Severe hypoglycemic reactions with coma, seizure, or other neurological impairment.
Glycodiazine is used with diet to lower blood glucose by increasing the secretion of insulin from pancreas and increasing the sensitivity of peripheral tissues to insulin. The mechanism of action of glycodiazine in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells, and increasing sensitivity of peripheral tissues to insulin. Glycodiazine likely binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Membrane depolarization stimulates calcium ion influx through voltage-sensitive calcium channels. This increase in intracellular calcium ion concentration induces the secretion of insulin. It is used for the concomitant use with insulin for the treatment of noninsulin-dependent (type 2) diabetes mellitus.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Pegvisomant | The risk or severity of hypoglycemia can be increased when Pegvisomant is combined with Glymidine. |
| Nicotine | The risk or severity of adverse effects can be increased when Glymidine is combined with Nicotine. |
| Mecamylamine | The risk or severity of adverse effects can be increased when Glymidine is combined with Mecamylamine. |
| Pentolinium | The risk or severity of adverse effects can be increased when Glymidine is combined with Pentolinium. |
| Trimethaphan | The risk or severity of adverse effects can be increased when Glymidine is combined with Trimethaphan. |
| Hexamethonium | The risk or severity of adverse effects can be increased when Glymidine is combined with Hexamethonium. |
| Cyclopentamine | The risk or severity of adverse effects can be increased when Glymidine is combined with Cyclopentamine. |
| Methotrexate | The protein binding of Methotrexate can be increased when combined with Glymidine. |
| Lipoic acid | The risk or severity of hypoglycemia can be increased when Lipoic acid is combined with Glymidine. |
| Moxifloxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Moxifloxacin. |
| Grepafloxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Grepafloxacin. |
| Enoxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Enoxacin. |
| Pefloxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Pefloxacin. |
| Ciprofloxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Ciprofloxacin. |
| Trovafloxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Trovafloxacin. |
| Nalidixic acid | The therapeutic efficacy of Glymidine can be increased when used in combination with Nalidixic acid. |
| Rosoxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Rosoxacin. |
| Cinoxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Cinoxacin. |
| Lomefloxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Lomefloxacin. |
| Gatifloxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Gatifloxacin. |
| Norfloxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Norfloxacin. |
| Levofloxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Levofloxacin. |
| Gemifloxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Gemifloxacin. |
| Ofloxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Ofloxacin. |
| Sparfloxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Sparfloxacin. |
| Temafloxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Temafloxacin. |
| Fleroxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Fleroxacin. |
| Technetium Tc-99m ciprofloxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Technetium Tc-99m ciprofloxacin. |
| Garenoxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Garenoxacin. |
| Nemonoxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Nemonoxacin. |
| Flumequine | The therapeutic efficacy of Glymidine can be increased when used in combination with Flumequine. |
| Enrofloxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Enrofloxacin. |
| Orbifloxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Orbifloxacin. |
| Sarafloxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Sarafloxacin. |
| Difloxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Difloxacin. |
| Pazufloxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Pazufloxacin. |
| Prulifloxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Prulifloxacin. |
| Delafloxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Delafloxacin. |
| Sitafloxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Sitafloxacin. |
| Oxolinic acid | The therapeutic efficacy of Glymidine can be increased when used in combination with Oxolinic acid. |
| Rufloxacin | The therapeutic efficacy of Glymidine can be increased when used in combination with Rufloxacin. |
| Pipemidic acid | The therapeutic efficacy of Glymidine can be increased when used in combination with Pipemidic acid. |
| Methyclothiazide | The therapeutic efficacy of Glymidine can be decreased when used in combination with Methyclothiazide. |
| Chlorthalidone | The therapeutic efficacy of Glymidine can be decreased when used in combination with Chlorthalidone. |
| Bendroflumethiazide | The therapeutic efficacy of Glymidine can be decreased when used in combination with Bendroflumethiazide. |
| Metolazone | The therapeutic efficacy of Glymidine can be decreased when used in combination with Metolazone. |
| Benzthiazide | The therapeutic efficacy of Glymidine can be decreased when used in combination with Benzthiazide. |
| Hydroflumethiazide | The therapeutic efficacy of Glymidine can be decreased when used in combination with Hydroflumethiazide. |
