Mibefradil

DB01388

small molecule investigational withdrawn

Deskripsi

Mibefradil was withdrawn from the market in 1998 because of potentially harmful interactions with other drugs.

Struktur Molekul 2D

Berat 495.6287
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 17 to 25 hours at steady state.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Bioavailability after a single dose is 70%. After multiple dosing, the proportion of mibefradil undergoing first-pass metabolism is reduced, resulting in a steady state bioavailability of approximately 90%. Food does not affect the rate or extent of absorption of mibefradil.

Metabolisme

The two metabolic pathways that mibefradil undergoes are esterase-catalyzed hydrolysis of the ester side chain (producing an alcohol metabolite) and cytochrome P450 3A4-catalyzed oxidation (that becomes less important during chronic dosing). The pharmacologic effect of the metabolite is approximately 10% of that of the parent mibefradil.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1642 Data
Afatinib The serum concentration of Afatinib can be increased when it is combined with Mibefradil.
Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Mibefradil.
Brentuximab vedotin The serum concentration of Brentuximab vedotin can be increased when it is combined with Mibefradil.
Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Mibefradil.
Ledipasvir The serum concentration of Ledipasvir can be increased when it is combined with Mibefradil.
Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Mibefradil.
Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Mibefradil.
Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Mibefradil.
Ranolazine The serum concentration of Ranolazine can be increased when it is combined with Mibefradil.
Silodosin The excretion of Silodosin can be decreased when combined with Mibefradil.
Topotecan The serum concentration of Topotecan can be increased when it is combined with Mibefradil.
Ceritinib Mibefradil may increase the bradycardic activities of Ceritinib.
Ivabradine Mibefradil may increase the bradycardic activities of Ivabradine.
Ruxolitinib Ruxolitinib may increase the bradycardic activities of Mibefradil.
Amifostine Mibefradil may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Mibefradil.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Mibefradil.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Mibefradil.
Obinutuzumab Mibefradil may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Mibefradil.
Rituximab Mibefradil may increase the hypotensive activities of Rituximab.
Desmopressin Desmopressin may decrease the antihypertensive activities of Mibefradil.
Isoetharine Isoetharine may decrease the antihypertensive activities of Mibefradil.
Etomidate Etomidate may decrease the antihypertensive activities of Mibefradil.
Norepinephrine Norepinephrine may decrease the antihypertensive activities of Mibefradil.
Phenylpropanolamine Phenylpropanolamine may decrease the antihypertensive activities of Mibefradil.
Doxapram Doxapram may decrease the antihypertensive activities of Mibefradil.
Metaraminol Metaraminol may decrease the antihypertensive activities of Mibefradil.
Methoxamine Methoxamine may decrease the antihypertensive activities of Mibefradil.
Orciprenaline Orciprenaline may decrease the antihypertensive activities of Mibefradil.
Phenmetrazine Phenmetrazine may decrease the antihypertensive activities of Mibefradil.
Dobutamine Dobutamine may decrease the antihypertensive activities of Mibefradil.
Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Mibefradil.
Ritodrine Ritodrine may decrease the antihypertensive activities of Mibefradil.
Bitolterol Bitolterol may decrease the antihypertensive activities of Mibefradil.
Diethylpropion Diethylpropion may decrease the antihypertensive activities of Mibefradil.
Naratriptan Naratriptan may decrease the antihypertensive activities of Mibefradil.
Rizatriptan Rizatriptan may decrease the antihypertensive activities of Mibefradil.
Dopamine Dopamine may decrease the antihypertensive activities of Mibefradil.
Isoprenaline Isoprenaline may decrease the antihypertensive activities of Mibefradil.
Arbutamine Arbutamine may decrease the antihypertensive activities of Mibefradil.
Fenoterol Fenoterol may decrease the antihypertensive activities of Mibefradil.
Pirbuterol Pirbuterol may decrease the antihypertensive activities of Mibefradil.
Ephedra sinica root Ephedra sinica root may decrease the antihypertensive activities of Mibefradil.
Ephedrine Ephedrine may decrease the antihypertensive activities of Mibefradil.
Mephentermine Mephentermine may decrease the antihypertensive activities of Mibefradil.
Procaterol Procaterol may decrease the antihypertensive activities of Mibefradil.
Clenbuterol Clenbuterol may decrease the antihypertensive activities of Mibefradil.
Bambuterol Bambuterol may decrease the antihypertensive activities of Mibefradil.
MMDA MMDA may decrease the antihypertensive activities of Mibefradil.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Mibefradil.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Mibefradil.
