Peringatan Keamanan

Side effects include inhibition of bone formation, suppression of calcium absorption delayed wound healing, immune suppression, and hyperglycemia.

Paramethasone

DB01384

small molecule experimental

Deskripsi

A glucocorticoid with the general properties of corticosteroids. It has been used by mouth in the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than hydrocortisone with supplementary fludrocortisone. (From Martindale, The Extra Pharmacopoeia, 30th ed, p737)

Struktur Molekul 2D

Berat 392.4611
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Hepatic.

Rute Eliminasi

Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.

Interaksi Obat

1246 Data
Denosumab The risk or severity of adverse effects can be increased when Denosumab is combined with Paramethasone.
Peginterferon alfa-2a The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Paramethasone.
Interferon alfa-n1 The risk or severity of adverse effects can be increased when Interferon alfa-n1 is combined with Paramethasone.
Interferon alfa-n3 The risk or severity of adverse effects can be increased when Interferon alfa-n3 is combined with Paramethasone.
Peginterferon alfa-2b The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Paramethasone.
Interferon gamma-1b The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Paramethasone.
Interferon alfa-2a The risk or severity of adverse effects can be increased when Interferon alfa-2a is combined with Paramethasone.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Paramethasone.
Pegaspargase The serum concentration of Paramethasone can be increased when it is combined with Pegaspargase.
Interferon beta-1b The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Paramethasone.
Interferon alfacon-1 The risk or severity of adverse effects can be increased when Interferon alfacon-1 is combined with Paramethasone.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Paramethasone.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Paramethasone.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Paramethasone.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Paramethasone.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Paramethasone.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Paramethasone.
Alefacept The risk or severity of adverse effects can be increased when Alefacept is combined with Paramethasone.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Paramethasone.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Paramethasone.
Interferon alfa-2b The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Paramethasone.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Paramethasone.
Phenylalanine The risk or severity of adverse effects can be increased when Phenylalanine is combined with Paramethasone.
Cladribine Paramethasone may increase the immunosuppressive activities of Cladribine.
Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Paramethasone.
Amsacrine The risk or severity of adverse effects can be increased when Amsacrine is combined with Paramethasone.
Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Paramethasone.
Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Paramethasone.
Raltitrexed The risk or severity of adverse effects can be increased when Raltitrexed is combined with Paramethasone.
Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Paramethasone.
Bexarotene The risk or severity of adverse effects can be increased when Bexarotene is combined with Paramethasone.
Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Paramethasone.
Tioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Paramethasone.
Dexrazoxane The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Paramethasone.
Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Paramethasone.
Trifluridine The risk or severity of adverse effects can be increased when Trifluridine is combined with Paramethasone.
Gemcitabine The risk or severity of adverse effects can be increased when Gemcitabine is combined with Paramethasone.
Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Paramethasone.
Chloramphenicol The risk or severity of adverse effects can be increased when Chloramphenicol is combined with Paramethasone.
Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Paramethasone.
Altretamine The risk or severity of adverse effects can be increased when Altretamine is combined with Paramethasone.
Zidovudine The risk or severity of adverse effects can be increased when Zidovudine is combined with Paramethasone.
Oxaliplatin The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Paramethasone.
Fluorouracil The risk or severity of adverse effects can be increased when Fluorouracil is combined with Paramethasone.
Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Paramethasone.
Pentostatin The risk or severity of adverse effects can be increased when Pentostatin is combined with Paramethasone.
Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Paramethasone.
Clofarabine The risk or severity of adverse effects can be increased when Clofarabine is combined with Paramethasone.
Pemetrexed The risk or severity of adverse effects can be increased when Pemetrexed is combined with Paramethasone.
Mycophenolate mofetil The risk or severity of adverse effects can be increased when Mycophenolate mofetil is combined with Paramethasone.
Tretinoin The metabolism of Tretinoin can be increased when combined with Paramethasone.
Dacarbazine The risk or severity of adverse effects can be increased when Dacarbazine is combined with Paramethasone.
Temozolomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Paramethasone.
