Mephentermine

DB01365

small molecule approved

Deskripsi

A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1248)

Struktur Molekul 2D

Berat 163.2594
Wujud liquid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 17 to 18 hours.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Hepatic, by N-demethylation and then p-hydroxylation.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1020 Data
Valsartan Mephentermine may decrease the antihypertensive activities of Valsartan.
Ramipril Mephentermine may decrease the antihypertensive activities of Ramipril.
Remikiren Mephentermine may decrease the antihypertensive activities of Remikiren.
Torasemide Mephentermine may decrease the antihypertensive activities of Torasemide.
Isradipine Mephentermine may decrease the antihypertensive activities of Isradipine.
Olmesartan Mephentermine may decrease the antihypertensive activities of Olmesartan.
Chlorthalidone Mephentermine may decrease the antihypertensive activities of Chlorthalidone.
Nitroprusside Mephentermine may decrease the antihypertensive activities of Nitroprusside.
Diltiazem Mephentermine may decrease the antihypertensive activities of Diltiazem.
Minoxidil Mephentermine may decrease the antihypertensive activities of Minoxidil.
Treprostinil Mephentermine may decrease the antihypertensive activities of Treprostinil.
Amlodipine Mephentermine may decrease the antihypertensive activities of Amlodipine.
Nimodipine Mephentermine may decrease the antihypertensive activities of Nimodipine.
Nisoldipine Mephentermine may decrease the antihypertensive activities of Nisoldipine.
Bendroflumethiazide Mephentermine may decrease the antihypertensive activities of Bendroflumethiazide.
Fosinopril Mephentermine may decrease the antihypertensive activities of Fosinopril.
Trandolapril Mephentermine may decrease the antihypertensive activities of Trandolapril.
Metolazone Mephentermine may decrease the antihypertensive activities of Metolazone.
Lercanidipine Mephentermine may decrease the antihypertensive activities of Lercanidipine.
Benazepril Mephentermine may decrease the antihypertensive activities of Benazepril.
Bosentan Mephentermine may decrease the antihypertensive activities of Bosentan.
Enalapril Mephentermine may decrease the antihypertensive activities of Enalapril.
Cyclothiazide Mephentermine may decrease the antihypertensive activities of Cyclothiazide.
Candoxatril Mephentermine may decrease the antihypertensive activities of Candoxatril.
Mecamylamine Mephentermine may decrease the antihypertensive activities of Mecamylamine.
Losartan Mephentermine may decrease the antihypertensive activities of Losartan.
Moexipril Mephentermine may decrease the antihypertensive activities of Moexipril.
Eplerenone Mephentermine may decrease the antihypertensive activities of Eplerenone.
Lisinopril Mephentermine may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Mephentermine may decrease the antihypertensive activities of Nitroglycerin.
Metyrosine Mephentermine may decrease the antihypertensive activities of Metyrosine.
Hydroflumethiazide Mephentermine may decrease the antihypertensive activities of Hydroflumethiazide.
Cryptenamine Mephentermine may decrease the antihypertensive activities of Cryptenamine.
Perindopril Mephentermine may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil Mephentermine may decrease the antihypertensive activities of Candesartan cilexetil.
Fenoldopam Mephentermine may decrease the antihypertensive activities of Fenoldopam.
Indapamide Mephentermine may decrease the antihypertensive activities of Indapamide.
Tadalafil Mephentermine may decrease the antihypertensive activities of Tadalafil.
Eprosartan Mephentermine may decrease the antihypertensive activities of Eprosartan.
Chlorothiazide Mephentermine may decrease the antihypertensive activities of Chlorothiazide.
Quinapril Mephentermine may decrease the antihypertensive activities of Quinapril.
Telmisartan Mephentermine may decrease the antihypertensive activities of Telmisartan.
Methyldopa Mephentermine may decrease the antihypertensive activities of Methyldopa.
Hydrochlorothiazide Mephentermine may decrease the antihypertensive activities of Hydrochlorothiazide.
Trichlormethiazide Mephentermine may decrease the antihypertensive activities of Trichlormethiazide.
Irbesartan Mephentermine may decrease the antihypertensive activities of Irbesartan.
Nitrendipine Mephentermine may decrease the antihypertensive activities of Nitrendipine.
Deserpidine Mephentermine may decrease the antihypertensive activities of Deserpidine.
Pentolinium Mephentermine may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Mephentermine may decrease the antihypertensive activities of Trimethaphan.
Diazoxide Mephentermine may decrease the antihypertensive activities of Diazoxide.
Captopril Mephentermine may decrease the antihypertensive activities of Captopril.
Epoprostenol Mephentermine may decrease the antihypertensive activities of Epoprostenol.
Bepridil Mephentermine may decrease the antihypertensive activities of Bepridil.
Hydralazine Mephentermine may decrease the antihypertensive activities of Hydralazine.
Polythiazide Mephentermine may decrease the antihypertensive activities of Polythiazide.
Cilazapril Mephentermine may decrease the antihypertensive activities of Cilazapril.
Saprisartan Mephentermine may decrease the antihypertensive activities of Saprisartan.
Spirapril Mephentermine may decrease the antihypertensive activities of Spirapril.
Mibefradil Mephentermine may decrease the antihypertensive activities of Mibefradil.
Tienilic acid Mephentermine may decrease the antihypertensive activities of Tienilic acid.
Debrisoquine Mephentermine may decrease the antihypertensive activities of Debrisoquine.
Sitaxentan Mephentermine may decrease the antihypertensive activities of Sitaxentan.
Ambrisentan Mephentermine may decrease the antihypertensive activities of Ambrisentan.
Diethylnorspermine Mephentermine may decrease the antihypertensive activities of Diethylnorspermine.
Nilvadipine Mephentermine may decrease the antihypertensive activities of Nilvadipine.
Pinacidil Mephentermine may decrease the antihypertensive activities of Pinacidil.
Temocapril Mephentermine may decrease the antihypertensive activities of Temocapril.
Riociguat Mephentermine may decrease the antihypertensive activities of Riociguat.
Macitentan Mephentermine may decrease the antihypertensive activities of Macitentan.
Hexamethonium Mephentermine may decrease the antihypertensive activities of Hexamethonium.
Aliskiren Mephentermine may decrease the antihypertensive activities of Aliskiren.
Nicorandil Mephentermine may decrease the antihypertensive activities of Nicorandil.
Efonidipine Mephentermine may decrease the antihypertensive activities of Efonidipine.
Lacidipine Mephentermine may decrease the antihypertensive activities of Lacidipine.
Manidipine Mephentermine may decrease the antihypertensive activities of Manidipine.
Rauwolfia serpentina root Mephentermine may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Mephentermine may decrease the antihypertensive activities of Enalaprilat.
Selexipag Mephentermine may decrease the antihypertensive activities of Selexipag.
Angiotensin 1-7 Mephentermine may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Mephentermine may decrease the antihypertensive activities of Imidapril.
BQ-123 Mephentermine may decrease the antihypertensive activities of BQ-123.
Cicletanine Mephentermine may decrease the antihypertensive activities of Cicletanine.
Dihydralazine Mephentermine may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Mephentermine may decrease the antihypertensive activities of Zofenopril.
Guanoxan Mephentermine may decrease the antihypertensive activities of Guanoxan.
Delapril Mephentermine may decrease the antihypertensive activities of Delapril.
Vincamine Mephentermine may decrease the antihypertensive activities of Vincamine.
Linsidomine Mephentermine may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Mephentermine may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Mephentermine may decrease the antihypertensive activities of Tolonidine.
Endralazine Mephentermine may decrease the antihypertensive activities of Endralazine.
Cadralazine Mephentermine may decrease the antihypertensive activities of Cadralazine.
Cyclopenthiazide Mephentermine may decrease the antihypertensive activities of Cyclopenthiazide.
Bietaserpine Mephentermine may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Mephentermine may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Mephentermine may decrease the antihypertensive activities of Methoserpidine.
Guanoclor Mephentermine may decrease the antihypertensive activities of Guanoclor.
Muzolimine Mephentermine may decrease the antihypertensive activities of Muzolimine.
Xipamide Mephentermine may decrease the antihypertensive activities of Xipamide.

Target Protein

Alpha adrenergic receptor ADRA1A
D(2) dopamine receptor DRD2
Beta adrenergic receptor ADRB1

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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