Peringatan Keamanan

Non-ionic radiocontrast agents like iohexol are cytotoxic to renal cells. The toxic effects include apoptosis, cellular energy failure, disruption of calcium homeostasis, and disturbance of tubular cell polarity, and are thought to be linked to oxidative stress.

Iohexol

DB01362

small molecule approved

Deskripsi

Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality.

Struktur Molekul 2D

Berat 821.1379
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Intrathecal half-life is 3.4 hours (mean). Intravascular is approximately 2 hours (with normal renal function).
Volume Distribusi * 350-849 mL/kg
Klirens (Clearance) * 109 mL/min [Adult patients receiving 16-18 ml of iohexol (180 mgI/mL) by lumbar intrathecal injection]

Absorpsi

Small amounts are absorbed through the bladder via intravesical instillation. Following intrauterine instillation, the majority of the medium within the uterine cavity is discharged into the vagina immediately upon termination of procedure. However, any medium retained in the uterine or peritoneal cavity is absorbed systemically within 60 minutes. May not be absorbed for up to 24 hours if tubes are obstructed and dilated.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Iohexol is absorbed from cerebrospinal fluid (CSF) into the bloodstream and is eliminated by renal excretion. No significant metabolism, deiodination, or biotransformation occurs.

Interaksi Obat

93 Data
Aldesleukin The risk of a hypersensitivity reaction to Iohexol is increased when it is combined with Aldesleukin.
Metformin The risk or severity of adverse effects can be increased when Iohexol is combined with Metformin.
Lorazepam The therapeutic efficacy of Lorazepam can be decreased when used in combination with Iohexol.
Pregabalin The therapeutic efficacy of Pregabalin can be decreased when used in combination with Iohexol.
Butalbital The therapeutic efficacy of Butalbital can be decreased when used in combination with Iohexol.
Phenytoin The therapeutic efficacy of Phenytoin can be decreased when used in combination with Iohexol.
Topiramate The therapeutic efficacy of Topiramate can be decreased when used in combination with Iohexol.
Pentobarbital The therapeutic efficacy of Pentobarbital can be decreased when used in combination with Iohexol.
Valproic acid The therapeutic efficacy of Valproic acid can be decreased when used in combination with Iohexol.
Trimethadione The therapeutic efficacy of Trimethadione can be decreased when used in combination with Iohexol.
Clobazam The therapeutic efficacy of Clobazam can be decreased when used in combination with Iohexol.
Secobarbital The therapeutic efficacy of Secobarbital can be decreased when used in combination with Iohexol.
Metharbital The therapeutic efficacy of Metharbital can be decreased when used in combination with Iohexol.
Methohexital The therapeutic efficacy of Methohexital can be decreased when used in combination with Iohexol.
Mephenytoin The therapeutic efficacy of Mephenytoin can be decreased when used in combination with Iohexol.
Lamotrigine The therapeutic efficacy of Lamotrigine can be decreased when used in combination with Iohexol.
Carbamazepine The therapeutic efficacy of Carbamazepine can be decreased when used in combination with Iohexol.
Ethosuximide The therapeutic efficacy of Ethosuximide can be decreased when used in combination with Iohexol.
Thiopental The therapeutic efficacy of Thiopental can be decreased when used in combination with Iohexol.
Paramethadione The therapeutic efficacy of Paramethadione can be decreased when used in combination with Iohexol.
Clorazepic acid The therapeutic efficacy of Clorazepic acid can be decreased when used in combination with Iohexol.
Magnesium sulfate The therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Iohexol.
Tizanidine The therapeutic efficacy of Tizanidine can be decreased when used in combination with Iohexol.
Riluzole The therapeutic efficacy of Riluzole can be decreased when used in combination with Iohexol.
Ethotoin The therapeutic efficacy of Ethotoin can be decreased when used in combination with Iohexol.
Oxcarbazepine The therapeutic efficacy of Oxcarbazepine can be decreased when used in combination with Iohexol.
Primidone The therapeutic efficacy of Primidone can be decreased when used in combination with Iohexol.
Acetazolamide The therapeutic efficacy of Acetazolamide can be decreased when used in combination with Iohexol.
Diazepam The therapeutic efficacy of Diazepam can be decreased when used in combination with Iohexol.
Phensuximide The therapeutic efficacy of Phensuximide can be decreased when used in combination with Iohexol.
Progabide The therapeutic efficacy of Progabide can be decreased when used in combination with Iohexol.
Methylphenobarbital The therapeutic efficacy of Methylphenobarbital can be decreased when used in combination with Iohexol.
Tiagabine The therapeutic efficacy of Tiagabine can be decreased when used in combination with Iohexol.
Zonisamide The therapeutic efficacy of Zonisamide can be decreased when used in combination with Iohexol.
Felbamate The therapeutic efficacy of Felbamate can be decreased when used in combination with Iohexol.
Zaleplon The therapeutic efficacy of Zaleplon can be decreased when used in combination with Iohexol.
Gabapentin The therapeutic efficacy of Gabapentin can be decreased when used in combination with Iohexol.
Clonazepam The therapeutic efficacy of Clonazepam can be decreased when used in combination with Iohexol.
Vigabatrin The therapeutic efficacy of Vigabatrin can be decreased when used in combination with Iohexol.
Phenacemide The therapeutic efficacy of Phenacemide can be decreased when used in combination with Iohexol.