Tenamfetamine Tenamfetamine may decrease the antihypertensive activities of Mibefradil.
Chlorphentermine Chlorphentermine may decrease the antihypertensive activities of Mibefradil.
Phendimetrazine Phendimetrazine may decrease the antihypertensive activities of Mibefradil.
Epicaptopril Epicaptopril may decrease the antihypertensive activities of Mibefradil.
1-benzylimidazole 1-benzylimidazole may decrease the antihypertensive activities of Mibefradil.
Amineptine Amineptine may decrease the antihypertensive activities of Mibefradil.
Amibegron Amibegron may decrease the antihypertensive activities of Mibefradil.
Naluzotan Naluzotan may decrease the antihypertensive activities of Mibefradil.
Solabegron Solabegron may decrease the antihypertensive activities of Mibefradil.
Droxidopa Droxidopa may decrease the antihypertensive activities of Mibefradil.
Nitrous oxide Nitrous oxide may decrease the antihypertensive activities of Mibefradil.
Isometheptene Isometheptene may decrease the antihypertensive activities of Mibefradil.
Levonordefrin Levonordefrin may decrease the antihypertensive activities of Mibefradil.
Naphazoline Naphazoline may decrease the antihypertensive activities of Mibefradil.
Tetryzoline Tetryzoline may decrease the antihypertensive activities of Mibefradil.
Cinitapride Cinitapride may decrease the antihypertensive activities of Mibefradil.
Tyramine Tyramine may decrease the antihypertensive activities of Mibefradil.
Adrafinil Adrafinil may decrease the antihypertensive activities of Mibefradil.
Ifenprodil Ifenprodil may decrease the antihypertensive activities of Mibefradil.
Hexoprenaline Hexoprenaline may decrease the antihypertensive activities of Mibefradil.
Etilefrine Etilefrine may decrease the antihypertensive activities of Mibefradil.
Dimetacrine Dimetacrine may decrease the antihypertensive activities of Mibefradil.
Cirazoline Cirazoline may decrease the antihypertensive activities of Mibefradil.
Synephrine Synephrine may decrease the antihypertensive activities of Mibefradil.
Moxisylyte Moxisylyte may decrease the antihypertensive activities of Mibefradil.
Oxaprotiline Oxaprotiline may decrease the antihypertensive activities of Mibefradil.
Iofetamine I-123 Iofetamine I-123 may decrease the antihypertensive activities of Mibefradil.
Racepinephrine Racepinephrine may decrease the antihypertensive activities of Mibefradil.
DL-Methylephedrine DL-Methylephedrine may decrease the antihypertensive activities of Mibefradil.
Amitraz Amitraz may decrease the antihypertensive activities of Mibefradil.
Medetomidine Medetomidine may decrease the antihypertensive activities of Mibefradil.
Xylazine Xylazine may decrease the antihypertensive activities of Mibefradil.
Atipamezole Atipamezole may decrease the antihypertensive activities of Mibefradil.
Ractopamine Ractopamine may decrease the antihypertensive activities of Mibefradil.
Romifidine Romifidine may decrease the antihypertensive activities of Mibefradil.
Detomidine Detomidine may decrease the antihypertensive activities of Mibefradil.
Etafedrine Etafedrine may decrease the antihypertensive activities of Mibefradil.
Tetrahydrocannabivarin Tetrahydrocannabivarin may decrease the antihypertensive activities of Mibefradil.
PF-00610355 PF-00610355 may decrease the antihypertensive activities of Mibefradil.
Ritobegron Ritobegron may decrease the antihypertensive activities of Mibefradil.
Abediterol Abediterol may decrease the antihypertensive activities of Mibefradil.
Tulobuterol Tulobuterol may decrease the antihypertensive activities of Mibefradil.
Dopexamine Dopexamine may decrease the antihypertensive activities of Mibefradil.
Piclozotan Piclozotan may decrease the antihypertensive activities of Mibefradil.
Idazoxan Idazoxan may decrease the antihypertensive activities of Mibefradil.
Higenamine Higenamine may decrease the antihypertensive activities of Mibefradil.
Reproterol Reproterol may decrease the antihypertensive activities of Mibefradil.
Tramazoline Tramazoline may decrease the antihypertensive activities of Mibefradil.

Target Protein

Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G
Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H
Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C
Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D
Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F
Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I
Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S
Voltage-dependent L-type calcium channel subunit beta-1 CACNB1
Voltage-dependent L-type calcium channel subunit beta-2 CACNB2
Voltage-dependent L-type calcium channel subunit beta-3 CACNB3
Voltage-dependent L-type calcium channel subunit beta-4 CACNB4

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 0 • International brands: 6
International Brands
  • Batenac — Solvay Pharma
  • Befral — Orion
  • Cerate — Asta Medica
  • Posicor — Roche
  • Quota
  • Taxben — Berenguer Infale

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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