Quinupristin/dalfopristin is a combination of two antibiotics used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome and quinupristin inhibits the late phase of protein synthesis. The combination of the two components acts synergistically and is more effective in vitro than each component alone.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Lomitapide | The metabolism of Lomitapide can be decreased when combined with Quinupristin. |
| Cyclosporine | The serum concentration of Cyclosporine can be increased when it is combined with Quinupristin. |
| Eliglustat | The metabolism of Eliglustat can be decreased when combined with Quinupristin. |
| Ibrutinib | The metabolism of Ibrutinib can be decreased when combined with Quinupristin. |
| Cilostazol | The metabolism of Cilostazol can be decreased when combined with Quinupristin. |
| Colchicine | The metabolism of Colchicine can be decreased when combined with Quinupristin. |
| Iloperidone | The metabolism of Iloperidone can be decreased when combined with Quinupristin. |
| Retapamulin | The metabolism of Retapamulin can be decreased when combined with Quinupristin. |
| Tofacitinib | The metabolism of Tofacitinib can be decreased when combined with Quinupristin. |
| Vardenafil | The metabolism of Vardenafil can be decreased when combined with Quinupristin. |
| Eszopiclone | The metabolism of Eszopiclone can be decreased when combined with Quinupristin. |
| Zopiclone | The metabolism of Zopiclone can be decreased when combined with Quinupristin. |
| Lovastatin | The metabolism of Lovastatin can be decreased when combined with Quinupristin. |
| Alfuzosin | The metabolism of Alfuzosin can be decreased when combined with Quinupristin. |
| Alprazolam | The metabolism of Alprazolam can be decreased when combined with Quinupristin. |
| Warfarin | The serum concentration of Warfarin can be increased when it is combined with Quinupristin. |
| Acenocoumarol | The serum concentration of Acenocoumarol can be increased when it is combined with Quinupristin. |
| (R)-warfarin | The serum concentration of (R)-warfarin can be increased when it is combined with Quinupristin. |
| R,S-Warfarin alcohol | The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Quinupristin. |
| S,R-Warfarin alcohol | The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Quinupristin. |
| (S)-Warfarin | The serum concentration of (S)-Warfarin can be increased when it is combined with Quinupristin. |
| Midazolam | The serum concentration of Midazolam can be increased when it is combined with Quinupristin. |
| Tacrolimus | The serum concentration of Tacrolimus can be increased when it is combined with Quinupristin. |
| Atorvastatin | The metabolism of Atorvastatin can be decreased when combined with Quinupristin. |
| BCG vaccine | The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Quinupristin. |
| Typhoid vaccine | The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Quinupristin. |
| Aripiprazole | The metabolism of Aripiprazole can be decreased when combined with Quinupristin. |
| Aripiprazole lauroxil | The metabolism of Aripiprazole lauroxil can be decreased when combined with Quinupristin. |
| Dicoumarol | The risk or severity of bleeding can be increased when Quinupristin is combined with Dicoumarol. |
| Phenindione | The risk or severity of bleeding can be increased when Quinupristin is combined with Phenindione. |
| Coumarin | The risk or severity of bleeding can be increased when Quinupristin is combined with Coumarin. |
| Tioclomarol | The risk or severity of bleeding can be increased when Quinupristin is combined with Tioclomarol. |
| Ethyl biscoumacetate | The risk or severity of bleeding can be increased when Quinupristin is combined with Ethyl biscoumacetate. |
| Diphenadione | The risk or severity of bleeding can be increased when Quinupristin is combined with Diphenadione. |
| 4-hydroxycoumarin | The risk or severity of bleeding can be increased when Quinupristin is combined with 4-hydroxycoumarin. |
| Fluindione | The risk or severity of bleeding can be increased when Quinupristin is combined with Fluindione. |
| Clorindione | The risk or severity of bleeding can be increased when Quinupristin is combined with Clorindione. |
| Azithromycin | The metabolism of Azithromycin can be decreased when combined with Quinupristin. |
| Ziprasidone | The metabolism of Ziprasidone can be decreased when combined with Quinupristin. |
| Chlorpromazine | The metabolism of Chlorpromazine can be decreased when combined with Quinupristin. |
| Albendazole | The metabolism of Albendazole can be decreased when combined with Quinupristin. |
| Cephalexin | The metabolism of Cephalexin can be decreased when combined with Quinupristin. |
| Doxazosin | The metabolism of Doxazosin can be decreased when combined with Quinupristin. |
| Norethisterone | The metabolism of Norethisterone can be decreased when combined with Quinupristin. |
| Fenofibrate | The metabolism of Fenofibrate can be decreased when combined with Quinupristin. |
| Atazanavir | The metabolism of Atazanavir can be decreased when combined with Quinupristin. |
| Rosuvastatin | The metabolism of Rosuvastatin can be decreased when combined with Quinupristin. |
