Magnesium oxide

DB01377

small molecule approved

Deskripsi

Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses.

Struktur Molekul 2D

Berat 40.304
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

2 Data
  • 1. Take with food. When using magnesium to treat calcium oxalate nephrolithiasis, magnesium oxide should be taken with food.
  • 2. Take with or without food. Many different products contain magnesium oxide; refer to the product monograph for more specific instruction. Taking magnesium supplements with food may reduce the risk of diarrhea.

Interaksi Obat

736 Data
Succinylcholine The therapeutic efficacy of Succinylcholine can be increased when used in combination with Magnesium oxide.
Metocurine iodide The therapeutic efficacy of Metocurine iodide can be increased when used in combination with Magnesium oxide.
Gallamine triethiodide The therapeutic efficacy of Gallamine triethiodide can be increased when used in combination with Magnesium oxide.
Cisatracurium Magnesium oxide may increase the neuromuscular blocking activities of Cisatracurium.
Rocuronium The therapeutic efficacy of Rocuronium can be increased when used in combination with Magnesium oxide.
Atracurium besylate The therapeutic efficacy of Atracurium besylate can be increased when used in combination with Magnesium oxide.
Doxacurium The therapeutic efficacy of Doxacurium can be increased when used in combination with Magnesium oxide.
Mivacurium The therapeutic efficacy of Mivacurium can be increased when used in combination with Magnesium oxide.
Decamethonium The therapeutic efficacy of Decamethonium can be increased when used in combination with Magnesium oxide.
Metocurine The therapeutic efficacy of Metocurine can be increased when used in combination with Magnesium oxide.
Pancuronium The therapeutic efficacy of Pancuronium can be increased when used in combination with Magnesium oxide.
Pipecuronium The therapeutic efficacy of Pipecuronium can be increased when used in combination with Magnesium oxide.
Vecuronium The therapeutic efficacy of Vecuronium can be increased when used in combination with Magnesium oxide.
Rapacuronium The therapeutic efficacy of Rapacuronium can be increased when used in combination with Magnesium oxide.
Pyrantel The therapeutic efficacy of Pyrantel can be increased when used in combination with Magnesium oxide.
Neosaxitoxin The therapeutic efficacy of Neosaxitoxin can be increased when used in combination with Magnesium oxide.
Atracurium The therapeutic efficacy of Atracurium can be increased when used in combination with Magnesium oxide.
Gallamine The therapeutic efficacy of Gallamine can be increased when used in combination with Magnesium oxide.
Alcuronium The therapeutic efficacy of Alcuronium can be increased when used in combination with Magnesium oxide.
Tubocurarine The therapeutic efficacy of Tubocurarine can be increased when used in combination with Magnesium oxide.
Atazanavir Magnesium oxide can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Bosutinib Magnesium oxide can cause a decrease in the absorption of Bosutinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cefditoren The serum concentration of Cefditoren can be decreased when it is combined with Magnesium oxide.
Dabigatran etexilate Magnesium oxide can cause a decrease in the absorption of Dabigatran etexilate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dabrafenib Magnesium oxide can cause a decrease in the absorption of Dabrafenib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dasatinib Magnesium oxide can cause a decrease in the absorption of Dasatinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Delavirdine Magnesium oxide can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Erlotinib Magnesium oxide can cause a decrease in the absorption of Erlotinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gefitinib Magnesium oxide can cause a decrease in the absorption of Gefitinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Itraconazole Magnesium oxide can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ledipasvir Magnesium oxide can cause a decrease in the absorption of Ledipasvir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Methylphenidate Magnesium oxide can cause an increase in the absorption of Methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.
Pazopanib Magnesium oxide can cause a decrease in the absorption of Pazopanib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Riociguat Magnesium oxide can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcitriol The serum concentration of Magnesium oxide can be increased when it is combined with Calcitriol.
Calcifediol The serum concentration of Magnesium oxide can be increased when it is combined with Calcifediol.
Paricalcitol The serum concentration of Magnesium oxide can be increased when it is combined with Paricalcitol.
Dihydrotachysterol The serum concentration of Magnesium oxide can be increased when it is combined with Dihydrotachysterol.
Alfacalcidol The serum concentration of Magnesium oxide can be increased when it is combined with Alfacalcidol.
Seocalcitol The serum concentration of Magnesium oxide can be increased when it is combined with Seocalcitol.
Inecalcitol The serum concentration of Magnesium oxide can be increased when it is combined with Inecalcitol.
Becocalcidiol The serum concentration of Magnesium oxide can be increased when it is combined with Becocalcidiol.
Eldecalcitol The serum concentration of Magnesium oxide can be increased when it is combined with Eldecalcitol.
1alpha,24S-Dihydroxyvitamin D2 The serum concentration of Magnesium oxide can be increased when it is combined with 1alpha,24S-Dihydroxyvitamin D2.
Elocalcitol The serum concentration of Magnesium oxide can be increased when it is combined with Elocalcitol.
Maxacalcitol The serum concentration of Magnesium oxide can be increased when it is combined with Maxacalcitol.
Doxercalciferol The serum concentration of Magnesium oxide can be increased when it is combined with Doxercalciferol.
1alpha-Hydroxyvitamin D5 The serum concentration of Magnesium oxide can be increased when it is combined with 1alpha-Hydroxyvitamin D5.