Thiamylal The therapeutic efficacy of Thiamylal can be decreased when used in combination with Iohexol.
Phenobarbital The therapeutic efficacy of Phenobarbital can be decreased when used in combination with Iohexol.
Levetiracetam The therapeutic efficacy of Levetiracetam can be decreased when used in combination with Iohexol.
Estazolam The therapeutic efficacy of Estazolam can be decreased when used in combination with Iohexol.
Fosphenytoin The therapeutic efficacy of Fosphenytoin can be decreased when used in combination with Iohexol.
Amobarbital The therapeutic efficacy of Amobarbital can be decreased when used in combination with Iohexol.
Hexobarbital The therapeutic efficacy of Hexobarbital can be decreased when used in combination with Iohexol.
Barbital The therapeutic efficacy of Barbital can be decreased when used in combination with Iohexol.
Delorazepam The therapeutic efficacy of Delorazepam can be decreased when used in combination with Iohexol.
Nitrazepam The therapeutic efficacy of Nitrazepam can be decreased when used in combination with Iohexol.
7-Nitroindazole The therapeutic efficacy of 7-Nitroindazole can be decreased when used in combination with Iohexol.
Valpromide The therapeutic efficacy of Valpromide can be decreased when used in combination with Iohexol.
Flunarizine The therapeutic efficacy of Flunarizine can be decreased when used in combination with Iohexol.
Ezogabine The therapeutic efficacy of Ezogabine can be decreased when used in combination with Iohexol.
Methsuximide The therapeutic efficacy of Methsuximide can be decreased when used in combination with Iohexol.
Brivaracetam The therapeutic efficacy of Brivaracetam can be decreased when used in combination with Iohexol.
Rufinamide The therapeutic efficacy of Rufinamide can be decreased when used in combination with Iohexol.
Lacosamide The therapeutic efficacy of Lacosamide can be decreased when used in combination with Iohexol.
Remacemide The therapeutic efficacy of Remacemide can be decreased when used in combination with Iohexol.
Clomethiazole The therapeutic efficacy of Clomethiazole can be decreased when used in combination with Iohexol.
Deramciclane The therapeutic efficacy of Deramciclane can be decreased when used in combination with Iohexol.
Tramiprosate The therapeutic efficacy of Tramiprosate can be decreased when used in combination with Iohexol.
Gaboxadol The therapeutic efficacy of Gaboxadol can be decreased when used in combination with Iohexol.
Sulthiame The therapeutic efficacy of Sulthiame can be decreased when used in combination with Iohexol.
Perampanel The therapeutic efficacy of Perampanel can be decreased when used in combination with Iohexol.
Ifenprodil The therapeutic efficacy of Ifenprodil can be decreased when used in combination with Iohexol.
Barbexaclone The therapeutic efficacy of Barbexaclone can be decreased when used in combination with Iohexol.
Beclamide The therapeutic efficacy of Beclamide can be decreased when used in combination with Iohexol.
Cannabidiol The therapeutic efficacy of Cannabidiol can be decreased when used in combination with Iohexol.
Paraldehyde The therapeutic efficacy of Paraldehyde can be decreased when used in combination with Iohexol.
Stiripentol The therapeutic efficacy of Stiripentol can be decreased when used in combination with Iohexol.
Eslicarbazepine acetate The therapeutic efficacy of Eslicarbazepine acetate can be decreased when used in combination with Iohexol.
Doramectin The therapeutic efficacy of Doramectin can be decreased when used in combination with Iohexol.
Tiletamine The therapeutic efficacy of Tiletamine can be decreased when used in combination with Iohexol.
Brexanolone The therapeutic efficacy of Brexanolone can be decreased when used in combination with Iohexol.
Etiracetam The therapeutic efficacy of Etiracetam can be decreased when used in combination with Iohexol.
Vinpocetine The therapeutic efficacy of Vinpocetine can be decreased when used in combination with Iohexol.
Carisbamate The therapeutic efficacy of Carisbamate can be decreased when used in combination with Iohexol.
Pheneturide The therapeutic efficacy of Pheneturide can be decreased when used in combination with Iohexol.
Neocitrullamon The therapeutic efficacy of Neocitrullamon can be decreased when used in combination with Iohexol.
Medazepam The therapeutic efficacy of Medazepam can be decreased when used in combination with Iohexol.
Phenibut The therapeutic efficacy of Phenibut can be decreased when used in combination with Iohexol.
Ethadione The therapeutic efficacy of Ethadione can be decreased when used in combination with Iohexol.
Cannabidivarin The therapeutic efficacy of Cannabidivarin can be decreased when used in combination with Iohexol.
Eslicarbazepine The therapeutic efficacy of Eslicarbazepine can be decreased when used in combination with Iohexol.
JNJ-26489112 The therapeutic efficacy of JNJ-26489112 can be decreased when used in combination with Iohexol.
Cenobamate The therapeutic efficacy of Cenobamate can be decreased when used in combination with Iohexol.
Amifampridine The risk or severity of seizure can be increased when Iohexol is combined with Amifampridine.
Dalfampridine The risk or severity of seizure can be increased when Iohexol is combined with Dalfampridine.
Bupropion The risk or severity of seizure can be increased when Bupropion is combined with Iohexol.
Fenfluramine The therapeutic efficacy of Fenfluramine can be decreased when used in combination with Iohexol.
Ganaxolone The therapeutic efficacy of Ganaxolone can be decreased when used in combination with Iohexol.
Hydroxychloroquine The risk or severity of seizure can be increased when Hydroxychloroquine is combined with Iohexol.

Referensi & Sumber

Synthesis reference: Xiu C. Wang, Steve A. Chamberlin, Ashok V. Bhatia, Gregg E. Robinson, John Hufnagel, "Process for the preparation of iohexol." U.S. Patent US5705692, issued December, 1985.
Artikel (PubMed)
  • PMID: 3896713
    Kawada TK: Iohexol and iopamidol: second-generation nonionic radiographic contrast media. Drug Intell Clin Pharm. 1985 Jul-Aug;19(7-8):525-9.
  • PMID: 3882609
    Shaw DD, Potts DG: Toxicology of iohexol. Invest Radiol. 1985 Jan-Feb;20(1 Suppl):S10-3.

Contoh Produk & Brand

Produk: 25 • International brands: 2
Produk
  • Betalido-C
    Injection, solution; Injection, suspension; Kit; Solution; Swab • - • Infiltration; Intra-articular; Intralesional; Intramuscular; Intrathecal; Intravascular; Intravenous; Topical • US
  • BL-Contrast
    Kit • - • Infiltration; Intra-articular; Intralesional; Intramuscular; Intrathecal; Intravascular; Intravenous; Perineural; Topical • US
  • Dexlido M-C
    Injection, solution; Kit; Solution; Swab • - • Epidural; Infiltration; Intra-articular; Intracaudal; Intramuscular; Intrathecal; Intravascular; Intravenous; Perineural; Topical • US
  • Dyural 80 LM-C
    Injection, solution; Injection, suspension; Kit; Solution; Swab • - • Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intrathecal; Intravascular; Intravenous; Perineural; Soft tissue; Topical • US
  • Dyural LM- C
    Injection, solution; Injection, suspension; Kit; Solution; Swab • - • Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intrasynovial; Intrathecal; Intravascular; Intravenous; Perineural; Soft tissue; Topical • US
  • Mlk F4-C
    Injection, solution; Injection, suspension; Kit; Solution; Swab • - • Epidural; Infiltration; Intra-articular; Intramuscular; Intrathecal; Intravascular; Intravenous; Perineural; Topical • US
  • Omnipaque
    Solution • 388.3 mg/1mL • Intravenous • US • Approved
  • Omnipaque
    Solution • 518 mg/1mL • Intravenous • US • Approved
Menampilkan 8 dari 25 produk.
International Brands
  • Histodenz — Sigma
  • Nycodenz

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