| Drospirenone | The metabolism of Drospirenone can be decreased when combined with Quinupristin. |
| Allylestrenol | The metabolism of Allylestrenol can be decreased when combined with Quinupristin. |
| Zuclopenthixol | The metabolism of Zuclopenthixol can be decreased when combined with Quinupristin. |
| Roflumilast | The serum concentration of Roflumilast can be increased when it is combined with Quinupristin. |
| Lacosamide | The metabolism of Lacosamide can be decreased when combined with Quinupristin. |
| Linagliptin | The metabolism of Linagliptin can be decreased when combined with Quinupristin. |
| Vorapaxar | The metabolism of Vorapaxar can be decreased when combined with Quinupristin. |
| Suvorexant | The metabolism of Suvorexant can be decreased when combined with Quinupristin. |
| Netupitant | The metabolism of Netupitant can be decreased when combined with Quinupristin. |
| Tasimelteon | The metabolism of Tasimelteon can be decreased when combined with Quinupristin. |
| Nintedanib | The metabolism of Nintedanib can be decreased when combined with Quinupristin. |
| Tenofovir alafenamide | The metabolism of Tenofovir alafenamide can be decreased when combined with Quinupristin. |
| Dihydroergocornine | The metabolism of Dihydroergocornine can be decreased when combined with Quinupristin. |
| Duvelisib | The metabolism of Duvelisib can be decreased when combined with Quinupristin. |
| Gilteritinib | The metabolism of Gilteritinib can be decreased when combined with Quinupristin. |
| 9-aminocamptothecin | The metabolism of 9-aminocamptothecin can be decreased when combined with Quinupristin. |
| Methylprednisone | The metabolism of Methylprednisone can be decreased when combined with Quinupristin. |
| Dihydroergocristine | The metabolism of Dihydroergocristine can be decreased when combined with Quinupristin. |
| Dihydroergocryptine | The metabolism of Dihydroergocryptine can be decreased when combined with Quinupristin. |
| Medical Cannabis | The metabolism of Medical Cannabis can be decreased when combined with Quinupristin. |
| Elexacaftor | The metabolism of Elexacaftor can be decreased when combined with Quinupristin. |
| Fosaprepitant | The metabolism of Fosaprepitant can be decreased when combined with Quinupristin. |
| Lefamulin | The metabolism of Lefamulin can be decreased when combined with Quinupristin. |
| Tazemetostat | The metabolism of Tazemetostat can be decreased when combined with Quinupristin. |
| Methysergide | The metabolism of Methysergide can be decreased when combined with Quinupristin. |
| Meperidine | The metabolism of Meperidine can be decreased when combined with Quinupristin. |
| Ebastine | The metabolism of Ebastine can be decreased when combined with Quinupristin. |
| Terfenadine | The metabolism of Terfenadine can be decreased when combined with Quinupristin. |
| Cisapride | The metabolism of Cisapride can be decreased when combined with Quinupristin. |
| Isavuconazole | The metabolism of Isavuconazole can be decreased when combined with Quinupristin. |
| Pretomanid | The metabolism of Pretomanid can be decreased when combined with Quinupristin. |
| Pimavanserin | The metabolism of Pimavanserin can be decreased when combined with Quinupristin. |
| Infigratinib | The metabolism of Infigratinib can be decreased when combined with Quinupristin. |
| Dofetilide | The metabolism of Dofetilide can be decreased when combined with Quinupristin. |
| Theophylline | The metabolism of Theophylline can be decreased when combined with Quinupristin. |
| Carbamazepine | The metabolism of Carbamazepine can be decreased when combined with Quinupristin. |
| Sirolimus | The metabolism of Sirolimus can be decreased when combined with Quinupristin. |
| Quinidine | The metabolism of Quinidine can be decreased when combined with Quinupristin. |
| Phenprocoumon | The metabolism of Phenprocoumon can be decreased when combined with Quinupristin. |
| Busulfan | The metabolism of Busulfan can be decreased when combined with Quinupristin. |
| Pimozide | The metabolism of Pimozide can be decreased when combined with Quinupristin. |
| Amiodarone | The metabolism of Amiodarone can be decreased when combined with Quinupristin. |
| Aminophylline | The metabolism of Aminophylline can be decreased when combined with Quinupristin. |
| Paclitaxel | The metabolism of Paclitaxel can be decreased when combined with Quinupristin. |
| Dasatinib | The metabolism of Dasatinib can be decreased when combined with Quinupristin. |
| Fosphenytoin | The metabolism of Fosphenytoin can be decreased when combined with Quinupristin. |
| Digitoxin | The metabolism of Digitoxin can be decreased when combined with Quinupristin. |
| Everolimus | The metabolism of Everolimus can be decreased when combined with Quinupristin. |
| Dronedarone | The metabolism of Dronedarone can be decreased when combined with Quinupristin. |
| Cobimetinib | The metabolism of Cobimetinib can be decreased when combined with Quinupristin. |
| Temsirolimus | The metabolism of Temsirolimus can be decreased when combined with Quinupristin. |
| Idelalisib | The metabolism of Idelalisib can be decreased when combined with Quinupristin. |
| Ceritinib | The metabolism of Ceritinib can be decreased when combined with Quinupristin. |