined with Digitoxin.
Furosemide The risk or severity of adverse effects can be increased when Furosemide is combined with Digitoxin.
Bumetanide The risk or severity of adverse effects can be increased when Bumetanide is combined with Digitoxin.
Etacrynic acid The risk or severity of adverse effects can be increased when Etacrynic acid is combined with Digitoxin.
Piretanide The risk or severity of adverse effects can be increased when Piretanide is combined with Digitoxin.
Azosemide The risk or severity of adverse effects can be increased when Azosemide is combined with Digitoxin.
Torasemide The risk or severity of adverse effects can be increased when Torasemide is combined with Digitoxin.
Tripamide The risk or severity of adverse effects can be increased when Tripamide is combined with Digitoxin.
Chlorthalidone The risk or severity of adverse effects can be increased when Chlorthalidone is combined with Digitoxin.
Metolazone The risk or severity of adverse effects can be increased when Metolazone is combined with Digitoxin.
Quinethazone The risk or severity of adverse effects can be increased when Quinethazone is combined with Digitoxin.
Epitizide The risk or severity of adverse effects can be increased when Epitizide is combined with Digitoxin.
Indapamide The risk or severity of adverse effects can be increased when Indapamide is combined with Digitoxin.
Aminosalicylic acid The serum concentration of Digitoxin can be decreased when it is combined with Aminosalicylic acid.
Mesalazine The serum concentration of Digitoxin can be decreased when it is combined with Mesalazine.
Sulfasalazine The serum concentration of Digitoxin can be decreased when it is combined with Sulfasalazine.
Diflunisal The serum concentration of Digitoxin can be decreased when it is combined with Diflunisal.
Salicylic acid The serum concentration of Digitoxin can be decreased when it is combined with Salicylic acid.
Balsalazide The serum concentration of Digitoxin can be decreased when it is combined with Balsalazide.
Olsalazine The serum concentration of Digitoxin can be decreased when it is combined with Olsalazine.
Bismuth subsalicylate The serum concentration of Digitoxin can be decreased when it is combined with Bismuth subsalicylate.
Dersalazine The serum concentration of Digitoxin can be decreased when it is combined with Dersalazine.
Phenyl aminosalicylate The serum concentration of Digitoxin can be decreased when it is combined with Phenyl aminosalicylate.
Methyl salicylate The serum concentration of Digitoxin can be decreased when it is combined with Methyl salicylate.
Nitroaspirin The serum concentration of Digitoxin can be decreased when it is combined with Nitroaspirin.
Aloxiprin The serum concentration of Digitoxin can be decreased when it is combined with Aloxiprin.

Target Protein

Sodium/potassium-transporting ATPase subunit beta-2 ATP1B2
Sodium/potassium-transporting ATPase subunit beta-3 ATP1B3
Sodium/potassium-transporting ATPase subunit alpha-1 ATP1A1
Sodium/potassium-transporting ATPase subunit alpha-3 ATP1A3
Sodium/potassium-transporting ATPase subunit beta-1 ATP1B1
Sodium/potassium-transporting ATPase subunit alpha-2 ATP1A2

Referensi & Sumber

Artikel (PubMed)
  • PMID: 11525233
    Belz GG, Breithaupt-Grogler K, Osowski U: Treatment of congestive heart failure--current status of use of digitoxin. Eur J Clin Invest. 2001;31 Suppl 2:10-7.
  • PMID: 1469187
    Kurowski V, Iven H, Djonlagic H: Treatment of a patient with severe digitoxin intoxication by Fab fragments of anti-digitalis antibodies. Intensive Care Med. 1992;18(7):439-42.
  • PMID: 11395576
    Johansson S, Lindholm P, Gullbo J, Larsson R, Bohlin L, Claeson P: Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells. Anticancer Drugs. 2001 Jun;12(5):475-83.
  • PMID: 11515708
    Hippius M, Humaid B, Sicker T, Hoffmann A, Gottler M, Hasford J: Adverse drug reaction monitoring--digitoxin overdosage in the elderly. Int J Clin Pharmacol Ther. 2001 Aug;39(8):336-43.

Contoh Produk & Brand

Produk: 1 • International brands: 2
Produk
  • Digitaline Welcker Tab 0.1mg
    Tablet • .1 mg / tab • Oral • Canada • Approved
International Brands
  • Crystodigin
  • Tardigal

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul