Yohimbine

DB01392

small molecule approved investigational vet_approved

Deskripsi

A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.

Struktur Molekul 2D

Berat 354.4427
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Elimination half-life is approximately 36 minutes.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Rapidly absorbed following oral administration. Bioavailability is highly variable, ranging from 7 to 87% (mean 33%).

Metabolisme

Yohimbine appears to undergo extensive metabolism in an organ of high flow such as the liver or kidney, however, the precise metabolic fate of yohimbine has not been fully determined.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Take with or without food.

Interaksi Obat

1317 Data
Valsartan Yohimbine may decrease the antihypertensive activities of Valsartan.
Ramipril Yohimbine may decrease the antihypertensive activities of Ramipril.
Esmolol Yohimbine may decrease the antihypertensive activities of Esmolol.
Betaxolol Yohimbine may decrease the antihypertensive activities of Betaxolol.
Remikiren Yohimbine may decrease the antihypertensive activities of Remikiren.
Torasemide Yohimbine may decrease the antihypertensive activities of Torasemide.
Bethanidine Yohimbine may decrease the antihypertensive activities of Bethanidine.
Guanadrel Yohimbine may decrease the antihypertensive activities of Guanadrel.
Olmesartan Yohimbine may decrease the antihypertensive activities of Olmesartan.
Chlorthalidone Yohimbine may decrease the antihypertensive activities of Chlorthalidone.
Nitroprusside Yohimbine may decrease the antihypertensive activities of Nitroprusside.
Atenolol Yohimbine may decrease the antihypertensive activities of Atenolol.
Minoxidil Yohimbine may decrease the antihypertensive activities of Minoxidil.
Treprostinil Yohimbine may decrease the antihypertensive activities of Treprostinil.
Bendroflumethiazide Yohimbine may decrease the antihypertensive activities of Bendroflumethiazide.
Fosinopril Yohimbine may decrease the antihypertensive activities of Fosinopril.
Trandolapril Yohimbine may decrease the antihypertensive activities of Trandolapril.
Metolazone Yohimbine may decrease the antihypertensive activities of Metolazone.
Benazepril Yohimbine may decrease the antihypertensive activities of Benazepril.
Enalapril Yohimbine may decrease the antihypertensive activities of Enalapril.
Cyclothiazide Yohimbine may decrease the antihypertensive activities of Cyclothiazide.
Candoxatril Yohimbine may decrease the antihypertensive activities of Candoxatril.
Guanabenz Yohimbine may decrease the antihypertensive activities of Guanabenz.
Mecamylamine Yohimbine may decrease the antihypertensive activities of Mecamylamine.
Moexipril Yohimbine may decrease the antihypertensive activities of Moexipril.
Phentolamine Yohimbine may decrease the antihypertensive activities of Phentolamine.
Lisinopril Yohimbine may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Yohimbine may decrease the antihypertensive activities of Nitroglycerin.
Hydroflumethiazide Yohimbine may decrease the antihypertensive activities of Hydroflumethiazide.
Cryptenamine Yohimbine may decrease the antihypertensive activities of Cryptenamine.
Perindopril Yohimbine may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil Yohimbine may decrease the antihypertensive activities of Candesartan cilexetil.
Tolazoline Yohimbine may decrease the antihypertensive activities of Tolazoline.
Eprosartan Yohimbine may decrease the antihypertensive activities of Eprosartan.
Chlorothiazide Yohimbine may decrease the antihypertensive activities of Chlorothiazide.
Quinapril Yohimbine may decrease the antihypertensive activities of Quinapril.
Omapatrilat Yohimbine may decrease the antihypertensive activities of Omapatrilat.
Phenoxybenzamine Yohimbine may decrease the antihypertensive activities of Phenoxybenzamine.
Telmisartan Yohimbine may decrease the antihypertensive activities of Telmisartan.
Methyldopa Yohimbine may decrease the antihypertensive activities of Methyldopa.
Hydrochlorothiazide Yohimbine may decrease the antihypertensive activities of Hydrochlorothiazide.
Trichlormethiazide Yohimbine may decrease the antihypertensive activities of Trichlormethiazide.
Deserpidine Yohimbine may decrease the antihypertensive activities of Deserpidine.
Pentolinium Yohimbine may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Yohimbine may decrease the antihypertensive activities of Trimethaphan.
Diazoxide Yohimbine may decrease the antihypertensive activities of Diazoxide.
Bretylium Yohimbine may decrease the antihypertensive activities of Bretylium.
Terazosin Yohimbine may decrease the antihypertensive activities of Terazosin.
Rescinnamine Yohimbine may decrease the antihypertensive activities of Rescinnamine.
Captopril Yohimbine may decrease the antihypertensive activities of Captopril.
Epoprostenol Yohimbine may decrease the antihypertensive activities of Epoprostenol.
Bevantolol Yohimbine may decrease the antihypertensive activities of Bevantolol.
Practolol Yohimbine may decrease the antihypertensive activities of Practolol.
Polythiazide Yohimbine may decrease the antihypertensive activities of Polythiazide.
Cilazapril Yohimbine may decrease the antihypertensive activities of Cilazapril.
Saprisartan Yohimbine may decrease the antihypertensive activities of Saprisartan.
Spirapril Yohimbine may decrease the antihypertensive activities of Spirapril.
Dexpropranolol Yohimbine may decrease the antihypertensive activities of Dexpropranolol.
Tienilic acid Yohimbine may decrease the antihypertensive activities of Tienilic acid.
Diethylnorspermine Yohimbine may decrease the antihypertensive activities of Diethylnorspermine.
Bupranolol Yohimbine may decrease the antihypertensive activities of Bupranolol.
Temocapril Yohimbine may decrease the antihypertensive activities of Temocapril.
Indoramin Yohimbine may decrease the antihypertensive activities of Indoramin.
Indenolol Yohimbine may decrease the antihypertensive activities of Indenolol.
Trimazosin Yohimbine may decrease the antihypertensive activities of Trimazosin.
Nicorandil Yohimbine may decrease the antihypertensive activities of Nicorandil.
Moxonidine Yohimbine may decrease the antihypertensive activities of Moxonidine.
Rauwolfia serpentina root Yohimbine may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Yohimbine may decrease the antihypertensive activities of Enalaprilat.
Angiotensin 1-7 Yohimbine may decrease the antihypertensive activities of Angiotensin 1-7.
Rilmenidine Yohimbine may decrease the antihypertensive activities of Rilmenidine.
Imidapril Yohimbine may decrease the antihypertensive activities of Imidapril.
BQ-123 Yohimbine may decrease the antihypertensive activities of BQ-123.
Cicletanine Yohimbine may decrease the antihypertensive activities of Cicletanine.
Dihydralazine Yohimbine may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Yohimbine may decrease the antihypertensive activities of Zofenopril.
Guanoxan Yohimbine may decrease the antihypertensive activities of Guanoxan.
Delapril Yohimbine may decrease the antihypertensive activities of Delapril.
Vincamine Yohimbine may decrease the antihypertensive activities of Vincamine.
Linsidomine Yohimbine may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Yohimbine may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Yohimbine may decrease the antihypertensive activities of Tolonidine.
Endralazine Yohimbine may decrease the antihypertensive activities of Endralazine.
Esatenolol Yohimbine may decrease the antihypertensive activities of Esatenolol.
Cadralazine Yohimbine may decrease the antihypertensive activities of Cadralazine.
Cloranolol Yohimbine may decrease the antihypertensive activities of Cloranolol.
Cyclopenthiazide Yohimbine may decrease the antihypertensive activities of Cyclopenthiazide.
Bietaserpine Yohimbine may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Yohimbine may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Yohimbine may decrease the antihypertensive activities of Methoserpidine.
Epanolol Yohimbine may decrease the antihypertensive activities of Epanolol.
Guanoclor Yohimbine may decrease the antihypertensive activities of Guanoclor.
Muzolimine Yohimbine may decrease the antihypertensive activities of Muzolimine.
Xipamide Yohimbine may decrease the antihypertensive activities of Xipamide.
Candesartan Yohimbine may decrease the antihypertensive activities of Candesartan.
Tocopherylquinone Yohimbine may decrease the antihypertensive activities of Tocopherylquinone.
Benazeprilat Yohimbine may decrease the antihypertensive activities of Benazeprilat.
Fosinoprilat Yohimbine may decrease the antihypertensive activities of Fosinoprilat.
Ramiprilat Yohimbine may decrease the antihypertensive activities of Ramiprilat.
Perindoprilat Yohimbine may decrease the antihypertensive activities of Perindoprilat.