Penicillamine The risk or severity of adverse effects can be increased when Penicillamine is combined with Paramethasone.
Azacitidine The risk or severity of adverse effects can be increased when Azacitidine is combined with Paramethasone.
Carboplatin The risk or severity of adverse effects can be increased when Carboplatin is combined with Paramethasone.
Dactinomycin The risk or severity of adverse effects can be increased when Dactinomycin is combined with Paramethasone.
Azathioprine The risk or severity of adverse effects can be increased when Azathioprine is combined with Paramethasone.
Hydroxyurea The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Paramethasone.
Mycophenolic acid The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Paramethasone.
Topotecan The risk or severity of adverse effects can be increased when Topotecan is combined with Paramethasone.
Mercaptopurine The risk or severity of adverse effects can be increased when Mercaptopurine is combined with Paramethasone.
Thalidomide The risk or severity of adverse effects can be increased when Thalidomide is combined with Paramethasone.
Melphalan The risk or severity of adverse effects can be increased when Melphalan is combined with Paramethasone.
Fludarabine The risk or severity of adverse effects can be increased when Fludarabine is combined with Paramethasone.
Flucytosine The risk or severity of adverse effects can be increased when Flucytosine is combined with Paramethasone.
Capecitabine The risk or severity of adverse effects can be increased when Capecitabine is combined with Paramethasone.
Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Paramethasone.
Arsenic trioxide The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Paramethasone.
Idarubicin The risk or severity of adverse effects can be increased when Idarubicin is combined with Paramethasone.
Estramustine The risk or severity of adverse effects can be increased when Estramustine is combined with Paramethasone.
Mitoxantrone The risk or severity of adverse effects can be increased when Mitoxantrone is combined with Paramethasone.
Lomustine The risk or severity of adverse effects can be increased when Lomustine is combined with Paramethasone.
Eculizumab The risk or severity of adverse effects can be increased when Eculizumab is combined with Paramethasone.
Decitabine The risk or severity of adverse effects can be increased when Decitabine is combined with Paramethasone.
Nelarabine The risk or severity of adverse effects can be increased when Nelarabine is combined with Paramethasone.
Stepronin The risk or severity of adverse effects can be increased when Paramethasone is combined with Stepronin.
Hydroxychloroquine The risk or severity of adverse effects can be increased when Paramethasone is combined with Hydroxychloroquine.
Castanospermine The risk or severity of adverse effects can be increased when Paramethasone is combined with Castanospermine.
Vorinostat The risk or severity of adverse effects can be increased when Paramethasone is combined with Vorinostat.
2-Methoxyethanol The risk or severity of adverse effects can be increased when Paramethasone is combined with 2-Methoxyethanol.
Brequinar The risk or severity of adverse effects can be increased when Paramethasone is combined with Brequinar.
Pirfenidone The risk or severity of adverse effects can be increased when Paramethasone is combined with Pirfenidone.
Interferon alfa The risk or severity of adverse effects can be increased when Paramethasone is combined with Interferon alfa.
Glatiramer The risk or severity of adverse effects can be increased when Paramethasone is combined with Glatiramer.
Briakinumab The risk or severity of adverse effects can be increased when Paramethasone is combined with Briakinumab.
Human interferon omega-1 The risk or severity of adverse effects can be increased when Paramethasone is combined with Human interferon omega-1.
Mepolizumab The risk or severity of adverse effects can be increased when Paramethasone is combined with Mepolizumab.
Abetimus The risk or severity of adverse effects can be increased when Paramethasone is combined with Abetimus.
Belatacept The risk or severity of adverse effects can be increased when Paramethasone is combined with Belatacept.
Bendamustine The risk or severity of adverse effects can be increased when Paramethasone is combined with Bendamustine.
Pralatrexate The risk or severity of adverse effects can be increased when Paramethasone is combined with Pralatrexate.
Wortmannin The risk or severity of adverse effects can be increased when Paramethasone is combined with Wortmannin.
Eribulin The risk or severity of adverse effects can be increased when Paramethasone is combined with Eribulin.
Belimumab The risk or severity of adverse effects can be increased when Paramethasone is combined with Belimumab.
Teriflunomide The risk or severity of adverse effects can be increased when Paramethasone is combined with Teriflunomide.
Carfilzomib The risk or severity of adverse effects can be increased when Paramethasone is combined with Carfilzomib.
Dimethyl fumarate The risk or severity of adverse effects can be increased when Paramethasone is combined with Dimethyl fumarate.
Obinutuzumab The risk or severity of adverse effects can be increased when Paramethasone is combined with Obinutuzumab.
Vedolizumab The risk or severity of adverse effects can be increased when Paramethasone is combined with Vedolizumab.

Target Protein

Corticosteroid-binding globulin SERPINA6
Glucocorticoid receptor NR3C1

Referensi & Sumber

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