Deferiprone Magnesium oxide can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dolutegravir Magnesium oxide can cause a decrease in the absorption of Dolutegravir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Eltrombopag Magnesium oxide can cause a decrease in the absorption of Eltrombopag resulting in a reduced serum concentration and potentially a decrease in efficacy.
Levothyroxine Magnesium oxide can cause a decrease in the absorption of Levothyroxine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tolevamer The risk or severity of adverse effects can be increased when Tolevamer is combined with Magnesium oxide.
Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Magnesium oxide.
Captopril Magnesium oxide can cause a decrease in the absorption of Captopril resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cefpodoxime The serum concentration of Cefpodoxime can be decreased when it is combined with Magnesium oxide.
Cefuroxime The serum concentration of Cefuroxime can be decreased when it is combined with Magnesium oxide.
Chloroquine Magnesium oxide can cause a decrease in the absorption of Chloroquine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Elvitegravir Magnesium oxide can cause a decrease in the absorption of Elvitegravir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gabapentin enacarbil The serum concentration of Gabapentin enacarbil can be decreased when it is combined with Magnesium oxide.
Hyoscyamine Magnesium oxide can cause a decrease in the absorption of Hyoscyamine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rifampin Magnesium oxide can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Mecamylamine Magnesium oxide may decrease the excretion rate of Mecamylamine which could result in a higher serum level.
Memantine Magnesium oxide may decrease the excretion rate of Memantine which could result in a higher serum level.
Penicillamine Magnesium oxide can cause a decrease in the absorption of Penicillamine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Quinidine Magnesium oxide may decrease the excretion rate of Quinidine which could result in a higher serum level.
Quinine Magnesium oxide can cause a decrease in the absorption of Quinine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sotalol The serum concentration of Sotalol can be decreased when it is combined with Magnesium oxide.
Sulpiride The therapeutic efficacy of Sulpiride can be increased when used in combination with Magnesium oxide.
Deferasirox Magnesium oxide can cause a decrease in the absorption of Deferasirox resulting in a reduced serum concentration and potentially a decrease in efficacy.
Allopurinol The therapeutic efficacy of Allopurinol can be decreased when used in combination with Magnesium oxide.
Fexofenadine Magnesium oxide can cause a decrease in the absorption of Fexofenadine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Raltegravir Magnesium oxide can cause a decrease in the absorption of Raltegravir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Halofantrine Magnesium oxide can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Misoprostol The risk or severity of adverse effects can be increased when Magnesium oxide is combined with Misoprostol.
Mesalazine Magnesium oxide can cause a decrease in the absorption of Mesalazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Mycophenolic acid The serum concentration of Mycophenolic acid can be decreased when it is combined with Magnesium oxide.
Cysteamine The bioavailability of Cysteamine can be decreased when combined with Magnesium oxide.
Ketoconazole Magnesium oxide can cause a decrease in the absorption of Ketoconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tramadol The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Tramadol.
Trospium The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Trospium.
Oxyphenonium The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Oxyphenonium.
Benzatropine The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Benzatropine.
Ziprasidone The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Ziprasidone.
Disopyramide The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Disopyramide.
Amitriptyline The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Amitriptyline.
Ipratropium The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Ipratropium.
Olanzapine The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Olanzapine.
Metixene The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Metixene.
Terfenadine The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Terfenadine.
Buclizine The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Buclizine.
Clozapine The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Clozapine.
Doxylamine The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Doxylamine.
Trihexyphenidyl The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Trihexyphenidyl.
Oxyphencyclimine The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Oxyphencyclimine.
Procyclidine The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Procyclidine.
Profenamine The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Profenamine.
Cyproheptadine The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Cyproheptadine.
Imipramine The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Imipramine.
Methscopolamine bromide The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Methscopolamine bromide.

Referensi & Sumber

Synthesis reference: Jajnya D. Panda, Santosh K. Mahapatra, "Process for the production of magnesium oxide from brine or bittern." U.S. Patent US4370422, issued June, 1921.
Artikel (PubMed)
  • PMID: 10930190
    Kh R, Khullar M, Kashyap M, Pandhi P, Uppal R: Effect of oral magnesium supplementation on blood pressure, platelet aggregation and calcium handling in deoxycorticosterone acetate induced hypertension in rats. J Hypertens. 2000 Jul;18(7):919-26.
  • PMID: 10426331
    Shechter M, Merz CN, Paul-Labrador M, Meisel SR, Rude RK, Molloy MD, Dwyer JH, Shah PK, Kaul S: Oral magnesium supplementation inhibits platelet-dependent thrombosis in patients with coronary artery disease. Am J Cardiol. 1999 Jul 15;84(2):152-6.

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