Target Protein

Alpha-2A adrenergic receptor ADRA2A
Alpha-2B adrenergic receptor ADRA2B
Alpha-2C adrenergic receptor ADRA2C
5-hydroxytryptamine receptor 1A HTR1A
5-hydroxytryptamine receptor 1B HTR1B
5-hydroxytryptamine receptor 1D HTR1D
D(2) dopamine receptor DRD2
D(3) dopamine receptor DRD3
5-hydroxytryptamine receptor 2A HTR2A
5-hydroxytryptamine receptor 2C HTR2C
ATP-sensitive potassium channel KCNJ1
5-hydroxytryptamine receptor 2B HTR2B

Referensi & Sumber

Synthesis reference: Germain Saint-Ruf, Pham Huu Chanh, Buu Hoi, "Yohimbine derivatives, process for their preparation and their applications." U.S. Patent US3940387, issued April, 1960.
Artikel (PubMed)
  • PMID: 20036429
    Holmes A, Quirk GJ: Pharmacological facilitation of fear extinction and the search for adjunct treatments for anxiety disorders--the case of yohimbine. Trends Pharmacol Sci. 2010 Jan;31(1):2-7. doi: 10.1016/j.tips.2009.10.003. Epub 2009 Dec 28.

Contoh Produk & Brand

Produk: 9 • International brands: 12
Produk
  • Yocon Tablet 5.4mg
    Tablet • 5.4 mg • Oral • Canada • Approved
  • Yohimbine HCl 2mg
    Tablet • 2 mg • Oral • Canada • Approved
  • Yohimbine HCl 5.4mg
    Tablet • 5.4 mg • Oral • Canada • Approved
  • Yohimbine Hydrochloride Tab 2mg
    Tablet • 2 mg • Oral • Canada • Approved
  • Yohimbine Hydrochloride Tablets 5.4mg
    Tablet • 5.4 mg • Oral • Canada • Approved
  • Yohimbine Tab 2mg
    Tablet • 2 mg • Oral • Canada • Approved
  • Yohimbine Tab 5.4mg
    Tablet • 5.4 mg • Oral • Canada • Approved
  • Yohimbine Tab 6mg
    Tablet • 6 mg • Oral • Canada • Approved
Menampilkan 8 dari 9 produk.
International Brands
  • Actibine
  • Aphrodine
  • Aphrodyne
  • Baron-X
  • Corynine
  • Dayto himbin
  • Thybine
  • Yocon
  • Yohimar
  • Yohimex

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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