| Indapamide | The therapeutic efficacy of Glymidine can be decreased when used in combination with Indapamide. |
| Chlorothiazide | The therapeutic efficacy of Glymidine can be decreased when used in combination with Chlorothiazide. |
| Hydrochlorothiazide | The therapeutic efficacy of Glymidine can be decreased when used in combination with Hydrochlorothiazide. |
| Trichlormethiazide | The therapeutic efficacy of Glymidine can be decreased when used in combination with Trichlormethiazide. |
| Polythiazide | The therapeutic efficacy of Glymidine can be decreased when used in combination with Polythiazide. |
| Quinethazone | The therapeutic efficacy of Glymidine can be decreased when used in combination with Quinethazone. |
| Cyclopenthiazide | The therapeutic efficacy of Glymidine can be decreased when used in combination with Cyclopenthiazide. |
| Epitizide | The therapeutic efficacy of Glymidine can be decreased when used in combination with Epitizide. |
| Amitriptyline | Amitriptyline may decrease the hypoglycemic activities of Glymidine. |
| Protriptyline | Protriptyline may decrease the hypoglycemic activities of Glymidine. |
| Imipramine | Imipramine may decrease the hypoglycemic activities of Glymidine. |
| Nortriptyline | Nortriptyline may decrease the hypoglycemic activities of Glymidine. |
| Amoxapine | Amoxapine may decrease the hypoglycemic activities of Glymidine. |
| Trimipramine | Trimipramine may decrease the hypoglycemic activities of Glymidine. |
| Doxepin | Doxepin may decrease the hypoglycemic activities of Glymidine. |
| Desipramine | Desipramine may decrease the hypoglycemic activities of Glymidine. |
| Clomipramine | Clomipramine may decrease the hypoglycemic activities of Glymidine. |
| Amineptine | Amineptine may decrease the hypoglycemic activities of Glymidine. |
| Dimetacrine | Dimetacrine may decrease the hypoglycemic activities of Glymidine. |
| Butriptyline | Butriptyline may decrease the hypoglycemic activities of Glymidine. |
| Dosulepin | Dosulepin may decrease the hypoglycemic activities of Glymidine. |
| Tianeptine | Tianeptine may decrease the hypoglycemic activities of Glymidine. |
| Oxaprotiline | Oxaprotiline may decrease the hypoglycemic activities of Glymidine. |
| Opipramol | Opipramol may decrease the hypoglycemic activities of Glymidine. |
| Amitriptylinoxide | Amitriptylinoxide may decrease the hypoglycemic activities of Glymidine. |
| Dibenzepin | Dibenzepin may decrease the hypoglycemic activities of Glymidine. |
| Quinupramine | Quinupramine may decrease the hypoglycemic activities of Glymidine. |
| Melitracen | Melitracen may decrease the hypoglycemic activities of Glymidine. |
| Lofepramine | Lofepramine may decrease the hypoglycemic activities of Glymidine. |
| Iprindole | Iprindole may decrease the hypoglycemic activities of Glymidine. |
| Imipramine oxide | Imipramine oxide may decrease the hypoglycemic activities of Glymidine. |
| Ketoprofen | The risk or severity of adverse effects can be increased when Ketoprofen is combined with Glymidine. |
| Dexketoprofen | The risk or severity of adverse effects can be increased when Dexketoprofen is combined with Glymidine. |
| Cyclosporine | The risk or severity of renal failure can be increased when Glymidine is combined with Cyclosporine. |
| Dapagliflozin | Dapagliflozin may increase the hypoglycemic activities of Glymidine. |
| Canagliflozin | Canagliflozin may increase the hypoglycemic activities of Glymidine. |
| Leuprolide | The therapeutic efficacy of Glymidine can be decreased when used in combination with Leuprolide. |
| Goserelin | The therapeutic efficacy of Glymidine can be decreased when used in combination with Goserelin. |
| Nelfinavir | The therapeutic efficacy of Glymidine can be decreased when used in combination with Nelfinavir. |
| Indinavir | The therapeutic efficacy of Glymidine can be decreased when used in combination with Indinavir. |
| Ziprasidone | The therapeutic efficacy of Glymidine can be decreased when used in combination with Ziprasidone. |
| Etonogestrel | The therapeutic efficacy of Glymidine can be decreased when used in combination with Etonogestrel. |
| Desogestrel | The therapeutic efficacy of Glymidine can be decreased when used in combination with Desogestrel. |
| Olanzapine | The therapeutic efficacy of Glymidine can be decreased when used in combination with Olanzapine. |
| Megestrol acetate | The therapeutic efficacy of Glymidine can be decreased when used in combination with Megestrol acetate. |
| Clozapine | The therapeutic efficacy of Glymidine can be decreased when used in combination with Clozapine. |
| Levonorgestrel | The therapeutic efficacy of Glymidine can be decreased when used in combination with Levonorgestrel. |
| Progesterone | The therapeutic efficacy of Glymidine can be decreased when used in combination with Progesterone. |
| Chlorpromazine | The therapeutic efficacy of Glymidine can be decreased when used in combination with Chlorpromazine. |
| Haloperidol | The therapeutic efficacy of Glymidine can be decreased when used in combination with Haloperidol. |
| Ritonavir | The therapeutic efficacy of Glymidine can be decreased when used in combination with Ritonavir. |
| Piperazine | The therapeutic efficacy of Glymidine can be decreased when used in combination with Piperazine. |